Putative radial spoke protein 3

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

radial spoke protein 3, putative

Species:

Leishmania braziliensis

UniProt:

A4HFH8_LEIBR

TriTrypDb:

LbrM.27.0630 , LBRM2903_270028500

Length:

357

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	11
GO:0005856	cytoskeleton	5	10
GO:0042995	cell projection	2	11
GO:0043226	organelle	2	11
GO:0043228	non-membrane-bounded organelle	3	10
GO:0043229	intracellular organelle	3	10
GO:0043232	intracellular non-membrane-bounded organelle	4	10
GO:0110165	cellular anatomical entity	1	11
GO:0005929	cilium	4	1
GO:0005930	axoneme	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0120025	plasma membrane bounded cell projection	3	1

Expansion

Sequence features

A4HFH8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HFH8

Function

Biological processes
Term	Name	Level	Count
GO:0001539	cilium or flagellum-dependent cell motility	3	1
GO:0009987	cellular process	1	1
GO:0048870	cell motility	2	1
GO:0060285	cilium-dependent cell motility	4	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	164	168	PF00656	0.430
CLV_NRD_NRD_1	100	102	PF00675	0.251
CLV_NRD_NRD_1	108	110	PF00675	0.238
CLV_NRD_NRD_1	222	224	PF00675	0.238
CLV_NRD_NRD_1	238	240	PF00675	0.262
CLV_NRD_NRD_1	246	248	PF00675	0.210
CLV_NRD_NRD_1	3	5	PF00675	0.482
CLV_NRD_NRD_1	56	58	PF00675	0.273
CLV_NRD_NRD_1	87	89	PF00675	0.236
CLV_PCSK_KEX2_1	108	110	PF00082	0.238
CLV_PCSK_KEX2_1	222	224	PF00082	0.238
CLV_PCSK_KEX2_1	238	240	PF00082	0.238
CLV_PCSK_KEX2_1	246	248	PF00082	0.238
CLV_PCSK_KEX2_1	3	5	PF00082	0.482
CLV_PCSK_KEX2_1	56	58	PF00082	0.234
CLV_PCSK_KEX2_1	79	81	PF00082	0.258
CLV_PCSK_KEX2_1	87	89	PF00082	0.214
CLV_PCSK_KEX2_1	99	101	PF00082	0.106
CLV_PCSK_PC1ET2_1	79	81	PF00082	0.303
CLV_PCSK_PC1ET2_1	99	101	PF00082	0.186
CLV_PCSK_SKI1_1	153	157	PF00082	0.229
CLV_PCSK_SKI1_1	353	357	PF00082	0.451
CLV_Separin_Metazoa	210	214	PF03568	0.438
CLV_Separin_Metazoa	332	336	PF03568	0.479
DEG_Nend_UBRbox_3	1	3	PF02207	0.631
DOC_CKS1_1	111	116	PF01111	0.438
DOC_CKS1_1	154	159	PF01111	0.438
DOC_MAPK_MEF2A_6	295	304	PF00069	0.518
DOC_PP4_FxxP_1	17	20	PF00568	0.542
DOC_PP4_FxxP_1	24	27	PF00568	0.592
DOC_USP7_MATH_1	161	165	PF00917	0.438
DOC_USP7_MATH_1	5	9	PF00917	0.465
DOC_USP7_MATH_1	67	71	PF00917	0.518
DOC_USP7_UBL2_3	240	244	PF12436	0.445
DOC_USP7_UBL2_3	314	318	PF12436	0.479
DOC_WW_Pin1_4	110	115	PF00397	0.438
DOC_WW_Pin1_4	153	158	PF00397	0.438
DOC_WW_Pin1_4	63	68	PF00397	0.454
LIG_14-3-3_CanoR_1	40	49	PF00244	0.475
LIG_14-3-3_CanoR_1	60	65	PF00244	0.419
LIG_14-3-3_CanoR_1	88	98	PF00244	0.516
LIG_Clathr_ClatBox_1	177	181	PF01394	0.438
LIG_EVH1_2	20	24	PF00568	0.558
