Putative ABC transporter

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

glycosomal transporter (GAT3), putative

Species:

Leishmania braziliensis

UniProt:

A4HFH3_LEIBR

TriTrypDb:

LbrM.27.0580 , LBRM2903_270009600

Length:

688

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	12
GO:0110165	cellular anatomical entity	1	12
GO:0005777	peroxisome	6	1
GO:0005778	peroxisomal membrane	6	1
GO:0020015	glycosome	7	1
GO:0020022	acidocalcisome	5	1
GO:0031090	organelle membrane	3	1
GO:0031903	microbody membrane	5	1
GO:0042579	microbody	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0098588	bounding membrane of organelle	4	1

Expansion

Sequence features

A4HFH3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HFH3

Function

Biological processes
Term	Name	Level	Count
GO:0000038	very long-chain fatty acid metabolic process	5	1
GO:0006082	organic acid metabolic process	3	1
GO:0006629	lipid metabolic process	3	1
GO:0006631	fatty acid metabolic process	4	1
GO:0006635	fatty acid beta-oxidation	6	1
GO:0006810	transport	3	1
GO:0006869	lipid transport	5	1
GO:0006996	organelle organization	4	1
GO:0007031	peroxisome organization	5	1
GO:0008152	metabolic process	1	1
GO:0009056	catabolic process	2	1
GO:0009062	fatty acid catabolic process	5	1
GO:0009987	cellular process	1	1
GO:0015849	organic acid transport	5	1
GO:0015908	fatty acid transport	6	1
GO:0015909	long-chain fatty acid transport	7	1
GO:0015910	long-chain fatty acid import into peroxisome	5	1
GO:0015919	peroxisomal membrane transport	5	1
GO:0016042	lipid catabolic process	4	1
GO:0016043	cellular component organization	3	1
GO:0016054	organic acid catabolic process	4	1
GO:0019395	fatty acid oxidation	5	1
GO:0019752	carboxylic acid metabolic process	5	1
GO:0030258	lipid modification	4	1
GO:0032365	intracellular lipid transport	4	1
GO:0032787	monocarboxylic acid metabolic process	6	1
GO:0034440	lipid oxidation	5	1
GO:0042760	very long-chain fatty acid catabolic process	6	1
GO:0043436	oxoacid metabolic process	4	1
GO:0043574	peroxisomal transport	4	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044242	cellular lipid catabolic process	4	1
GO:0044248	cellular catabolic process	3	1
GO:0044255	cellular lipid metabolic process	3	1
GO:0044281	small molecule metabolic process	2	1
GO:0044282	small molecule catabolic process	3	1
GO:0046395	carboxylic acid catabolic process	5	1
GO:0046907	intracellular transport	3	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0051641	cellular localization	2	1
GO:0051649	establishment of localization in cell	3	1
GO:0055085	transmembrane transport	2	1
GO:0071702	organic substance transport	4	1
GO:0071704	organic substance metabolic process	2	1
GO:0071840	cellular component organization or biogenesis	2	1
GO:0072329	monocarboxylic acid catabolic process	6	1
GO:1901575	organic substance catabolic process	3	1
GO:1902001	fatty acid transmembrane transport	5	1
GO:1903825	organic acid transmembrane transport	3	1
