Trichohyalin

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Trichohyalin

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HFI7_LEIBR

TriTrypDb:

LbrM.27.0720 , LBRM2903_270012300

Length:

467

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005929	cilium	4	1
GO:0042995	cell projection	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0110165	cellular anatomical entity	1	1
GO:0120025	plasma membrane bounded cell projection	3	1

Expansion

Sequence features

A4HFI7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HFI7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	100	102	PF00675	0.503
CLV_NRD_NRD_1	169	171	PF00675	0.552
CLV_NRD_NRD_1	199	201	PF00675	0.564
CLV_NRD_NRD_1	224	226	PF00675	0.649
CLV_NRD_NRD_1	282	284	PF00675	0.636
CLV_NRD_NRD_1	304	306	PF00675	0.474
CLV_NRD_NRD_1	319	321	PF00675	0.386
CLV_NRD_NRD_1	379	381	PF00675	0.452
CLV_NRD_NRD_1	390	392	PF00675	0.353
CLV_NRD_NRD_1	63	65	PF00675	0.356
CLV_PCSK_KEX2_1	110	112	PF00082	0.507
CLV_PCSK_KEX2_1	169	171	PF00082	0.468
CLV_PCSK_KEX2_1	224	226	PF00082	0.584
CLV_PCSK_KEX2_1	239	241	PF00082	0.614
CLV_PCSK_KEX2_1	282	284	PF00082	0.493
CLV_PCSK_KEX2_1	304	306	PF00082	0.522
CLV_PCSK_KEX2_1	325	327	PF00082	0.468
CLV_PCSK_KEX2_1	379	381	PF00082	0.459
CLV_PCSK_KEX2_1	390	392	PF00082	0.484
CLV_PCSK_KEX2_1	63	65	PF00082	0.305
CLV_PCSK_KEX2_1	99	101	PF00082	0.512
CLV_PCSK_PC1ET2_1	110	112	PF00082	0.566
CLV_PCSK_PC1ET2_1	239	241	PF00082	0.601
CLV_PCSK_PC1ET2_1	325	327	PF00082	0.484
CLV_PCSK_PC1ET2_1	99	101	PF00082	0.410
CLV_PCSK_PC7_1	375	381	PF00082	0.565
CLV_PCSK_SKI1_1	228	232	PF00082	0.613
CLV_PCSK_SKI1_1	325	329	PF00082	0.338
CLV_PCSK_SKI1_1	42	46	PF00082	0.523
CLV_PCSK_SKI1_1	64	68	PF00082	0.338
DEG_APCC_DBOX_1	315	323	PF00400	0.369
DOC_CYCLIN_RxL_1	39	49	PF00134	0.528
DOC_MAPK_gen_1	325	333	PF00069	0.553
DOC_USP7_MATH_1	249	253	PF00917	0.561
DOC_USP7_UBL2_3	242	246	PF12436	0.689
DOC_USP7_UBL2_3	321	325	PF12436	0.601
DOC_WW_Pin1_4	17	22	PF00397	0.699
DOC_WW_Pin1_4	458	463	PF00397	0.557
LIG_14-3-3_CanoR_1	181	188	PF00244	0.444
LIG_APCC_ABBA_1	366	371	PF00400	0.328
LIG_FHA_1	118	124	PF00498	0.375
LIG_FHA_1	126	132	PF00498	0.338
LIG_FHA_1	169	175	PF00498	0.673
LIG_FHA_1	326	332	PF00498	0.333
LIG_FHA_1	56	62	PF00498	0.502
LIG_FHA_2	182	188	PF00498	0.579
LIG_FHA_2	211	217	PF00498	0.543
LIG_LIR_Apic_2	3	7	PF02991	0.489
LIG_LIR_Nem_3	33	37	PF02991	0.392
LIG_NRBOX	40	46	PF00104	0.513
LIG_PCNA_TLS_4	294	301	PF02747	0.336
LIG_PDZ_Class_2	462	467	PF00595	0.584
LIG_Rb_LxCxE_1	25	47	PF01857	0.314
LIG_RPA_C_Fungi	365	377	PF08784	0.544
LIG_SH2_CRK	4	8	PF00017	0.491
LIG_SH2_CRK	454	458	PF00017	0.477
LIG_SH2_SRC	454	457	PF00017	0.425
LIG_SH2_STAP1	198	202	PF00017	0.644
LIG_SH2_STAT3	300	303	PF00017	0.430
LIG_SH2_STAT3	37	40	PF00017	0.483
LIG_SH2_STAT5	300	303	PF00017	0.537
LIG_SH2_STAT5	355	358	PF00017	0.495
LIG_SH2_STAT5	37	40	PF00017	0.483
LIG_SH3_3	444	450	PF00018	0.555
LIG_SH3_3	454	460	PF00018	0.419
LIG_SUMO_SIM_par_1	455	461	PF11976	0.486
