Putative calpain-like cysteine peptidase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

cysteine peptidase, Clan CA, family C2, putative (fragment)

Species:

Leishmania braziliensis

UniProt:

A4HFH7_LEIBR

TriTrypDb:

LbrM.27.0620 , LBRM2903_270028400

Length:

530

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 2
NetGPI	no	yes: 0, no: 2

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HFH7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HFH7

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	3
GO:0006807	nitrogen compound metabolic process	2	3
GO:0008152	metabolic process	1	3
GO:0019538	protein metabolic process	3	3
GO:0043170	macromolecule metabolic process	3	3
GO:0044238	primary metabolic process	2	3
GO:0071704	organic substance metabolic process	2	3
GO:1901564	organonitrogen compound metabolic process	3	3

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	3
GO:0004175	endopeptidase activity	4	3
GO:0004197	cysteine-type endopeptidase activity	5	3
GO:0004198	calcium-dependent cysteine-type endopeptidase activity	6	3
GO:0008233	peptidase activity	3	3
GO:0008234	cysteine-type peptidase activity	4	3
GO:0016787	hydrolase activity	2	3
GO:0140096	catalytic activity, acting on a protein	2	3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	183	187	PF00656	0.495
CLV_C14_Caspase3-7	505	509	PF00656	0.693
CLV_C14_Caspase3-7	7	11	PF00656	0.448
CLV_NRD_NRD_1	330	332	PF00675	0.452
CLV_NRD_NRD_1	358	360	PF00675	0.492
CLV_NRD_NRD_1	525	527	PF00675	0.613
CLV_PCSK_KEX2_1	358	360	PF00082	0.492
CLV_PCSK_KEX2_1	525	527	PF00082	0.613
CLV_PCSK_SKI1_1	12	16	PF00082	0.583
CLV_PCSK_SKI1_1	175	179	PF00082	0.282
CLV_PCSK_SKI1_1	288	292	PF00082	0.378
CLV_PCSK_SKI1_1	396	400	PF00082	0.448
CLV_PCSK_SKI1_1	44	48	PF00082	0.378
DEG_SPOP_SBC_1	311	315	PF00917	0.589
DOC_CYCLIN_RxL_1	395	408	PF00134	0.429
DOC_CYCLIN_RxL_1	41	49	PF00134	0.578
DOC_CYCLIN_yCln2_LP_2	168	174	PF00134	0.495
DOC_MAPK_gen_1	101	110	PF00069	0.504
DOC_MAPK_gen_1	175	184	PF00069	0.578
DOC_MAPK_gen_1	331	337	PF00069	0.541
DOC_MAPK_gen_1	476	483	PF00069	0.562
DOC_MAPK_HePTP_8	277	289	PF00069	0.578
DOC_MAPK_MEF2A_6	101	110	PF00069	0.495
DOC_MAPK_MEF2A_6	280	289	PF00069	0.495
DOC_PP1_RVXF_1	478	484	PF00149	0.494
DOC_PP2B_LxvP_1	168	171	PF13499	0.495
DOC_PP2B_LxvP_1	456	459	PF13499	0.469
DOC_PP4_FxxP_1	360	363	PF00568	0.619
DOC_USP7_MATH_1	457	461	PF00917	0.605
DOC_USP7_MATH_1	500	504	PF00917	0.684
DOC_USP7_UBL2_3	12	16	PF12436	0.583
DOC_USP7_UBL2_3	138	142	PF12436	0.495
DOC_USP7_UBL2_3	262	266	PF12436	0.495
DOC_USP7_UBL2_3	288	292	PF12436	0.495
DOC_USP7_UBL2_3	396	400	PF12436	0.390
DOC_WW_Pin1_4	123	128	PF00397	0.495
DOC_WW_Pin1_4	462	467	PF00397	0.554
LIG_14-3-3_CanoR_1	272	278	PF00244	0.578
LIG_14-3-3_CanoR_1	94	98	PF00244	0.492
LIG_APCC_ABBA_1	517	522	PF00400	0.489
LIG_BIR_II_1	1	5	PF00653	0.564
LIG_BRCT_BRCA1_1	1	5	PF00533	0.681
LIG_EH_1	246	250	PF12763	0.495
LIG_eIF4E_1	369	375	PF01652	0.349
LIG_FHA_1	111	117	PF00498	0.513
LIG_FHA_1	16	22	PF00498	0.449
LIG_FHA_1	255	261	PF00498	0.532
LIG_FHA_1	385	391	PF00498	0.391
LIG_FHA_1	410	416	PF00498	0.456
LIG_FHA_1	418	424	PF00498	0.367
LIG_FHA_1	466	472	PF00498	0.623
LIG_FHA_1	84	90	PF00498	0.469
LIG_FHA_2	143	149	PF00498	0.501
LIG_FHA_2	152	158	PF00498	0.423
LIG_Integrin_RGD_1	199	201	PF01839	0.295
LIG_KLC1_Yacidic_2	482	486	PF13176	0.613
LIG_LIR_Apic_2	253	259	PF02991	0.495
LIG_LIR_Apic_2	378	384	PF02991	0.467
LIG_LIR_Apic_2	419	425	PF02991	0.339
LIG_LIR_Apic_2	460	466	PF02991	0.616
LIG_LIR_Gen_1	137	147	PF02991	0.487
LIG_LIR_Gen_1	157	167	PF02991	0.328
LIG_LIR_Gen_1	2	9	PF02991	0.624
LIG_LIR_Gen_1	221	232	PF02991	0.495
LIG_LIR_Gen_1	445	456	PF02991	0.559
LIG_LIR_Gen_1	96	104	PF02991	0.513
LIG_LIR_Nem_3	104	108	PF02991	0.481
LIG_LIR_Nem_3	128	134	PF02991	0.467
LIG_LIR_Nem_3	137	143	PF02991	0.481
LIG_LIR_Nem_3	145	150	PF02991	0.453
LIG_LIR_Nem_3	157	162	PF02991	0.328
LIG_LIR_Nem_3	2	8	PF02991	0.629
LIG_LIR_Nem_3	221	227	PF02991	0.495
LIG_LIR_Nem_3	282	287	PF02991	0.455
LIG_LIR_Nem_3	29	34	PF02991	0.453
LIG_LIR_Nem_3	445	451	PF02991	0.449
LIG_LIR_Nem_3	96	100	PF02991	0.495
LIG_MLH1_MIPbox_1	1	5	PF16413	0.681
LIG_Pex14_2	399	403	PF04695	0.546
LIG_PTB_Apo_2	321	328	PF02174	0.419
LIG_PTB_Apo_2	330	337	PF02174	0.336
LIG_REV1ctd_RIR_1	97	107	PF16727	0.495
LIG_SH2_CRK	224	228	PF00017	0.578
LIG_SH2_CRK	256	260	PF00017	0.453
LIG_SH2_GRB2like	293	296	PF00017	0.566
LIG_SH2_SRC	293	296	PF00017	0.578
LIG_SH2_STAP1	140	144	PF00017	0.453
LIG_SH2_STAP1	312	316	PF00017	0.581
LIG_SH2_STAP1	62	66	PF00017	0.495
LIG_SH2_STAP1	95	99	PF00017	0.495
LIG_SH2_STAT3	95	98	PF00017	0.578
LIG_SH2_STAT5	144	147	PF00017	0.578
LIG_SH2_STAT5	202	205	PF00017	0.490
LIG_SH2_STAT5	256	259	PF00017	0.517
LIG_SH2_STAT5	293	296	PF00017	0.556
LIG_SH2_STAT5	369	372	PF00017	0.377
LIG_SH2_STAT5	422	425	PF00017	0.385
LIG_SH2_STAT5	484	487	PF00017	0.622
LIG_SH2_STAT5	501	504	PF00017	0.385
LIG_SH2_STAT5	518	521	PF00017	0.262
LIG_SH2_STAT5	95	98	PF00017	0.495
LIG_SH3_3	42	48	PF00018	0.458
LIG_SH3_3	71	77	PF00018	0.495
LIG_SH3_4	396	403	PF00018	0.554
LIG_SUMO_SIM_anti_2	344	350	PF11976	0.554
LIG_SUMO_SIM_par_1	132	137	PF11976	0.453
LIG_SUMO_SIM_par_1	373	380	PF11976	0.517
LIG_TRAF2_1	154	157	PF00917	0.578
LIG_UBA3_1	283	292	PF00899	0.495
LIG_WRC_WIRS_1	1	6	PF05994	0.672
LIG_WRC_WIRS_1	385	390	PF05994	0.565
MOD_CDK_SPxxK_3	462	469	PF00069	0.618
MOD_CK1_1	205	211	PF00069	0.495
MOD_CK1_1	265	271	PF00069	0.453
MOD_CK1_1	341	347	PF00069	0.533
MOD_CK1_1	449	455	PF00069	0.443
MOD_CK1_1	465	471	PF00069	0.503
MOD_CK2_1	123	129	PF00069	0.495
MOD_CK2_1	151	157	PF00069	0.495
MOD_CK2_1	189	195	PF00069	0.495
MOD_GlcNHglycan	204	207	PF01048	0.307
MOD_GlcNHglycan	267	270	PF01048	0.337
MOD_GlcNHglycan	319	322	PF01048	0.449
MOD_GlcNHglycan	340	343	PF01048	0.550
MOD_GlcNHglycan	504	507	PF01048	0.708
MOD_GlcNHglycan	67	70	PF01048	0.271
MOD_GSK3_1	151	158	PF00069	0.495
MOD_GSK3_1	189	196	PF00069	0.495
MOD_GSK3_1	201	208	PF00069	0.495
MOD_GSK3_1	228	235	PF00069	0.462
MOD_GSK3_1	384	391	PF00069	0.392
MOD_GSK3_1	457	464	PF00069	0.612
MOD_GSK3_1	65	72	PF00069	0.524
MOD_N-GLC_1	260	265	PF02516	0.265
MOD_N-GLC_1	446	451	PF02516	0.557
MOD_N-GLC_1	461	466	PF02516	0.349
MOD_NEK2_1	155	160	PF00069	0.495
MOD_NEK2_1	193	198	PF00069	0.572
MOD_NEK2_1	230	235	PF00069	0.495
MOD_NEK2_1	376	381	PF00069	0.476
MOD_NEK2_1	388	393	PF00069	0.391
MOD_NEK2_1	461	466	PF00069	0.612
MOD_NEK2_1	495	500	PF00069	0.525
MOD_NEK2_1	65	70	PF00069	0.495
MOD_NEK2_2	417	422	PF00069	0.420
MOD_OFUCOSY	421	427	PF10250	0.507
MOD_PIKK_1	446	452	PF00454	0.557
MOD_PIKK_1	83	89	PF00454	0.495
MOD_PKA_2	279	285	PF00069	0.495
MOD_PKA_2	93	99	PF00069	0.492
MOD_Plk_1	110	116	PF00069	0.495
MOD_Plk_1	117	123	PF00069	0.495
MOD_Plk_1	344	350	PF00069	0.554
MOD_Plk_1	446	452	PF00069	0.557
MOD_Plk_2-3	151	157	PF00069	0.495
MOD_Plk_2-3	508	514	PF00069	0.674
MOD_Plk_4	10	16	PF00069	0.576
MOD_Plk_4	193	199	PF00069	0.578
MOD_Plk_4	233	239	PF00069	0.537
MOD_Plk_4	279	285	PF00069	0.465
MOD_Plk_4	365	371	PF00069	0.416
MOD_Plk_4	384	390	PF00069	0.280
MOD_Plk_4	398	404	PF00069	0.430
MOD_Plk_4	436	442	PF00069	0.403
MOD_Plk_4	69	75	PF00069	0.510
MOD_ProDKin_1	123	129	PF00069	0.495
MOD_ProDKin_1	462	468	PF00069	0.555
MOD_SUMO_rev_2	263	268	PF00179	0.498
MOD_SUMO_rev_2	6	14	PF00179	0.581
TRG_DiLeu_BaLyEn_6	130	135	PF01217	0.453
TRG_DiLeu_BaLyEn_6	42	47	PF01217	0.495
TRG_ENDOCYTIC_2	140	143	PF00928	0.467
TRG_ENDOCYTIC_2	147	150	PF00928	0.476
TRG_ENDOCYTIC_2	224	227	PF00928	0.453
TRG_ENDOCYTIC_2	448	451	PF00928	0.391
TRG_ENDOCYTIC_2	514	517	PF00928	0.630
TRG_ENDOCYTIC_2	62	65	PF00928	0.492
TRG_ER_diArg_1	100	103	PF00400	0.578
TRG_ER_diArg_1	358	360	PF00400	0.609

