Vasohibin

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Vasohibin

Gene product:

Vasohibin, putative

Species:

Leishmania braziliensis

UniProt:

A4HFH0_LEIBR

TriTrypDb:

LbrM.27.0550 , LBRM2903_270010900

Length:

630

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	7
GO:0110165	cellular anatomical entity	1	7

Expansion

Sequence features

A4HFH0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HFH0

Function

Biological processes
Term	Name	Level	Count
GO:0022603	regulation of anatomical structure morphogenesis	4	7
GO:0045765	regulation of angiogenesis	5	7
GO:0050789	regulation of biological process	2	7
GO:0050793	regulation of developmental process	3	7
GO:0051239	regulation of multicellular organismal process	3	7
GO:0065007	biological regulation	1	7
GO:1901342	regulation of vasculature development	5	7
GO:2000026	regulation of multicellular organismal development	4	7

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	335	339	PF00656	0.703
CLV_C14_Caspase3-7	389	393	PF00656	0.401
CLV_NRD_NRD_1	147	149	PF00675	0.346
CLV_NRD_NRD_1	227	229	PF00675	0.605
CLV_NRD_NRD_1	399	401	PF00675	0.527
CLV_NRD_NRD_1	473	475	PF00675	0.722
CLV_NRD_NRD_1	591	593	PF00675	0.795
CLV_PCSK_KEX2_1	399	401	PF00082	0.527
CLV_PCSK_KEX2_1	416	418	PF00082	0.588
CLV_PCSK_KEX2_1	458	460	PF00082	0.821
CLV_PCSK_PC1ET2_1	416	418	PF00082	0.690
CLV_PCSK_PC1ET2_1	458	460	PF00082	0.824
CLV_PCSK_SKI1_1	160	164	PF00082	0.260
CLV_PCSK_SKI1_1	218	222	PF00082	0.741
CLV_PCSK_SKI1_1	377	381	PF00082	0.530
CLV_PCSK_SKI1_1	422	426	PF00082	0.706
CLV_PCSK_SKI1_1	435	439	PF00082	0.714
CLV_PCSK_SKI1_1	62	66	PF00082	0.318
CLV_PCSK_SKI1_1	81	85	PF00082	0.212
DEG_SPOP_SBC_1	241	245	PF00917	0.577
DOC_CKS1_1	506	511	PF01111	0.614
DOC_CKS1_1	583	588	PF01111	0.704
DOC_CYCLIN_RxL_1	155	164	PF00134	0.460
DOC_MAPK_gen_1	377	386	PF00069	0.512
DOC_MAPK_gen_1	455	464	PF00069	0.829
DOC_MAPK_gen_1	69	78	PF00069	0.619
DOC_PP1_RVXF_1	378	384	PF00149	0.616
DOC_PP2B_LxvP_1	424	427	PF13499	0.814
DOC_PP2B_LxvP_1	462	465	PF13499	0.728
DOC_PP4_FxxP_1	579	582	PF00568	0.811
DOC_PP4_MxPP_1	490	493	PF00568	0.593
DOC_USP7_MATH_1	158	162	PF00917	0.619
DOC_USP7_MATH_1	252	256	PF00917	0.760
DOC_USP7_MATH_1	28	32	PF00917	0.546
DOC_USP7_MATH_1	449	453	PF00917	0.741
DOC_USP7_MATH_1	523	527	PF00917	0.562
DOC_USP7_MATH_1	553	557	PF00917	0.782
DOC_USP7_MATH_1	591	595	PF00917	0.546
DOC_USP7_UBL2_3	117	121	PF12436	0.460
DOC_USP7_UBL2_3	425	429	PF12436	0.579
DOC_USP7_UBL2_3	431	435	PF12436	0.566
DOC_WW_Pin1_4	229	234	PF00397	0.688
DOC_WW_Pin1_4	237	242	PF00397	0.702
DOC_WW_Pin1_4	248	253	PF00397	0.766
DOC_WW_Pin1_4	324	329	PF00397	0.710
