Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HFH9_LEIBR

TriTrypDb:

LbrM.27.0640 , LBRM2903_270028600

Length:

584

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HFH9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HFH9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	113	115	PF00675	0.500
CLV_NRD_NRD_1	167	169	PF00675	0.521
CLV_NRD_NRD_1	232	234	PF00675	0.702
CLV_NRD_NRD_1	300	302	PF00675	0.644
CLV_NRD_NRD_1	39	41	PF00675	0.497
CLV_NRD_NRD_1	482	484	PF00675	0.578
CLV_NRD_NRD_1	531	533	PF00675	0.524
CLV_NRD_NRD_1	548	550	PF00675	0.561
CLV_NRD_NRD_1	581	583	PF00675	0.564
CLV_NRD_NRD_1	72	74	PF00675	0.338
CLV_PCSK_KEX2_1	113	115	PF00082	0.505
CLV_PCSK_KEX2_1	157	159	PF00082	0.445
CLV_PCSK_KEX2_1	166	168	PF00082	0.527
CLV_PCSK_KEX2_1	300	302	PF00082	0.644
CLV_PCSK_KEX2_1	482	484	PF00082	0.578
CLV_PCSK_KEX2_1	531	533	PF00082	0.524
CLV_PCSK_KEX2_1	548	550	PF00082	0.561
CLV_PCSK_KEX2_1	580	582	PF00082	0.560
CLV_PCSK_PC1ET2_1	157	159	PF00082	0.413
CLV_PCSK_PC7_1	163	169	PF00082	0.480
CLV_PCSK_SKI1_1	114	118	PF00082	0.341
CLV_PCSK_SKI1_1	149	153	PF00082	0.402
CLV_PCSK_SKI1_1	282	286	PF00082	0.420
CLV_PCSK_SKI1_1	538	542	PF00082	0.533
CLV_PCSK_SKI1_1	559	563	PF00082	0.517
CLV_PCSK_SKI1_1	569	573	PF00082	0.493
CLV_PCSK_SKI1_1	82	86	PF00082	0.399
CLV_Separin_Metazoa	70	74	PF03568	0.458
DEG_APCC_DBOX_1	148	156	PF00400	0.402
DEG_Nend_UBRbox_3	1	3	PF02207	0.588
DOC_CKS1_1	174	179	PF01111	0.536
DOC_CKS1_1	374	379	PF01111	0.537
DOC_CKS1_1	415	420	PF01111	0.564
DOC_CKS1_1	447	452	PF01111	0.623
DOC_MAPK_DCC_7	520	530	PF00069	0.473
DOC_MAPK_FxFP_2	562	565	PF00069	0.516
DOC_PP4_FxxP_1	562	565	PF00568	0.516
DOC_USP7_MATH_1	196	200	PF00917	0.522
DOC_USP7_MATH_1	241	245	PF00917	0.569
DOC_USP7_MATH_1	261	265	PF00917	0.725
DOC_USP7_MATH_1	378	382	PF00917	0.596
DOC_USP7_MATH_1	418	422	PF00917	0.586
DOC_USP7_MATH_1	64	68	PF00917	0.330
DOC_USP7_MATH_2	196	202	PF00917	0.523
DOC_WW_Pin1_4	140	145	PF00397	0.460
DOC_WW_Pin1_4	173	178	PF00397	0.604
DOC_WW_Pin1_4	272	277	PF00397	0.572
DOC_WW_Pin1_4	350	355	PF00397	0.671
DOC_WW_Pin1_4	362	367	PF00397	0.590
DOC_WW_Pin1_4	373	378	PF00397	0.565
DOC_WW_Pin1_4	400	405	PF00397	0.598
DOC_WW_Pin1_4	414	419	PF00397	0.653
DOC_WW_Pin1_4	42	47	PF00397	0.498
DOC_WW_Pin1_4	446	451	PF00397	0.625
DOC_WW_Pin1_4	453	458	PF00397	0.612
DOC_WW_Pin1_4	495	500	PF00397	0.700
DOC_WW_Pin1_4	515	520	PF00397	0.458
