LisH domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HFI4_LEIBR

TriTrypDb:

LbrM.27.0690 , LBRM2903_270012000

Length:

696

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005681	spliceosomal complex	3	1
GO:0032991	protein-containing complex	1	1
GO:0071011	precatalytic spliceosome	4	1
GO:0140513	nuclear protein-containing complex	2	1
GO:1990904	ribonucleoprotein complex	2	1

Expansion

Sequence features

A4HFI4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HFI4

Function

Biological processes
Term	Name	Level	Count
GO:0000375	RNA splicing, via transesterification reactions	8	11
GO:0000377	RNA splicing, via transesterification reactions with bulged adenosine as nucleophile	9	11
GO:0000398	mRNA splicing, via spliceosome	8	11
GO:0006139	nucleobase-containing compound metabolic process	3	11
GO:0006396	RNA processing	6	11
GO:0006397	mRNA processing	7	11
GO:0006725	cellular aromatic compound metabolic process	3	11
GO:0006807	nitrogen compound metabolic process	2	11
GO:0008152	metabolic process	1	11
GO:0008380	RNA splicing	7	11
GO:0009987	cellular process	1	11
GO:0016070	RNA metabolic process	5	11
GO:0016071	mRNA metabolic process	6	11
GO:0034641	cellular nitrogen compound metabolic process	3	11
GO:0043170	macromolecule metabolic process	3	11
GO:0044237	cellular metabolic process	2	11
GO:0044238	primary metabolic process	2	11
GO:0046483	heterocycle metabolic process	3	11
GO:0071704	organic substance metabolic process	2	11
GO:0090304	nucleic acid metabolic process	4	11
GO:1901360	organic cyclic compound metabolic process	3	11

