Calcium uniporter protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

calcium uniporter protein, mitochondrial

Species:

Leishmania braziliensis

UniProt:

A4HFK2_LEIBR

TriTrypDb:

LbrM.27.0870 , LBRM2903_270014400

Length:

319

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0005743	mitochondrial inner membrane	5	12
GO:0016020	membrane	2	13
GO:0019866	organelle inner membrane	4	12
GO:0031090	organelle membrane	3	13
GO:0031966	mitochondrial membrane	4	13
GO:0110165	cellular anatomical entity	1	13
GO:0005783	endoplasmic reticulum	5	1
GO:0032991	protein-containing complex	1	1
GO:0034702	monoatomic ion channel complex	4	1
GO:0034703	cation channel complex	5	1
GO:0034704	calcium channel complex	6	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0098796	membrane protein complex	2	1
GO:0098798	mitochondrial protein-containing complex	2	1
GO:0098800	inner mitochondrial membrane protein complex	3	1
GO:1902495	transmembrane transporter complex	3	1
GO:1990246	uniplex complex	4	1
GO:1990351	transporter complex	2	1

Expansion

Sequence features

A4HFK2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HFK2

Function

Biological processes
Term	Name	Level	Count
GO:0006873	intracellular monoatomic ion homeostasis	4	13
GO:0006874	intracellular calcium ion homeostasis	7	13
GO:0006875	obsolete intracellular metal ion homeostasis	6	13
GO:0009987	cellular process	1	13
GO:0019725	cellular homeostasis	2	13
GO:0030003	intracellular monoatomic cation homeostasis	5	13
GO:0042592	homeostatic process	3	13
GO:0048878	chemical homeostasis	4	13
GO:0050801	monoatomic ion homeostasis	5	13
GO:0051560	mitochondrial calcium ion homeostasis	8	13
GO:0055065	obsolete metal ion homeostasis	7	13
GO:0055074	calcium ion homeostasis	8	13
GO:0055080	monoatomic cation homeostasis	6	13
GO:0055082	intracellular chemical homeostasis	3	13
GO:0065007	biological regulation	1	13
GO:0065008	regulation of biological quality	2	13
GO:0072503	obsolete cellular divalent inorganic cation homeostasis	6	13
GO:0072507	obsolete divalent inorganic cation homeostasis	7	13
GO:0098771	inorganic ion homeostasis	6	13
GO:0006810	transport	3	1
GO:0006811	monoatomic ion transport	4	1
GO:0006812	monoatomic cation transport	5	1
GO:0006816	calcium ion transport	7	1
GO:0006851	mitochondrial calcium ion transmembrane transport	4	1
GO:0030001	metal ion transport	6	1
GO:0034220	monoatomic ion transmembrane transport	3	1
GO:0036444	calcium import into the mitochondrion	5	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0055085	transmembrane transport	2	1
GO:0070588	calcium ion transmembrane transport	6	1
GO:0098655	monoatomic cation transmembrane transport	4	1
GO:0098660	inorganic ion transmembrane transport	4	1
GO:0098662	inorganic cation transmembrane transport	5	1
GO:1990542	mitochondrial transmembrane transport	3	1

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	13
GO:0005216	monoatomic ion channel activity	4	13
GO:0005261	monoatomic cation channel activity	5	13
GO:0005262	calcium channel activity	6	13
GO:0008324	monoatomic cation transmembrane transporter activity	4	13
GO:0015075	monoatomic ion transmembrane transporter activity	3	13
GO:0015085	calcium ion transmembrane transporter activity	6	13
GO:0015267	channel activity	4	13
GO:0015291	secondary active transmembrane transporter activity	4	13
GO:0015292	uniporter activity	5	13
GO:0015318	inorganic molecular entity transmembrane transporter activity	3	13
GO:0022803	passive transmembrane transporter activity	3	13
GO:0022804	active transmembrane transporter activity	3	13
GO:0022857	transmembrane transporter activity	2	13
GO:0022890	inorganic cation transmembrane transporter activity	4	13
GO:0046873	metal ion transmembrane transporter activity	5	13

