Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HFK6_LEIBR

TriTrypDb:

LbrM.27.0910 , LBRM2903_270015000

Length:

869

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 9
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HFK6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HFK6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	825	829	PF00656	0.608
CLV_NRD_NRD_1	222	224	PF00675	0.513
CLV_NRD_NRD_1	411	413	PF00675	0.448
CLV_NRD_NRD_1	61	63	PF00675	0.472
CLV_NRD_NRD_1	7	9	PF00675	0.570
CLV_NRD_NRD_1	800	802	PF00675	0.508
CLV_PCSK_KEX2_1	222	224	PF00082	0.498
CLV_PCSK_KEX2_1	411	413	PF00082	0.443
CLV_PCSK_KEX2_1	43	45	PF00082	0.570
CLV_PCSK_KEX2_1	6	8	PF00082	0.598
CLV_PCSK_KEX2_1	61	63	PF00082	0.364
CLV_PCSK_KEX2_1	800	802	PF00082	0.508
CLV_PCSK_KEX2_1	826	828	PF00082	0.502
CLV_PCSK_PC1ET2_1	43	45	PF00082	0.472
CLV_PCSK_PC1ET2_1	826	828	PF00082	0.502
CLV_PCSK_PC7_1	3	9	PF00082	0.406
CLV_PCSK_SKI1_1	155	159	PF00082	0.331
CLV_PCSK_SKI1_1	181	185	PF00082	0.376
CLV_PCSK_SKI1_1	222	226	PF00082	0.461
CLV_PCSK_SKI1_1	246	250	PF00082	0.413
CLV_PCSK_SKI1_1	265	269	PF00082	0.226
CLV_PCSK_SKI1_1	43	47	PF00082	0.448
CLV_PCSK_SKI1_1	516	520	PF00082	0.494
CLV_PCSK_SKI1_1	524	528	PF00082	0.570
CLV_PCSK_SKI1_1	559	563	PF00082	0.378
CLV_PCSK_SKI1_1	69	73	PF00082	0.493
CLV_PCSK_SKI1_1	800	804	PF00082	0.509
DEG_APCC_DBOX_1	5	13	PF00400	0.561
DEG_APCC_DBOX_1	68	76	PF00400	0.477
DEG_APCC_DBOX_1	768	776	PF00400	0.295
DEG_MDM2_SWIB_1	274	281	PF02201	0.272
DEG_Nend_Nbox_1	1	3	PF02207	0.476
DEG_SPOP_SBC_1	639	643	PF00917	0.468
DEG_SPOP_SBC_1	757	761	PF00917	0.452
DEG_SPOP_SBC_1	811	815	PF00917	0.545
DOC_CKS1_1	792	797	PF01111	0.453
DOC_CYCLIN_RxL_1	259	272	PF00134	0.245
DOC_CYCLIN_RxL_1	360	369	PF00134	0.425
DOC_CYCLIN_yClb1_LxF_4	242	248	PF00134	0.387
DOC_CYCLIN_yCln2_LP_2	295	301	PF00134	0.378
DOC_MAPK_gen_1	3	11	PF00069	0.538
DOC_MAPK_gen_1	43	53	PF00069	0.570
DOC_MAPK_gen_1	462	472	PF00069	0.471
DOC_MAPK_gen_1	541	549	PF00069	0.323
DOC_MAPK_gen_1	826	832	PF00069	0.492
DOC_MAPK_MEF2A_6	383	390	PF00069	0.538
DOC_MAPK_NFAT4_5	383	391	PF00069	0.423
DOC_PP1_RVXF_1	142	148	PF00149	0.365
DOC_PP1_RVXF_1	153	159	PF00149	0.329
DOC_PP1_SILK_1	512	517	PF00149	0.413
DOC_PP2B_LxvP_1	295	298	PF13499	0.487
DOC_PP2B_LxvP_1	783	786	PF13499	0.360
DOC_PP4_FxxP_1	659	662	PF00568	0.473
DOC_PP4_FxxP_1	803	806	PF00568	0.536
DOC_USP7_MATH_1	118	122	PF00917	0.395
DOC_USP7_MATH_1	189	193	PF00917	0.652
DOC_USP7_MATH_1	233	237	PF00917	0.382
DOC_USP7_MATH_1	304	308	PF00917	0.698
DOC_USP7_MATH_1	510	514	PF00917	0.526
DOC_USP7_MATH_1	566	570	PF00917	0.457
DOC_USP7_MATH_1	640	644	PF00917	0.512
DOC_USP7_MATH_1	90	94	PF00917	0.503