LIG_TRAF2_1	104	107	PF00917	0.494
LIG_TRAF2_1	165	168	PF00917	0.589
LIG_TRAF2_1	336	339	PF00917	0.497
LIG_TRAF2_1	408	411	PF00917	0.464
LIG_TRAF2_1	71	74	PF00917	0.316
LIG_ULM_U2AF65_1	239	244	PF00076	0.677
MOD_CDC14_SPxK_1	20	23	PF00782	0.689
MOD_CDK_SPK_2	17	22	PF00069	0.509
MOD_CDK_SPxK_1	17	23	PF00069	0.663
MOD_CDK_SPxxK_3	17	24	PF00069	0.631
MOD_CK1_1	238	244	PF00069	0.704
MOD_CK1_1	251	257	PF00069	0.762
MOD_CK1_1	440	446	PF00069	0.697
MOD_CK1_1	458	464	PF00069	0.564
MOD_CK2_1	161	167	PF00069	0.603
MOD_CK2_1	181	187	PF00069	0.576
MOD_CK2_1	210	216	PF00069	0.544
MOD_CK2_1	458	464	PF00069	0.571
MOD_CK2_1	67	73	PF00069	0.572
MOD_Cter_Amidation	13	16	PF01082	0.504
MOD_GlcNHglycan	430	433	PF01048	0.682
MOD_GlcNHglycan	442	445	PF01048	0.646
MOD_GlcNHglycan	69	72	PF01048	0.504
MOD_GSK3_1	247	254	PF00069	0.641
MOD_N-GLC_1	381	386	PF02516	0.489
MOD_N-GLC_2	437	439	PF02516	0.482
MOD_NEK2_1	161	166	PF00069	0.530
MOD_NEK2_1	362	367	PF00069	0.327
MOD_NEK2_1	381	386	PF00069	0.281
MOD_NEK2_1	45	50	PF00069	0.584
MOD_NEK2_1	67	72	PF00069	0.496
MOD_NEK2_1	9	14	PF00069	0.709
MOD_PIKK_1	181	187	PF00454	0.468
MOD_PKA_1	22	28	PF00069	0.682
MOD_PKA_1	325	331	PF00069	0.334
MOD_PKA_2	168	174	PF00069	0.653
MOD_PKA_2	235	241	PF00069	0.588
MOD_PKA_2	325	331	PF00069	0.402
MOD_PKA_2	428	434	PF00069	0.691
MOD_Plk_1	156	162	PF00069	0.607
MOD_Plk_1	362	368	PF00069	0.334
MOD_Plk_1	381	387	PF00069	0.410
MOD_Plk_1	409	415	PF00069	0.371
MOD_Plk_2-3	210	216	PF00069	0.544
MOD_Plk_4	156	162	PF00069	0.589
MOD_Plk_4	251	257	PF00069	0.737
MOD_ProDKin_1	17	23	PF00069	0.697
MOD_ProDKin_1	458	464	PF00069	0.557
MOD_SUMO_for_1	245	248	PF00179	0.692
MOD_SUMO_for_1	414	417	PF00179	0.497
MOD_SUMO_rev_2	139	145	PF00179	0.516
MOD_SUMO_rev_2	227	232	PF00179	0.701
MOD_SUMO_rev_2	262	269	PF00179	0.460
MOD_SUMO_rev_2	287	295	PF00179	0.508
TRG_DiLeu_BaEn_4	124	130	PF01217	0.354
TRG_DiLeu_BaEn_4	292	298	PF01217	0.342
TRG_DiLeu_BaEn_4	73	79	PF01217	0.298
TRG_ENDOCYTIC_2	454	457	PF00928	0.478
TRG_ER_diArg_1	100	102	PF00400	0.493
TRG_ER_diArg_1	169	172	PF00400	0.553
TRG_ER_diArg_1	223	225	PF00400	0.597
TRG_ER_diArg_1	282	284	PF00400	0.604
TRG_ER_diArg_1	379	381	PF00400	0.478
TRG_ER_diArg_1	389	391	PF00400	0.479
TRG_ER_diArg_1	63	65	PF00400	0.356
TRG_NLS_Bipartite_1	224	243	PF00514	0.450
TRG_NLS_MonoExtN_4	236	243	PF00514	0.624
TRG_Pf-PMV_PEXEL_1	200	204	PF00026	0.710
TRG_Pf-PMV_PEXEL_1	282	286	PF00026	0.457
TRG_Pf-PMV_PEXEL_1	320	324	PF00026	0.560
TRG_Pf-PMV_PEXEL_1	360	364	PF00026	0.493
TRG_Pf-PMV_PEXEL_1	42	46	PF00026	0.523

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1ILN1	Leptomonas seymouri	58%	100%
A0A1X0P3Z6	Trypanosomatidae	32%	100%
A0A3Q8IE88	Leishmania donovani	74%	100%
A0A3R7MQZ8	Trypanosoma rangeli	30%	100%
D0A5R3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	100%
E9AD38	Leishmania major	73%	99%
E9AHD1	Leishmania infantum	74%	100%
E9AYW2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	71%	100%
V5BE50	Trypanosoma cruzi	28%	100%