Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania braziliensis

UniProt:

A4HFJ3_LEIBR

TriTrypDb:

LbrM.27.0780 , LBRM2903_270013200

Length:

922

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	7
GO:0042995	cell projection	2	7
GO:0043226	organelle	2	7
GO:0043227	membrane-bounded organelle	3	7
GO:0110165	cellular anatomical entity	1	7
GO:0120025	plasma membrane bounded cell projection	3	7

Expansion

Sequence features

A4HFJ3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HFJ3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	320	324	PF00656	0.597
CLV_C14_Caspase3-7	43	47	PF00656	0.473
CLV_C14_Caspase3-7	868	872	PF00656	0.536
CLV_NRD_NRD_1	161	163	PF00675	0.432
CLV_NRD_NRD_1	186	188	PF00675	0.508
CLV_NRD_NRD_1	517	519	PF00675	0.494
CLV_NRD_NRD_1	537	539	PF00675	0.301
CLV_NRD_NRD_1	646	648	PF00675	0.334
CLV_NRD_NRD_1	763	765	PF00675	0.631
CLV_NRD_NRD_1	835	837	PF00675	0.588
CLV_PCSK_KEX2_1	161	163	PF00082	0.432
CLV_PCSK_KEX2_1	186	188	PF00082	0.477
CLV_PCSK_KEX2_1	517	519	PF00082	0.494
CLV_PCSK_KEX2_1	646	648	PF00082	0.334
CLV_PCSK_KEX2_1	835	837	PF00082	0.608
CLV_PCSK_SKI1_1	231	235	PF00082	0.381
CLV_PCSK_SKI1_1	286	290	PF00082	0.370
CLV_PCSK_SKI1_1	450	454	PF00082	0.407
CLV_PCSK_SKI1_1	461	465	PF00082	0.412
CLV_PCSK_SKI1_1	651	655	PF00082	0.329
CLV_PCSK_SKI1_1	734	738	PF00082	0.677
CLV_PCSK_SKI1_1	806	810	PF00082	0.608
CLV_PCSK_SKI1_1	838	842	PF00082	0.659
CLV_PCSK_SKI1_1	909	913	PF00082	0.671
CLV_Separin_Metazoa	447	451	PF03568	0.559
DEG_APCC_DBOX_1	230	238	PF00400	0.613
DEG_SCF_FBW7_1	267	272	PF00400	0.598
DEG_SPOP_SBC_1	316	320	PF00917	0.678
DOC_CKS1_1	266	271	PF01111	0.598
DOC_CKS1_1	485	490	PF01111	0.533
DOC_CKS1_1	64	69	PF01111	0.383
DOC_CYCLIN_yCln2_LP_2	665	671	PF00134	0.222
DOC_CYCLIN_yCln2_LP_2	674	680	PF00134	0.507
DOC_MAPK_DCC_7	551	561	PF00069	0.594
DOC_MAPK_gen_1	167	175	PF00069	0.598
DOC_MAPK_gen_1	646	652	PF00069	0.517
DOC_MAPK_MEF2A_6	167	175	PF00069	0.594
DOC_MAPK_RevD_3	750	765	PF00069	0.410
DOC_PP1_RVXF_1	465	471	PF00149	0.574
DOC_PP2B_LxvP_1	674	677	PF13499	0.347
DOC_PP2B_LxvP_1	752	755	PF13499	0.458
DOC_PP2B_LxvP_1	85	88	PF13499	0.340
DOC_PP4_FxxP_1	214	217	PF00568	0.690
DOC_USP7_MATH_1	310	314	PF00917	0.684
DOC_USP7_MATH_1	452	456	PF00917	0.599
DOC_USP7_MATH_1	479	483	PF00917	0.662
DOC_USP7_MATH_1	486	490	PF00917	0.584
DOC_USP7_MATH_1	631	635	PF00917	0.635
DOC_USP7_MATH_1	736	740	PF00917	0.479
DOC_USP7_MATH_1	760	764	PF00917	0.419
DOC_WW_Pin1_4	120	125	PF00397	0.465
DOC_WW_Pin1_4	265	270	PF00397	0.616
DOC_WW_Pin1_4	484	489	PF00397	0.550
DOC_WW_Pin1_4	63	68	PF00397	0.403
DOC_WW_Pin1_4	686	691	PF00397	0.499