GO:1905039	carboxylic acid transmembrane transport	4	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	12
GO:0005215	transporter activity	1	12
GO:0005488	binding	1	12
GO:0005524	ATP binding	5	12
GO:0015399	primary active transmembrane transporter activity	4	12
GO:0017076	purine nucleotide binding	4	12
GO:0022804	active transmembrane transporter activity	3	12
GO:0022857	transmembrane transporter activity	2	12
GO:0030554	adenyl nucleotide binding	5	12
GO:0032553	ribonucleotide binding	3	12
GO:0032555	purine ribonucleotide binding	4	12
GO:0032559	adenyl ribonucleotide binding	5	12
GO:0035639	purine ribonucleoside triphosphate binding	4	12
GO:0036094	small molecule binding	2	12
GO:0042626	ATPase-coupled transmembrane transporter activity	2	12
GO:0043167	ion binding	2	12
GO:0043168	anion binding	3	12
GO:0097159	organic cyclic compound binding	2	12
GO:0097367	carbohydrate derivative binding	2	12
GO:0140359	ABC-type transporter activity	3	12
GO:0140657	ATP-dependent activity	1	12
GO:1901265	nucleoside phosphate binding	3	12
GO:1901363	heterocyclic compound binding	2	12
GO:0005319	lipid transporter activity	2	1
GO:0005324	long-chain fatty acid transporter activity	3	1
GO:0003824	catalytic activity	1	1
GO:0016787	hydrolase activity	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	186	190	PF00656	0.239
CLV_NRD_NRD_1	174	176	PF00675	0.441
CLV_NRD_NRD_1	25	27	PF00675	0.237
CLV_NRD_NRD_1	635	637	PF00675	0.488
CLV_PCSK_KEX2_1	174	176	PF00082	0.439
CLV_PCSK_KEX2_1	25	27	PF00082	0.159
CLV_PCSK_KEX2_1	300	302	PF00082	0.188
CLV_PCSK_KEX2_1	635	637	PF00082	0.511
CLV_PCSK_PC1ET2_1	300	302	PF00082	0.213
CLV_PCSK_PC7_1	170	176	PF00082	0.378
CLV_PCSK_SKI1_1	102	106	PF00082	0.256
CLV_PCSK_SKI1_1	139	143	PF00082	0.211
CLV_PCSK_SKI1_1	238	242	PF00082	0.388
CLV_PCSK_SKI1_1	255	259	PF00082	0.203
CLV_PCSK_SKI1_1	277	281	PF00082	0.228
CLV_PCSK_SKI1_1	430	434	PF00082	0.595
CLV_PCSK_SKI1_1	508	512	PF00082	0.433
CLV_PCSK_SKI1_1	546	550	PF00082	0.403
CLV_PCSK_SKI1_1	597	601	PF00082	0.469
CLV_PCSK_SKI1_1	78	82	PF00082	0.453
DOC_CDC14_PxL_1	216	224	PF14671	0.284
DOC_MAPK_gen_1	128	138	PF00069	0.414
DOC_MAPK_gen_1	607	615	PF00069	0.259
DOC_MAPK_gen_1	670	677	PF00069	0.378
DOC_MAPK_MEF2A_6	102	109	PF00069	0.347
DOC_MAPK_MEF2A_6	131	140	PF00069	0.448
DOC_MAPK_MEF2A_6	353	362	PF00069	0.303
DOC_PP1_RVXF_1	595	601	PF00149	0.319
DOC_PP2B_LxvP_1	493	496	PF13499	0.255
DOC_PP4_FxxP_1	217	220	PF00568	0.217
DOC_PP4_FxxP_1	510	513	PF00568	0.193
DOC_USP7_MATH_1	346	350	PF00917	0.434
DOC_USP7_MATH_1	513	517	PF00917	0.256
DOC_USP7_MATH_1	89	93	PF00917	0.334
DOC_WW_Pin1_4	255	260	PF00397	0.388
DOC_WW_Pin1_4	419	424	PF00397	0.374
DOC_WW_Pin1_4	450	455	PF00397	0.294
DOC_WW_Pin1_4	608	613	PF00397	0.275
LIG_14-3-3_CanoR_1	167	173	PF00244	0.277
LIG_14-3-3_CanoR_1	263	270	PF00244	0.421
LIG_14-3-3_CanoR_1	347	355	PF00244	0.412
LIG_14-3-3_CanoR_1	640	645	PF00244	0.224
LIG_14-3-3_CterR_2	685	688	PF00244	0.370
LIG_Actin_WH2_2	222	240	PF00022	0.313
LIG_Actin_WH2_2	385	402	PF00022	0.313
LIG_BRCT_BRCA1_1	168	172	PF00533	0.241
