Ribosome biogenesis protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ribosome production factor 1, putative

Species:

Leishmania braziliensis

UniProt:

A4HFG9_LEIBR

TriTrypDb:

LbrM.27.0540 , LBRM2903_270010800

Length:

330

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005730	nucleolus	5	1
GO:0030684	preribosome	3	1
GO:0030687	preribosome, large subunit precursor	4	1
GO:0032991	protein-containing complex	1	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1
GO:1990904	ribonucleoprotein complex	2	1

Expansion

Sequence features

A4HFG9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HFG9

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	12
GO:0006364	rRNA processing	8	12
GO:0006396	RNA processing	6	12
GO:0006725	cellular aromatic compound metabolic process	3	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0009987	cellular process	1	12
GO:0016070	RNA metabolic process	5	12
GO:0016072	rRNA metabolic process	7	12
GO:0034470	ncRNA processing	7	12
GO:0034641	cellular nitrogen compound metabolic process	3	12
GO:0034660	ncRNA metabolic process	6	12
GO:0043170	macromolecule metabolic process	3	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0046483	heterocycle metabolic process	3	12
GO:0071704	organic substance metabolic process	2	12
GO:0090304	nucleic acid metabolic process	4	12
GO:1901360	organic cyclic compound metabolic process	3	12
GO:0000460	maturation of 5.8S rRNA	9	1
GO:0000470	maturation of LSU-rRNA	9	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	12
GO:0003723	RNA binding	4	12
GO:0005488	binding	1	12
GO:0019843	rRNA binding	5	12
GO:0042134	rRNA primary transcript binding	6	12
GO:0097159	organic cyclic compound binding	2	12
GO:1901363	heterocyclic compound binding	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	157	159	PF00675	0.243
CLV_NRD_NRD_1	239	241	PF00675	0.243
CLV_NRD_NRD_1	316	318	PF00675	0.374
CLV_NRD_NRD_1	43	45	PF00675	0.524
CLV_NRD_NRD_1	63	65	PF00675	0.293
CLV_NRD_NRD_1	88	90	PF00675	0.491
CLV_NRD_NRD_1	91	93	PF00675	0.461
CLV_PCSK_FUR_1	61	65	PF00082	0.462
CLV_PCSK_FUR_1	89	93	PF00082	0.517
CLV_PCSK_KEX2_1	16	18	PF00082	0.564
CLV_PCSK_KEX2_1	239	241	PF00082	0.243
CLV_PCSK_KEX2_1	60	62	PF00082	0.466
CLV_PCSK_KEX2_1	63	65	PF00082	0.487
CLV_PCSK_KEX2_1	90	92	PF00082	0.496
CLV_PCSK_PC1ET2_1	16	18	PF00082	0.564
CLV_PCSK_PC1ET2_1	60	62	PF00082	0.466
CLV_PCSK_PC1ET2_1	90	92	PF00082	0.591
CLV_PCSK_PC7_1	12	18	PF00082	0.626
CLV_PCSK_SKI1_1	144	148	PF00082	0.243
CLV_PCSK_SKI1_1	164	168	PF00082	0.112
CLV_PCSK_SKI1_1	173	177	PF00082	0.243
CLV_PCSK_SKI1_1	276	280	PF00082	0.243
DEG_APCC_DBOX_1	292	300	PF00400	0.454
DOC_CYCLIN_RxL_1	293	305	PF00134	0.476
DOC_MAPK_gen_1	184	193	PF00069	0.449
DOC_MAPK_gen_1	63	74	PF00069	0.621
DOC_MAPK_gen_1	87	97	PF00069	0.469
DOC_MAPK_MEF2A_6	221	230	PF00069	0.443
DOC_MAPK_MEF2A_6	89	97	PF00069	0.434
DOC_PP1_RVXF_1	142	149	PF00149	0.529
DOC_USP7_MATH_1	157	161	PF00917	0.529
DOC_USP7_UBL2_3	140	144	PF12436	0.438
DOC_USP7_UBL2_3	56	60	PF12436	0.520
DOC_USP7_UBL2_3	77	81	PF12436	0.558
DOC_WW_Pin1_4	80	85	PF00397	0.612
LIG_14-3-3_CanoR_1	126	135	PF00244	0.418
LIG_14-3-3_CanoR_1	156	162	PF00244	0.518
LIG_14-3-3_CanoR_1	258	264	PF00244	0.443
LIG_14-3-3_CanoR_1	293	297	PF00244	0.439
LIG_14-3-3_CanoR_1	35	43	PF00244	0.562
LIG_14-3-3_CanoR_1	44	52	PF00244	0.472
LIG_AP_GAE_1	112	118	PF02883	0.457
LIG_APCC_ABBAyCdc20_2	45	51	PF00400	0.489
LIG_BRCT_BRCA1_1	302	306	PF00533	0.375