LIG_14-3-3_CanoR_1	186	195	PF00244	0.654
LIG_14-3-3_CanoR_1	206	214	PF00244	0.582
LIG_14-3-3_CanoR_1	302	308	PF00244	0.572
LIG_14-3-3_CanoR_1	344	353	PF00244	0.754
LIG_14-3-3_CanoR_1	355	360	PF00244	0.645
LIG_14-3-3_CanoR_1	384	388	PF00244	0.659
LIG_14-3-3_CanoR_1	562	568	PF00244	0.592
LIG_14-3-3_CanoR_1	646	653	PF00244	0.532
LIG_14-3-3_CanoR_1	801	808	PF00244	0.445
LIG_14-3-3_CanoR_1	909	919	PF00244	0.379
LIG_Actin_WH2_2	191	208	PF00022	0.566
LIG_BIR_III_4	767	771	PF00653	0.438
LIG_BIR_III_4	861	865	PF00653	0.452
LIG_BRCT_BRCA1_1	210	214	PF00533	0.546
LIG_BRCT_BRCA1_1	68	72	PF00533	0.392
LIG_Clathr_ClatBox_1	793	797	PF01394	0.492
LIG_eIF4E_1	675	681	PF01652	0.535
LIG_FHA_1	136	142	PF00498	0.369
LIG_FHA_1	170	176	PF00498	0.588
LIG_FHA_1	202	208	PF00498	0.540
LIG_FHA_1	266	272	PF00498	0.579
LIG_FHA_1	324	330	PF00498	0.690
LIG_FHA_1	355	361	PF00498	0.668
LIG_FHA_1	438	444	PF00498	0.613
LIG_FHA_1	494	500	PF00498	0.606
LIG_FHA_1	50	56	PF00498	0.467
LIG_FHA_1	564	570	PF00498	0.505
LIG_FHA_1	595	601	PF00498	0.569
LIG_FHA_1	655	661	PF00498	0.333
LIG_FHA_1	788	794	PF00498	0.470
LIG_FHA_2	124	130	PF00498	0.418
LIG_FHA_2	280	286	PF00498	0.575
LIG_FHA_2	526	532	PF00498	0.591
LIG_FHA_2	587	593	PF00498	0.581
LIG_FHA_2	807	813	PF00498	0.412
LIG_LIR_Apic_2	131	137	PF02991	0.304
LIG_LIR_Apic_2	211	217	PF02991	0.664
LIG_LIR_Apic_2	575	581	PF02991	0.571
LIG_LIR_Gen_1	336	346	PF02991	0.580
LIG_LIR_Gen_1	587	595	PF02991	0.622
LIG_LIR_Gen_1	69	79	PF02991	0.376
LIG_LIR_Gen_1	776	786	PF02991	0.415
LIG_LIR_Gen_1	899	908	PF02991	0.429
LIG_LIR_Nem_3	336	342	PF02991	0.595
LIG_LIR_Nem_3	413	419	PF02991	0.797
LIG_LIR_Nem_3	531	537	PF02991	0.581
LIG_LIR_Nem_3	542	548	PF02991	0.590
LIG_LIR_Nem_3	587	593	PF02991	0.616
LIG_LIR_Nem_3	621	626	PF02991	0.698
LIG_LIR_Nem_3	69	75	PF02991	0.380
LIG_LIR_Nem_3	776	782	PF02991	0.416
LIG_LIR_Nem_3	899	904	PF02991	0.424
LIG_MAD2	244	252	PF02301	0.552
LIG_OCRL_FandH_1	736	748	PF00620	0.481
LIG_PCNA_yPIPBox_3	224	234	PF02747	0.610
LIG_Pex14_1	663	667	PF04695	0.369
LIG_Pex14_1	91	95	PF04695	0.309
LIG_Pex14_2	667	671	PF04695	0.369
LIG_PTB_Apo_2	895	902	PF02174	0.425
LIG_RPA_C_Fungi	831	843	PF08784	0.461
LIG_SH2_CRK	134	138	PF00017	0.227
LIG_SH2_CRK	363	367	PF00017	0.523
LIG_SH2_CRK	678	682	PF00017	0.518
LIG_SH2_CRK	893	897	PF00017	0.532
LIG_SH2_NCK_1	363	367	PF00017	0.523
LIG_SH2_NCK_1	590	594	PF00017	0.392
LIG_SH2_NCK_1	893	897	PF00017	0.597
LIG_SH2_SRC	568	571	PF00017	0.479
LIG_SH2_SRC	590	593	PF00017	0.389
LIG_SH2_SRC	673	676	PF00017	0.347
LIG_SH2_STAP1	893	897	PF00017	0.455
LIG_SH2_STAT3	547	550	PF00017	0.524
LIG_SH2_STAT5	416	419	PF00017	0.593
