Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HFI8_LEIBR

TriTrypDb:

LbrM.27.0730 , LBRM2903_270012400

Length:

480

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	9
GO:0110165	cellular anatomical entity	1	9

Expansion

Sequence features

A4HFI8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HFI8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	231	233	PF00675	0.409
CLV_NRD_NRD_1	272	274	PF00675	0.604
CLV_NRD_NRD_1	469	471	PF00675	0.506
CLV_NRD_NRD_1	93	95	PF00675	0.455
CLV_PCSK_KEX2_1	231	233	PF00082	0.415
CLV_PCSK_KEX2_1	272	274	PF00082	0.604
CLV_PCSK_KEX2_1	93	95	PF00082	0.463
CLV_PCSK_SKI1_1	236	240	PF00082	0.327
CLV_PCSK_SKI1_1	414	418	PF00082	0.295
CLV_PCSK_SKI1_1	419	423	PF00082	0.244
CLV_PCSK_SKI1_1	93	97	PF00082	0.478
DEG_SCF_FBW7_1	127	134	PF00400	0.650
DEG_SCF_FBW7_2	286	292	PF00400	0.203
DEG_SPOP_SBC_1	30	34	PF00917	0.444
DOC_CKS1_1	286	291	PF01111	0.203
DOC_MAPK_gen_1	231	239	PF00069	0.582
DOC_MAPK_gen_1	312	322	PF00069	0.581
DOC_MAPK_MEF2A_6	252	260	PF00069	0.286
DOC_MAPK_MEF2A_6	368	376	PF00069	0.365
DOC_MAPK_MEF2A_6	419	428	PF00069	0.486
DOC_PP1_RVXF_1	234	240	PF00149	0.566
DOC_PP1_RVXF_1	91	98	PF00149	0.629
DOC_PP2B_LxvP_1	188	191	PF13499	0.573
DOC_SPAK_OSR1_1	273	277	PF12202	0.291
DOC_USP7_MATH_1	399	403	PF00917	0.612
DOC_USP7_MATH_1	464	468	PF00917	0.458
DOC_USP7_UBL2_3	312	316	PF12436	0.683
DOC_WW_Pin1_4	127	132	PF00397	0.730
DOC_WW_Pin1_4	154	159	PF00397	0.603
DOC_WW_Pin1_4	17	22	PF00397	0.590
DOC_WW_Pin1_4	285	290	PF00397	0.203
DOC_WW_Pin1_4	304	309	PF00397	0.667
DOC_WW_Pin1_4	31	36	PF00397	0.452
LIG_14-3-3_CanoR_1	31	35	PF00244	0.501
LIG_14-3-3_CanoR_1	328	333	PF00244	0.656
LIG_14-3-3_CanoR_1	398	408	PF00244	0.548
LIG_APCC_ABBA_1	1	6	PF00400	0.374
LIG_APCC_ABBA_1	202	207	PF00400	0.578
LIG_BRCT_BRCA1_1	140	144	PF00533	0.611
LIG_BRCT_BRCA1_1	475	479	PF00533	0.398
LIG_CaM_IQ_9	86	102	PF13499	0.608
LIG_deltaCOP1_diTrp_1	268	274	PF00928	0.360
LIG_EH1_1	292	300	PF00400	0.569
LIG_EH1_1	320	328	PF00400	0.629
LIG_eIF4E_1	293	299	PF01652	0.513
LIG_eIF4E_1	373	379	PF01652	0.365
LIG_FHA_1	165	171	PF00498	0.712
LIG_FHA_1	292	298	PF00498	0.479
LIG_FHA_1	304	310	PF00498	0.696
LIG_FHA_1	315	321	PF00498	0.671
LIG_FHA_1	337	343	PF00498	0.553
LIG_FHA_1	420	426	PF00498	0.300
LIG_FHA_1	55	61	PF00498	0.331
LIG_FHA_2	198	204	PF00498	0.570
LIG_FHA_2	443	449	PF00498	0.367
LIG_FHA_2	452	458	PF00498	0.428