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	77	81	PF00656	0.731
CLV_NRD_NRD_1	184	186	PF00675	0.298
CLV_NRD_NRD_1	211	213	PF00675	0.232
CLV_NRD_NRD_1	279	281	PF00675	0.290
CLV_NRD_NRD_1	30	32	PF00675	0.451
CLV_PCSK_FUR_1	209	213	PF00082	0.343
CLV_PCSK_KEX2_1	184	186	PF00082	0.273
CLV_PCSK_KEX2_1	191	193	PF00082	0.227
CLV_PCSK_KEX2_1	211	213	PF00082	0.234
CLV_PCSK_KEX2_1	30	32	PF00082	0.451
CLV_PCSK_PC1ET2_1	191	193	PF00082	0.291
CLV_PCSK_SKI1_1	139	143	PF00082	0.354
CLV_PCSK_SKI1_1	306	310	PF00082	0.367
CLV_PCSK_SKI1_1	70	74	PF00082	0.427
DEG_APCC_DBOX_1	305	313	PF00400	0.537
DEG_COP1_1	163	172	PF00400	0.377
DEG_Nend_UBRbox_1	1	4	PF02207	0.550
DOC_CKS1_1	87	92	PF01111	0.561
DOC_CYCLIN_yClb1_LxF_4	252	258	PF00134	0.328
DOC_USP7_MATH_1	154	158	PF00917	0.523
DOC_USP7_MATH_1	165	169	PF00917	0.453
DOC_USP7_MATH_1	49	53	PF00917	0.674
DOC_USP7_UBL2_3	314	318	PF12436	0.589
DOC_WW_Pin1_4	160	165	PF00397	0.452
DOC_WW_Pin1_4	61	66	PF00397	0.676
DOC_WW_Pin1_4	86	91	PF00397	0.617
LIG_14-3-3_CanoR_1	209	215	PF00244	0.553
LIG_14-3-3_CanoR_1	231	235	PF00244	0.287
LIG_14-3-3_CanoR_1	263	270	PF00244	0.401
LIG_14-3-3_CanoR_1	30	36	PF00244	0.672
LIG_Actin_WH2_2	123	141	PF00022	0.488
LIG_Actin_WH2_2	56	72	PF00022	0.513
LIG_APCC_ABBAyCdc20_2	139	145	PF00400	0.543
LIG_BRCT_BRCA1_1	253	257	PF00533	0.208
LIG_FHA_1	106	112	PF00498	0.647
LIG_FHA_1	144	150	PF00498	0.466
LIG_FHA_1	164	170	PF00498	0.513
LIG_FHA_1	250	256	PF00498	0.226
LIG_FHA_1	62	68	PF00498	0.665
LIG_FHA_2	188	194	PF00498	0.536
LIG_FHA_2	231	237	PF00498	0.290
LIG_FHA_2	75	81	PF00498	0.677
LIG_FHA_2	87	93	PF00498	0.615
LIG_HCF-1_HBM_1	267	270	PF13415	0.488
LIG_LIR_Gen_1	100	109	PF02991	0.633
LIG_LIR_Gen_1	236	247	PF02991	0.241
LIG_LIR_Gen_1	59	68	PF02991	0.579
LIG_LIR_Nem_3	100	105	PF02991	0.605
LIG_LIR_Nem_3	233	237	PF02991	0.237
LIG_LIR_Nem_3	254	260	PF02991	0.270
LIG_LIR_Nem_3	267	273	PF02991	0.454
LIG_LIR_Nem_3	289	295	PF02991	0.451
LIG_LIR_Nem_3	59	63	PF02991	0.587
LIG_Pex14_2	235	239	PF04695	0.281
LIG_Pex14_2	273	277	PF04695	0.488
LIG_SH2_SRC	295	298	PF00017	0.493
LIG_SH2_STAT5	143	146	PF00017	0.556
LIG_SH2_STAT5	234	237	PF00017	0.257
LIG_SH2_STAT5	247	250	PF00017	0.232
LIG_SH2_STAT5	261	264	PF00017	0.373
LIG_SH3_3	108	114	PF00018	0.642