LIG_BRCT_BRCA1_1	45	49	PF00533	0.442
LIG_DLG_GKlike_1	297	305	PF00625	0.479
LIG_FHA_1	137	143	PF00498	0.558
LIG_FHA_1	174	180	PF00498	0.443
LIG_FHA_1	201	207	PF00498	0.468
LIG_FHA_1	293	299	PF00498	0.443
LIG_FHA_1	48	54	PF00498	0.544
LIG_FHA_2	128	134	PF00498	0.391
LIG_FHA_2	160	166	PF00498	0.454
LIG_FHA_2	94	100	PF00498	0.448
LIG_LIR_Apic_2	145	151	PF02991	0.443
LIG_LIR_Gen_1	112	119	PF02991	0.458
LIG_LIR_Gen_1	174	181	PF02991	0.459
LIG_LIR_Gen_1	211	220	PF02991	0.518
LIG_LIR_Gen_1	268	277	PF02991	0.443
LIG_LIR_Gen_1	46	53	PF02991	0.442
LIG_LIR_LC3C_4	176	181	PF02991	0.484
LIG_LIR_Nem_3	112	118	PF02991	0.386
LIG_LIR_Nem_3	174	178	PF02991	0.451
LIG_LIR_Nem_3	207	212	PF02991	0.518
LIG_LIR_Nem_3	222	228	PF02991	0.405
LIG_LIR_Nem_3	268	272	PF02991	0.484
LIG_LIR_Nem_3	307	313	PF02991	0.415
LIG_LIR_Nem_3	46	52	PF02991	0.441
LIG_LYPXL_yS_3	225	228	PF13949	0.443
LIG_Pex14_2	115	119	PF04695	0.427
LIG_Pex14_2	306	310	PF04695	0.415
LIG_PTB_Apo_2	149	156	PF02174	0.443
LIG_PTB_Phospho_1	149	155	PF10480	0.443
LIG_REV1ctd_RIR_1	116	124	PF16727	0.515
LIG_SH2_PTP2	269	272	PF00017	0.484
LIG_SH2_STAT5	161	164	PF00017	0.454
LIG_SH2_STAT5	269	272	PF00017	0.440
LIG_SH2_STAT5	277	280	PF00017	0.428
LIG_SH3_3	194	200	PF00018	0.443
LIG_SH3_3	24	30	PF00018	0.437
LIG_SUMO_SIM_anti_2	176	183	PF11976	0.443
LIG_SUMO_SIM_anti_2	94	99	PF11976	0.471
LIG_SUMO_SIM_par_1	176	183	PF11976	0.443
LIG_SUMO_SIM_par_1	297	303	PF11976	0.487
LIG_TYR_ITIM	210	215	PF00017	0.400
LIG_UBA3_1	278	283	PF00899	0.190
LIG_UBA3_1	48	57	PF00899	0.443
LIG_WRC_WIRS_1	260	265	PF05994	0.295
MOD_CDK_SPK_2	80	85	PF00069	0.612
MOD_CDK_SPxxK_3	80	87	PF00069	0.602
MOD_CK1_1	300	306	PF00069	0.367
MOD_CK2_1	127	133	PF00069	0.385
MOD_CK2_1	159	165	PF00069	0.295
MOD_CK2_1	93	99	PF00069	0.461
MOD_Cter_Amidation	237	240	PF01082	0.295
MOD_GlcNHglycan	302	305	PF01048	0.371
MOD_GSK3_1	124	131	PF00069	0.463
MOD_GSK3_1	200	207	PF00069	0.295
MOD_GSK3_1	4	11	PF00069	0.661
MOD_GSK3_1	43	50	PF00069	0.554
MOD_NEK2_1	191	196	PF00069	0.282
MOD_NEK2_1	204	209	PF00069	0.280
MOD_NEK2_1	271	276	PF00069	0.311
MOD_NEK2_2	200	205	PF00069	0.330
MOD_NEK2_2	292	297	PF00069	0.295
MOD_PIKK_1	164	170	PF00454	0.181
MOD_PIKK_1	36	42	PF00454	0.515
MOD_PIKK_1	43	49	PF00454	0.379
MOD_PKA_1	56	62	PF00069	0.533
MOD_PKA_1	63	69	PF00069	0.543
MOD_PKA_2	157	163	PF00069	0.416
MOD_PKA_2	204	210	PF00069	0.295
MOD_PKA_2	292	298	PF00069	0.290
MOD_PKA_2	36	42	PF00069	0.469
MOD_PKA_2	43	49	PF00069	0.432
MOD_PKA_2	63	69	PF00069	0.290
MOD_PKB_1	61	69	PF00069	0.551
MOD_Plk_1	164	170	PF00069	0.308
MOD_Plk_1	93	99	PF00069	0.452
MOD_Plk_2-3	322	328	PF00069	0.512
MOD_Plk_4	150	156	PF00069	0.337
MOD_Plk_4	259	265	PF00069	0.431
MOD_Plk_4	93	99	PF00069	0.452
MOD_ProDKin_1	80	86	PF00069	0.605
TRG_AP2beta_CARGO_1	112	122	PF09066	0.502
TRG_DiLeu_BaEn_1	145	150	PF01217	0.416
TRG_DiLeu_BaEn_1	174	179	PF01217	0.324
TRG_DiLeu_BaEn_1	187	192	PF01217	0.278
TRG_DiLeu_BaLyEn_6	294	299	PF01217	0.295
TRG_ENDOCYTIC_2	212	215	PF00928	0.343
TRG_ENDOCYTIC_2	225	228	PF00928	0.252
TRG_ENDOCYTIC_2	269	272	PF00928	0.287
TRG_ER_diArg_1	10	13	PF00400	0.639
TRG_ER_diArg_1	155	158	PF00400	0.295
TRG_ER_diArg_1	239	241	PF00400	0.295
TRG_ER_diArg_1	61	64	PF00400	0.459
TRG_ER_diArg_1	89	92	PF00400	0.486
TRG_NLS_Bipartite_1	44	64	PF00514	0.435
TRG_NLS_MonoExtC_3	59	64	PF00514	0.455
TRG_NLS_MonoExtN_4	57	64	PF00514	0.447
TRG_Pf-PMV_PEXEL_1	276	280	PF00026	0.295
TRG_Pf-PMV_PEXEL_1	297	302	PF00026	0.337