LIG_BRCT_BRCA1_1	505	509	PF00533	0.284
LIG_BRCT_BRCA1_1	91	95	PF00533	0.347
LIG_Clathr_ClatBox_1	443	447	PF01394	0.334
LIG_CSL_BTD_1	493	496	PF09270	0.241
LIG_EH1_1	35	43	PF00400	0.283
LIG_eIF4E_1	359	365	PF01652	0.375
LIG_FHA_1	224	230	PF00498	0.157
LIG_FHA_1	246	252	PF00498	0.451
LIG_FHA_1	256	262	PF00498	0.519
LIG_FHA_1	278	284	PF00498	0.441
LIG_FHA_1	35	41	PF00498	0.407
LIG_FHA_1	438	444	PF00498	0.370
LIG_FHA_1	482	488	PF00498	0.227
LIG_FHA_1	536	542	PF00498	0.321
LIG_FHA_1	64	70	PF00498	0.418
LIG_FHA_1	653	659	PF00498	0.260
LIG_FHA_2	184	190	PF00498	0.222
LIG_FHA_2	521	527	PF00498	0.217
LIG_FHA_2	57	63	PF00498	0.394
LIG_FHA_2	624	630	PF00498	0.348
LIG_FHA_2	643	649	PF00498	0.186
LIG_GBD_Chelix_1	140	148	PF00786	0.409
LIG_LIR_Apic_2	516	520	PF02991	0.218
LIG_LIR_Gen_1	208	218	PF02991	0.197
LIG_LIR_Gen_1	272	283	PF02991	0.350
LIG_LIR_Gen_1	327	338	PF02991	0.458
LIG_LIR_Gen_1	406	414	PF02991	0.474
LIG_LIR_Gen_1	470	478	PF02991	0.229
LIG_LIR_Gen_1	523	533	PF02991	0.281
LIG_LIR_Gen_1	66	74	PF02991	0.322
LIG_LIR_Gen_1	92	103	PF02991	0.317
LIG_LIR_Nem_3	208	213	PF02991	0.213
LIG_LIR_Nem_3	327	333	PF02991	0.472
LIG_LIR_Nem_3	439	444	PF02991	0.310
LIG_LIR_Nem_3	470	476	PF02991	0.229
LIG_LIR_Nem_3	523	528	PF02991	0.281
LIG_LIR_Nem_3	579	585	PF02991	0.217
LIG_LIR_Nem_3	66	70	PF02991	0.306
LIG_LIR_Nem_3	92	98	PF02991	0.318
LIG_PCNA_yPIPBox_3	347	359	PF02747	0.264
LIG_PCNA_yPIPBox_3	369	380	PF02747	0.339
LIG_Pex14_2	172	176	PF04695	0.241
LIG_Pex14_2	206	210	PF04695	0.197
LIG_Pex14_2	375	379	PF04695	0.305
LIG_Pex14_2	70	74	PF04695	0.217
LIG_Pex14_2	95	99	PF04695	0.253
LIG_PTB_Apo_2	410	417	PF02174	0.312
LIG_PTB_Phospho_1	410	416	PF10480	0.312
LIG_SH2_CRK	517	521	PF00017	0.241
LIG_SH2_PTP2	416	419	PF00017	0.303
LIG_SH2_SRC	359	362	PF00017	0.348
LIG_SH2_STAP1	19	23	PF00017	0.489
LIG_SH2_STAP1	564	568	PF00017	0.271
LIG_SH2_STAT3	6	9	PF00017	0.543
LIG_SH2_STAT5	202	205	PF00017	0.224
LIG_SH2_STAT5	216	219	PF00017	0.198
LIG_SH2_STAT5	282	285	PF00017	0.501
LIG_SH2_STAT5	359	362	PF00017	0.292
LIG_SH2_STAT5	416	419	PF00017	0.303
LIG_SH2_STAT5	426	429	PF00017	0.350
LIG_SH2_STAT5	46	49	PF00017	0.362
LIG_SH3_3	414	420	PF00018	0.397
LIG_SH3_3	531	537	PF00018	0.240
LIG_SH3_3	668	674	PF00018	0.367
LIG_SUMO_SIM_anti_2	226	233	PF11976	0.199
LIG_SUMO_SIM_anti_2	248	255	PF11976	0.179
LIG_SUMO_SIM_anti_2	37	42	PF11976	0.172
LIG_SUMO_SIM_anti_2	556	562	PF11976	0.168
LIG_SUMO_SIM_anti_2	610	618	PF11976	0.256
LIG_SUMO_SIM_par_1	226	233	PF11976	0.180
LIG_SUMO_SIM_par_1	537	543	PF11976	0.159
LIG_SUMO_SIM_par_1	610	618	PF11976	0.225
LIG_SUMO_SIM_par_1	640	645	PF11976	0.273
LIG_TRFH_1	509	513	PF08558	0.319
LIG_TYR_ITIM	213	218	PF00017	0.217
LIG_TYR_ITSM	521	528	PF00017	0.319
LIG_UBA3_1	364	373	PF00899	0.403
LIG_UBA3_1	489	497	PF00899	0.319
LIG_UBA3_1	657	665	PF00899	0.344
LIG_UBA3_1	94	102	PF00899	0.297
MOD_CK1_1	13	19	PF00069	0.687
MOD_CK1_1	383	389	PF00069	0.293
MOD_CK1_1	502	508	PF00069	0.271
MOD_CK1_1	581	587	PF00069	0.264
MOD_CK2_1	281	287	PF00069	0.397
MOD_CK2_1	520	526	PF00069	0.217
