Dynein_C domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Domain of unknown function (DUF4470)/Domain of unknown function (DUF4471), putative

Species:

Leishmania braziliensis

UniProt:

A4HFI5_LEIBR

TriTrypDb:

LbrM.27.0700 , LBRM2903_270012100

Length:

593

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	10
GO:0110165	cellular anatomical entity	1	10

Expansion

Sequence features

A4HFI5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HFI5

Function

Biological processes
Term	Name	Level	Count
GO:0009987	cellular process	1	10
GO:0016043	cellular component organization	3	10
GO:0022607	cellular component assembly	4	10
GO:0043933	protein-containing complex organization	4	10
GO:0065003	protein-containing complex assembly	5	10
GO:0070286	axonemal dynein complex assembly	6	10
GO:0071840	cellular component organization or biogenesis	2	10
GO:0006996	organelle organization	4	1
GO:0030030	cell projection organization	4	1
GO:0030031	cell projection assembly	5	1
GO:0044458	motile cilium assembly	7	1
GO:0044782	cilium organization	5	1
GO:0060271	cilium assembly	6	1
GO:0070925	organelle assembly	5	1
GO:0120031	plasma membrane bounded cell projection assembly	6	1
GO:0120036	plasma membrane bounded cell projection organization	5	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	299	303	PF00656	0.463
CLV_C14_Caspase3-7	567	571	PF00656	0.615
CLV_NRD_NRD_1	343	345	PF00675	0.263
CLV_NRD_NRD_1	96	98	PF00675	0.596
CLV_PCSK_KEX2_1	343	345	PF00082	0.263
CLV_PCSK_KEX2_1	37	39	PF00082	0.508
CLV_PCSK_KEX2_1	96	98	PF00082	0.466
CLV_PCSK_PC1ET2_1	37	39	PF00082	0.580
CLV_PCSK_SKI1_1	150	154	PF00082	0.291
CLV_PCSK_SKI1_1	189	193	PF00082	0.263
CLV_PCSK_SKI1_1	224	228	PF00082	0.421
CLV_PCSK_SKI1_1	239	243	PF00082	0.453
CLV_PCSK_SKI1_1	469	473	PF00082	0.225
CLV_PCSK_SKI1_1	97	101	PF00082	0.587
DEG_APCC_DBOX_1	149	157	PF00400	0.528
DEG_APCC_DBOX_1	410	418	PF00400	0.463
DEG_SPOP_SBC_1	121	125	PF00917	0.456
DOC_CKS1_1	443	448	PF01111	0.503
DOC_CKS1_1	494	499	PF01111	0.441
DOC_CYCLIN_RxL_1	352	363	PF00134	0.534
DOC_MAPK_gen_1	326	335	PF00069	0.463
DOC_MAPK_gen_1	457	465	PF00069	0.503
DOC_MAPK_MEF2A_6	210	217	PF00069	0.480
DOC_MAPK_NFAT4_5	210	218	PF00069	0.480
DOC_PIKK_1	82	89	PF02985	0.705
DOC_PP1_RVXF_1	187	194	PF00149	0.463
DOC_PP1_RVXF_1	208	215	PF00149	0.463
DOC_PP1_RVXF_1	353	360	PF00149	0.508