LIG_14-3-3_CanoR_1	325	329	PF00244	0.571
LIG_14-3-3_CanoR_1	356	361	PF00244	0.535
LIG_14-3-3_CanoR_1	40	47	PF00244	0.394
LIG_14-3-3_CanoR_1	482	488	PF00244	0.573
LIG_14-3-3_CterR_2	580	584	PF00244	0.494
LIG_APCC_ABBA_1	100	105	PF00400	0.386
LIG_CSL_BTD_1	516	519	PF09270	0.503
LIG_FHA_1	173	179	PF00498	0.596
LIG_FHA_1	454	460	PF00498	0.591
LIG_FHA_1	5	11	PF00498	0.483
LIG_FHA_1	519	525	PF00498	0.603
LIG_FHA_2	25	31	PF00498	0.458
LIG_FHA_2	267	273	PF00498	0.459
LIG_LIR_Apic_2	560	565	PF02991	0.508
LIG_LIR_Apic_2	67	71	PF02991	0.317
LIG_LYPXL_yS_3	251	254	PF13949	0.536
LIG_MAD2	442	450	PF02301	0.549
LIG_MYND_3	525	529	PF01753	0.592
LIG_RPA_C_Fungi	527	539	PF08784	0.526
LIG_SH2_CRK	217	221	PF00017	0.529
LIG_SH2_PTP2	68	71	PF00017	0.388
LIG_SH2_SRC	68	71	PF00017	0.454
LIG_SH2_STAT5	103	106	PF00017	0.396
LIG_SH2_STAT5	407	410	PF00017	0.563
LIG_SH2_STAT5	68	71	PF00017	0.408
LIG_SH3_2	174	179	PF14604	0.517
LIG_SH3_3	171	177	PF00018	0.510
LIG_SH3_3	371	377	PF00018	0.625
LIG_SH3_3	391	397	PF00018	0.660
LIG_SH3_3	513	519	PF00018	0.510
LIG_SUMO_SIM_anti_2	150	156	PF11976	0.392
LIG_SUMO_SIM_par_1	18	23	PF11976	0.372
LIG_TRAF2_1	131	134	PF00917	0.469
LIG_TRAF2_1	305	308	PF00917	0.511
LIG_TRAF2_1	540	543	PF00917	0.466
LIG_UBA3_1	151	157	PF00899	0.373
LIG_UBA3_1	84	90	PF00899	0.460
LIG_WW_1	396	399	PF00397	0.539
LIG_WW_1	404	407	PF00397	0.523
MOD_CDC14_SPxK_1	460	463	PF00782	0.608
MOD_CDK_SPK_2	495	500	PF00069	0.688
MOD_CDK_SPK_2	515	520	PF00069	0.458
MOD_CDK_SPxK_1	173	179	PF00069	0.596
MOD_CDK_SPxK_1	350	356	PF00069	0.673
MOD_CDK_SPxK_1	414	420	PF00069	0.673
MOD_CDK_SPxK_1	457	463	PF00069	0.612
MOD_CK1_1	359	365	PF00069	0.533
MOD_CK1_1	466	472	PF00069	0.658
MOD_CK1_1	504	510	PF00069	0.633
MOD_CK1_1	518	524	PF00069	0.523
MOD_CK2_1	128	134	PF00069	0.419
MOD_CK2_1	198	204	PF00069	0.530
MOD_CK2_1	24	30	PF00069	0.458
MOD_CK2_1	261	267	PF00069	0.593
MOD_CK2_1	302	308	PF00069	0.470
MOD_CK2_1	343	349	PF00069	0.686
MOD_CK2_1	470	476	PF00069	0.690
MOD_CK2_1	64	70	PF00069	0.323
MOD_Cter_Amidation	231	234	PF01082	0.599
MOD_GlcNHglycan	130	133	PF01048	0.507
MOD_GlcNHglycan	243	246	PF01048	0.711
MOD_GlcNHglycan	304	307	PF01048	0.462
MOD_GlcNHglycan	333	336	PF01048	0.539
MOD_GlcNHglycan	35	38	PF01048	0.555
MOD_GlcNHglycan	436	439	PF01048	0.661
MOD_GlcNHglycan	468	471	PF01048	0.626
MOD_GlcNHglycan	505	509	PF01048	0.777