MOD_CK2_1	642	648	PF00069	0.236
MOD_GlcNHglycan	238	241	PF01048	0.313
MOD_GlcNHglycan	243	246	PF01048	0.319
MOD_GlcNHglycan	248	251	PF01048	0.292
MOD_GlcNHglycan	343	346	PF01048	0.508
MOD_GlcNHglycan	460	463	PF01048	0.539
MOD_GlcNHglycan	497	500	PF01048	0.489
MOD_GlcNHglycan	54	57	PF01048	0.553
MOD_GlcNHglycan	565	568	PF01048	0.555
MOD_GlcNHglycan	585	588	PF01048	0.435
MOD_GSK3_1	194	201	PF00069	0.234
MOD_GSK3_1	241	248	PF00069	0.381
MOD_GSK3_1	277	284	PF00069	0.478
MOD_GSK3_1	328	335	PF00069	0.355
MOD_GSK3_1	383	390	PF00069	0.284
MOD_GSK3_1	495	502	PF00069	0.290
MOD_GSK3_1	52	59	PF00069	0.444
MOD_GSK3_1	576	583	PF00069	0.250
MOD_GSK3_1	8	15	PF00069	0.690
MOD_N-GLC_1	351	356	PF02516	0.575
MOD_N-GLC_1	368	373	PF02516	0.508
MOD_N-GLC_1	430	435	PF02516	0.539
MOD_N-GLC_2	479	481	PF02516	0.441
MOD_NEK2_1	168	173	PF00069	0.319
MOD_NEK2_1	241	246	PF00069	0.391
MOD_NEK2_1	27	32	PF00069	0.124
MOD_NEK2_1	302	307	PF00069	0.527
MOD_NEK2_1	36	41	PF00069	0.158
MOD_NEK2_1	368	373	PF00069	0.290
MOD_NEK2_1	395	400	PF00069	0.284
MOD_NEK2_1	424	429	PF00069	0.471
MOD_NEK2_1	8	13	PF00069	0.649
MOD_NEK2_2	520	525	PF00069	0.284
MOD_PIKK_1	263	269	PF00454	0.519
MOD_PIKK_1	424	430	PF00454	0.388
MOD_PIKK_1	499	505	PF00454	0.271
MOD_PIKK_1	60	66	PF00454	0.459
MOD_PK_1	640	646	PF00069	0.271
MOD_PKA_2	166	172	PF00069	0.217
MOD_PKA_2	346	352	PF00069	0.442
MOD_PKA_2	591	597	PF00069	0.268
MOD_Plk_1	302	308	PF00069	0.522
MOD_Plk_1	351	357	PF00069	0.279
MOD_Plk_1	368	374	PF00069	0.293
MOD_Plk_1	380	386	PF00069	0.242
MOD_Plk_1	395	401	PF00069	0.290
MOD_Plk_1	503	509	PF00069	0.230
MOD_Plk_1	576	582	PF00069	0.219
MOD_Plk_1	60	66	PF00069	0.390
MOD_Plk_1	617	623	PF00069	0.217
MOD_Plk_2-3	466	472	PF00069	0.280
MOD_Plk_2-3	535	541	PF00069	0.159
MOD_Plk_2-3	618	624	PF00069	0.312
MOD_Plk_4	116	122	PF00069	0.384
MOD_Plk_4	183	189	PF00069	0.239
MOD_Plk_4	224	230	PF00069	0.160
MOD_Plk_4	329	335	PF00069	0.289
MOD_Plk_4	36	42	PF00069	0.223
MOD_Plk_4	403	409	PF00069	0.382
MOD_Plk_4	482	488	PF00069	0.217
MOD_Plk_4	513	519	PF00069	0.243
MOD_Plk_4	520	526	PF00069	0.264
MOD_Plk_4	553	559	PF00069	0.224
MOD_Plk_4	618	624	PF00069	0.312
MOD_Plk_4	89	95	PF00069	0.356
MOD_ProDKin_1	255	261	PF00069	0.388
MOD_ProDKin_1	419	425	PF00069	0.365
MOD_ProDKin_1	450	456	PF00069	0.299
MOD_ProDKin_1	608	614	PF00069	0.275
MOD_SUMO_for_1	444	447	PF00179	0.307
TRG_DiLeu_BaEn_1	540	545	PF01217	0.159
TRG_ENDOCYTIC_2	177	180	PF00928	0.227
TRG_ENDOCYTIC_2	215	218	PF00928	0.217
TRG_ENDOCYTIC_2	275	278	PF00928	0.434
TRG_ENDOCYTIC_2	359	362	PF00928	0.305
TRG_ENDOCYTIC_2	416	419	PF00928	0.398
TRG_ENDOCYTIC_2	426	429	PF00928	0.350
TRG_ENDOCYTIC_2	46	49	PF00928	0.346
TRG_ENDOCYTIC_2	525	528	PF00928	0.277
TRG_ER_diArg_1	174	176	PF00400	0.236
TRG_ER_diArg_1	25	27	PF00400	0.359
TRG_ER_diArg_1	634	636	PF00400	0.321
TRG_ER_diArg_1	84	87	PF00400	0.319
TRG_NES_CRM1_1	324	339	PF08389	0.519
TRG_NES_CRM1_1	366	381	PF08389	0.297
TRG_NES_CRM1_1	540	555	PF08389	0.271
TRG_Pf-PMV_PEXEL_1	542	547	PF00026	0.437
TRG_PTS1	685	688	PF00515	0.370