LIG_SH2_STAT5	547	550	PF00017	0.459
LIG_SH2_STAT5	560	563	PF00017	0.408
LIG_SH2_STAT5	568	571	PF00017	0.415
LIG_SH2_STAT5	578	581	PF00017	0.342
LIG_SH2_STAT5	673	676	PF00017	0.354
LIG_SH2_STAT5	74	77	PF00017	0.422
LIG_SH3_3	168	174	PF00018	0.639
LIG_SH3_3	470	476	PF00018	0.533
LIG_SH3_3	507	513	PF00018	0.487
LIG_SH3_3	518	524	PF00018	0.549
LIG_SH3_3	58	64	PF00018	0.544
LIG_SUMO_SIM_anti_2	444	450	PF11976	0.435
LIG_SUMO_SIM_anti_2	784	790	PF11976	0.670
LIG_SUMO_SIM_par_1	138	145	PF11976	0.355
LIG_SUMO_SIM_par_1	244	249	PF11976	0.414
LIG_SUMO_SIM_par_1	272	279	PF11976	0.427
LIG_SUMO_SIM_par_1	741	747	PF11976	0.542
LIG_SUMO_SIM_par_1	792	797	PF11976	0.557
LIG_TRAF2_1	863	866	PF00917	0.559
MOD_CK1_1	123	129	PF00069	0.563
MOD_CK1_1	270	276	PF00069	0.406
MOD_CK1_1	317	323	PF00069	0.592
MOD_CK1_1	399	405	PF00069	0.649
MOD_CK1_1	40	46	PF00069	0.699
MOD_CK1_1	49	55	PF00069	0.635
MOD_CK1_1	563	569	PF00069	0.333
MOD_CK1_1	784	790	PF00069	0.606
MOD_CK2_1	106	112	PF00069	0.620
MOD_CK2_1	279	285	PF00069	0.457
MOD_CK2_1	30	36	PF00069	0.667
MOD_CK2_1	371	377	PF00069	0.618
MOD_CK2_1	418	424	PF00069	0.535
MOD_CK2_1	525	531	PF00069	0.482
MOD_CK2_1	586	592	PF00069	0.424
MOD_CK2_1	96	102	PF00069	0.496
MOD_Cter_Amidation	165	168	PF01082	0.510
MOD_GlcNHglycan	107	111	PF01048	0.552
MOD_GlcNHglycan	129	133	PF01048	0.245
MOD_GlcNHglycan	164	167	PF01048	0.566
MOD_GlcNHglycan	247	251	PF01048	0.413
MOD_GlcNHglycan	312	315	PF01048	0.524
MOD_GlcNHglycan	323	326	PF01048	0.507
MOD_GlcNHglycan	346	349	PF01048	0.543
MOD_GlcNHglycan	42	45	PF01048	0.769
MOD_GlcNHglycan	488	491	PF01048	0.610
MOD_GlcNHglycan	562	565	PF01048	0.353
MOD_GlcNHglycan	633	636	PF01048	0.580
MOD_GlcNHglycan	647	650	PF01048	0.354
MOD_GlcNHglycan	783	786	PF01048	0.586
MOD_GlcNHglycan	856	859	PF01048	0.611
MOD_GSK3_1	150	157	PF00069	0.447
MOD_GSK3_1	182	189	PF00069	0.499
MOD_GSK3_1	201	208	PF00069	0.454
MOD_GSK3_1	265	272	PF00069	0.500
MOD_GSK3_1	304	311	PF00069	0.525
MOD_GSK3_1	314	321	PF00069	0.607
MOD_GSK3_1	368	375	PF00069	0.588
MOD_GSK3_1	390	397	PF00069	0.516
MOD_GSK3_1	415	422	PF00069	0.631
MOD_GSK3_1	46	53	PF00069	0.674
MOD_GSK3_1	569	576	PF00069	0.376
MOD_GSK3_1	580	587	PF00069	0.358
MOD_GSK3_1	627	634	PF00069	0.537
MOD_GSK3_1	73	80	PF00069	0.440
MOD_GSK3_1	766	773	PF00069	0.686
MOD_GSK3_1	842	849	PF00069	0.646
MOD_GSK3_1	865	872	PF00069	0.559
MOD_N-GLC_1	371	376	PF02516	0.530
MOD_N-GLC_1	47	52	PF02516	0.548
MOD_N-GLC_1	869	874	PF02516	0.529
MOD_N-GLC_2	388	390	PF02516	0.508
MOD_NEK2_1	130	135	PF00069	0.284
MOD_NEK2_1	205	210	PF00069	0.461
MOD_NEK2_1	212	217	PF00069	0.552
MOD_NEK2_1	246	251	PF00069	0.408