LIG_GBD_Chelix_1	219	227	PF00786	0.428
LIG_IRF3_LxIS_1	323	330	PF10401	0.625
LIG_LIR_Gen_1	251	262	PF02991	0.481
LIG_LIR_Gen_1	292	300	PF02991	0.606
LIG_LIR_Gen_1	345	355	PF02991	0.287
LIG_LIR_Gen_1	57	66	PF02991	0.391
LIG_LIR_Nem_3	240	244	PF02991	0.645
LIG_LIR_Nem_3	251	257	PF02991	0.462
LIG_LIR_Nem_3	268	274	PF02991	0.331
LIG_LIR_Nem_3	345	350	PF02991	0.287
LIG_LIR_Nem_3	467	472	PF02991	0.386
LIG_LIR_Nem_3	57	61	PF02991	0.420
LIG_PDZ_Class_2	475	480	PF00595	0.342
LIG_Pex14_1	377	381	PF04695	0.239
LIG_Pex14_2	465	469	PF04695	0.409
LIG_REV1ctd_RIR_1	142	150	PF16727	0.625
LIG_SH2_NCK_1	139	143	PF00017	0.660
LIG_SH2_PTP2	245	248	PF00017	0.478
LIG_SH2_PTP2	373	376	PF00017	0.354
LIG_SH2_SRC	446	449	PF00017	0.354
LIG_SH2_STAP1	293	297	PF00017	0.577
LIG_SH2_STAT5	192	195	PF00017	0.623
LIG_SH2_STAT5	245	248	PF00017	0.388
LIG_SH2_STAT5	259	262	PF00017	0.529
LIG_SH2_STAT5	293	296	PF00017	0.520
LIG_SH2_STAT5	369	372	PF00017	0.359
LIG_SH2_STAT5	373	376	PF00017	0.348
LIG_SH2_STAT5	380	383	PF00017	0.356
LIG_SH3_3	102	108	PF00018	0.687
LIG_SH3_3	211	217	PF00018	0.629
LIG_SH3_3	294	300	PF00018	0.554
LIG_SH3_3	350	356	PF00018	0.310
LIG_SH3_3	50	56	PF00018	0.401
LIG_SUMO_SIM_anti_2	167	173	PF11976	0.703
LIG_SUMO_SIM_anti_2	422	429	PF11976	0.211
LIG_SUMO_SIM_anti_2	57	65	PF11976	0.344
LIG_SUMO_SIM_par_1	167	173	PF11976	0.593
LIG_SUMO_SIM_par_1	216	221	PF11976	0.510
LIG_SUMO_SIM_par_1	306	314	PF11976	0.698
LIG_SUMO_SIM_par_1	422	429	PF11976	0.300
LIG_SUMO_SIM_par_1	57	65	PF11976	0.355
LIG_TRAF2_1	454	457	PF00917	0.255
LIG_TYR_ITIM	367	372	PF00017	0.445
LIG_TYR_ITIM	378	383	PF00017	0.296
LIG_WRC_WIRS_1	55	60	PF05994	0.324
LIG_WRC_WIRS_1	86	91	PF05994	0.662
LIG_WW_1	2	5	PF00397	0.368
MOD_CK1_1	164	170	PF00069	0.703
MOD_CK1_1	20	26	PF00069	0.480
MOD_CK1_1	64	70	PF00069	0.239
MOD_CK2_1	131	137	PF00069	0.689
MOD_CK2_1	197	203	PF00069	0.566
MOD_CK2_1	327	333	PF00069	0.658
MOD_CK2_1	442	448	PF00069	0.394
MOD_CK2_1	451	457	PF00069	0.431
MOD_DYRK1A_RPxSP_1	31	35	PF00069	0.412
MOD_GlcNHglycan	10	13	PF01048	0.607
MOD_GlcNHglycan	108	111	PF01048	0.482
MOD_GlcNHglycan	140	143	PF01048	0.443
MOD_GlcNHglycan	164	167	PF01048	0.569
MOD_GlcNHglycan	283	286	PF01048	0.293
MOD_GlcNHglycan	363	366	PF01048	0.586
MOD_GlcNHglycan	395	398	PF01048	0.402
MOD_GlcNHglycan	401	404	PF01048	0.411
MOD_GSK3_1	123	130	PF00069	0.696
MOD_GSK3_1	154	161	PF00069	0.716
