Leucine_Rich_repeat

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Leucine_Rich_repeat

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HFK3_LEIBR

TriTrypDb:

LbrM.27.0880 , LBRM2903_270014500

Length:

358

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	9
GO:0042995	cell projection	2	9
GO:0043226	organelle	2	9
GO:0043227	membrane-bounded organelle	3	9
GO:0110165	cellular anatomical entity	1	9
GO:0120025	plasma membrane bounded cell projection	3	9

Expansion

Sequence features

A4HFK3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HFK3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	187	191	PF00656	0.362
CLV_NRD_NRD_1	20	22	PF00675	0.369
CLV_NRD_NRD_1	208	210	PF00675	0.499
CLV_NRD_NRD_1	284	286	PF00675	0.363
CLV_NRD_NRD_1	56	58	PF00675	0.594
CLV_PCSK_KEX2_1	20	22	PF00082	0.369
CLV_PCSK_KEX2_1	208	210	PF00082	0.449
CLV_PCSK_KEX2_1	284	286	PF00082	0.363
CLV_PCSK_SKI1_1	144	148	PF00082	0.562
CLV_PCSK_SKI1_1	208	212	PF00082	0.366
CLV_PCSK_SKI1_1	37	41	PF00082	0.440
CLV_Separin_Metazoa	333	337	PF03568	0.285
DEG_APCC_DBOX_1	36	44	PF00400	0.369
DEG_Nend_UBRbox_3	1	3	PF02207	0.475
DOC_CYCLIN_RxL_1	205	214	PF00134	0.329
DOC_USP7_MATH_1	107	111	PF00917	0.699
DOC_USP7_MATH_1	113	117	PF00917	0.655
DOC_USP7_MATH_1	261	265	PF00917	0.407
DOC_USP7_MATH_1	81	85	PF00917	0.549
DOC_WW_Pin1_4	277	282	PF00397	0.327
DOC_WW_Pin1_4	64	69	PF00397	0.629
LIG_14-3-3_CanoR_1	273	283	PF00244	0.417
LIG_14-3-3_CterR_2	354	358	PF00244	0.352
LIG_Actin_WH2_2	268	286	PF00022	0.449
LIG_deltaCOP1_diTrp_1	265	272	PF00928	0.328
LIG_deltaCOP1_diTrp_1	343	351	PF00928	0.293
LIG_FHA_1	145	151	PF00498	0.534
LIG_FHA_1	178	184	PF00498	0.327
LIG_FHA_1	241	247	PF00498	0.423
LIG_FHA_1	293	299	PF00498	0.438
LIG_FHA_1	318	324	PF00498	0.364
LIG_FHA_1	64	70	PF00498	0.614
LIG_FHA_1	86	92	PF00498	0.304
LIG_FHA_2	302	308	PF00498	0.254
LIG_LIR_Gen_1	297	306	PF02991	0.320
LIG_LIR_Gen_1	80	90	PF02991	0.477
LIG_LIR_Nem_3	270	275	PF02991	0.455
LIG_LIR_Nem_3	297	302	PF02991	0.345
LIG_LIR_Nem_3	80	85	PF02991	0.459
LIG_NRBOX	206	212	PF00104	0.426
LIG_NRBOX	301	307	PF00104	0.250
LIG_NRBOX	86	92	PF00104	0.312
LIG_OCRL_FandH_1	298	310	PF00620	0.252
LIG_Pex14_1	268	272	PF04695	0.255
LIG_Pex14_1	347	351	PF04695	0.274
LIG_Rb_LxCxE_1	180	198	PF01857	0.362
LIG_SH2_PTP2	175	178	PF00017	0.400
LIG_SH2_STAT5	175	178	PF00017	0.471
LIG_SH2_STAT5	322	325	PF00017	0.401
LIG_SH3_3	153	159	PF00018	0.398
LIG_SH3_3	167	173	PF00018	0.468
LIG_Sin3_3	167	174	PF02671	0.415