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PE93	Leptomonas seymouri	91%	100%
A0A0S4IS82	Bodo saltans	34%	100%
A0A0S4JV56	Bodo saltans	69%	100%
A0A1X0P3X9	Trypanosomatidae	75%	100%
A0A3S7X0F1	Leishmania donovani	95%	100%
A0A3S7X394	Leishmania donovani	35%	100%
A0A422NTE1	Trypanosoma rangeli	77%	100%
A4HI82	Leishmania braziliensis	35%	100%
A4I2N1	Leishmania infantum	95%	100%
A4I5G1	Leishmania infantum	35%	100%
D0A5P7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	75%	100%
E9AD22	Leishmania major	95%	100%
E9AYU7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
E9B0Q9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	36%	100%
O14180	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	35%	100%
P38805	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	34%	100%
P54073	Caenorhabditis elegans	44%	86%
Q4Q7H4	Leishmania major	34%	100%
Q5R631	Pongo abelii	47%	95%
Q5RJS9	Rattus norvegicus	45%	96%
Q6FNN7	Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)	33%	100%
Q6IQU6	Danio rerio	47%	100%
Q7TND5	Mus musculus	45%	95%
Q8AVP1	Xenopus laevis	45%	96%
Q9H9Y2	Homo sapiens	45%	95%
Q9VKB4	Drosophila melanogaster	39%	84%
V5B7H7	Trypanosoma cruzi	76%	100%