Putative reductase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Putative reductase

Gene product:

reductase, putative

Species:

Leishmania braziliensis

UniProt:

A4HFJ6_LEIBR

TriTrypDb:

LbrM.27.0810 , LBRM2903_270013800

Length:

200

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 1
NetGPI	no	yes: 0, no: 1

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HFJ6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HFJ6

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	2
GO:0016491	oxidoreductase activity	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	55	59	PF00656	0.405
CLV_NRD_NRD_1	90	92	PF00675	0.522
CLV_PCSK_KEX2_1	90	92	PF00082	0.522
CLV_PCSK_SKI1_1	50	54	PF00082	0.522
CLV_PCSK_SKI1_1	77	81	PF00082	0.522
DEG_SCF_FBW7_1	153	160	PF00400	0.651
DOC_MAPK_gen_1	137	143	PF00069	0.405
DOC_MAPK_gen_1	95	104	PF00069	0.522
DOC_MAPK_MEF2A_6	97	106	PF00069	0.522
DOC_PP1_RVXF_1	15	22	PF00149	0.654
DOC_PP1_RVXF_1	64	70	PF00149	0.522
DOC_WW_Pin1_4	153	158	PF00397	0.632
DOC_WW_Pin1_4	40	45	PF00397	0.522
LIG_BRCT_BRCA1_1	17	21	PF00533	0.658
LIG_BRCT_BRCA1_1	67	71	PF00533	0.347
LIG_deltaCOP1_diTrp_1	109	118	PF00928	0.522
LIG_FHA_1	122	128	PF00498	0.505
LIG_FHA_1	41	47	PF00498	0.522
LIG_FHA_1	99	105	PF00498	0.441
LIG_FHA_2	58	64	PF00498	0.405
LIG_LIR_Gen_1	43	53	PF02991	0.366
LIG_LIR_Nem_3	115	121	PF02991	0.522
LIG_LIR_Nem_3	13	19	PF02991	0.639
LIG_LIR_Nem_3	40	45	PF02991	0.351
LIG_LIR_Nem_3	94	99	PF02991	0.522
LIG_NRBOX	182	188	PF00104	0.585
LIG_PDZ_Class_2	195	200	PF00595	0.583
LIG_SH2_GRB2like	192	195	PF00017	0.599
LIG_SH2_STAP1	100	104	PF00017	0.522
LIG_SH2_STAT5	100	103	PF00017	0.522
LIG_SH2_STAT5	121	124	PF00017	0.522
LIG_TRAF2_1	133	136	PF00917	0.431
MOD_CK1_1	159	165	PF00069	0.714
MOD_CK1_1	57	63	PF00069	0.405
MOD_GlcNHglycan	164	167	PF01048	0.645
MOD_GSK3_1	153	160	PF00069	0.651
MOD_N-GLC_1	72	77	PF02516	0.522
MOD_NEK2_1	15	20	PF00069	0.655
MOD_NEK2_1	164	169	PF00069	0.752
MOD_Plk_4	10	16	PF00069	0.625
MOD_Plk_4	65	71	PF00069	0.347
MOD_ProDKin_1	153	159	PF00069	0.645
MOD_ProDKin_1	40	46	PF00069	0.522
MOD_SUMO_rev_2	130	140	PF00179	0.405
MOD_SUMO_rev_2	58	68	PF00179	0.504
TRG_DiLeu_BaEn_1	76	81	PF01217	0.522
TRG_DiLeu_BaEn_3	135	141	PF01217	0.522
TRG_DiLeu_BaLyEn_6	145	150	PF01217	0.522
TRG_ER_diArg_1	90	92	PF00400	0.522

