Amastin_surface_glycoprotein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Amastin surface glycoprotein, putative

Species:

Leishmania braziliensis

UniProt:

A4HFI0_LEIBR

TriTrypDb:

LbrM.27.0650 , LBRM2903_270028700

Length:

208

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	8
GO:0110165	cellular anatomical entity	1	8

Expansion

Sequence features

A4HFI0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HFI0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
DEG_Nend_UBRbox_4	1	3	PF02207	0.529
DOC_MAPK_MEF2A_6	141	150	PF00069	0.525
DOC_PP4_FxxP_1	135	138	PF00568	0.287
DOC_PP4_FxxP_1	30	33	PF00568	0.417
DOC_USP7_MATH_1	39	43	PF00917	0.319
DOC_USP7_MATH_1	72	76	PF00917	0.393
DOC_USP7_MATH_1	89	93	PF00917	0.380
LIG_14-3-3_CanoR_1	81	85	PF00244	0.224
LIG_14-3-3_CanoR_1	88	95	PF00244	0.184
LIG_BRCT_BRCA1_1	183	187	PF00533	0.224
LIG_deltaCOP1_diTrp_1	180	187	PF00928	0.396
LIG_FHA_1	117	123	PF00498	0.438
LIG_FHA_1	197	203	PF00498	0.393
LIG_Integrin_RGD_1	96	98	PF01839	0.425
LIG_LIR_Gen_1	113	122	PF02991	0.259
LIG_LIR_Gen_1	130	140	PF02991	0.433
LIG_LIR_Gen_1	184	192	PF02991	0.249
LIG_LIR_Nem_3	113	118	PF02991	0.362
LIG_LIR_Nem_3	130	135	PF02991	0.416
LIG_LIR_Nem_3	184	190	PF02991	0.391
LIG_LIR_Nem_3	62	67	PF02991	0.459
LIG_LIR_Nem_3	98	103	PF02991	0.360
LIG_Pex14_1	80	84	PF04695	0.359
LIG_Pex14_2	132	136	PF04695	0.356
LIG_SH2_STAT5	147	150	PF00017	0.356
LIG_SH2_STAT5	166	169	PF00017	0.301
LIG_SH2_STAT5	26	29	PF00017	0.249
LIG_SH2_STAT5	3	6	PF00017	0.614
LIG_SH2_STAT5	99	102	PF00017	0.301
LIG_SH3_3	137	143	PF00018	0.553
LIG_SH3_3	22	28	PF00018	0.438
LIG_SUMO_SIM_anti_2	201	207	PF11976	0.249
LIG_SUMO_SIM_anti_2	6	12	PF11976	0.518
LIG_SUMO_SIM_par_1	201	207	PF11976	0.490
LIG_WRC_WIRS_1	187	192	PF05994	0.249
MOD_CK1_1	172	178	PF00069	0.297
MOD_CK1_1	179	185	PF00069	0.245
MOD_CK1_1	75	81	PF00069	0.368
MOD_CK1_1	83	89	PF00069	0.244
MOD_GlcNHglycan	171	174	PF01048	0.529
MOD_GlcNHglycan	68	71	PF01048	0.654
MOD_GSK3_1	172	179	PF00069	0.250
MOD_GSK3_1	186	193	PF00069	0.360
MOD_GSK3_1	194	201	PF00069	0.352
MOD_GSK3_1	39	46	PF00069	0.333
MOD_GSK3_1	53	60	PF00069	0.355
MOD_GSK3_1	80	87	PF00069	0.370
MOD_N-GLC_1	43	48	PF02516	0.650
MOD_N-GLC_1	52	57	PF02516	0.672
MOD_N-GLC_1	89	94	PF02516	0.535
MOD_NEK2_1	1	6	PF00069	0.599
MOD_NEK2_1	127	132	PF00069	0.356
MOD_NEK2_1	190	195	PF00069	0.430
MOD_NEK2_1	198	203	PF00069	0.359
MOD_NEK2_1	43	48	PF00069	0.450
MOD_PKA_2	80	86	PF00069	0.224
MOD_Plk_1	179	185	PF00069	0.294
MOD_Plk_1	43	49	PF00069	0.453
MOD_Plk_1	89	95	PF00069	0.376
MOD_Plk_2-3	57	63	PF00069	0.385
MOD_Plk_4	127	133	PF00069	0.438
MOD_Plk_4	198	204	PF00069	0.365
MOD_Plk_4	75	81	PF00069	0.337
TRG_ENDOCYTIC_2	147	150	PF00928	0.356
TRG_ENDOCYTIC_2	26	29	PF00928	0.249

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6T4	Leptomonas seymouri	48%	99%
A0A1X0NW81	Trypanosomatidae	31%	100%
A0A3S7X0F7	Leishmania donovani	67%	100%
E9AD31	Leishmania major	68%	100%
E9AHC4	Leishmania infantum	67%	100%
E9AYV5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	65%	100%
V5BK21	Trypanosoma cruzi	34%	100%