MOD_GSK3_1	16	23	PF00069	0.520
MOD_GSK3_1	25	32	PF00069	0.458
MOD_GSK3_1	281	288	PF00069	0.313
MOD_GSK3_1	426	433	PF00069	0.295
MOD_GSK3_1	62	69	PF00069	0.414
MOD_N-GLC_1	40	45	PF02516	0.630
MOD_NEK2_1	138	143	PF00069	0.607
MOD_NEK2_1	248	253	PF00069	0.300
MOD_NEK2_1	303	308	PF00069	0.549
MOD_NEK2_1	327	332	PF00069	0.653
MOD_NEK2_1	361	366	PF00069	0.218
MOD_NEK2_1	426	431	PF00069	0.311
MOD_NEK2_1	465	470	PF00069	0.432
MOD_NEK2_1	61	66	PF00069	0.324
MOD_NEK2_1	96	101	PF00069	0.582
MOD_PIKK_1	114	120	PF00454	0.721
MOD_PIKK_1	231	237	PF00454	0.587
MOD_PIKK_1	25	31	PF00454	0.434
MOD_PIKK_1	452	458	PF00454	0.292
MOD_PIKK_1	473	479	PF00454	0.313
MOD_PK_1	316	322	PF00069	0.667
MOD_PKA_1	231	237	PF00069	0.561
MOD_PKA_2	231	237	PF00069	0.625
MOD_PKA_2	30	36	PF00069	0.541
MOD_PKA_2	327	333	PF00069	0.657
MOD_PKA_2	399	405	PF00069	0.572
MOD_Plk_1	291	297	PF00069	0.461
MOD_Plk_1	40	46	PF00069	0.436
MOD_Plk_2-3	442	448	PF00069	0.403
MOD_Plk_4	20	26	PF00069	0.526
MOD_Plk_4	291	297	PF00069	0.589
MOD_Plk_4	316	322	PF00069	0.602
MOD_Plk_4	336	342	PF00069	0.452
MOD_Plk_4	343	349	PF00069	0.449
MOD_Plk_4	41	47	PF00069	0.452
MOD_Plk_4	419	425	PF00069	0.458
MOD_Plk_4	430	436	PF00069	0.265
MOD_Plk_4	54	60	PF00069	0.207
MOD_ProDKin_1	127	133	PF00069	0.722
MOD_ProDKin_1	154	160	PF00069	0.603
MOD_ProDKin_1	17	23	PF00069	0.590
MOD_ProDKin_1	285	291	PF00069	0.203
MOD_ProDKin_1	304	310	PF00069	0.669
MOD_ProDKin_1	31	37	PF00069	0.451
MOD_SUMO_for_1	311	314	PF00179	0.679
MOD_SUMO_rev_2	313	317	PF00179	0.653
TRG_DiLeu_BaLyEn_6	353	358	PF01217	0.402
TRG_ENDOCYTIC_2	244	247	PF00928	0.337
TRG_ENDOCYTIC_2	293	296	PF00928	0.599
TRG_ENDOCYTIC_2	369	372	PF00928	0.348
TRG_ENDOCYTIC_2	373	376	PF00928	0.312
TRG_ENDOCYTIC_2	380	383	PF00928	0.314
TRG_ENDOCYTIC_2	5	8	PF00928	0.376
TRG_ER_diArg_1	230	232	PF00400	0.596
TRG_ER_diArg_1	271	273	PF00400	0.416
TRG_ER_diArg_1	92	94	PF00400	0.633
TRG_NES_CRM1_1	324	336	PF08389	0.590
TRG_Pf-PMV_PEXEL_1	236	240	PF00026	0.325

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I8L9	Leptomonas seymouri	61%	100%
A0A1X0P3Y2	Trypanosomatidae	33%	100%
A0A3S7X0H3	Leishmania donovani	75%	100%
D0A5R4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	100%
E9AD39	Leishmania major	75%	100%
E9AHD2	Leishmania infantum	76%	100%
E9AYW3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	74%	100%
V5BIJ3	Trypanosoma cruzi	32%	100%