DOC_PP1_RVXF_1	457	463	PF00149	0.526
DOC_USP7_MATH_1	103	107	PF00917	0.713
DOC_USP7_MATH_1	108	112	PF00917	0.726
DOC_USP7_MATH_1	121	125	PF00917	0.382
DOC_USP7_MATH_1	144	148	PF00917	0.562
DOC_USP7_MATH_1	161	165	PF00917	0.453
DOC_USP7_MATH_1	549	553	PF00917	0.307
DOC_USP7_MATH_1	580	584	PF00917	0.270
DOC_USP7_MATH_1	64	68	PF00917	0.686
DOC_USP7_MATH_1	74	78	PF00917	0.720
DOC_WW_Pin1_4	116	121	PF00397	0.701
DOC_WW_Pin1_4	23	28	PF00397	0.363
DOC_WW_Pin1_4	381	386	PF00397	0.390
DOC_WW_Pin1_4	442	447	PF00397	0.480
DOC_WW_Pin1_4	493	498	PF00397	0.478
DOC_WW_Pin1_4	59	64	PF00397	0.784
LIG_14-3-3_CanoR_1	154	160	PF00244	0.463
LIG_14-3-3_CanoR_1	251	256	PF00244	0.467
LIG_14-3-3_CanoR_1	343	349	PF00244	0.453
LIG_14-3-3_CanoR_1	390	400	PF00244	0.424
LIG_14-3-3_CanoR_1	573	579	PF00244	0.442
LIG_Actin_WH2_2	145	162	PF00022	0.534
LIG_Actin_WH2_2	235	253	PF00022	0.433
LIG_APCC_ABBA_1	211	216	PF00400	0.463
LIG_APCC_ABBAyCdc20_2	210	216	PF00400	0.463
LIG_BIR_II_1	1	5	PF00653	0.597
LIG_BRCT_BRCA1_1	118	122	PF00533	0.534
LIG_Clathr_ClatBox_1	212	216	PF01394	0.472
LIG_deltaCOP1_diTrp_1	20	25	PF00928	0.412
LIG_deltaCOP1_diTrp_1	306	311	PF00928	0.463
LIG_deltaCOP1_diTrp_1	466	470	PF00928	0.517
LIG_DLG_GKlike_1	344	352	PF00625	0.390
LIG_eIF4E_1	579	585	PF01652	0.466
LIG_FHA_1	138	144	PF00498	0.432
LIG_FHA_1	315	321	PF00498	0.463
LIG_FHA_1	450	456	PF00498	0.554
LIG_FHA_1	46	52	PF00498	0.658
LIG_FHA_1	494	500	PF00498	0.482
LIG_FHA_1	527	533	PF00498	0.477
LIG_FHA_1	549	555	PF00498	0.412
LIG_FHA_2	238	244	PF00498	0.433
LIG_FHA_2	543	549	PF00498	0.390
LIG_FHA_2	565	571	PF00498	0.591
LIG_GBD_Chelix_1	234	242	PF00786	0.442
LIG_LIR_Apic_2	347	353	PF02991	0.461
LIG_LIR_Apic_2	492	497	PF02991	0.454
LIG_LIR_Apic_2	577	582	PF02991	0.424
LIG_LIR_Gen_1	254	262	PF02991	0.463
LIG_LIR_Gen_1	30	39	PF02991	0.417
LIG_LIR_Gen_1	306	313	PF02991	0.480
LIG_LIR_Gen_1	314	323	PF02991	0.445
LIG_LIR_Gen_1	466	472	PF02991	0.465
LIG_LIR_Nem_3	174	180	PF02991	0.453
LIG_LIR_Nem_3	30	34	PF02991	0.379
LIG_LIR_Nem_3	306	310	PF02991	0.472
LIG_LIR_Nem_3	314	319	PF02991	0.452
LIG_LIR_Nem_3	379	383	PF02991	0.534
LIG_LIR_Nem_3	466	470	PF02991	0.469
LIG_NRBOX	193	199	PF00104	0.463
LIG_PCNA_yPIPBox_3	189	202	PF02747	0.480
LIG_PCNA_yPIPBox_3	578	588	PF02747	0.462
LIG_PDZ_Class_2	588	593	PF00595	0.461
LIG_Pex14_1	307	311	PF04695	0.463