DOC_WW_Pin1_4	406	411	PF00397	0.524
DOC_WW_Pin1_4	484	489	PF00397	0.725
DOC_WW_Pin1_4	505	510	PF00397	0.669
DOC_WW_Pin1_4	549	554	PF00397	0.744
DOC_WW_Pin1_4	563	568	PF00397	0.656
DOC_WW_Pin1_4	582	587	PF00397	0.708
DOC_WW_Pin1_4	622	627	PF00397	0.671
LIG_14-3-3_CanoR_1	111	117	PF00244	0.538
LIG_14-3-3_CanoR_1	133	138	PF00244	0.604
LIG_14-3-3_CanoR_1	148	153	PF00244	0.463
LIG_14-3-3_CanoR_1	228	233	PF00244	0.767
LIG_14-3-3_CanoR_1	246	252	PF00244	0.579
LIG_14-3-3_CanoR_1	278	287	PF00244	0.553
LIG_14-3-3_CanoR_1	459	463	PF00244	0.803
LIG_14-3-3_CanoR_1	592	602	PF00244	0.796
LIG_14-3-3_CanoR_1	603	612	PF00244	0.612
LIG_14-3-3_CanoR_1	62	68	PF00244	0.511
LIG_AP2alpha_2	577	579	PF02296	0.562
LIG_BRCT_BRCA1_1	600	604	PF00533	0.703
LIG_BRCT_BRCA1_1	608	612	PF00533	0.682
LIG_BRCT_BRCA1_1	74	78	PF00533	0.619
LIG_CtBP_PxDLS_1	284	288	PF00389	0.551
LIG_deltaCOP1_diTrp_1	198	203	PF00928	0.546
LIG_EH_1	15	19	PF12763	0.569
LIG_eIF4E_1	125	131	PF01652	0.546
LIG_EVH1_1	24	28	PF00568	0.619
LIG_FHA_1	101	107	PF00498	0.513
LIG_FHA_1	134	140	PF00498	0.505
LIG_FHA_1	242	248	PF00498	0.579
LIG_FHA_1	274	280	PF00498	0.561
LIG_FHA_1	318	324	PF00498	0.654
LIG_FHA_1	325	331	PF00498	0.706
LIG_FHA_1	494	500	PF00498	0.629
LIG_FHA_1	549	555	PF00498	0.602
LIG_FHA_2	103	109	PF00498	0.619
LIG_FHA_2	188	194	PF00498	0.546
LIG_FHA_2	358	364	PF00498	0.592
LIG_FHA_2	387	393	PF00498	0.396
LIG_FHA_2	77	83	PF00498	0.516
LIG_GBD_Chelix_1	347	355	PF00786	0.578
LIG_Integrin_isoDGR_2	216	218	PF01839	0.498
LIG_LIR_Apic_2	561	567	PF02991	0.626
LIG_LIR_Apic_2	576	582	PF02991	0.716
LIG_LIR_Gen_1	161	169	PF02991	0.546
LIG_LIR_Gen_1	172	181	PF02991	0.501
LIG_LIR_Gen_1	352	361	PF02991	0.480
LIG_LIR_Gen_1	56	65	PF02991	0.546
LIG_LIR_Gen_1	94	102	PF02991	0.529
LIG_LIR_Nem_3	151	157	PF02991	0.526
LIG_LIR_Nem_3	161	166	PF02991	0.546
LIG_LIR_Nem_3	172	176	PF02991	0.501
LIG_LIR_Nem_3	198	204	PF02991	0.536
LIG_LIR_Nem_3	342	347	PF02991	0.521
LIG_LIR_Nem_3	352	357	PF02991	0.478
LIG_LIR_Nem_3	363	369	PF02991	0.504
LIG_LIR_Nem_3	56	60	PF02991	0.546
LIG_LIR_Nem_3	63	67	PF02991	0.546
LIG_LIR_Nem_3	94	100	PF02991	0.529
LIG_MYND_1	582	586	PF01753	0.707
LIG_PTB_Apo_2	13	20	PF02174	0.413
LIG_PTB_Phospho_1	13	19	PF10480	0.407
LIG_Rb_LxCxE_1	85	108	PF01857	0.547
LIG_SH2_CRK	141	145	PF00017	0.546
LIG_SH2_CRK	154	158	PF00017	0.546
LIG_SH2_CRK	159	163	PF00017	0.546
LIG_SH2_CRK	344	348	PF00017	0.552
LIG_SH2_CRK	354	358	PF00017	0.412
LIG_SH2_CRK	366	370	PF00017	0.520
LIG_SH2_CRK	564	568	PF00017	0.597
LIG_SH2_STAP1	102	106	PF00017	0.619
LIG_SH2_STAP1	598	602	PF00017	0.572
LIG_SH2_STAT5	102	105	PF00017	0.619
