Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HFK5_LEIBR

TriTrypDb:

LbrM.27.0900 , LBRM2903_270014900

Length:

476

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HFK5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HFK5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	19	21	PF00675	0.720
CLV_NRD_NRD_1	296	298	PF00675	0.618
CLV_NRD_NRD_1	392	394	PF00675	0.540
CLV_NRD_NRD_1	395	397	PF00675	0.566
CLV_NRD_NRD_1	461	463	PF00675	0.539
CLV_NRD_NRD_1	473	475	PF00675	0.592
CLV_NRD_NRD_1	78	80	PF00675	0.562
CLV_PCSK_FUR_1	393	397	PF00082	0.553
CLV_PCSK_KEX2_1	122	124	PF00082	0.705
CLV_PCSK_KEX2_1	19	21	PF00082	0.720
CLV_PCSK_KEX2_1	298	300	PF00082	0.616
CLV_PCSK_KEX2_1	394	396	PF00082	0.558
CLV_PCSK_KEX2_1	460	462	PF00082	0.542
CLV_PCSK_KEX2_1	472	474	PF00082	0.680
CLV_PCSK_KEX2_1	78	80	PF00082	0.697
CLV_PCSK_PC1ET2_1	122	124	PF00082	0.705
CLV_PCSK_PC1ET2_1	298	300	PF00082	0.616
CLV_PCSK_PC1ET2_1	394	396	PF00082	0.558
CLV_PCSK_SKI1_1	122	126	PF00082	0.659
CLV_PCSK_SKI1_1	161	165	PF00082	0.777
CLV_PCSK_SKI1_1	395	399	PF00082	0.517
CLV_PCSK_SKI1_1	437	441	PF00082	0.533
DOC_CKS1_1	56	61	PF01111	0.611
DOC_CYCLIN_yClb1_LxF_4	208	213	PF00134	0.513
DOC_CYCLIN_yCln2_LP_2	211	217	PF00134	0.518
DOC_MAPK_gen_1	196	205	PF00069	0.554
DOC_MAPK_gen_1	216	224	PF00069	0.672
DOC_MAPK_MEF2A_6	145	152	PF00069	0.535
DOC_MAPK_MEF2A_6	199	207	PF00069	0.517
DOC_PP2B_LxvP_1	110	113	PF13499	0.646
DOC_PP2B_LxvP_1	205	208	PF13499	0.760
DOC_PP4_FxxP_1	324	327	PF00568	0.543
DOC_SPAK_OSR1_1	323	327	PF12202	0.596
DOC_USP7_MATH_1	114	118	PF00917	0.731
DOC_USP7_MATH_1	133	137	PF00917	0.485
DOC_USP7_MATH_1	361	365	PF00917	0.721
DOC_WW_Pin1_4	11	16	PF00397	0.584
DOC_WW_Pin1_4	140	145	PF00397	0.617
DOC_WW_Pin1_4	169	174	PF00397	0.672
DOC_WW_Pin1_4	276	281	PF00397	0.630
DOC_WW_Pin1_4	329	334	PF00397	0.713
DOC_WW_Pin1_4	55	60	PF00397	0.600
LIG_14-3-3_CanoR_1	123	131	PF00244	0.692
LIG_14-3-3_CanoR_1	179	188	PF00244	0.623
LIG_14-3-3_CanoR_1	19	23	PF00244	0.514
LIG_14-3-3_CanoR_1	460	470	PF00244	0.465
LIG_14-3-3_CanoR_1	78	82	PF00244	0.704
LIG_APCC_ABBA_1	300	305	PF00400	0.754
LIG_CtBP_PxDLS_1	221	225	PF00389	0.554
LIG_deltaCOP1_diTrp_1	371	377	PF00928	0.446