LIG_Pex14_2	192	196	PF04695	0.463
LIG_PTB_Apo_2	371	378	PF02174	0.463
LIG_Rb_LxCxE_1	468	489	PF01857	0.491
LIG_REV1ctd_RIR_1	357	366	PF16727	0.467
LIG_SH2_CRK	316	320	PF00017	0.463
LIG_SH2_CRK	350	354	PF00017	0.463
LIG_SH2_CRK	438	442	PF00017	0.534
LIG_SH2_CRK	494	498	PF00017	0.531
LIG_SH2_CRK	579	583	PF00017	0.411
LIG_SH2_GRB2like	298	301	PF00017	0.498
LIG_SH2_GRB2like	316	319	PF00017	0.372
LIG_SH2_NCK_1	350	354	PF00017	0.401
LIG_SH2_NCK_1	579	583	PF00017	0.323
LIG_SH2_SRC	180	183	PF00017	0.467
LIG_SH2_SRC	348	351	PF00017	0.390
LIG_SH2_SRC	440	443	PF00017	0.534
LIG_SH2_STAP1	316	320	PF00017	0.463
LIG_SH2_STAP1	348	352	PF00017	0.463
LIG_SH2_STAP1	451	455	PF00017	0.534
LIG_SH2_STAT5	178	181	PF00017	0.463
LIG_SH2_STAT5	316	319	PF00017	0.466
LIG_SH2_STAT5	415	418	PF00017	0.534
LIG_SH2_STAT5	440	443	PF00017	0.534
LIG_SH2_STAT5	451	454	PF00017	0.534
LIG_SH2_STAT5	5	8	PF00017	0.568
LIG_SH2_STAT5	531	534	PF00017	0.534
LIG_SH2_STAT5	553	556	PF00017	0.307
LIG_SH2_STAT5	587	590	PF00017	0.496
LIG_SH3_1	440	446	PF00018	0.562
LIG_SH3_3	440	446	PF00018	0.503
LIG_SUMO_SIM_anti_2	136	143	PF11976	0.536
LIG_SUMO_SIM_anti_2	30	36	PF11976	0.531
LIG_TRAF2_1	203	206	PF00917	0.534
LIG_TRAF2_1	254	257	PF00917	0.534
LIG_TRAF2_1	80	83	PF00917	0.496
LIG_WRC_WIRS_1	252	257	PF05994	0.316
LIG_WRC_WIRS_1	377	382	PF05994	0.399
MOD_CK1_1	111	117	PF00069	0.748
MOD_CK1_1	123	129	PF00069	0.369
MOD_CK1_1	16	22	PF00069	0.589
MOD_CK1_1	200	206	PF00069	0.231
MOD_CK1_1	50	56	PF00069	0.707
MOD_CK1_1	65	71	PF00069	0.687
MOD_CK1_1	77	83	PF00069	0.606
MOD_CK2_1	200	206	PF00069	0.231
MOD_CK2_1	237	243	PF00069	0.294
MOD_CK2_1	251	257	PF00069	0.316
MOD_CK2_1	77	83	PF00069	0.636
MOD_Cter_Amidation	94	97	PF01082	0.468
MOD_GlcNHglycan	163	166	PF01048	0.427
MOD_GlcNHglycan	168	171	PF01048	0.395
MOD_GlcNHglycan	245	249	PF01048	0.546
MOD_GlcNHglycan	362	365	PF01048	0.439
MOD_GlcNHglycan	368	371	PF01048	0.341
MOD_GlcNHglycan	446	449	PF01048	0.416
MOD_GlcNHglycan	64	67	PF01048	0.720
MOD_GSK3_1	116	123	PF00069	0.693
MOD_GSK3_1	237	244	PF00069	0.482
MOD_GSK3_1	324	331	PF00069	0.321
MOD_GSK3_1	344	351	PF00069	0.128
MOD_GSK3_1	390	397	PF00069	0.348
MOD_GSK3_1	45	52	PF00069	0.579
MOD_GSK3_1	489	496	PF00069	0.313
MOD_GSK3_1	70	77	PF00069	0.662
MOD_LATS_1	388	394	PF00433	0.341
MOD_N-GLC_1	353	358	PF02516	0.316
MOD_NEK2_1	122	127	PF00069	0.215