LIG_SUMO_SIM_anti_2	145	151	PF11976	0.404
LIG_SUMO_SIM_anti_2	64	70	PF11976	0.615
LIG_SUMO_SIM_par_1	125	131	PF11976	0.448
LIG_SUMO_SIM_par_1	246	252	PF11976	0.191
LIG_TYR_ITIM	232	237	PF00017	0.346
LIG_UBA3_1	308	314	PF00899	0.616
MOD_CK1_1	168	174	PF00069	0.497
MOD_CK1_1	18	24	PF00069	0.693
MOD_CK1_1	230	236	PF00069	0.300
MOD_CK1_1	266	272	PF00069	0.541
MOD_CK2_1	187	193	PF00069	0.509
MOD_CK2_1	86	92	PF00069	0.756
MOD_GlcNHglycan	20	23	PF01048	0.358
MOD_GlcNHglycan	4	7	PF01048	0.477
MOD_GlcNHglycan	51	54	PF01048	0.462
MOD_GlcNHglycan	55	58	PF01048	0.438
MOD_GSK3_1	168	175	PF00069	0.587
MOD_GSK3_1	243	250	PF00069	0.328
MOD_GSK3_1	31	38	PF00069	0.619
MOD_GSK3_1	49	56	PF00069	0.619
MOD_N-GLC_1	160	165	PF02516	0.336
MOD_N-GLC_1	172	177	PF02516	0.152
MOD_NEK2_1	105	110	PF00069	0.603
MOD_NEK2_1	35	40	PF00069	0.587
MOD_NEK2_1	4	9	PF00069	0.703
MOD_PKA_1	30	36	PF00069	0.751
MOD_PKA_2	210	216	PF00069	0.519
MOD_PKA_2	230	236	PF00069	0.287
MOD_PKA_2	30	36	PF00069	0.692
MOD_PKA_2	47	53	PF00069	0.654
MOD_Plk_1	266	272	PF00069	0.467
MOD_Plk_4	131	137	PF00069	0.523
MOD_Plk_4	173	179	PF00069	0.462
MOD_Plk_4	230	236	PF00069	0.305
MOD_Plk_4	243	249	PF00069	0.275
MOD_Plk_4	251	257	PF00069	0.303
MOD_Plk_4	35	41	PF00069	0.617
MOD_Plk_4	4	10	PF00069	0.662
MOD_ProDKin_1	160	166	PF00069	0.452
MOD_ProDKin_1	61	67	PF00069	0.679
MOD_ProDKin_1	86	92	PF00069	0.616
TRG_DiLeu_BaLyEn_6	62	67	PF01217	0.655
TRG_ENDOCYTIC_2	234	237	PF00928	0.272
TRG_ENDOCYTIC_2	261	264	PF00928	0.402
TRG_ENDOCYTIC_2	270	273	PF00928	0.481
TRG_ENDOCYTIC_2	295	298	PF00928	0.456
TRG_ER_diArg_1	184	186	PF00400	0.490
TRG_ER_diArg_1	210	212	PF00400	0.422
TRG_ER_diArg_1	30	32	PF00400	0.731
TRG_NLS_MonoExtN_4	279	284	PF00514	0.511
TRG_Pf-PMV_PEXEL_1	306	310	PF00026	0.247

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P418	Leptomonas seymouri	26%	100%
A0A0N1I8M7	Leptomonas seymouri	60%	96%
A0A0S4JRI1	Bodo saltans	41%	100%
A0A1X0P3Z9	Trypanosomatidae	42%	100%
A0A3Q8IHI0	Leishmania donovani	75%	100%
A0A422NMN9	Trypanosoma rangeli	44%	100%
D0A5S5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	100%
E9AD55	Leishmania major	72%	100%
E9AHF0	Leishmania infantum	75%	100%
E9AYY0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	75%	100%
V5DA35	Trypanosoma cruzi	42%	100%