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	352	356	PF00656	0.404
CLV_C14_Caspase3-7	459	463	PF00656	0.601
CLV_C14_Caspase3-7	471	475	PF00656	0.426
CLV_C14_Caspase3-7	513	517	PF00656	0.441
CLV_NRD_NRD_1	189	191	PF00675	0.515
CLV_NRD_NRD_1	260	262	PF00675	0.698
CLV_NRD_NRD_1	292	294	PF00675	0.461
CLV_NRD_NRD_1	385	387	PF00675	0.347
CLV_PCSK_KEX2_1	189	191	PF00082	0.372
CLV_PCSK_KEX2_1	262	264	PF00082	0.705
CLV_PCSK_KEX2_1	291	293	PF00082	0.479
CLV_PCSK_KEX2_1	385	387	PF00082	0.334
CLV_PCSK_KEX2_1	485	487	PF00082	0.511
CLV_PCSK_KEX2_1	71	73	PF00082	0.618
CLV_PCSK_PC1ET2_1	262	264	PF00082	0.694
CLV_PCSK_PC1ET2_1	485	487	PF00082	0.357
CLV_PCSK_PC1ET2_1	71	73	PF00082	0.618
CLV_PCSK_PC7_1	481	487	PF00082	0.464
CLV_PCSK_SKI1_1	135	139	PF00082	0.373
CLV_PCSK_SKI1_1	167	171	PF00082	0.522
CLV_PCSK_SKI1_1	180	184	PF00082	0.463
CLV_PCSK_SKI1_1	190	194	PF00082	0.324
CLV_PCSK_SKI1_1	465	469	PF00082	0.481
CLV_PCSK_SKI1_1	593	597	PF00082	0.370
CLV_PCSK_SKI1_1	661	665	PF00082	0.507
CLV_Separin_Metazoa	497	501	PF03568	0.433
DEG_Nend_UBRbox_2	1	3	PF02207	0.492
DEG_SPOP_SBC_1	537	541	PF00917	0.513
DOC_CYCLIN_yCln2_LP_2	280	286	PF00134	0.558
DOC_MAPK_gen_1	557	566	PF00069	0.399
DOC_MAPK_MEF2A_6	560	568	PF00069	0.397
DOC_PP2B_LxvP_1	106	109	PF13499	0.333
DOC_PP2B_LxvP_1	139	142	PF13499	0.498
DOC_PP2B_LxvP_1	284	287	PF13499	0.515
DOC_PP2B_LxvP_1	454	457	PF13499	0.310
DOC_PP4_FxxP_1	400	403	PF00568	0.417
DOC_USP7_MATH_1	133	137	PF00917	0.469
DOC_USP7_MATH_1	221	225	PF00917	0.595
DOC_USP7_MATH_1	251	255	PF00917	0.748
DOC_USP7_MATH_1	307	311	PF00917	0.309
DOC_USP7_MATH_1	531	535	PF00917	0.473
DOC_USP7_MATH_1	57	61	PF00917	0.571
DOC_USP7_MATH_1	591	595	PF00917	0.450
DOC_USP7_MATH_1	8	12	PF00917	0.596
DOC_WW_Pin1_4	148	153	PF00397	0.383
DOC_WW_Pin1_4	180	185	PF00397	0.529
DOC_WW_Pin1_4	2	7	PF00397	0.651
DOC_WW_Pin1_4	303	308	PF00397	0.361
DOC_WW_Pin1_4	670	675	PF00397	0.436
LIG_14-3-3_CanoR_1	167	175	PF00244	0.608
LIG_14-3-3_CanoR_1	189	197	PF00244	0.456
LIG_14-3-3_CanoR_1	202	209	PF00244	0.411
LIG_14-3-3_CanoR_1	218	227	PF00244	0.501
LIG_14-3-3_CanoR_1	233	242	PF00244	0.459
LIG_14-3-3_CanoR_1	404	410	PF00244	0.594
LIG_14-3-3_CanoR_1	565	569	PF00244	0.384
LIG_Actin_WH2_2	579	595	PF00022	0.454
LIG_Actin_WH2_2	6	23	PF00022	0.370
LIG_APCC_ABBA_1	99	104	PF00400	0.476
LIG_BIR_III_2	516	520	PF00653	0.417
LIG_Clathr_ClatBox_1	451	455	PF01394	0.416
LIG_CSL_BTD_1	671	674	PF09270	0.420
LIG_deltaCOP1_diTrp_1	271	279	PF00928	0.612
LIG_deltaCOP1_diTrp_1	627	636	PF00928	0.473
LIG_eIF4E_1	102	108	PF01652	0.339
LIG_FHA_1	181	187	PF00498	0.524
LIG_FHA_1	189	195	PF00498	0.495
LIG_FHA_1	297	303	PF00498	0.455
LIG_FHA_1	390	396	PF00498	0.375
LIG_FHA_1	404	410	PF00498	0.456
LIG_FHA_1	430	436	PF00498	0.543
LIG_FHA_1	474	480	PF00498	0.436
LIG_FHA_1	493	499	PF00498	0.536
LIG_FHA_1	618	624	PF00498	0.404
LIG_FHA_1	678	684	PF00498	0.338
LIG_FHA_2	113	119	PF00498	0.436
LIG_FHA_2	166	172	PF00498	0.538
