RRM domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HFJ4_LEIBR

TriTrypDb:

LbrM.27.0790 , LBRM2903_270013300

Length:

458

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HFJ4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HFJ4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	174	178	PF00656	0.583
CLV_C14_Caspase3-7	326	330	PF00656	0.441
CLV_C14_Caspase3-7	381	385	PF00656	0.537
CLV_NRD_NRD_1	160	162	PF00675	0.685
CLV_NRD_NRD_1	368	370	PF00675	0.722
CLV_NRD_NRD_1	379	381	PF00675	0.657
CLV_NRD_NRD_1	421	423	PF00675	0.654
CLV_PCSK_KEX2_1	160	162	PF00082	0.685
CLV_PCSK_KEX2_1	310	312	PF00082	0.429
CLV_PCSK_KEX2_1	368	370	PF00082	0.722
CLV_PCSK_KEX2_1	379	381	PF00082	0.708
CLV_PCSK_KEX2_1	421	423	PF00082	0.660
CLV_PCSK_PC1ET2_1	310	312	PF00082	0.429
CLV_PCSK_PC7_1	306	312	PF00082	0.438
CLV_PCSK_SKI1_1	160	164	PF00082	0.532
CLV_PCSK_SKI1_1	201	205	PF00082	0.502
CLV_PCSK_SKI1_1	310	314	PF00082	0.380
DEG_Nend_UBRbox_3	1	3	PF02207	0.790
DEG_SCF_FBW7_1	140	146	PF00400	0.812
DEG_SPOP_SBC_1	58	62	PF00917	0.625
DOC_CKS1_1	140	145	PF01111	0.741
DOC_CKS1_1	37	42	PF01111	0.730
DOC_CYCLIN_RxL_1	306	315	PF00134	0.425
DOC_MAPK_gen_1	204	212	PF00069	0.519
DOC_MAPK_gen_1	347	355	PF00069	0.461
DOC_MAPK_MEF2A_6	35	44	PF00069	0.534
DOC_PP1_RVXF_1	206	213	PF00149	0.517
DOC_PP1_RVXF_1	308	315	PF00149	0.414
DOC_PP2B_LxvP_1	337	340	PF13499	0.566
DOC_PP4_FxxP_1	192	195	PF00568	0.557
DOC_USP7_MATH_1	109	113	PF00917	0.762
DOC_USP7_MATH_1	193	197	PF00917	0.469
DOC_USP7_MATH_1	279	283	PF00917	0.505
DOC_USP7_MATH_1	349	353	PF00917	0.460
DOC_USP7_MATH_1	362	366	PF00917	0.628
DOC_USP7_MATH_1	400	404	PF00917	0.789
DOC_USP7_MATH_1	58	62	PF00917	0.630
DOC_WW_Pin1_4	101	106	PF00397	0.547
DOC_WW_Pin1_4	133	138	PF00397	0.655
DOC_WW_Pin1_4	139	144	PF00397	0.685
DOC_WW_Pin1_4	19	24	PF00397	0.797
DOC_WW_Pin1_4	262	267	PF00397	0.381
DOC_WW_Pin1_4	33	38	PF00397	0.681
DOC_WW_Pin1_4	87	92	PF00397	0.662
LIG_14-3-3_CanoR_1	138	143	PF00244	0.637
LIG_14-3-3_CanoR_1	379	387	PF00244	0.770
LIG_14-3-3_CanoR_1	396	405	PF00244	0.486
LIG_14-3-3_CanoR_1	78	87	PF00244	0.609
LIG_AP2alpha_2	157	159	PF02296	0.504
LIG_BRCT_BRCA1_1	127	131	PF00533	0.534
LIG_Clathr_ClatBox_1	84	88	PF01394	0.755
LIG_EVH1_2	40	44	PF00568	0.591
LIG_FHA_1	37	43	PF00498	0.758
LIG_FHA_1	63	69	PF00498	0.569
LIG_FHA_2	263	269	PF00498	0.428
LIG_FHA_2	322	328	PF00498	0.495
LIG_FHA_2	379	385	PF00498	0.538
LIG_FHA_2	81	87	PF00498	0.693
LIG_IBAR_NPY_1	125	127	PF08397	0.650
LIG_LIR_Apic_2	104	109	PF02991	0.715
LIG_LIR_Apic_2	189	195	PF02991	0.595
LIG_LIR_Apic_2	61	67	PF02991	0.667
LIG_LIR_Gen_1	333	342	PF02991	0.589
LIG_LIR_Gen_1	4	13	PF02991	0.532
LIG_LIR_Nem_3	333	337	PF02991	0.581
LIG_LIR_Nem_3	4	9	PF02991	0.530
LIG_LIR_Nem_3	71	75	PF02991	0.518
LIG_LYPXL_yS_3	72	75	PF13949	0.517
LIG_SH2_CRK	106	110	PF00017	0.798
LIG_SH2_PTP2	334	337	PF00017	0.577
LIG_SH2_SRC	436	439	PF00017	0.794
LIG_SH2_STAP1	127	131	PF00017	0.715
LIG_SH2_STAP1	436	440	PF00017	0.796
LIG_SH2_STAP1	6	10	PF00017	0.536
LIG_SH2_STAT5	209	212	PF00017	0.513
LIG_SH2_STAT5	292	295	PF00017	0.460
LIG_SH2_STAT5	334	337	PF00017	0.495
LIG_SH2_STAT5	64	67	PF00017	0.559
LIG_SH3_3	17	23	PF00018	0.771
LIG_SH3_3	31	37	PF00018	0.713
LIG_SH3_3	441	447	PF00018	0.689
LIG_SH3_3	7	13	PF00018	0.699
LIG_SUMO_SIM_anti_2	301	307	PF11976	0.492
