RING-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Ring finger domain containing protein, putative

Species:

Leishmania braziliensis

UniProt:

A4HFI3_LEIBR

TriTrypDb:

LbrM.27.0680 , LBRM2903_270011900

Length:

544

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HFI3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HFI3

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	6
GO:0043167	ion binding	2	6
GO:0043169	cation binding	3	6
GO:0046872	metal ion binding	4	6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	205	209	PF00656	0.520
CLV_NRD_NRD_1	110	112	PF00675	0.483
CLV_NRD_NRD_1	159	161	PF00675	0.406
CLV_NRD_NRD_1	301	303	PF00675	0.806
CLV_NRD_NRD_1	310	312	PF00675	0.564
CLV_NRD_NRD_1	344	346	PF00675	0.634
CLV_NRD_NRD_1	419	421	PF00675	0.599
CLV_NRD_NRD_1	448	450	PF00675	0.460
CLV_NRD_NRD_1	456	458	PF00675	0.406
CLV_NRD_NRD_1	470	472	PF00675	0.421
CLV_NRD_NRD_1	510	512	PF00675	0.608
CLV_PCSK_FUR_1	468	472	PF00082	0.433
CLV_PCSK_FUR_1	508	512	PF00082	0.437
CLV_PCSK_KEX2_1	112	114	PF00082	0.511
CLV_PCSK_KEX2_1	159	161	PF00082	0.406
CLV_PCSK_KEX2_1	301	303	PF00082	0.835
CLV_PCSK_KEX2_1	310	312	PF00082	0.564
CLV_PCSK_KEX2_1	344	346	PF00082	0.634
CLV_PCSK_KEX2_1	421	423	PF00082	0.582
CLV_PCSK_KEX2_1	448	450	PF00082	0.460
CLV_PCSK_KEX2_1	468	470	PF00082	0.509
CLV_PCSK_KEX2_1	508	510	PF00082	0.439
CLV_PCSK_PC1ET2_1	112	114	PF00082	0.572
CLV_PCSK_PC1ET2_1	421	423	PF00082	0.582
CLV_PCSK_SKI1_1	153	157	PF00082	0.357
CLV_PCSK_SKI1_1	176	180	PF00082	0.402
CLV_PCSK_SKI1_1	458	462	PF00082	0.476
DEG_ODPH_VHL_1	365	378	PF01847	0.519
DOC_CKS1_1	216	221	PF01111	0.642
DOC_MAPK_gen_1	159	165	PF00069	0.315
DOC_MAPK_gen_1	189	197	PF00069	0.427
DOC_PP1_RVXF_1	174	181	PF00149	0.404
DOC_PP2B_LxvP_1	7	10	PF13499	0.505
DOC_PP4_FxxP_1	324	327	PF00568	0.724
DOC_PP4_FxxP_1	364	367	PF00568	0.496
DOC_PP4_FxxP_1	442	445	PF00568	0.503
DOC_USP7_MATH_1	10	14	PF00917	0.565
DOC_USP7_MATH_1	117	121	PF00917	0.425
DOC_USP7_MATH_1	17	21	PF00917	0.561
DOC_USP7_MATH_1	183	187	PF00917	0.375
DOC_USP7_MATH_1	207	211	PF00917	0.618
DOC_USP7_MATH_1	28	32	PF00917	0.514
DOC_USP7_MATH_1	340	344	PF00917	0.558
DOC_USP7_MATH_1	35	39	PF00917	0.605
DOC_USP7_UBL2_3	187	191	PF12436	0.360
DOC_WW_Pin1_4	215	220	PF00397	0.583
DOC_WW_Pin1_4	31	36	PF00397	0.611
DOC_WW_Pin1_4	336	341	PF00397	0.648