LIG_FHA_2	329	335	PF00498	0.303
LIG_FHA_2	457	463	PF00498	0.574
LIG_FHA_2	565	571	PF00498	0.299
LIG_FHA_2	78	84	PF00498	0.346
LIG_GBD_Chelix_1	460	468	PF00786	0.312
LIG_LIR_Apic_2	520	526	PF02991	0.476
LIG_LIR_Gen_1	115	125	PF02991	0.303
LIG_LIR_Gen_1	326	334	PF02991	0.534
LIG_LIR_Gen_1	362	368	PF02991	0.311
LIG_LIR_Gen_1	370	378	PF02991	0.288
LIG_LIR_Gen_1	633	643	PF02991	0.501
LIG_LIR_Gen_1	92	103	PF02991	0.356
LIG_LIR_LC3C_4	313	318	PF02991	0.359
LIG_LIR_Nem_3	115	120	PF02991	0.314
LIG_LIR_Nem_3	277	282	PF02991	0.483
LIG_LIR_Nem_3	326	330	PF02991	0.491
LIG_LIR_Nem_3	362	366	PF02991	0.319
LIG_LIR_Nem_3	370	375	PF02991	0.284
LIG_LIR_Nem_3	594	599	PF02991	0.431
LIG_LIR_Nem_3	633	639	PF02991	0.443
LIG_LIR_Nem_3	92	98	PF02991	0.358
LIG_PCNA_yPIPBox_3	135	147	PF02747	0.474
LIG_Pex14_1	275	279	PF04695	0.604
LIG_Pex14_1	372	376	PF04695	0.330
LIG_Rb_LxCxE_1	520	542	PF01857	0.388
LIG_SH2_CRK	47	51	PF00017	0.513
LIG_SH2_CRK	523	527	PF00017	0.501
LIG_SH2_NCK_1	631	635	PF00017	0.282
LIG_SH2_PTP2	155	158	PF00017	0.487
LIG_SH2_SRC	102	105	PF00017	0.368
LIG_SH2_STAP1	117	121	PF00017	0.329
LIG_SH2_STAP1	685	689	PF00017	0.439
LIG_SH2_STAT5	102	105	PF00017	0.375
LIG_SH2_STAT5	155	158	PF00017	0.487
LIG_SH2_STAT5	22	25	PF00017	0.468
LIG_SH2_STAT5	466	469	PF00017	0.511
LIG_SH2_STAT5	575	578	PF00017	0.418
LIG_SH3_3	51	57	PF00018	0.635
LIG_SH3_3	684	690	PF00018	0.390
LIG_SUMO_SIM_anti_2	313	319	PF11976	0.358
LIG_SUMO_SIM_anti_2	495	500	PF11976	0.343
LIG_SUMO_SIM_anti_2	652	658	PF11976	0.427
LIG_SUMO_SIM_par_1	405	410	PF11976	0.350
LIG_SUMO_SIM_par_1	426	432	PF11976	0.303
LIG_TRAF2_1	311	314	PF00917	0.535
LIG_TYR_ITIM	45	50	PF00017	0.418
LIG_TYR_ITSM	113	120	PF00017	0.434
LIG_UBA3_1	193	198	PF00899	0.419
MOD_CDK_SPxK_1	148	154	PF00069	0.471
MOD_CK1_1	329	335	PF00069	0.313
MOD_CK1_1	442	448	PF00069	0.393
MOD_CK1_1	646	652	PF00069	0.332
MOD_CK1_1	7	13	PF00069	0.667
MOD_CK1_1	79	85	PF00069	0.384
MOD_CK2_1	112	118	PF00069	0.438
MOD_CK2_1	165	171	PF00069	0.573
MOD_CK2_1	307	313	PF00069	0.531
MOD_CK2_1	328	334	PF00069	0.403
MOD_CK2_1	644	650	PF00069	0.436
MOD_CK2_1	77	83	PF00069	0.568
MOD_CK2_1	91	97	PF00069	0.441
MOD_Cter_Amidation	69	72	PF01082	0.618
MOD_GlcNHglycan	223	226	PF01048	0.644
MOD_GlcNHglycan	235	238	PF01048	0.750
MOD_GlcNHglycan	243	246	PF01048	0.654
MOD_GlcNHglycan	309	312	PF01048	0.594
MOD_GlcNHglycan	342	345	PF01048	0.360
MOD_GlcNHglycan	400	403	PF01048	0.434
MOD_GlcNHglycan	409	412	PF01048	0.498
MOD_GlcNHglycan	444	447	PF01048	0.511
MOD_GlcNHglycan	470	473	PF01048	0.321
MOD_GlcNHglycan	593	596	PF01048	0.447
MOD_GlcNHglycan	60	63	PF01048	0.663
MOD_GlcNHglycan	646	649	PF01048	0.479
MOD_GlcNHglycan	650	654	PF01048	0.450
MOD_GlcNHglycan	68	71	PF01048	0.669
MOD_GlcNHglycan	73	76	PF01048	0.674
MOD_GSK3_1	227	234	PF00069	0.572
MOD_GSK3_1	241	248	PF00069	0.602
MOD_GSK3_1	303	310	PF00069	0.294
MOD_GSK3_1	328	335	PF00069	0.307
MOD_GSK3_1	389	396	PF00069	0.338
