UBA domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

UBA/TS-N domain containing protein, putative

Species:

Leishmania braziliensis

UniProt:

A4HFJ5_LEIBR

TriTrypDb:

LbrM.27.0800 , LBRM2903_270013500 , LBRM2903_270013600

Length:

410

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005829	cytosol	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HFJ5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HFJ5

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	1
GO:0006511	ubiquitin-dependent protein catabolic process	7	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009056	catabolic process	2	1
GO:0009057	macromolecule catabolic process	4	1
GO:0009987	cellular process	1	1
GO:0019538	protein metabolic process	3	1
GO:0019941	modification-dependent protein catabolic process	6	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043632	modification-dependent macromolecule catabolic process	5	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044248	cellular catabolic process	3	1
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0044265	obsolete cellular macromolecule catabolic process	4	1
GO:0051603	proteolysis involved in protein catabolic process	5	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1
GO:1901575	organic substance catabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0031593	polyubiquitin modification-dependent protein binding	4	1
GO:0140030	modification-dependent protein binding	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	121	125	PF00656	0.460
CLV_NRD_NRD_1	176	178	PF00675	0.451
CLV_NRD_NRD_1	75	77	PF00675	0.490
CLV_PCSK_KEX2_1	175	177	PF00082	0.441
CLV_PCSK_SKI1_1	12	16	PF00082	0.592
CLV_PCSK_SKI1_1	155	159	PF00082	0.523
CLV_PCSK_SKI1_1	164	168	PF00082	0.559
CLV_PCSK_SKI1_1	387	391	PF00082	0.357
CLV_PCSK_SKI1_1	49	53	PF00082	0.612
CLV_PCSK_SKI1_1	76	80	PF00082	0.446
CLV_Separin_Metazoa	94	98	PF03568	0.650
DEG_Nend_UBRbox_2	1	3	PF02207	0.524
DEG_SCF_FBW7_1	250	257	PF00400	0.749
DEG_SCF_FBW7_1	336	342	PF00400	0.501
DOC_CKS1_1	251	256	PF01111	0.751
DOC_CKS1_1	336	341	PF01111	0.578
DOC_CYCLIN_RxL_1	158	170	PF00134	0.500
DOC_CYCLIN_RxL_1	215	226	PF00134	0.434
DOC_CYCLIN_RxL_1	72	83	PF00134	0.490
DOC_MAPK_FxFP_2	283	286	PF00069	0.602
DOC_MAPK_gen_1	9	17	PF00069	0.519
DOC_MAPK_MEF2A_6	9	17	PF00069	0.571
DOC_PP2B_LxvP_1	34	37	PF13499	0.559
DOC_PP4_FxxP_1	279	282	PF00568	0.633
DOC_PP4_FxxP_1	283	286	PF00568	0.595
DOC_USP7_MATH_1	118	122	PF00917	0.654
DOC_USP7_MATH_1	354	358	PF00917	0.656
DOC_USP7_UBL2_3	111	115	PF12436	0.455
DOC_USP7_UBL2_3	144	148	PF12436	0.523
DOC_WW_Pin1_4	147	152	PF00397	0.597
DOC_WW_Pin1_4	250	255	PF00397	0.745
DOC_WW_Pin1_4	332	337	PF00397	0.614
DOC_WW_Pin1_4	343	348	PF00397	0.601
LIG_14-3-3_CanoR_1	221	229	PF00244	0.664
LIG_14-3-3_CanoR_1	330	336	PF00244	0.437
LIG_14-3-3_CanoR_1	64	74	PF00244	0.589
LIG_EH_1	280	284	PF12763	0.477
LIG_EVH1_1	285	289	PF00568	0.434
LIG_FHA_1	222	228	PF00498	0.694
LIG_FHA_1	295	301	PF00498	0.681
LIG_FHA_1	41	47	PF00498	0.493