LIG_14-3-3_CanoR_1	176	181	PF00244	0.398
LIG_14-3-3_CanoR_1	266	275	PF00244	0.501
LIG_14-3-3_CanoR_1	301	305	PF00244	0.616
LIG_14-3-3_CanoR_1	310	318	PF00244	0.554
LIG_14-3-3_CanoR_1	408	416	PF00244	0.494
LIG_14-3-3_CanoR_1	422	431	PF00244	0.521
LIG_14-3-3_CanoR_1	457	467	PF00244	0.317
LIG_14-3-3_CanoR_1	62	70	PF00244	0.305
LIG_BIR_II_1	1	5	PF00653	0.775
LIG_CtBP_PxDLS_1	504	510	PF00389	0.350
LIG_EH1_1	369	377	PF00400	0.425
LIG_FHA_1	236	242	PF00498	0.558
LIG_FHA_1	246	252	PF00498	0.583
LIG_FHA_1	430	436	PF00498	0.385
LIG_FHA_1	459	465	PF00498	0.438
LIG_FHA_2	32	38	PF00498	0.517
LIG_FHA_2	354	360	PF00498	0.500
LIG_FHA_2	424	430	PF00498	0.466
LIG_FHA_2	476	482	PF00498	0.444
LIG_LIR_Apic_2	323	327	PF02991	0.747
LIG_LIR_Apic_2	439	445	PF02991	0.508
LIG_LIR_Gen_1	274	283	PF02991	0.504
LIG_LIR_Gen_1	40	50	PF02991	0.302
LIG_LIR_Nem_3	359	365	PF02991	0.546
LIG_LIR_Nem_3	40	45	PF02991	0.502
LIG_LRP6_Inhibitor_1	376	382	PF00058	0.376
LIG_MAD2	284	292	PF02301	0.538
LIG_Pex14_1	118	122	PF04695	0.502
LIG_PTAP_UEV_1	345	350	PF05743	0.556
LIG_RPA_C_Fungi	488	500	PF08784	0.385
LIG_SH2_CRK	407	411	PF00017	0.476
LIG_SH2_GRB2like	42	45	PF00017	0.441
LIG_SH2_SRC	42	45	PF00017	0.441
LIG_SH2_SRC	472	475	PF00017	0.456
LIG_SH2_STAP1	96	100	PF00017	0.487
LIG_SH2_STAT5	115	118	PF00017	0.489
LIG_SH2_STAT5	164	167	PF00017	0.401
LIG_SH2_STAT5	363	366	PF00017	0.562
LIG_SH2_STAT5	472	475	PF00017	0.473
LIG_SH2_STAT5	96	99	PF00017	0.405
LIG_SH3_3	210	216	PF00018	0.627
LIG_SH3_3	343	349	PF00018	0.771
LIG_SH3_3	53	59	PF00018	0.370
LIG_SUMO_SIM_anti_2	247	254	PF11976	0.513
LIG_SUMO_SIM_par_1	247	254	PF11976	0.513
LIG_TRAF2_1	131	134	PF00917	0.538
LIG_TRFH_1	363	367	PF08558	0.506
LIG_UBA3_1	375	382	PF00899	0.427
LIG_WW_3	539	543	PF00397	0.435
MOD_CDK_SPK_2	336	341	PF00069	0.552
MOD_CK1_1	2	8	PF00069	0.772
MOD_CK1_1	20	26	PF00069	0.471
MOD_CK1_1	202	208	PF00069	0.592
MOD_CK1_1	268	274	PF00069	0.667
MOD_CK1_1	300	306	PF00069	0.636
MOD_CK1_1	309	315	PF00069	0.622
MOD_CK1_1	31	37	PF00069	0.538
MOD_CK1_1	333	339	PF00069	0.646
MOD_CK2_1	169	175	PF00069	0.326
MOD_CK2_1	31	37	PF00069	0.514
MOD_CK2_1	395	401	PF00069	0.493
MOD_CK2_1	475	481	PF00069	0.369
MOD_CK2_1	99	105	PF00069	0.477
MOD_GlcNHglycan	101	104	PF01048	0.572
MOD_GlcNHglycan	201	204	PF01048	0.663
MOD_GlcNHglycan	25	28	PF01048	0.679
MOD_GlcNHglycan	270	273	PF01048	0.559