LIG_SH2_STAT5	211	214	PF00017	0.380
LIG_SH3_3	22	28	PF00018	0.552
LIG_SH3_3	303	309	PF00018	0.692
LIG_SH3_3	316	322	PF00018	0.672
LIG_SH3_3	499	505	PF00018	0.653
LIG_SH3_3	580	586	PF00018	0.726
LIG_SH3_3	620	626	PF00018	0.605
LIG_SH3_4	425	432	PF00018	0.581
LIG_SUMO_SIM_par_1	128	134	PF11976	0.546
LIG_SUMO_SIM_par_1	3	10	PF11976	0.527
LIG_SUMO_SIM_par_1	409	414	PF11976	0.382
LIG_TRAF2_1	270	273	PF00917	0.556
LIG_TYR_ITIM	139	144	PF00017	0.505
LIG_TYR_ITIM	152	157	PF00017	0.588
LIG_TYR_ITIM	55	60	PF00017	0.546
LIG_UBA3_1	180	184	PF00899	0.619
LIG_WW_3	26	30	PF00397	0.546
MOD_CDC14_SPxK_1	625	628	PF00782	0.798
MOD_CDK_SPK_2	237	242	PF00069	0.645
MOD_CDK_SPK_2	484	489	PF00069	0.665
MOD_CDK_SPK_2	582	587	PF00069	0.708
MOD_CDK_SPxK_1	622	628	PF00069	0.810
MOD_CK1_1	115	121	PF00069	0.546
MOD_CK1_1	147	153	PF00069	0.460
MOD_CK1_1	232	238	PF00069	0.703
MOD_CK1_1	288	294	PF00069	0.565
MOD_CK1_1	324	330	PF00069	0.710
MOD_CK1_1	333	339	PF00069	0.663
MOD_CK1_1	409	415	PF00069	0.531
MOD_CK1_1	494	500	PF00069	0.821
MOD_CK1_1	511	517	PF00069	0.729
MOD_CK1_1	53	59	PF00069	0.626
MOD_CK1_1	549	555	PF00069	0.735
MOD_CK1_1	606	612	PF00069	0.674
MOD_CK1_1	613	619	PF00069	0.667
MOD_CK1_1	72	78	PF00069	0.404
MOD_CK2_1	187	193	PF00069	0.546
MOD_CK2_1	267	273	PF00069	0.606
MOD_CK2_1	292	298	PF00069	0.817
MOD_CK2_1	357	363	PF00069	0.588
MOD_CK2_1	390	396	PF00069	0.662
MOD_CK2_1	593	599	PF00069	0.803
MOD_CK2_1	76	82	PF00069	0.516
MOD_Cter_Amidation	472	475	PF01082	0.726
MOD_GlcNHglycan	222	225	PF01048	0.516
MOD_GlcNHglycan	286	290	PF01048	0.673
MOD_GlcNHglycan	292	295	PF01048	0.583
MOD_GlcNHglycan	392	395	PF01048	0.660
MOD_GlcNHglycan	40	43	PF01048	0.391
MOD_GlcNHglycan	432	435	PF01048	0.758
MOD_GlcNHglycan	438	441	PF01048	0.805
MOD_GlcNHglycan	451	454	PF01048	0.600
MOD_GlcNHglycan	493	496	PF01048	0.692
MOD_GlcNHglycan	510	513	PF01048	0.840
MOD_GlcNHglycan	520	523	PF01048	0.600
MOD_GlcNHglycan	555	558	PF01048	0.762
MOD_GlcNHglycan	606	609	PF01048	0.715
MOD_GlcNHglycan	618	621	PF01048	0.660
MOD_GSK3_1	144	151	PF00069	0.546
MOD_GSK3_1	216	223	PF00069	0.735
MOD_GSK3_1	228	235	PF00069	0.731
MOD_GSK3_1	237	244	PF00069	0.714
MOD_GSK3_1	248	255	PF00069	0.490
MOD_GSK3_1	267	274	PF00069	0.724
MOD_GSK3_1	288	295	PF00069	0.814
MOD_GSK3_1	309	316	PF00069	0.626
MOD_GSK3_1	317	324	PF00069	0.717
MOD_GSK3_1	326	333	PF00069	0.496
MOD_GSK3_1	368	375	PF00069	0.437
MOD_GSK3_1	386	393	PF00069	0.417
MOD_GSK3_1	544	551	PF00069	0.704
MOD_GSK3_1	568	575	PF00069	0.578
MOD_GSK3_1	598	605	PF00069	0.706
MOD_GSK3_1	606	613	PF00069	0.673
MOD_GSK3_1	622	629	PF00069	0.647
MOD_GSK3_1	72	79	PF00069	0.507
MOD_N-GLC_1	248	253	PF02516	0.829