MOD_GSK3_1	4	11	PF00069	0.690
MOD_GSK3_1	403	410	PF00069	0.471
MOD_GSK3_1	411	418	PF00069	0.390
MOD_GSK3_1	435	442	PF00069	0.288
MOD_GSK3_1	529	536	PF00069	0.677
MOD_GSK3_1	540	547	PF00069	0.600
MOD_GSK3_1	666	673	PF00069	0.487
MOD_N-GLC_1	58	63	PF02516	0.571
MOD_NEK2_1	250	255	PF00069	0.494
MOD_NEK2_1	340	345	PF00069	0.411
MOD_NEK2_1	389	394	PF00069	0.454
MOD_NEK2_1	415	420	PF00069	0.392
MOD_NEK2_1	467	472	PF00069	0.352
MOD_NEK2_1	553	558	PF00069	0.359
MOD_NEK2_1	576	581	PF00069	0.399
MOD_NEK2_1	643	648	PF00069	0.447
MOD_NEK2_1	666	671	PF00069	0.426
MOD_NEK2_1	91	96	PF00069	0.445
MOD_NEK2_2	608	613	PF00069	0.298
MOD_NEK2_2	619	624	PF00069	0.312
MOD_PIKK_1	228	234	PF00454	0.625
MOD_PIKK_1	517	523	PF00454	0.404
MOD_PIKK_1	546	552	PF00454	0.442
MOD_PIKK_1	672	678	PF00454	0.545
MOD_PKA_1	71	77	PF00069	0.609
MOD_PKA_2	188	194	PF00069	0.488
MOD_PKA_2	201	207	PF00069	0.422
MOD_PKA_2	340	346	PF00069	0.487
MOD_PKA_2	350	356	PF00069	0.546
MOD_PKA_2	403	409	PF00069	0.569
MOD_PKA_2	564	570	PF00069	0.408
MOD_PKA_2	643	649	PF00069	0.494
MOD_PKA_2	71	77	PF00069	0.712
MOD_Plk_1	649	655	PF00069	0.412
MOD_Plk_4	112	118	PF00069	0.439
MOD_Plk_4	170	176	PF00069	0.530
MOD_Plk_4	235	241	PF00069	0.580
MOD_Plk_4	245	251	PF00069	0.425
MOD_Plk_4	275	281	PF00069	0.500
MOD_Plk_4	411	417	PF00069	0.403
MOD_Plk_4	456	462	PF00069	0.572
MOD_Plk_4	475	481	PF00069	0.251
MOD_Plk_4	598	604	PF00069	0.477
MOD_Plk_4	608	614	PF00069	0.247
MOD_Plk_4	678	684	PF00069	0.416
MOD_ProDKin_1	148	154	PF00069	0.377
MOD_ProDKin_1	180	186	PF00069	0.515
MOD_ProDKin_1	2	8	PF00069	0.646
MOD_ProDKin_1	303	309	PF00069	0.370
MOD_ProDKin_1	670	676	PF00069	0.439
MOD_SUMO_for_1	568	571	PF00179	0.285
MOD_SUMO_rev_2	110	115	PF00179	0.459
MOD_SUMO_rev_2	41	46	PF00179	0.645
TRG_DiLeu_BaEn_1	126	131	PF01217	0.376
TRG_DiLeu_BaEn_4	122	128	PF01217	0.346
TRG_DiLeu_BaLyEn_6	605	610	PF01217	0.352
TRG_ENDOCYTIC_2	117	120	PF00928	0.301
TRG_ENDOCYTIC_2	155	158	PF00928	0.356
TRG_ENDOCYTIC_2	24	27	PF00928	0.419
TRG_ENDOCYTIC_2	47	50	PF00928	0.450
TRG_ENDOCYTIC_2	631	634	PF00928	0.285
TRG_ER_diArg_1	290	293	PF00400	0.455
TRG_ER_diArg_1	384	386	PF00400	0.347
TRG_NES_CRM1_1	97	111	PF08389	0.436
TRG_Pf-PMV_PEXEL_1	37	41	PF00026	0.313

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HYM3	Leptomonas seymouri	60%	100%
A0A1X0P521	Trypanosomatidae	33%	100%
A0A3R7KHV4	Trypanosoma rangeli	33%	100%
A0A3S5H7H4	Leishmania donovani	78%	100%
D0A5R0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	100%
E9AD35	Leishmania major	78%	100%
E9AHC8	Leishmania infantum	79%	100%
E9AYV9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	100%
Q2TAY7	Homo sapiens	24%	100%
Q2TBS9	Bos taurus	24%	100%
Q3UKJ7	Mus musculus	24%	100%
Q5ZME8	Gallus gallus	24%	100%
Q6NRT3	Xenopus laevis	24%	100%
Q6P4J8	Xenopus tropicalis	24%	100%
Q76B40	Cricetulus griseus	24%	100%
Q7ZVA0	Danio rerio	24%	100%
Q99M63	Rattus norvegicus	24%	100%
V5B9I2	Trypanosoma cruzi	33%	100%