LIG_EVH1_1	110	114	PF00568	0.806
LIG_FHA_1	105	111	PF00498	0.697
LIG_FHA_1	304	310	PF00498	0.763
LIG_FHA_1	374	380	PF00498	0.640
LIG_FHA_1	396	402	PF00498	0.587
LIG_FHA_1	428	434	PF00498	0.632
LIG_FHA_1	50	56	PF00498	0.479
LIG_FHA_1	59	65	PF00498	0.545
LIG_FHA_1	92	98	PF00498	0.628
LIG_FHA_2	181	187	PF00498	0.589
LIG_FHA_2	373	379	PF00498	0.455
LIG_GBD_Chelix_1	292	300	PF00786	0.517
LIG_LIR_Apic_2	204	209	PF02991	0.761
LIG_LIR_Apic_2	321	327	PF02991	0.606
LIG_LIR_Gen_1	279	288	PF02991	0.535
LIG_LIR_Gen_1	45	56	PF02991	0.581
LIG_LIR_Nem_3	262	266	PF02991	0.658
LIG_LIR_Nem_3	279	285	PF02991	0.714
LIG_LIR_Nem_3	45	51	PF02991	0.588
LIG_Pex14_2	213	217	PF04695	0.672
LIG_Pex14_2	341	345	PF04695	0.509
LIG_RPA_C_Fungi	284	296	PF08784	0.515
LIG_SH2_CRK	266	270	PF00017	0.759
LIG_SH2_GRB2like	344	347	PF00017	0.453
LIG_SH2_SRC	206	209	PF00017	0.766
LIG_SH2_STAP1	303	307	PF00017	0.504
LIG_SH2_STAP1	385	389	PF00017	0.521
LIG_SH2_STAT5	206	209	PF00017	0.766
LIG_SH2_STAT5	266	269	PF00017	0.687
LIG_SH2_STAT5	344	347	PF00017	0.513
LIG_SH2_STAT5	57	60	PF00017	0.775
LIG_SH3_1	206	212	PF00018	0.761
LIG_SH3_3	108	114	PF00018	0.681
LIG_SH3_3	138	144	PF00018	0.546
LIG_SH3_3	206	212	PF00018	0.606
LIG_SH3_3	53	59	PF00018	0.685
LIG_SH3_3	96	102	PF00018	0.740
LIG_SUMO_SIM_par_1	100	109	PF11976	0.769
LIG_SUMO_SIM_par_1	220	227	PF11976	0.805
LIG_TRAF2_1	14	17	PF00917	0.823
LIG_TRAF2_1	318	321	PF00917	0.471
LIG_TYR_ITSM	262	269	PF00017	0.756
LIG_WW_3	207	211	PF00397	0.762
MOD_CDK_SPK_2	140	145	PF00069	0.543
MOD_CDK_SPK_2	169	174	PF00069	0.672
MOD_CDK_SPK_2	276	281	PF00069	0.543
MOD_CDK_SPK_2	329	334	PF00069	0.713
MOD_CK1_1	11	17	PF00069	0.828
MOD_CK1_1	129	135	PF00069	0.756
MOD_CK1_1	201	207	PF00069	0.764
MOD_CK2_1	10	16	PF00069	0.759
MOD_CK2_1	180	186	PF00069	0.588
MOD_CK2_1	220	226	PF00069	0.802
MOD_CK2_1	362	368	PF00069	0.553
MOD_CK2_1	432	438	PF00069	0.400
MOD_CK2_1	44	50	PF00069	0.725
MOD_GlcNHglycan	10	13	PF01048	0.840
MOD_GlcNHglycan	114	117	PF01048	0.610
MOD_GlcNHglycan	131	134	PF01048	0.692
MOD_GlcNHglycan	2	5	PF01048	0.832
MOD_GlcNHglycan	200	203	PF01048	0.520
MOD_GlcNHglycan	246	249	PF01048	0.772
MOD_GlcNHglycan	35	38	PF01048	0.728
MOD_GSK3_1	101	108	PF00069	0.552
MOD_GSK3_1	11	18	PF00069	0.826
