LeishMANIAdb
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Stress-response A/B barrel domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Stress-response A/B barrel domain-containing protein
Gene product:
Stress responsive A/B Barrel Domain, putative
Species:
Leishmania braziliensis
UniProt:
A4HFJ9_LEIBR
TriTrypDb:
LbrM.27.0840 , LBRM2903_270014100
Length:
127

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 12
NetGPI no yes: 0, no: 12
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HFJ9
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HFJ9

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_PCSK_KEX2_1 46 48 PF00082 0.454
CLV_PCSK_PC1ET2_1 46 48 PF00082 0.454
CLV_PCSK_SKI1_1 113 117 PF00082 0.532
DOC_ANK_TNKS_1 48 55 PF00023 0.422
DOC_CYCLIN_yCln2_LP_2 32 38 PF00134 0.474
DOC_MAPK_gen_1 31 38 PF00069 0.472
DOC_USP7_MATH_1 5 9 PF00917 0.656
LIG_14-3-3_CanoR_1 113 118 PF00244 0.513
LIG_14-3-3_CanoR_1 47 53 PF00244 0.503
LIG_FHA_1 76 82 PF00498 0.437
LIG_FHA_2 114 120 PF00498 0.490
LIG_LIR_Gen_1 119 127 PF02991 0.523
LIG_LIR_Nem_3 119 123 PF02991 0.486
LIG_NRBOX 40 46 PF00104 0.434
LIG_PDZ_Class_1 122 127 PF00595 0.517
LIG_SH2_SRC 94 97 PF00017 0.397
LIG_SH2_STAT5 106 109 PF00017 0.294
LIG_SH2_STAT5 90 93 PF00017 0.456
LIG_TRAF2_1 8 11 PF00917 0.672
MOD_CK2_1 106 112 PF00069 0.473
MOD_CK2_1 5 11 PF00069 0.423
MOD_GlcNHglycan 72 75 PF01048 0.648
MOD_GSK3_1 60 67 PF00069 0.601
MOD_N-GLC_1 121 126 PF02516 0.356
MOD_N-GLC_1 68 73 PF02516 0.645
MOD_NEK2_1 20 25 PF00069 0.289
MOD_NEK2_1 60 65 PF00069 0.616
MOD_NMyristoyl 1 7 PF02799 0.445
MOD_PKA_2 48 54 PF00069 0.491
MOD_Plk_1 13 19 PF00069 0.369
MOD_Plk_4 113 119 PF00069 0.450
TRG_ENDOCYTIC_2 90 93 PF00928 0.483

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P783 Leptomonas seymouri 62% 99%
A0A0S4JU83 Bodo saltans 40% 100%
A0A0S4JUQ9 Bodo saltans 39% 100%
A0A1X0P411 Trypanosomatidae 47% 100%
A0A3R7NRY9 Trypanosoma rangeli 34% 100%
A0A3S7X0I8 Leishmania donovani 78% 100%
E9AD52 Leishmania major 77% 100%
E9AHE7 Leishmania infantum 78% 100%
E9AYX7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 76% 100%
V5AU50 Trypanosoma cruzi 38% 100%
V5DA48 Trypanosoma cruzi 35% 100%

Download

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS