Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Nucleolar protein 60, putative

Species:

Leishmania braziliensis

UniProt:

A4HFH4_LEIBR

TriTrypDb:

LbrM.27.0590 , LBRM2903_270011000 , LBRM2903_270011100

Length:

599

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005730	nucleolus	5	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HFH4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HFH4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	207	211	PF00656	0.663
CLV_C14_Caspase3-7	33	37	PF00656	0.621
CLV_C14_Caspase3-7	355	359	PF00656	0.749
CLV_NRD_NRD_1	130	132	PF00675	0.607
CLV_NRD_NRD_1	172	174	PF00675	0.531
CLV_NRD_NRD_1	196	198	PF00675	0.643
CLV_NRD_NRD_1	273	275	PF00675	0.498
CLV_NRD_NRD_1	487	489	PF00675	0.677
CLV_NRD_NRD_1	88	90	PF00675	0.385
CLV_PCSK_FUR_1	271	275	PF00082	0.533
CLV_PCSK_KEX2_1	130	132	PF00082	0.658
CLV_PCSK_KEX2_1	141	143	PF00082	0.391
CLV_PCSK_KEX2_1	172	174	PF00082	0.531
CLV_PCSK_KEX2_1	196	198	PF00082	0.643
CLV_PCSK_KEX2_1	273	275	PF00082	0.496
CLV_PCSK_KEX2_1	290	292	PF00082	0.534
CLV_PCSK_KEX2_1	487	489	PF00082	0.700
CLV_PCSK_KEX2_1	517	519	PF00082	0.587
CLV_PCSK_KEX2_1	87	89	PF00082	0.410
CLV_PCSK_PC1ET2_1	141	143	PF00082	0.391
CLV_PCSK_PC1ET2_1	290	292	PF00082	0.337
CLV_PCSK_PC1ET2_1	517	519	PF00082	0.549
CLV_PCSK_SKI1_1	104	108	PF00082	0.503
CLV_PCSK_SKI1_1	416	420	PF00082	0.622
CLV_PCSK_SKI1_1	470	474	PF00082	0.640
CLV_PCSK_SKI1_1	520	524	PF00082	0.539
DOC_CKS1_1	401	406	PF01111	0.586
DOC_CYCLIN_RxL_1	412	422	PF00134	0.348
DOC_CYCLIN_yCln2_LP_2	108	114	PF00134	0.554
DOC_CYCLIN_yCln2_LP_2	443	449	PF00134	0.640
DOC_CYCLIN_yCln2_LP_2	54	60	PF00134	0.588
DOC_MAPK_DCC_7	104	114	PF00069	0.280
DOC_MAPK_DCC_7	70	78	PF00069	0.326
DOC_MAPK_gen_1	22	30	PF00069	0.510
DOC_MAPK_gen_1	87	94	PF00069	0.526
DOC_MAPK_MEF2A_6	22	30	PF00069	0.487
DOC_MAPK_MEF2A_6	406	413	PF00069	0.377
DOC_MAPK_MEF2A_6	70	78	PF00069	0.334
DOC_PP2B_LxvP_1	108	111	PF13499	0.531
DOC_PP2B_LxvP_1	112	115	PF13499	0.524
DOC_PP2B_LxvP_1	443	446	PF13499	0.637
DOC_PP2B_LxvP_1	54	57	PF13499	0.514
DOC_PP4_FxxP_1	476	479	PF00568	0.566
DOC_USP7_MATH_1	133	137	PF00917	0.604
DOC_USP7_MATH_1	320	324	PF00917	0.484
DOC_USP7_MATH_1	343	347	PF00917	0.396
DOC_USP7_MATH_1	373	377	PF00917	0.737
DOC_USP7_MATH_1	381	385	PF00917	0.585
DOC_USP7_MATH_1	472	476	PF00917	0.639
DOC_USP7_MATH_1	77	81	PF00917	0.563
DOC_USP7_MATH_1	90	94	PF00917	0.369
DOC_WW_Pin1_4	134	139	PF00397	0.644
DOC_WW_Pin1_4	3	8	PF00397	0.536
DOC_WW_Pin1_4	361	366	PF00397	0.577
DOC_WW_Pin1_4	400	405	PF00397	0.572
DOC_WW_Pin1_4	512	517	PF00397	0.705
DOC_WW_Pin1_4	536	541	PF00397	0.747
DOC_WW_Pin1_4	69	74	PF00397	0.356
DOC_WW_Pin1_4	82	87	PF00397	0.562
LIG_14-3-3_CanoR_1	196	204	PF00244	0.496
LIG_14-3-3_CanoR_1	206	212	PF00244	0.464
LIG_14-3-3_CanoR_1	22	27	PF00244	0.530
LIG_14-3-3_CanoR_1	297	301	PF00244	0.605
LIG_14-3-3_CanoR_1	382	386	PF00244	0.507
LIG_14-3-3_CanoR_1	470	479	PF00244	0.593
LIG_14-3-3_CanoR_1	546	553	PF00244	0.710
LIG_14-3-3_CanoR_1	554	560	PF00244	0.591
LIG_14-3-3_CanoR_1	89	95	PF00244	0.636
LIG_Actin_WH2_2	552	570	PF00022	0.570
LIG_AP2alpha_1	63	67	PF02296	0.672
LIG_AP2alpha_2	300	302	PF02296	0.612
LIG_APCC_ABBA_1	248	253	PF00400	0.414
LIG_BRCT_BRCA1_1	595	599	PF00533	0.680
LIG_FHA_1	13	19	PF00498	0.485
LIG_FHA_1	151	157	PF00498	0.501
LIG_FHA_1	23	29	PF00498	0.453
LIG_FHA_1	267	273	PF00498	0.563
LIG_FHA_1	322	328	PF00498	0.569
LIG_FHA_1	343	349	PF00498	0.529
LIG_FHA_1	427	433	PF00498	0.560
LIG_FHA_1	438	444	PF00498	0.560
LIG_FHA_1	448	454	PF00498	0.387
LIG_FHA_1	45	51	PF00498	0.530
LIG_FHA_1	69	75	PF00498	0.531
LIG_FHA_2	521	527	PF00498	0.681
LIG_FHA_2	531	537	PF00498	0.559
LIG_LIR_Apic_2	473	479	PF02991	0.497
LIG_LIR_Gen_1	305	313	PF02991	0.412
LIG_LIR_Gen_1	323	330	PF02991	0.309
LIG_LIR_Nem_3	163	169	PF02991	0.454
LIG_LIR_Nem_3	305	310	PF02991	0.452
LIG_LIR_Nem_3	323	328	PF02991	0.317
LIG_LIR_Nem_3	400	405	PF02991	0.503
LIG_MLH1_MIPbox_1	595	599	PF16413	0.525
LIG_Pex14_2	63	67	PF04695	0.630
LIG_PTB_Apo_2	452	459	PF02174	0.332
LIG_Rb_pABgroove_1	245	253	PF01858	0.308
LIG_SH2_CRK	325	329	PF00017	0.370
LIG_SH2_CRK	402	406	PF00017	0.496
LIG_SH2_CRK	466	470	PF00017	0.519
LIG_SH2_NCK_1	325	329	PF00017	0.488
LIG_SH2_PTP2	307	310	PF00017	0.381
LIG_SH2_SRC	261	264	PF00017	0.562
LIG_SH2_SRC	279	282	PF00017	0.573
LIG_SH2_STAP1	190	194	PF00017	0.621
LIG_SH2_STAP1	279	283	PF00017	0.571
LIG_SH2_STAT3	180	183	PF00017	0.580
LIG_SH2_STAT5	180	183	PF00017	0.576
LIG_SH2_STAT5	307	310	PF00017	0.410
LIG_SH2_STAT5	311	314	PF00017	0.455
LIG_SH2_STAT5	335	338	PF00017	0.463
LIG_SH2_STAT5	402	405	PF00017	0.449
LIG_SH2_STAT5	49	52	PF00017	0.427
LIG_SH2_STAT5	68	71	PF00017	0.588
LIG_SH3_3	257	263	PF00018	0.463
LIG_SH3_3	307	313	PF00018	0.553
LIG_SH3_3	436	442	PF00018	0.575
LIG_SH3_3	443	449	PF00018	0.613
LIG_SH3_3	89	95	PF00018	0.636
LIG_SUMO_SIM_anti_2	157	163	PF11976	0.535
LIG_SUMO_SIM_anti_2	391	398	PF11976	0.397
LIG_SUMO_SIM_anti_2	434	440	PF11976	0.536
LIG_SUMO_SIM_par_1	110	116	PF11976	0.311
LIG_SUMO_SIM_par_1	25	31	PF11976	0.466
LIG_SUMO_SIM_par_1	345	353	PF11976	0.522
LIG_TRAF2_1	122	125	PF00917	0.455
LIG_TRAF2_1	313	316	PF00917	0.574
LIG_TRAF2_1	384	387	PF00917	0.501
LIG_TRAF2_1	528	531	PF00917	0.758
LIG_TRAF2_1	579	582	PF00917	0.536
LIG_TYR_ITSM	398	405	PF00017	0.510
MOD_CDC14_SPxK_1	515	518	PF00782	0.513
MOD_CDC14_SPxK_1	539	542	PF00782	0.509
MOD_CDK_SPK_2	512	517	PF00069	0.782
MOD_CDK_SPK_2	82	87	PF00069	0.433
MOD_CDK_SPxK_1	400	406	PF00069	0.587
MOD_CDK_SPxK_1	512	518	PF00069	0.514
MOD_CDK_SPxK_1	536	542	PF00069	0.615
MOD_CDK_SPxK_1	82	88	PF00069	0.426
MOD_CDK_SPxxK_3	134	141	PF00069	0.423
MOD_CDK_SPxxK_3	82	89	PF00069	0.588
MOD_CK1_1	100	106	PF00069	0.485
MOD_CK1_1	136	142	PF00069	0.610
MOD_CK1_1	208	214	PF00069	0.743
MOD_CK1_1	37	43	PF00069	0.714
MOD_CK1_1	380	386	PF00069	0.647
MOD_CK1_1	490	496	PF00069	0.661
MOD_CK1_1	525	531	PF00069	0.763
MOD_CK1_1	549	555	PF00069	0.686
MOD_CK1_1	80	86	PF00069	0.425
MOD_CK2_1	148	154	PF00069	0.554
MOD_CK2_1	381	387	PF00069	0.614
MOD_CK2_1	492	498	PF00069	0.602
MOD_CK2_1	520	526	PF00069	0.619
MOD_CK2_1	530	536	PF00069	0.568
MOD_CK2_1	555	561	PF00069	0.541
MOD_Cter_Amidation	194	197	PF01082	0.722
MOD_Cter_Amidation	288	291	PF01082	0.521
MOD_GlcNHglycan	104	107	PF01048	0.465
MOD_GlcNHglycan	150	153	PF01048	0.517
MOD_GlcNHglycan	190	193	PF01048	0.719
MOD_GlcNHglycan	197	200	PF01048	0.647
MOD_GlcNHglycan	207	210	PF01048	0.481
MOD_GlcNHglycan	213	216	PF01048	0.742
MOD_GlcNHglycan	358	362	PF01048	0.630
MOD_GlcNHglycan	379	382	PF01048	0.746
MOD_GlcNHglycan	39	42	PF01048	0.674
MOD_GlcNHglycan	543	546	PF01048	0.611
MOD_GlcNHglycan	590	594	PF01048	0.789
MOD_GlcNHglycan	595	598	PF01048	0.790
MOD_GlcNHglycan	82	85	PF01048	0.473
MOD_GlcNHglycan	98	102	PF01048	0.491
MOD_GSK3_1	150	157	PF00069	0.485
MOD_GSK3_1	195	202	PF00069	0.690
MOD_GSK3_1	204	211	PF00069	0.682
MOD_GSK3_1	296	303	PF00069	0.607
MOD_GSK3_1	357	364	PF00069	0.540
MOD_GSK3_1	373	380	PF00069	0.448
MOD_GSK3_1	536	543	PF00069	0.704
MOD_GSK3_1	555	562	PF00069	0.593
MOD_GSK3_1	589	596	PF00069	0.678
MOD_GSK3_1	8	15	PF00069	0.371
MOD_N-GLC_1	199	204	PF02516	0.559
MOD_N-GLC_1	470	475	PF02516	0.639
MOD_NEK2_1	266	271	PF00069	0.619
MOD_NEK2_1	34	39	PF00069	0.649
MOD_NEK2_1	418	423	PF00069	0.577
MOD_NEK2_1	563	568	PF00069	0.628
MOD_NEK2_1	8	13	PF00069	0.399
MOD_PK_1	487	493	PF00069	0.508
MOD_PKA_1	487	493	PF00069	0.508
MOD_PKA_2	148	154	PF00069	0.554
MOD_PKA_2	195	201	PF00069	0.697
MOD_PKA_2	205	211	PF00069	0.705
MOD_PKA_2	296	302	PF00069	0.605
MOD_PKA_2	34	40	PF00069	0.478
MOD_PKA_2	381	387	PF00069	0.735
MOD_PKA_2	487	493	PF00069	0.651
MOD_PKA_2	541	547	PF00069	0.656
MOD_PKB_1	518	526	PF00069	0.685
MOD_Plk_1	266	272	PF00069	0.562
MOD_Plk_1	44	50	PF00069	0.467
MOD_Plk_1	530	536	PF00069	0.520
MOD_Plk_1	549	555	PF00069	0.689
MOD_Plk_2-3	154	160	PF00069	0.378
MOD_Plk_2-3	530	536	PF00069	0.652
MOD_Plk_4	113	119	PF00069	0.577
MOD_Plk_4	176	182	PF00069	0.514
MOD_Plk_4	397	403	PF00069	0.563
MOD_Plk_4	419	425	PF00069	0.600
MOD_Plk_4	45	51	PF00069	0.413
MOD_Plk_4	464	470	PF00069	0.532
MOD_Plk_4	472	478	PF00069	0.592
MOD_Plk_4	77	83	PF00069	0.423
MOD_ProDKin_1	134	140	PF00069	0.614
MOD_ProDKin_1	3	9	PF00069	0.532
MOD_ProDKin_1	361	367	PF00069	0.578
MOD_ProDKin_1	400	406	PF00069	0.587
MOD_ProDKin_1	512	518	PF00069	0.709
MOD_ProDKin_1	536	542	PF00069	0.747
MOD_ProDKin_1	69	75	PF00069	0.349
MOD_ProDKin_1	82	88	PF00069	0.555
MOD_SUMO_rev_2	252	256	PF00179	0.548
TRG_DiLeu_BaEn_1	305	310	PF01217	0.409
TRG_DiLeu_BaLyEn_6	346	351	PF01217	0.588
TRG_DiLeu_BaLyEn_6	414	419	PF01217	0.346
TRG_DiLeu_LyEn_5	165	170	PF01217	0.553
TRG_ENDOCYTIC_2	257	260	PF00928	0.435
TRG_ENDOCYTIC_2	279	282	PF00928	0.573
TRG_ENDOCYTIC_2	307	310	PF00928	0.403
TRG_ENDOCYTIC_2	325	328	PF00928	0.312
TRG_ENDOCYTIC_2	402	405	PF00928	0.490
TRG_ENDOCYTIC_2	466	469	PF00928	0.505
TRG_ER_diArg_1	129	131	PF00400	0.572
TRG_ER_diArg_1	172	174	PF00400	0.533
TRG_ER_diArg_1	21	24	PF00400	0.595
TRG_ER_diArg_1	270	273	PF00400	0.429
TRG_ER_diArg_1	411	414	PF00400	0.312
TRG_ER_diArg_1	486	488	PF00400	0.690
TRG_ER_diArg_1	511	514	PF00400	0.538
TRG_ER_diArg_1	86	89	PF00400	0.546

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I592	Leptomonas seymouri	52%	97%
A0A1X0P512	Trypanosomatidae	35%	100%
A0A3S7X0H0	Leishmania donovani	74%	100%
A0A422NTD4	Trypanosoma rangeli	32%	100%
A4I2N4	Leishmania infantum	74%	100%
D0A5Q0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	100%
E9AD25	Leishmania major	74%	100%
E9AYV0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	76%	100%
V5BSP9	Trypanosoma cruzi	33%	100%