MOD_GSK3_1	122	129	PF00069	0.722
MOD_GSK3_1	133	140	PF00069	0.787
MOD_GSK3_1	157	164	PF00069	0.668
MOD_GSK3_1	227	234	PF00069	0.798
MOD_GSK3_1	410	417	PF00069	0.604
MOD_GSK3_1	51	58	PF00069	0.478
MOD_GSK3_1	65	72	PF00069	0.686
MOD_N-GLC_1	8	13	PF02516	0.594
MOD_NEK2_1	191	196	PF00069	0.640
MOD_NEK2_1	328	333	PF00069	0.712
MOD_NEK2_1	432	437	PF00069	0.544
MOD_NEK2_1	51	56	PF00069	0.541
MOD_NEK2_2	261	266	PF00069	0.757
MOD_OFUCOSY	120	126	PF10250	0.547
MOD_OFUCOSY	258	265	PF10250	0.762
MOD_PIKK_1	227	233	PF00454	0.745
MOD_PKA_1	122	128	PF00069	0.557
MOD_PKA_1	395	401	PF00069	0.580
MOD_PKA_1	461	467	PF00069	0.465
MOD_PKA_2	122	128	PF00069	0.693
MOD_PKA_2	18	24	PF00069	0.766
MOD_PKA_2	198	204	PF00069	0.634
MOD_PKA_2	288	294	PF00069	0.712
MOD_PKA_2	312	318	PF00069	0.778
MOD_PKA_2	355	361	PF00069	0.540
MOD_PKA_2	395	401	PF00069	0.580
MOD_PKA_2	413	419	PF00069	0.588
MOD_PKA_2	461	467	PF00069	0.439
MOD_PKA_2	77	83	PF00069	0.750
MOD_PKB_1	311	319	PF00069	0.689
MOD_PKB_1	393	401	PF00069	0.570
MOD_Plk_1	44	50	PF00069	0.507
MOD_Plk_4	201	207	PF00069	0.685
MOD_Plk_4	288	294	PF00069	0.506
MOD_Plk_4	44	50	PF00069	0.678
MOD_Plk_4	51	57	PF00069	0.611
MOD_ProDKin_1	11	17	PF00069	0.581
MOD_ProDKin_1	140	146	PF00069	0.615
MOD_ProDKin_1	169	175	PF00069	0.665
MOD_ProDKin_1	276	282	PF00069	0.629
MOD_ProDKin_1	329	335	PF00069	0.709
MOD_ProDKin_1	55	61	PF00069	0.607
TRG_DiLeu_BaEn_1	321	326	PF01217	0.457
TRG_DiLeu_BaEn_2	319	325	PF01217	0.455
TRG_DiLeu_BaEn_3	186	192	PF01217	0.472
TRG_DiLeu_BaEn_4	465	471	PF01217	0.430
TRG_ENDOCYTIC_2	266	269	PF00928	0.668
TRG_ER_diArg_1	296	299	PF00400	0.682
TRG_ER_diArg_1	393	396	PF00400	0.553
TRG_ER_diArg_1	460	462	PF00400	0.542
TRG_ER_diArg_1	472	474	PF00400	0.641
TRG_NLS_MonoExtC_3	296	301	PF00514	0.671
TRG_NLS_MonoExtN_4	295	302	PF00514	0.670
TRG_NLS_MonoExtN_4	393	398	PF00514	0.556
TRG_Pf-PMV_PEXEL_1	399	403	PF00026	0.700
TRG_Pf-PMV_PEXEL_1	79	83	PF00026	0.496

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4D2	Leptomonas seymouri	38%	84%
A0A3S7X0I5	Leishmania donovani	73%	100%
E9AD60	Leishmania major	73%	100%
E9AHF5	Leishmania infantum	73%	100%
E9AYY5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	73%	100%