LIG_SUMO_SIM_anti_2	115	123	PF11976	0.408
LIG_SUMO_SIM_anti_2	88	96	PF11976	0.275
LIG_SUMO_SIM_par_1	179	184	PF11976	0.283
LIG_WRC_WIRS_1	348	353	PF05994	0.428
LIG_WW_1	172	175	PF00397	0.389
LIG_WW_3	237	241	PF00397	0.308
MOD_CDK_SPxxK_3	277	284	PF00069	0.289
MOD_CK1_1	112	118	PF00069	0.599
MOD_CK1_1	277	283	PF00069	0.358
MOD_CK1_1	50	56	PF00069	0.460
MOD_CK1_1	72	78	PF00069	0.581
MOD_CK2_1	162	168	PF00069	0.374
MOD_CK2_1	291	297	PF00069	0.433
MOD_CK2_1	301	307	PF00069	0.465
MOD_CK2_1	337	343	PF00069	0.420
MOD_GlcNHglycan	111	114	PF01048	0.635
MOD_GlcNHglycan	115	118	PF01048	0.558
MOD_GlcNHglycan	197	200	PF01048	0.543
MOD_GlcNHglycan	218	221	PF01048	0.506
MOD_GlcNHglycan	52	55	PF01048	0.471
MOD_GlcNHglycan	71	74	PF01048	0.672
MOD_GSK3_1	109	116	PF00069	0.678
MOD_GSK3_1	144	151	PF00069	0.498
MOD_GSK3_1	211	218	PF00069	0.435
MOD_GSK3_1	240	247	PF00069	0.567
MOD_GSK3_1	297	304	PF00069	0.409
MOD_GSK3_1	81	88	PF00069	0.519
MOD_N-GLC_1	148	153	PF02516	0.292
MOD_N-GLC_1	163	168	PF02516	0.404
MOD_N-GLC_1	215	220	PF02516	0.514
MOD_N-GLC_1	50	55	PF02516	0.443
MOD_N-GLC_2	2	4	PF02516	0.382
MOD_N-GLC_2	233	235	PF02516	0.390
MOD_NEK2_1	15	20	PF00069	0.455
MOD_NEK2_1	162	167	PF00069	0.491
MOD_NEK2_1	195	200	PF00069	0.478
MOD_NEK2_1	211	216	PF00069	0.275
MOD_NEK2_1	225	230	PF00069	0.430
MOD_NEK2_1	337	342	PF00069	0.480
MOD_NEK2_1	69	74	PF00069	0.481
MOD_NEK2_1	85	90	PF00069	0.345
MOD_PIKK_1	107	113	PF00454	0.453
MOD_PIKK_1	228	234	PF00454	0.343
MOD_Plk_1	148	154	PF00069	0.290
MOD_Plk_4	116	122	PF00069	0.403
MOD_Plk_4	301	307	PF00069	0.426
MOD_Plk_4	317	323	PF00069	0.294
MOD_Plk_4	347	353	PF00069	0.430
MOD_Plk_4	72	78	PF00069	0.559
MOD_Plk_4	81	87	PF00069	0.362
MOD_Plk_4	89	95	PF00069	0.357
MOD_ProDKin_1	277	283	PF00069	0.323
MOD_ProDKin_1	64	70	PF00069	0.632
TRG_DiLeu_BaEn_1	333	338	PF01217	0.428
TRG_DiLeu_BaLyEn_6	191	196	PF01217	0.467
TRG_DiLeu_BaLyEn_6	206	211	PF01217	0.315
TRG_DiLeu_LyEn_5	333	338	PF01217	0.428
TRG_ENDOCYTIC_2	175	178	PF00928	0.484
TRG_ER_diArg_1	19	21	PF00400	0.359
TRG_ER_diArg_1	207	209	PF00400	0.444
TRG_ER_diArg_1	283	285	PF00400	0.364
TRG_NES_CRM1_1	38	49	PF08389	0.294
TRG_Pf-PMV_PEXEL_1	137	142	PF00026	0.396

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I0A7	Leptomonas seymouri	39%	100%
A0A3S5ISL8	Trypanosoma rangeli	28%	100%
A0A3S7X0J8	Leishmania donovani	68%	100%
E9AD57	Leishmania major	67%	100%
E9AHF2	Leishmania infantum	69%	91%
E9AYY2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	68%	100%
V5DMC7	Trypanosoma cruzi	27%	100%