Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HFG8_LEIBR

TriTrypDb:

LbrM.27.0530 , LBRM2903_270010700

Length:

557

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HFG8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HFG8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	119	123	PF00656	0.475
CLV_C14_Caspase3-7	191	195	PF00656	0.338
CLV_C14_Caspase3-7	527	531	PF00656	0.465
CLV_NRD_NRD_1	141	143	PF00675	0.573
CLV_NRD_NRD_1	169	171	PF00675	0.623
CLV_NRD_NRD_1	249	251	PF00675	0.512
CLV_NRD_NRD_1	324	326	PF00675	0.597
CLV_NRD_NRD_1	550	552	PF00675	0.515
CLV_NRD_NRD_1	88	90	PF00675	0.312
CLV_PCSK_FUR_1	169	173	PF00082	0.438
CLV_PCSK_FUR_1	86	90	PF00082	0.291
CLV_PCSK_KEX2_1	128	130	PF00082	0.537
CLV_PCSK_KEX2_1	141	143	PF00082	0.537
CLV_PCSK_KEX2_1	168	170	PF00082	0.606
CLV_PCSK_KEX2_1	171	173	PF00082	0.630
CLV_PCSK_KEX2_1	249	251	PF00082	0.527
CLV_PCSK_KEX2_1	69	71	PF00082	0.461
CLV_PCSK_KEX2_1	88	90	PF00082	0.312
CLV_PCSK_PC1ET2_1	128	130	PF00082	0.537
CLV_PCSK_PC1ET2_1	171	173	PF00082	0.651
CLV_PCSK_PC1ET2_1	69	71	PF00082	0.266
CLV_PCSK_SKI1_1	253	257	PF00082	0.578
CLV_PCSK_SKI1_1	357	361	PF00082	0.281
CLV_PCSK_SKI1_1	376	380	PF00082	0.440
CLV_PCSK_SKI1_1	38	42	PF00082	0.367
CLV_PCSK_SKI1_1	445	449	PF00082	0.487
CLV_PCSK_SKI1_1	49	53	PF00082	0.366
CLV_PCSK_SKI1_1	539	543	PF00082	0.445
CLV_PCSK_SKI1_1	78	82	PF00082	0.405
DEG_APCC_DBOX_1	312	320	PF00400	0.392
DOC_CYCLIN_RxL_1	249	257	PF00134	0.502
DOC_CYCLIN_RxL_1	370	381	PF00134	0.461
DOC_MAPK_gen_1	313	320	PF00069	0.308
DOC_MAPK_gen_1	33	43	PF00069	0.433
DOC_MAPK_MEF2A_6	313	320	PF00069	0.397
DOC_MAPK_NFAT4_5	313	321	PF00069	0.279
DOC_PP1_RVXF_1	76	83	PF00149	0.428
DOC_PP2B_LxvP_1	12	15	PF13499	0.374
DOC_PP4_FxxP_1	379	382	PF00568	0.313
DOC_USP7_MATH_1	101	105	PF00917	0.468
DOC_USP7_MATH_1	134	138	PF00917	0.322
DOC_USP7_MATH_1	192	196	PF00917	0.478
DOC_USP7_MATH_1	2	6	PF00917	0.606
DOC_USP7_MATH_1	232	236	PF00917	0.546
DOC_USP7_MATH_1	243	247	PF00917	0.461
DOC_USP7_MATH_1	293	297	PF00917	0.442
DOC_USP7_MATH_1	343	347	PF00917	0.548
DOC_USP7_UBL2_3	539	543	PF12436	0.399
DOC_WW_Pin1_4	217	222	PF00397	0.574
DOC_WW_Pin1_4	364	369	PF00397	0.546
DOC_WW_Pin1_4	378	383	PF00397	0.304
DOC_WW_Pin1_4	465	470	PF00397	0.596
DOC_WW_Pin1_4	519	524	PF00397	0.390
LIG_14-3-3_CanoR_1	357	362	PF00244	0.329
LIG_14-3-3_CanoR_1	400	408	PF00244	0.483
LIG_14-3-3_CanoR_1	503	513	PF00244	0.438
LIG_14-3-3_CanoR_1	70	76	PF00244	0.379
LIG_Actin_WH2_2	287	305	PF00022	0.503
LIG_APCC_ABBA_1	41	46	PF00400	0.412
LIG_BRCT_BRCA1_1	410	414	PF00533	0.398
LIG_BRCT_BRCA1_1	425	429	PF00533	0.538
LIG_Clathr_ClatBox_1	185	189	PF01394	0.471
LIG_CtBP_PxDLS_1	15	19	PF00389	0.435
LIG_deltaCOP1_diTrp_1	73	82	PF00928	0.346
LIG_EH_1	414	418	PF12763	0.367
LIG_FHA_1	122	128	PF00498	0.401
LIG_FHA_1	217	223	PF00498	0.484
LIG_FHA_2	133	139	PF00498	0.258
LIG_FHA_2	160	166	PF00498	0.426
LIG_FHA_2	206	212	PF00498	0.419
LIG_FHA_2	392	398	PF00498	0.494
LIG_LIR_Gen_1	264	272	PF02991	0.453
LIG_LIR_Nem_3	264	268	PF02991	0.523
LIG_LIR_Nem_3	411	417	PF02991	0.472
LIG_LIR_Nem_3	434	439	PF02991	0.290