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I6W7	Leptomonas seymouri	71%	100%
A0A0S4JRH8	Bodo saltans	37%	91%
A0A1X0P3R6	Trypanosomatidae	22%	100%
A0A1X0P474	Trypanosomatidae	53%	100%
A0A3Q8ICD7	Leishmania donovani	23%	82%
A0A3Q8ICJ2	Leishmania donovani	82%	100%
A0A3R7KWF0	Trypanosoma rangeli	23%	100%
A0A3S7X6Y1	Leishmania donovani	21%	95%
A0A422NTH3	Trypanosoma rangeli	50%	100%
A4HJ32	Leishmania braziliensis	23%	82%
A4HLP7	Leishmania braziliensis	20%	100%
A4I2N3	Leishmania infantum	83%	100%
A4I6L1	Leishmania infantum	23%	82%
C9ZN63	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	22%	100%
D0A5P9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	45%	100%
D3ZHR2	Rattus norvegicus	23%	93%
E9AD24	Leishmania major	81%	100%
E9AYU9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	100%
E9B1K4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	23%	84%
E9B422	Leishmania mexicana (strain MHOM/GT/2001/U1103)	20%	98%
F1RBC8	Danio rerio	24%	90%
O14678	Homo sapiens	22%	100%
O89016	Mus musculus	21%	100%
P16970	Rattus norvegicus	24%	100%
P28288	Homo sapiens	24%	100%
P33897	Homo sapiens	24%	92%
P48410	Mus musculus	23%	93%
P55096	Mus musculus	25%	100%
Q4Q402	Leishmania major	21%	98%
Q55774	Synechocystis sp. (strain PCC 6803 / Kazusa)	23%	100%
Q61285	Mus musculus	22%	93%
Q6NLC1	Arabidopsis thaliana	23%	97%
Q7JUN3	Drosophila melanogaster	23%	94%
Q8T8P3	Dictyostelium discoideum	21%	93%
Q9BHG2	Leishmania major	23%	100%
Q9QY44	Rattus norvegicus	22%	93%
Q9UBJ2	Homo sapiens	23%	93%
V5AYI7	Trypanosoma cruzi	23%	100%
V5BXE1	Trypanosoma cruzi	50%	100%