MOD_NEK2_1	276	281	PF00069	0.441
MOD_NEK2_1	353	358	PF00069	0.574
MOD_NEK2_1	383	388	PF00069	0.598
MOD_NEK2_1	412	417	PF00069	0.528
MOD_NEK2_1	454	459	PF00069	0.472
MOD_NEK2_1	468	473	PF00069	0.434
MOD_NEK2_1	498	503	PF00069	0.468
MOD_NEK2_1	584	589	PF00069	0.475
MOD_NEK2_1	77	82	PF00069	0.454
MOD_NEK2_1	800	805	PF00069	0.555
MOD_PIKK_1	156	162	PF00454	0.645
MOD_PIKK_1	323	329	PF00454	0.476
MOD_PIKK_1	540	546	PF00454	0.390
MOD_PIKK_1	787	793	PF00454	0.625
MOD_PIKK_1	910	916	PF00454	0.459
MOD_PK_1	517	523	PF00069	0.472
MOD_PKA_1	186	192	PF00069	0.571
MOD_PKA_1	517	523	PF00069	0.614
MOD_PKA_2	16	22	PF00069	0.636
MOD_PKA_2	186	192	PF00069	0.568
MOD_PKA_2	205	211	PF00069	0.581
MOD_PKA_2	301	307	PF00069	0.503
MOD_PKA_2	354	360	PF00069	0.550
MOD_PKA_2	383	389	PF00069	0.569
MOD_PKA_2	517	523	PF00069	0.614
MOD_PKA_2	645	651	PF00069	0.407
MOD_PKA_2	800	806	PF00069	0.577
MOD_Plk_1	200	206	PF00069	0.450
MOD_Plk_1	218	224	PF00069	0.536
MOD_Plk_1	276	282	PF00069	0.443
MOD_Plk_1	37	43	PF00069	0.544
MOD_Plk_1	371	377	PF00069	0.648
MOD_Plk_1	412	418	PF00069	0.534
MOD_Plk_4	136	142	PF00069	0.335
MOD_Plk_4	194	200	PF00069	0.494
MOD_Plk_4	270	276	PF00069	0.404
MOD_Plk_4	355	361	PF00069	0.505
MOD_Plk_4	412	418	PF00069	0.503
MOD_Plk_4	563	569	PF00069	0.475
MOD_Plk_4	573	579	PF00069	0.371
MOD_Plk_4	618	624	PF00069	0.467
MOD_Plk_4	784	790	PF00069	0.612
MOD_Plk_4	913	919	PF00069	0.475
MOD_ProDKin_1	120	126	PF00069	0.575
MOD_ProDKin_1	265	271	PF00069	0.501
MOD_ProDKin_1	484	490	PF00069	0.409
MOD_ProDKin_1	63	69	PF00069	0.475
MOD_ProDKin_1	686	692	PF00069	0.625
MOD_SUMO_rev_2	24	31	PF00179	0.551
MOD_SUMO_rev_2	283	289	PF00179	0.380
MOD_SUMO_rev_2	374	380	PF00179	0.522
MOD_SUMO_rev_2	99	106	PF00179	0.505
TRG_DiLeu_BaEn_1	778	783	PF01217	0.580
TRG_DiLeu_BaEn_2	745	751	PF01217	0.612
TRG_DiLeu_BaLyEn_6	789	794	PF01217	0.623
TRG_ENDOCYTIC_2	534	537	PF00928	0.458
TRG_ENDOCYTIC_2	590	593	PF00928	0.517
TRG_ENDOCYTIC_2	678	681	PF00928	0.514
TRG_ENDOCYTIC_2	735	738	PF00928	0.733
TRG_ENDOCYTIC_2	74	77	PF00928	0.448
TRG_ENDOCYTIC_2	779	782	PF00928	0.509
TRG_ENDOCYTIC_2	893	896	PF00928	0.540
TRG_ER_diArg_1	161	163	PF00400	0.532
TRG_ER_diArg_1	516	518	PF00400	0.586
TRG_ER_diArg_1	834	836	PF00400	0.459
TRG_NES_CRM1_1	266	278	PF08389	0.390
TRG_Pf-PMV_PEXEL_1	456	460	PF00026	0.467
TRG_Pf-PMV_PEXEL_1	604	609	PF00026	0.409

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PE25	Leptomonas seymouri	42%	97%
A0A3Q8IDB5	Leishmania donovani	66%	100%
E9AD46	Leishmania major	67%	100%
E9AHE0	Leishmania infantum	66%	100%
E9AYX0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	64%	100%