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6L4	Leptomonas seymouri	31%	69%
A0A0N0P705	Leptomonas seymouri	29%	69%
A0A0N1PBS9	Leptomonas seymouri	34%	67%
A0A0S4KHI4	Bodo saltans	32%	67%
A0A1X0NT99	Trypanosomatidae	30%	70%
A0A1X0NTX4	Trypanosomatidae	31%	70%
A0A1X0NV22	Trypanosomatidae	30%	67%
A0A3Q8IBE7	Leishmania donovani	29%	69%
A0A3Q8ILI9	Leishmania donovani	31%	69%
A0A3R7JSY9	Trypanosoma rangeli	31%	66%
A0A3R7MD20	Trypanosoma rangeli	31%	69%
A0A3S5H6T5	Leishmania donovani	36%	72%
A3GF86	Scheffersomyces stipitis (strain ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545)	32%	70%
A3LT66	Scheffersomyces stipitis (strain ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545)	30%	67%
A4H7X5	Leishmania braziliensis	36%	100%
A4HCD2	Leishmania braziliensis	30%	100%
A4HCD3	Leishmania braziliensis	30%	100%
A4HWA2	Leishmania infantum	36%	72%
A4HZV4	Leishmania infantum	31%	69%
A4HZV5	Leishmania infantum	29%	69%
A5DQ25	Meyerozyma guilliermondii (strain ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539 / NBRC 10279 / NRRL Y-324)	34%	70%
A5DQE4	Meyerozyma guilliermondii (strain ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539 / NBRC 10279 / NRRL Y-324)	30%	68%
A5E5C5	Lodderomyces elongisporus (strain ATCC 11503 / CBS 2605 / JCM 1781 / NBRC 1676 / NRRL YB-4239)	29%	67%
A5E7U2	Lodderomyces elongisporus (strain ATCC 11503 / CBS 2605 / JCM 1781 / NBRC 1676 / NRRL YB-4239)	32%	67%
A6ZVM6	Saccharomyces cerevisiae (strain YJM789)	30%	70%
A6ZZH2	Saccharomyces cerevisiae (strain YJM789)	30%	66%
A7THS1	Vanderwaltozyma polyspora (strain ATCC 22028 / DSM 70294 / BCRC 21397 / CBS 2163 / NBRC 10782 / NRRL Y-8283 / UCD 57-17)	34%	68%
A7TNL7	Vanderwaltozyma polyspora (strain ATCC 22028 / DSM 70294 / BCRC 21397 / CBS 2163 / NBRC 10782 / NRRL Y-8283 / UCD 57-17)	29%	70%
C9ZNT4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	68%
C9ZSH7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	70%
C9ZSH8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	70%
E9AQ02	Leishmania mexicana (strain MHOM/GT/2001/U1103)	36%	72%
E9AVR1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	69%
E9AVR2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	31%	69%
O74557	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	35%	66%
P00387	Homo sapiens	36%	66%
P07514	Bos taurus	36%	66%
P0CP14	Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565)	30%	68%
P0CP15	Cryptococcus neoformans var. neoformans serotype D (strain B-3501A)	30%	68%
P20070	Rattus norvegicus	33%	66%
P36060	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	30%	66%
P38626	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	30%	70%
P83686	Sus scrofa	36%	74%
Q0CY37	Aspergillus terreus (strain NIH 2624 / FGSC A1156)	38%	68%
Q0UEY4	Phaeosphaeria nodorum (strain SN15 / ATCC MYA-4574 / FGSC 10173)	34%	71%
Q0X0E5	Canis lupus familiaris	34%	66%
Q2UFN3	Aspergillus oryzae (strain ATCC 42149 / RIB 40)	35%	68%
Q3KNK3	Mus musculus	35%	72%
Q4QBR9	Leishmania major	31%	100%
Q4QBS0	Leishmania major	28%	100%
Q4QFH9	Leishmania major	36%	100%
Q54NC1	Dictyostelium discoideum	33%	70%
Q59M70	Candida albicans (strain SC5314 / ATCC MYA-2876)	30%	66%
Q59P03	Candida albicans (strain SC5314 / ATCC MYA-2876)	32%	68%
Q5PQA4	Xenopus laevis	34%	68%
Q60HG4	Macaca fascicularis	36%	66%
Q6AY12	Rattus norvegicus	35%	72%
Q6BCY4	Homo sapiens	36%	72%
Q6BQ54	Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968)	30%	67%
Q6BUX2	Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968)	31%	70%
Q6C9G8	Yarrowia lipolytica (strain CLIB 122 / E 150)	30%	69%
Q6CA86	Yarrowia lipolytica (strain CLIB 122 / E 150)	28%	69%
Q6CID0	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	33%	71%
Q6CS27	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	31%	68%
Q6FLT3	Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)	31%	70%
Q6FUX5	Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)	32%	67%
Q75AL4	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	31%	70%
Q9DCN2	Mus musculus	33%	66%
Q9UR35	Mortierella alpina	37%	67%
Q9ZNT1	Arabidopsis thaliana	32%	71%
V5BVT5	Trypanosoma cruzi	31%	69%
V5DCP7	Trypanosoma cruzi	32%	100%