DOC_USP7_UBL2_3	43	47	PF12436	0.522
DOC_WW_Pin1_4	114	119	PF00397	0.441
DOC_WW_Pin1_4	343	348	PF00397	0.644
DOC_WW_Pin1_4	435	440	PF00397	0.326
DOC_WW_Pin1_4	715	720	PF00397	0.518
DOC_WW_Pin1_4	791	796	PF00397	0.434
LIG_14-3-3_CanoR_1	144	153	PF00244	0.426
LIG_14-3-3_CanoR_1	433	439	PF00244	0.440
LIG_14-3-3_CanoR_1	44	54	PF00244	0.482
LIG_14-3-3_CanoR_1	599	603	PF00244	0.498
LIG_14-3-3_CanoR_1	61	71	PF00244	0.379
LIG_14-3-3_CanoR_1	650	654	PF00244	0.329
LIG_14-3-3_CanoR_1	769	773	PF00244	0.411
LIG_14-3-3_CanoR_1	89	95	PF00244	0.285
LIG_Actin_WH2_1	241	258	PF00022	0.459
LIG_Actin_WH2_2	233	248	PF00022	0.429
LIG_Actin_WH2_2	400	416	PF00022	0.409
LIG_Actin_WH2_2	447	464	PF00022	0.352
LIG_Actin_WH2_2	486	502	PF00022	0.412
LIG_Actin_WH2_2	511	529	PF00022	0.493
LIG_Actin_WH2_2	545	561	PF00022	0.396
LIG_Actin_WH2_2	580	598	PF00022	0.391
LIG_APCC_ABBA_1	656	661	PF00400	0.473
LIG_BIR_III_2	533	537	PF00653	0.416
LIG_BRCT_BRCA1_1	348	352	PF00533	0.528
LIG_Clathr_ClatBox_1	732	736	PF01394	0.302
LIG_DCNL_PONY_1	1	4	PF03556	0.613
LIG_deltaCOP1_diTrp_1	180	186	PF00928	0.411
LIG_FHA_1	32	38	PF00498	0.473
LIG_FHA_1	418	424	PF00498	0.511
LIG_FHA_1	425	431	PF00498	0.511
LIG_FHA_1	521	527	PF00498	0.373
LIG_FHA_1	818	824	PF00498	0.497
LIG_FHA_1	831	837	PF00498	0.341
LIG_FHA_2	131	137	PF00498	0.420
LIG_FHA_2	462	468	PF00498	0.467
LIG_FHA_2	55	61	PF00498	0.444
LIG_FHA_2	599	605	PF00498	0.482
LIG_FHA_2	757	763	PF00498	0.552
LIG_FHA_2	792	798	PF00498	0.467
LIG_GBD_Chelix_1	583	591	PF00786	0.451
LIG_LIR_Apic_2	550	554	PF02991	0.383
LIG_LIR_Gen_1	162	173	PF02991	0.459
LIG_LIR_Gen_1	180	189	PF02991	0.411
LIG_LIR_Gen_1	272	281	PF02991	0.502
LIG_LIR_Gen_1	355	366	PF02991	0.249
LIG_LIR_Gen_1	467	474	PF02991	0.438
LIG_LIR_Gen_1	736	742	PF02991	0.409
LIG_LIR_Gen_1	78	88	PF02991	0.348
LIG_LIR_Nem_3	136	141	PF02991	0.348
LIG_LIR_Nem_3	162	168	PF02991	0.470
LIG_LIR_Nem_3	180	185	PF02991	0.363
LIG_LIR_Nem_3	272	277	PF02991	0.451
LIG_LIR_Nem_3	283	287	PF02991	0.493
LIG_LIR_Nem_3	355	361	PF02991	0.480
LIG_LIR_Nem_3	467	472	PF02991	0.327
LIG_LIR_Nem_3	533	538	PF02991	0.392
LIG_LIR_Nem_3	678	683	PF02991	0.431
LIG_LIR_Nem_3	736	740	PF02991	0.365
LIG_LIR_Nem_3	78	84	PF02991	0.334
LIG_LYPXL_S_1	137	141	PF13949	0.391
LIG_LYPXL_yS_3	138	141	PF13949	0.396
LIG_LYPXL_yS_3	284	287	PF13949	0.432
LIG_NRBOX	23	29	PF00104	0.467
LIG_NRBOX	728	734	PF00104	0.344
LIG_Pex14_1	182	186	PF04695	0.384
LIG_Pex14_2	270	274	PF04695	0.393
LIG_Rb_LxCxE_1	622	641	PF01857	0.334
LIG_REV1ctd_RIR_1	850	860	PF16727	0.510
LIG_SH2_PTP2	551	554	PF00017	0.394
LIG_SH2_SRC	551	554	PF00017	0.394
LIG_SH2_STAP1	358	362	PF00017	0.246