LIG_FHA_1	111	117	PF00498	0.456
LIG_FHA_1	133	139	PF00498	0.518
LIG_FHA_1	145	151	PF00498	0.478
LIG_FHA_1	228	234	PF00498	0.540
LIG_FHA_2	143	149	PF00498	0.431
LIG_Integrin_isoDGR_2	34	36	PF01839	0.486
LIG_LIR_Apic_2	16	20	PF02991	0.545
LIG_LIR_Apic_2	26	32	PF02991	0.694
LIG_LIR_Apic_2	62	67	PF02991	0.518
LIG_LIR_Nem_3	303	308	PF02991	0.449
LIG_LIR_Nem_3	46	52	PF02991	0.396
LIG_PDZ_Class_2	352	357	PF00595	0.698
LIG_PTB_Apo_2	277	284	PF02174	0.437
LIG_PTB_Apo_2	48	55	PF02174	0.434
LIG_PTB_Phospho_1	48	54	PF10480	0.434
LIG_SH2_CRK	49	53	PF00017	0.438
LIG_SH2_CRK	64	68	PF00017	0.438
LIG_SH2_STAP1	54	58	PF00017	0.460
LIG_SH2_STAT5	130	133	PF00017	0.500
LIG_SH2_STAT5	15	18	PF00017	0.552
LIG_SH2_STAT5	159	162	PF00017	0.438
LIG_SH3_3	151	157	PF00018	0.438
LIG_SUMO_SIM_anti_2	206	213	PF11976	0.438
LIG_TRAF2_1	349	352	PF00917	0.505
LIG_UBA3_1	187	194	PF00899	0.438
MOD_CDK_SPK_2	153	158	PF00069	0.452
MOD_CK1_1	8	14	PF00069	0.706
MOD_DYRK1A_RPxSP_1	153	157	PF00069	0.438
MOD_GlcNHglycan	163	166	PF01048	0.228
MOD_GSK3_1	120	127	PF00069	0.540
MOD_GSK3_1	59	66	PF00069	0.448
MOD_N-GLC_1	336	341	PF02516	0.417
MOD_N-GLC_1	36	41	PF02516	0.673
MOD_NEK2_1	227	232	PF00069	0.525
MOD_NEK2_1	336	341	PF00069	0.617
MOD_NEK2_1	82	87	PF00069	0.510
MOD_NEK2_2	13	18	PF00069	0.668
MOD_PIKK_1	120	126	PF00454	0.537
MOD_PIKK_1	142	148	PF00454	0.445
MOD_PIKK_1	167	173	PF00454	0.438
MOD_PIKK_1	227	233	PF00454	0.540
MOD_PIKK_1	336	342	PF00454	0.619
MOD_PIKK_1	43	49	PF00454	0.656
MOD_PIKK_1	82	88	PF00454	0.518
MOD_PIKK_1	89	95	PF00454	0.518
MOD_PK_1	94	100	PF00069	0.438
MOD_PKA_2	59	65	PF00069	0.413
MOD_Plk_1	336	342	PF00069	0.619
MOD_Plk_1	36	42	PF00069	0.735
MOD_ProDKin_1	110	116	PF00069	0.438
MOD_ProDKin_1	153	159	PF00069	0.438
MOD_ProDKin_1	63	69	PF00069	0.454
TRG_DiLeu_BaEn_1	207	212	PF01217	0.438
TRG_DiLeu_BaEn_4	207	213	PF01217	0.438
TRG_DiLeu_BaLyEn_6	351	356	PF01217	0.438
TRG_ENDOCYTIC_2	49	52	PF00928	0.435
TRG_ER_diArg_1	56	58	PF00400	0.438
TRG_NLS_Bipartite_1	87	103	PF00514	0.516
TRG_NLS_MonoCore_2	98	103	PF00514	0.518
TRG_Pf-PMV_PEXEL_1	295	299	PF00026	0.268
TRG_Pf-PMV_PEXEL_1	323	327	PF00026	0.238

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PF18	Leptomonas seymouri	86%	100%
A0A1X0ND20	Trypanosomatidae	66%	100%
A0A3Q8IG75	Leishmania donovani	92%	100%
A0A422NMR1	Trypanosoma rangeli	68%	100%
D0A5Q5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	68%	100%
E9AD29	Leishmania major	90%	100%
E9AHC2	Leishmania infantum	92%	100%
E9AYV3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
P12759	Chlamydomonas reinhardtii	46%	69%
Q3UFY4	Mus musculus	44%	69%
Q9DA80	Mus musculus	44%	92%
V5D5G2	Trypanosoma cruzi	66%	100%