LIG_FHA_2	20	26	PF00498	0.404
LIG_FHA_2	206	212	PF00498	0.568
LIG_FHA_2	372	378	PF00498	0.318
LIG_FHA_2	55	61	PF00498	0.552
LIG_GBD_Chelix_1	13	21	PF00786	0.375
LIG_Integrin_isoDGR_2	47	49	PF01839	0.373
LIG_LIR_Nem_3	2	6	PF02991	0.477
LIG_LIR_Nem_3	299	305	PF02991	0.561
LIG_LIR_Nem_3	56	61	PF02991	0.435
LIG_MYND_2	347	351	PF01753	0.476
LIG_NRBOX	162	168	PF00104	0.491
LIG_PCNA_yPIPBox_3	318	330	PF02747	0.395
LIG_Pex14_2	279	283	PF04695	0.603
LIG_PTB_Apo_2	228	235	PF02174	0.445
LIG_PTB_Phospho_1	228	234	PF10480	0.446
LIG_SH2_CRK	3	7	PF00017	0.443
LIG_SH2_SRC	3	6	PF00017	0.497
LIG_SH2_STAT3	203	206	PF00017	0.587
LIG_SH2_STAT5	403	406	PF00017	0.525
LIG_SH3_3	283	289	PF00018	0.484
LIG_SH3_3	333	339	PF00018	0.776
LIG_TRAF2_1	101	104	PF00917	0.572
LIG_UBA3_1	136	144	PF00899	0.516
MOD_CK1_1	135	141	PF00069	0.465
MOD_CK1_1	331	337	PF00069	0.658
MOD_CK1_1	361	367	PF00069	0.597
MOD_CK2_1	205	211	PF00069	0.582
MOD_CK2_1	222	228	PF00069	0.433
MOD_CK2_1	54	60	PF00069	0.476
MOD_CK2_1	98	104	PF00069	0.576
MOD_GlcNHglycan	258	261	PF01048	0.631
MOD_GlcNHglycan	266	269	PF01048	0.591
MOD_GlcNHglycan	292	295	PF01048	0.568
MOD_GlcNHglycan	312	315	PF01048	0.630
MOD_GlcNHglycan	356	359	PF01048	0.660
MOD_GlcNHglycan	360	363	PF01048	0.577
MOD_GlcNHglycan	91	94	PF01048	0.540
MOD_GSK3_1	118	125	PF00069	0.628
MOD_GSK3_1	223	230	PF00069	0.641
MOD_GSK3_1	250	257	PF00069	0.659
MOD_GSK3_1	290	297	PF00069	0.552
MOD_GSK3_1	328	335	PF00069	0.631
MOD_GSK3_1	339	346	PF00069	0.767
MOD_GSK3_1	354	361	PF00069	0.708
MOD_N-GLC_1	80	85	PF02516	0.585
MOD_NEK2_1	122	127	PF00069	0.496
MOD_NEK2_1	132	137	PF00069	0.447
MOD_NEK2_1	166	171	PF00069	0.483
MOD_NEK2_1	222	227	PF00069	0.585
MOD_NEK2_1	328	333	PF00069	0.690
MOD_NEK2_1	42	47	PF00069	0.545
MOD_NEK2_1	65	70	PF00069	0.690
MOD_NEK2_2	371	376	PF00069	0.212
MOD_PIKK_1	205	211	PF00454	0.413
MOD_PIKK_1	65	71	PF00454	0.619
MOD_PIKK_1	87	93	PF00454	0.636
MOD_Plk_1	19	25	PF00069	0.438
MOD_Plk_2-3	19	25	PF00069	0.471
MOD_Plk_2-3	54	60	PF00069	0.476
MOD_Plk_4	118	124	PF00069	0.545
MOD_Plk_4	132	138	PF00069	0.444
MOD_ProDKin_1	147	153	PF00069	0.591
MOD_ProDKin_1	250	256	PF00069	0.749
MOD_ProDKin_1	332	338	PF00069	0.621
MOD_ProDKin_1	343	349	PF00069	0.598
MOD_SUMO_rev_2	101	107	PF00179	0.608
MOD_SUMO_rev_2	19	29	PF00179	0.467
TRG_DiLeu_BaLyEn_6	346	351	PF01217	0.479
TRG_DiLeu_BaLyEn_6	46	51	PF01217	0.420
TRG_ENDOCYTIC_2	3	6	PF00928	0.443
TRG_ER_diArg_1	175	177	PF00400	0.483
TRG_ER_diArg_1	61	64	PF00400	0.524
TRG_NES_CRM1_1	11	25	PF08389	0.517
TRG_Pf-PMV_PEXEL_1	155	159	PF00026	0.502
TRG_Pf-PMV_PEXEL_1	49	53	PF00026	0.533

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HYN2	Leptomonas seymouri	58%	100%
A0A0S4JV76	Bodo saltans	27%	98%
A0A1X0P4A2	Trypanosomatidae	33%	100%
A0A3R7MIY7	Trypanosoma rangeli	31%	100%
A0A3S7X0H9	Leishmania donovani	80%	100%
D0A5S0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	100%
E9AD49	Leishmania major	82%	100%
E9AHE3	Leishmania infantum	80%	100%
E9AYX3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	100%