LIG_SH2_STAP1	522	526	PF00017	0.398
LIG_SH2_STAT3	332	335	PF00017	0.487
LIG_SH2_STAT3	522	525	PF00017	0.446
LIG_SH2_STAT5	126	129	PF00017	0.460
LIG_SH2_STAT5	217	220	PF00017	0.423
LIG_SH2_STAT5	314	317	PF00017	0.485
LIG_SH2_STAT5	522	525	PF00017	0.308
LIG_SH2_STAT5	538	541	PF00017	0.453
LIG_SH2_STAT5	551	554	PF00017	0.434
LIG_SH2_STAT5	779	782	PF00017	0.407
LIG_SH3_1	789	795	PF00018	0.302
LIG_SH3_3	169	175	PF00018	0.452
LIG_SH3_3	614	620	PF00018	0.405
LIG_SH3_3	789	795	PF00018	0.302
LIG_SH3_3	840	846	PF00018	0.480
LIG_Sin3_3	81	88	PF02671	0.360
LIG_SUMO_SIM_anti_2	819	825	PF11976	0.496
LIG_SUMO_SIM_par_1	138	143	PF11976	0.458
LIG_SUMO_SIM_par_1	819	825	PF11976	0.486
LIG_TYR_ITIM	356	361	PF00017	0.479
LIG_UBA3_1	123	129	PF00899	0.333
LIG_UBA3_1	206	212	PF00899	0.275
MOD_CK1_1	346	352	PF00069	0.665
MOD_CK1_1	373	379	PF00069	0.593
MOD_CK1_1	416	422	PF00069	0.434
MOD_CK1_1	482	488	PF00069	0.514
MOD_CK1_1	626	632	PF00069	0.560
MOD_CK1_1	642	648	PF00069	0.455
MOD_CK1_1	715	721	PF00069	0.508
MOD_CK1_1	758	764	PF00069	0.628
MOD_CK1_1	810	816	PF00069	0.504
MOD_CK2_1	130	136	PF00069	0.423
MOD_CK2_1	146	152	PF00069	0.353
MOD_CK2_1	434	440	PF00069	0.481
MOD_CK2_1	598	604	PF00069	0.480
MOD_CK2_1	648	654	PF00069	0.332
MOD_Cter_Amidation	4	7	PF01082	0.567
MOD_GlcNHglycan	162	165	PF01048	0.430
MOD_GlcNHglycan	252	255	PF01048	0.271
MOD_GlcNHglycan	292	295	PF01048	0.528
MOD_GlcNHglycan	348	351	PF01048	0.536
MOD_GlcNHglycan	375	378	PF01048	0.578
MOD_GlcNHglycan	564	567	PF01048	0.502
MOD_GlcNHglycan	689	692	PF01048	0.490
MOD_GlcNHglycan	729	732	PF01048	0.380
MOD_GlcNHglycan	752	755	PF01048	0.518
MOD_GlcNHglycan	783	786	PF01048	0.470
MOD_GlcNHglycan	807	810	PF01048	0.612
MOD_GSK3_1	114	121	PF00069	0.352
MOD_GSK3_1	15	22	PF00069	0.410
MOD_GSK3_1	189	196	PF00069	0.593
MOD_GSK3_1	299	306	PF00069	0.644
MOD_GSK3_1	373	380	PF00069	0.460
MOD_GSK3_1	413	420	PF00069	0.466
MOD_GSK3_1	424	431	PF00069	0.385
MOD_GSK3_1	468	475	PF00069	0.420
MOD_GSK3_1	510	517	PF00069	0.432
MOD_GSK3_1	562	569	PF00069	0.523
MOD_GSK3_1	585	592	PF00069	0.481
MOD_GSK3_1	619	626	PF00069	0.272
MOD_GSK3_1	638	645	PF00069	0.550
MOD_GSK3_1	687	694	PF00069	0.428
MOD_GSK3_1	781	788	PF00069	0.367
MOD_GSK3_1	807	814	PF00069	0.553
MOD_GSK3_1	90	97	PF00069	0.278
MOD_N-GLC_1	145	150	PF02516	0.448
MOD_N-GLC_1	250	255	PF02516	0.387
MOD_N-GLC_1	302	307	PF02516	0.420
MOD_N-GLC_1	31	36	PF02516	0.493
MOD_N-GLC_1	63	68	PF02516	0.494
MOD_NEK2_1	145	150	PF00069	0.437
MOD_NEK2_1	160	165	PF00069	0.523
MOD_NEK2_1	210	215	PF00069	0.395
MOD_NEK2_1	28	33	PF00069	0.407
MOD_NEK2_1	354	359	PF00069	0.485
MOD_NEK2_1	434	439	PF00069	0.564
MOD_NEK2_1	461	466	PF00069	0.455