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1II07	Leptomonas seymouri	68%	100%
A0A0N1ILF1	Leptomonas seymouri	23%	77%
A0A0S4JJ49	Bodo saltans	22%	68%
A0A0S4KGT2	Bodo saltans	22%	70%
A0A3S7WW71	Leishmania donovani	23%	77%
A0A422MYX0	Trypanosoma rangeli	21%	73%
A4HJ14	Leishmania braziliensis	24%	68%
A4HYW2	Leishmania infantum	23%	77%
A6NHC0	Homo sapiens	23%	75%
E9AIH3	Leishmania braziliensis	22%	77%
E9AK26	Leishmania mexicana (strain MHOM/GT/2001/U1103)	23%	66%
E9AUQ9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	24%	77%
O08529	Mus musculus	22%	76%
O14815	Homo sapiens	22%	77%
O15484	Homo sapiens	23%	83%
O35350	Mus musculus	25%	74%
O35920	Rattus norvegicus	23%	77%
P00789	Gallus gallus	22%	75%
P17655	Homo sapiens	23%	76%
P27730	Schistosoma mansoni	22%	70%
P34308	Caenorhabditis elegans	24%	68%
Q07009	Rattus norvegicus	22%	76%
Q22036	Caenorhabditis elegans	24%	82%
Q27971	Bos taurus	22%	76%
Q4QCS7	Leishmania major	23%	77%
Q4V8Q1	Rattus norvegicus	21%	74%
Q6J756	Mus musculus	23%	74%
Q6ZSI9	Homo sapiens	23%	74%
Q78EJ9	Rattus norvegicus	22%	75%
Q8R4C0	Rattus norvegicus	21%	83%
Q91VA3	Mus musculus	25%	75%
Q92178	Gallus gallus	23%	76%
Q9D805	Mus musculus	23%	77%
Q9ER56	Mus musculus	24%	74%
Q9GLG1	Macaca fascicularis	23%	76%
Q9UMQ6	Homo sapiens	23%	72%