MOD_GlcNHglycan	566	569	PF01048	0.478
MOD_GSK3_1	314	321	PF00069	0.575
MOD_GSK3_1	355	362	PF00069	0.538
MOD_GSK3_1	378	385	PF00069	0.628
MOD_GSK3_1	414	421	PF00069	0.592
MOD_GSK3_1	42	49	PF00069	0.386
MOD_GSK3_1	453	460	PF00069	0.623
MOD_GSK3_1	466	473	PF00069	0.520
MOD_GSK3_1	511	518	PF00069	0.560
MOD_N-GLC_1	457	462	PF02516	0.611
MOD_NEK2_1	1	6	PF00069	0.481
MOD_NEK2_1	126	131	PF00069	0.418
MOD_NEK2_1	221	226	PF00069	0.558
MOD_NEK2_1	266	271	PF00069	0.468
MOD_NEK2_1	557	562	PF00069	0.521
MOD_NEK2_2	277	282	PF00069	0.531
MOD_NEK2_2	405	410	PF00069	0.555
MOD_PIKK_1	378	384	PF00454	0.800
MOD_PKA_1	40	46	PF00069	0.406
MOD_PKA_1	482	488	PF00069	0.573
MOD_PKA_2	222	228	PF00069	0.568
MOD_PKA_2	324	330	PF00069	0.576
MOD_PKA_2	355	361	PF00069	0.535
MOD_PKA_2	39	45	PF00069	0.412
MOD_PKA_2	419	425	PF00069	0.702
MOD_PKA_2	481	487	PF00069	0.575
MOD_PKB_1	414	422	PF00069	0.564
MOD_Plk_1	147	153	PF00069	0.407
MOD_Plk_1	266	272	PF00069	0.469
MOD_Plk_1	557	563	PF00069	0.522
MOD_Plk_4	46	52	PF00069	0.343
MOD_Plk_4	511	517	PF00069	0.521
MOD_Plk_4	64	70	PF00069	0.278
MOD_ProDKin_1	140	146	PF00069	0.453
MOD_ProDKin_1	173	179	PF00069	0.607
MOD_ProDKin_1	272	278	PF00069	0.565
MOD_ProDKin_1	350	356	PF00069	0.673
MOD_ProDKin_1	362	368	PF00069	0.593
MOD_ProDKin_1	373	379	PF00069	0.566
MOD_ProDKin_1	400	406	PF00069	0.598
MOD_ProDKin_1	414	420	PF00069	0.655
MOD_ProDKin_1	42	48	PF00069	0.490
MOD_ProDKin_1	446	452	PF00069	0.623
MOD_ProDKin_1	453	459	PF00069	0.613
MOD_ProDKin_1	495	501	PF00069	0.703
MOD_ProDKin_1	515	521	PF00069	0.456
TRG_DiLeu_BaEn_2	133	139	PF01217	0.459
TRG_DiLeu_BaEn_2	140	146	PF01217	0.406
TRG_DiLeu_BaLyEn_6	122	127	PF01217	0.363
TRG_ENDOCYTIC_2	103	106	PF00928	0.380
TRG_ENDOCYTIC_2	217	220	PF00928	0.607
TRG_ENDOCYTIC_2	251	254	PF00928	0.536
TRG_ER_diArg_1	112	114	PF00400	0.479
TRG_ER_diArg_1	166	168	PF00400	0.495
TRG_ER_diArg_1	530	532	PF00400	0.523
TRG_ER_diArg_1	580	582	PF00400	0.563
TRG_Pf-PMV_PEXEL_1	114	118	PF00026	0.478
TRG_Pf-PMV_PEXEL_1	268	272	PF00026	0.617
TRG_Pf-PMV_PEXEL_1	282	286	PF00026	0.418
TRG_Pf-PMV_PEXEL_1	77	81	PF00026	0.411
TRG_Pf-PMV_PEXEL_1	82	86	PF00026	0.399

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I5K9	Leptomonas seymouri	49%	94%
A0A3S7X0F9	Leishmania donovani	68%	98%
E9AD30	Leishmania major	69%	100%
E9AHC3	Leishmania infantum	68%	98%
E9AYV4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	68%	98%