MOD_N-GLC_1	324	329	PF02516	0.662
MOD_N-GLC_1	435	440	PF02516	0.773
MOD_NEK2_1	100	105	PF00069	0.521
MOD_NEK2_1	144	149	PF00069	0.543
MOD_NEK2_1	220	225	PF00069	0.646
MOD_NEK2_1	285	290	PF00069	0.815
MOD_NEK2_1	292	297	PF00069	0.767
MOD_NEK2_1	330	335	PF00069	0.571
MOD_NEK2_1	372	377	PF00069	0.418
MOD_NEK2_1	602	607	PF00069	0.782
MOD_NEK2_1	93	98	PF00069	0.546
MOD_NEK2_2	102	107	PF00069	0.619
MOD_NEK2_2	158	163	PF00069	0.619
MOD_NEK2_2	598	603	PF00069	0.544
MOD_PIKK_1	10	16	PF00454	0.532
MOD_PIKK_1	100	106	PF00454	0.546
MOD_PIKK_1	593	599	PF00454	0.589
MOD_PIKK_1	611	617	PF00454	0.475
MOD_PK_1	50	56	PF00069	0.619
MOD_PKA_1	148	154	PF00069	0.546
MOD_PKA_1	228	234	PF00069	0.625
MOD_PKA_1	458	464	PF00069	0.820
MOD_PKA_2	147	153	PF00069	0.460
MOD_PKA_2	227	233	PF00069	0.764
MOD_PKA_2	28	34	PF00069	0.546
MOD_PKA_2	38	44	PF00069	0.546
MOD_PKA_2	458	464	PF00069	0.820
MOD_PKA_2	591	597	PF00069	0.659
MOD_PKA_2	602	608	PF00069	0.751
MOD_Plk_1	192	198	PF00069	0.546
MOD_Plk_1	271	277	PF00069	0.642
MOD_Plk_1	568	574	PF00069	0.566
MOD_Plk_1	598	604	PF00069	0.544
MOD_Plk_1	93	99	PF00069	0.543
MOD_Plk_4	148	154	PF00069	0.589
MOD_Plk_4	313	319	PF00069	0.585
MOD_Plk_4	326	332	PF00069	0.574
MOD_Plk_4	72	78	PF00069	0.526
MOD_Plk_4	93	99	PF00069	0.546
MOD_ProDKin_1	229	235	PF00069	0.691
MOD_ProDKin_1	237	243	PF00069	0.699
MOD_ProDKin_1	248	254	PF00069	0.759
MOD_ProDKin_1	324	330	PF00069	0.710
MOD_ProDKin_1	406	412	PF00069	0.526
MOD_ProDKin_1	484	490	PF00069	0.725
MOD_ProDKin_1	505	511	PF00069	0.672
MOD_ProDKin_1	549	555	PF00069	0.744
MOD_ProDKin_1	563	569	PF00069	0.659
MOD_ProDKin_1	582	588	PF00069	0.706
MOD_ProDKin_1	622	628	PF00069	0.671
MOD_SUMO_for_1	116	119	PF00179	0.546
MOD_SUMO_rev_2	179	185	PF00179	0.619
MOD_SUMO_rev_2	409	418	PF00179	0.650
TRG_DiLeu_BaEn_2	42	48	PF01217	0.619
TRG_DiLeu_BaLyEn_6	260	265	PF01217	0.565
TRG_DiLeu_BaLyEn_6	353	358	PF01217	0.468
TRG_ENDOCYTIC_2	125	128	PF00928	0.533
TRG_ENDOCYTIC_2	141	144	PF00928	0.443
TRG_ENDOCYTIC_2	154	157	PF00928	0.504
TRG_ENDOCYTIC_2	159	162	PF00928	0.504
TRG_ENDOCYTIC_2	173	176	PF00928	0.522
TRG_ENDOCYTIC_2	344	347	PF00928	0.506
TRG_ENDOCYTIC_2	354	357	PF00928	0.475
TRG_ENDOCYTIC_2	366	369	PF00928	0.507
TRG_ENDOCYTIC_2	57	60	PF00928	0.546
TRG_ER_diArg_1	132	135	PF00400	0.546
TRG_ER_diArg_1	399	401	PF00400	0.527
TRG_Pf-PMV_PEXEL_1	160	164	PF00026	0.260

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IKY3	Leptomonas seymouri	49%	95%
A0A3Q8IE45	Leishmania donovani	74%	100%
A4I2N2	Leishmania infantum	74%	100%
E9AD23	Leishmania major	72%	99%
E9AYU8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	74%	99%