MOD_GlcNHglycan	31	34	PF01048	0.703
MOD_GlcNHglycan	333	336	PF01048	0.545
MOD_GlcNHglycan	346	349	PF01048	0.596
MOD_GlcNHglycan	37	40	PF01048	0.537
MOD_GlcNHglycan	4	7	PF01048	0.655
MOD_GlcNHglycan	416	419	PF01048	0.674
MOD_GlcNHglycan	436	439	PF01048	0.522
MOD_GSK3_1	18	25	PF00069	0.531
MOD_GSK3_1	195	202	PF00069	0.551
MOD_GSK3_1	247	254	PF00069	0.760
MOD_GSK3_1	267	274	PF00069	0.528
MOD_GSK3_1	302	309	PF00069	0.600
MOD_GSK3_1	31	38	PF00069	0.536
MOD_GSK3_1	330	337	PF00069	0.677
MOD_GSK3_1	340	347	PF00069	0.604
MOD_GSK3_1	349	356	PF00069	0.490
MOD_GSK3_1	475	482	PF00069	0.419
MOD_GSK3_1	487	494	PF00069	0.437
MOD_GSK3_1	90	97	PF00069	0.374
MOD_N-GLC_1	353	358	PF02516	0.509
MOD_N-GLC_2	44	46	PF02516	0.305
MOD_N-GLC_2	64	66	PF02516	0.183
MOD_N-GLC_2	83	85	PF02516	0.305
MOD_NEK2_1	1	6	PF00069	0.586
MOD_NEK2_1	136	141	PF00069	0.527
MOD_NEK2_1	197	202	PF00069	0.634
MOD_NEK2_1	22	27	PF00069	0.517
MOD_NEK2_1	251	256	PF00069	0.614
MOD_NEK2_1	331	336	PF00069	0.541
MOD_NEK2_1	69	74	PF00069	0.305
MOD_PIKK_1	487	493	PF00454	0.419
MOD_PKA_1	344	350	PF00069	0.577
MOD_PKA_1	420	426	PF00069	0.492
MOD_PKA_2	265	271	PF00069	0.553
MOD_PKA_2	300	306	PF00069	0.670
MOD_PKA_2	309	315	PF00069	0.549
MOD_PKA_2	340	346	PF00069	0.642
MOD_PKA_2	90	96	PF00069	0.377
MOD_PKB_1	60	68	PF00069	0.305
MOD_Plk_1	118	124	PF00069	0.513
MOD_Plk_1	312	318	PF00069	0.599
MOD_Plk_2-3	169	175	PF00069	0.326
MOD_Plk_4	118	124	PF00069	0.502
MOD_Plk_4	176	182	PF00069	0.354
MOD_Plk_4	247	253	PF00069	0.527
MOD_ProDKin_1	215	221	PF00069	0.581
MOD_ProDKin_1	31	37	PF00069	0.607
MOD_ProDKin_1	336	342	PF00069	0.651
MOD_SUMO_rev_2	101	110	PF00179	0.467
TRG_ENDOCYTIC_2	362	365	PF00928	0.581
TRG_ENDOCYTIC_2	42	45	PF00928	0.480
TRG_ER_diArg_1	110	113	PF00400	0.479
TRG_ER_diArg_1	344	346	PF00400	0.564
TRG_ER_diArg_1	448	450	PF00400	0.465
TRG_ER_diArg_1	467	470	PF00400	0.299
TRG_ER_diArg_1	507	510	PF00400	0.426
TRG_ER_diArg_1	59	62	PF00400	0.333
TRG_NLS_MonoExtN_4	109	115	PF00514	0.543
TRG_Pf-PMV_PEXEL_1	448	452	PF00026	0.505
TRG_Pf-PMV_PEXEL_1	531	535	PF00026	0.422

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6U0	Leptomonas seymouri	51%	97%
A0A3S7X0G9	Leishmania donovani	71%	99%
E9AD34	Leishmania major	71%	100%
E9AHC7	Leishmania infantum	72%	99%
E9AYV8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	70%	99%