LIG_SUMO_SIM_par_1	83	90	PF11976	0.685
LIG_TRAF2_1	435	438	PF00917	0.799
LIG_TRAF2_2	447	452	PF00917	0.520
LIG_TRAF2_2	52	57	PF00917	0.710
LIG_WRC_WIRS_1	149	154	PF05994	0.683
MOD_CDC14_SPxK_1	90	93	PF00782	0.759
MOD_CDK_SPK_2	133	138	PF00069	0.528
MOD_CDK_SPxK_1	87	93	PF00069	0.753
MOD_CK1_1	132	138	PF00069	0.657
MOD_CK1_1	141	147	PF00069	0.675
MOD_CK1_1	237	243	PF00069	0.794
MOD_CK1_1	36	42	PF00069	0.672
MOD_CK1_1	4	10	PF00069	0.749
MOD_CK1_1	439	445	PF00069	0.537
MOD_CK1_1	62	68	PF00069	0.676
MOD_CK1_1	71	77	PF00069	0.710
MOD_CK2_1	262	268	PF00069	0.442
MOD_CK2_1	279	285	PF00069	0.498
MOD_CK2_1	321	327	PF00069	0.440
MOD_CK2_1	432	438	PF00069	0.796
MOD_CK2_1	80	86	PF00069	0.698
MOD_Cter_Amidation	366	369	PF01082	0.772
MOD_GlcNHglycan	119	123	PF01048	0.745
MOD_GlcNHglycan	131	134	PF01048	0.580
MOD_GlcNHglycan	173	176	PF01048	0.650
MOD_GlcNHglycan	221	224	PF01048	0.643
MOD_GlcNHglycan	242	245	PF01048	0.716
MOD_GlcNHglycan	364	367	PF01048	0.754
MOD_GlcNHglycan	387	390	PF01048	0.707
MOD_GlcNHglycan	398	401	PF01048	0.561
MOD_GlcNHglycan	402	405	PF01048	0.537
MOD_GlcNHglycan	437	441	PF01048	0.727
MOD_GSK3_1	125	132	PF00069	0.635
MOD_GSK3_1	139	146	PF00069	0.589
MOD_GSK3_1	217	224	PF00069	0.586
MOD_GSK3_1	233	240	PF00069	0.764
MOD_GSK3_1	279	286	PF00069	0.501
MOD_GSK3_1	300	307	PF00069	0.457
MOD_GSK3_1	396	403	PF00069	0.719
MOD_GSK3_1	432	439	PF00069	0.733
MOD_GSK3_1	58	65	PF00069	0.613
MOD_GSK3_1	95	102	PF00069	0.594
MOD_N-GLC_1	2	7	PF02516	0.589
MOD_N-GLC_1	232	237	PF02516	0.803
MOD_N-GLC_1	385	390	PF02516	0.725
MOD_N-GLC_2	80	82	PF02516	0.520
MOD_NEK2_1	1	6	PF00069	0.783
MOD_NEK2_1	129	134	PF00069	0.684
MOD_NEK2_1	304	309	PF00069	0.445
MOD_NEK2_1	42	47	PF00069	0.594
MOD_NEK2_1	59	64	PF00069	0.762
MOD_NEK2_1	68	73	PF00069	0.730
MOD_PIKK_1	414	420	PF00454	0.678
MOD_PKA_2	171	177	PF00069	0.593
MOD_PKA_2	349	355	PF00069	0.455
MOD_PKA_2	378	384	PF00069	0.719
MOD_PKA_2	395	401	PF00069	0.457
MOD_PKB_1	97	105	PF00069	0.523
MOD_Plk_1	2	8	PF00069	0.529
MOD_Plk_1	300	306	PF00069	0.438
MOD_Plk_1	436	442	PF00069	0.544
MOD_Plk_2-3	378	384	PF00069	0.542
MOD_Plk_4	187	193	PF00069	0.575
MOD_Plk_4	300	306	PF00069	0.461
MOD_Plk_4	349	355	PF00069	0.445
MOD_Plk_4	59	65	PF00069	0.734
MOD_Plk_4	71	77	PF00069	0.625
MOD_Plk_4	80	86	PF00069	0.579
MOD_ProDKin_1	101	107	PF00069	0.548
MOD_ProDKin_1	133	139	PF00069	0.659
MOD_ProDKin_1	143	149	PF00069	0.688
MOD_ProDKin_1	19	25	PF00069	0.798
MOD_ProDKin_1	262	268	PF00069	0.378
MOD_ProDKin_1	33	39	PF00069	0.678
MOD_ProDKin_1	87	93	PF00069	0.665
MOD_SUMO_rev_2	351	360	PF00179	0.482
TRG_DiLeu_BaEn_1	268	273	PF01217	0.473
TRG_DiLeu_BaLyEn_6	337	342	PF01217	0.600
TRG_ENDOCYTIC_2	209	212	PF00928	0.513
TRG_ENDOCYTIC_2	334	337	PF00928	0.577
TRG_ENDOCYTIC_2	6	9	PF00928	0.538
TRG_ENDOCYTIC_2	72	75	PF00928	0.579
TRG_ER_diArg_1	159	161	PF00400	0.676
TRG_ER_diArg_1	206	209	PF00400	0.470
TRG_ER_diArg_1	420	422	PF00400	0.584
TRG_Pf-PMV_PEXEL_1	201	205	PF00026	0.487
TRG_Pf-PMV_PEXEL_1	311	315	PF00026	0.402

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I5L6	Leptomonas seymouri	56%	100%
A0A1X0P403	Trypanosomatidae	39%	100%
A0A3S7X0I2	Leishmania donovani	72%	100%
E9AD47	Leishmania major	73%	100%
E9AHE1	Leishmania infantum	72%	100%
E9AYX1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	73%	100%