MOD_NEK2_1	499	504	PF00069	0.455
MOD_NEK2_1	585	590	PF00069	0.375
MOD_NEK2_1	687	692	PF00069	0.428
MOD_NEK2_1	787	792	PF00069	0.360
MOD_NEK2_1	807	812	PF00069	0.624
MOD_NEK2_1	838	843	PF00069	0.556
MOD_NEK2_1	94	99	PF00069	0.312
MOD_NEK2_2	566	571	PF00069	0.347
MOD_PIKK_1	375	381	PF00454	0.469
MOD_PIKK_1	741	747	PF00454	0.466
MOD_PK_1	856	862	PF00069	0.532
MOD_PKA_1	222	228	PF00069	0.484
MOD_PKA_2	222	228	PF00069	0.429
MOD_PKA_2	413	419	PF00069	0.397
MOD_PKA_2	432	438	PF00069	0.408
MOD_PKA_2	461	467	PF00069	0.460
MOD_PKA_2	502	508	PF00069	0.500
MOD_PKA_2	570	576	PF00069	0.470
MOD_PKA_2	598	604	PF00069	0.575
MOD_PKA_2	649	655	PF00069	0.319
MOD_PKA_2	687	693	PF00069	0.361
MOD_PKA_2	768	774	PF00069	0.307
MOD_PKB_1	412	420	PF00069	0.332
MOD_Plk_1	145	151	PF00069	0.350
MOD_Plk_1	250	256	PF00069	0.405
MOD_Plk_1	354	360	PF00069	0.494
MOD_Plk_1	566	572	PF00069	0.517
MOD_Plk_1	626	632	PF00069	0.455
MOD_Plk_1	767	773	PF00069	0.329
MOD_Plk_4	402	408	PF00069	0.500
MOD_Plk_4	468	474	PF00069	0.427
MOD_Plk_4	488	494	PF00069	0.384
MOD_Plk_4	510	516	PF00069	0.460
MOD_Plk_4	817	823	PF00069	0.459
MOD_Plk_4	838	844	PF00069	0.537
MOD_Plk_4	856	862	PF00069	0.435
MOD_Plk_4	90	96	PF00069	0.397
MOD_ProDKin_1	114	120	PF00069	0.433
MOD_ProDKin_1	343	349	PF00069	0.636
MOD_ProDKin_1	435	441	PF00069	0.328
MOD_ProDKin_1	715	721	PF00069	0.514
MOD_ProDKin_1	791	797	PF00069	0.435
MOD_SUMO_for_1	46	49	PF00179	0.460
MOD_SUMO_rev_2	758	765	PF00179	0.559
TRG_DiLeu_BaEn_1	180	185	PF01217	0.287
TRG_DiLeu_BaEn_1	235	240	PF01217	0.516
TRG_DiLeu_BaEn_1	276	281	PF01217	0.278
TRG_DiLeu_BaEn_1	682	687	PF01217	0.418
TRG_DiLeu_BaEn_2	40	46	PF01217	0.526
TRG_DiLeu_BaLyEn_6	363	368	PF01217	0.419
TRG_ENDOCYTIC_2	138	141	PF00928	0.352
TRG_ENDOCYTIC_2	284	287	PF00928	0.482
TRG_ENDOCYTIC_2	358	361	PF00928	0.476
TRG_ENDOCYTIC_2	737	740	PF00928	0.414
TRG_ENDOCYTIC_2	779	782	PF00928	0.357
TRG_ER_diArg_1	108	111	PF00400	0.448
TRG_ER_diArg_1	410	412	PF00400	0.384
TRG_ER_diArg_1	6	8	PF00400	0.487
TRG_ER_diArg_1	799	801	PF00400	0.507
TRG_NES_CRM1_1	453	467	PF08389	0.352
TRG_Pf-PMV_PEXEL_1	246	250	PF00026	0.401
TRG_Pf-PMV_PEXEL_1	44	49	PF00026	0.460
TRG_Pf-PMV_PEXEL_1	607	611	PF00026	0.351
TRG_Pf-PMV_PEXEL_1	800	804	PF00026	0.458

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PC39	Leptomonas seymouri	49%	99%
A0A1X0P545	Trypanosomatidae	33%	99%
A0A3R7KBK6	Trypanosoma rangeli	34%	100%
A0A3S7X0J4	Leishmania donovani	80%	100%
A4I2N8	Leishmania infantum	79%	100%
D0A5T2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	100%
E9AD61	Leishmania major	79%	100%
E9AYY6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	100%
V5BE63	Trypanosoma cruzi	35%	100%