MOD_NEK2_1	13	18	PF00069	0.602
MOD_NEK2_1	152	157	PF00069	0.456
MOD_NEK2_1	197	202	PF00069	0.316
MOD_NEK2_1	265	270	PF00069	0.399
MOD_NEK2_1	360	365	PF00069	0.379
MOD_NEK2_1	486	491	PF00069	0.310
MOD_NEK2_2	403	408	PF00069	0.316
MOD_PIKK_1	265	271	PF00454	0.371
MOD_PIKK_1	45	51	PF00454	0.751
MOD_PIKK_1	489	495	PF00454	0.316
MOD_PIKK_1	572	578	PF00454	0.574
MOD_PK_1	275	281	PF00069	0.322
MOD_PKA_2	328	334	PF00069	0.341
MOD_PKA_2	391	397	PF00069	0.416
MOD_PKA_2	572	578	PF00069	0.570
MOD_PKA_2	95	101	PF00069	0.463
MOD_Plk_1	137	143	PF00069	0.215
MOD_Plk_1	244	250	PF00069	0.448
MOD_Plk_1	275	281	PF00069	0.233
MOD_Plk_1	348	354	PF00069	0.336
MOD_Plk_4	137	143	PF00069	0.336
MOD_Plk_4	197	203	PF00069	0.341
MOD_Plk_4	30	36	PF00069	0.492
MOD_Plk_4	413	419	PF00069	0.416
MOD_Plk_4	495	501	PF00069	0.404
MOD_Plk_4	549	555	PF00069	0.301
MOD_Plk_4	580	586	PF00069	0.458
MOD_ProDKin_1	116	122	PF00069	0.704
MOD_ProDKin_1	23	29	PF00069	0.361
MOD_ProDKin_1	381	387	PF00069	0.215
MOD_ProDKin_1	442	448	PF00069	0.341
MOD_ProDKin_1	493	499	PF00069	0.338
MOD_ProDKin_1	59	65	PF00069	0.785
MOD_SUMO_rev_2	110	116	PF00179	0.523
MOD_SUMO_rev_2	254	260	PF00179	0.379
MOD_SUMO_rev_2	552	559	PF00179	0.539
TRG_DiLeu_BaEn_1	138	143	PF01217	0.456
TRG_DiLeu_BaEn_1	208	213	PF01217	0.316
TRG_DiLeu_BaEn_1	315	320	PF01217	0.416
TRG_DiLeu_BaEn_1	85	90	PF01217	0.663
TRG_DiLeu_BaEn_1	9	14	PF01217	0.622
TRG_DiLeu_BaEn_2	465	471	PF01217	0.347
TRG_DiLeu_BaEn_2	514	520	PF01217	0.316
TRG_ENDOCYTIC_2	316	319	PF00928	0.316
TRG_ENDOCYTIC_2	415	418	PF00928	0.316
TRG_ENDOCYTIC_2	438	441	PF00928	0.316
TRG_ER_diArg_1	342	344	PF00400	0.316
TRG_ER_diArg_1	389	392	PF00400	0.341
TRG_NES_CRM1_1	502	515	PF08389	0.327

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1ILC1	Leptomonas seymouri	70%	100%
A0A1X0P5D9	Trypanosomatidae	51%	100%
A0A3R7RLZ6	Trypanosoma rangeli	53%	100%
A0A3S7X0G7	Leishmania donovani	84%	100%
D0A5R1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	53%	100%
D3ZCM9	Rattus norvegicus	27%	100%
E9AD36	Leishmania major	83%	100%
E9AHC9	Leishmania infantum	84%	100%
E9AYW0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	99%
F1MLB4	Bos taurus	31%	100%
F6S9E6	Xenopus tropicalis	27%	100%
Q32NQ7	Xenopus laevis	27%	100%
Q3UYV8	Mus musculus	28%	100%
Q8N9W5	Homo sapiens	29%	100%
Q95K25	Macaca fascicularis	28%	100%