LIG_MYND_1	11	15	PF01753	0.436
LIG_MYND_1	147	151	PF01753	0.517
LIG_MYND_1	96	100	PF01753	0.241
LIG_NBox_RRM_1	501	511	PF00076	0.402
LIG_NRBOX	224	230	PF00104	0.530
LIG_NRBOX	315	321	PF00104	0.436
LIG_SH2_CRK	265	269	PF00017	0.548
LIG_SH2_SRC	93	96	PF00017	0.428
LIG_SH2_STAP1	534	538	PF00017	0.425
LIG_SH2_STAT3	164	167	PF00017	0.475
LIG_SH2_STAT5	207	210	PF00017	0.303
LIG_SH2_STAT5	317	320	PF00017	0.261
LIG_SH3_3	356	362	PF00018	0.519
LIG_SUMO_SIM_par_1	10	17	PF11976	0.545
LIG_SUMO_SIM_par_1	223	230	PF11976	0.584
LIG_TRAF2_1	45	48	PF00917	0.417
MOD_CDK_SPxK_1	364	370	PF00069	0.492
MOD_CDK_SPxxK_3	217	224	PF00069	0.568
MOD_CDK_SPxxK_3	519	526	PF00069	0.388
MOD_CK1_1	241	247	PF00069	0.597
MOD_CK1_1	296	302	PF00069	0.446
MOD_CK1_1	423	429	PF00069	0.514
MOD_CK1_1	464	470	PF00069	0.696
MOD_CK1_1	490	496	PF00069	0.521
MOD_CK1_1	5	11	PF00069	0.510
MOD_CK2_1	343	349	PF00069	0.547
MOD_CK2_1	391	397	PF00069	0.500
MOD_CK2_1	42	48	PF00069	0.409
MOD_CK2_1	512	518	PF00069	0.493
MOD_Cter_Amidation	549	552	PF01082	0.487
MOD_GlcNHglycan	245	248	PF01048	0.516
MOD_GlcNHglycan	295	298	PF01048	0.479
MOD_GlcNHglycan	401	404	PF01048	0.370
MOD_GlcNHglycan	469	472	PF01048	0.743
MOD_GlcNHglycan	506	509	PF01048	0.433
MOD_GSK3_1	216	223	PF00069	0.537
MOD_GSK3_1	289	296	PF00069	0.555
MOD_GSK3_1	357	364	PF00069	0.388
MOD_GSK3_1	431	438	PF00069	0.479
MOD_GSK3_1	461	468	PF00069	0.649
MOD_LATS_1	67	73	PF00433	0.411
MOD_N-GLC_1	3	8	PF02516	0.467
MOD_N-GLC_2	37	39	PF02516	0.473
MOD_NEK2_1	152	157	PF00069	0.494
MOD_NEK2_1	3	8	PF00069	0.576
MOD_NEK2_1	318	323	PF00069	0.319
MOD_NEK2_1	408	413	PF00069	0.300
MOD_NEK2_2	159	164	PF00069	0.332
MOD_NEK2_2	431	436	PF00069	0.318
MOD_PIKK_1	227	233	PF00454	0.485
MOD_PIKK_1	5	11	PF00454	0.554
MOD_PK_1	326	332	PF00069	0.384
MOD_PKA_1	170	176	PF00069	0.700
MOD_PKA_1	69	75	PF00069	0.265
MOD_PKA_2	152	158	PF00069	0.479
MOD_PKA_2	32	38	PF00069	0.659
MOD_PKA_2	399	405	PF00069	0.418
MOD_PKA_2	423	429	PF00069	0.481
MOD_PKA_2	464	470	PF00069	0.718
MOD_PKA_2	490	496	PF00069	0.500
MOD_PKA_2	69	75	PF00069	0.340
MOD_PKB_1	168	176	PF00069	0.659
MOD_PKB_1	443	451	PF00069	0.486
MOD_Plk_1	121	127	PF00069	0.539
MOD_Plk_1	153	159	PF00069	0.391
MOD_Plk_1	431	437	PF00069	0.375
MOD_Plk_4	159	165	PF00069	0.432
MOD_Plk_4	180	186	PF00069	0.514
MOD_Plk_4	264	270	PF00069	0.519
MOD_Plk_4	306	312	PF00069	0.383
MOD_Plk_4	477	483	PF00069	0.488
MOD_ProDKin_1	217	223	PF00069	0.573
MOD_ProDKin_1	364	370	PF00069	0.541
MOD_ProDKin_1	378	384	PF00069	0.303
MOD_ProDKin_1	465	471	PF00069	0.594
MOD_ProDKin_1	519	525	PF00069	0.385
MOD_SUMO_for_1	51	54	PF00179	0.448
MOD_SUMO_rev_2	195	205	PF00179	0.463
MOD_SUMO_rev_2	522	531	PF00179	0.320
TRG_DiLeu_BaLyEn_6	8	13	PF01217	0.479
TRG_ENDOCYTIC_2	265	268	PF00928	0.475
TRG_ENDOCYTIC_2	317	320	PF00928	0.261
TRG_ENDOCYTIC_2	534	537	PF00928	0.433
TRG_ER_diArg_1	140	142	PF00400	0.566
TRG_ER_diArg_1	168	170	PF00400	0.639
TRG_ER_diArg_1	248	250	PF00400	0.488
TRG_ER_diArg_1	86	89	PF00400	0.285
TRG_NLS_MonoExtC_3	169	174	PF00514	0.727
TRG_NLS_MonoExtN_4	168	174	PF00514	0.691
TRG_Pf-PMV_PEXEL_1	253	257	PF00026	0.492
TRG_Pf-PMV_PEXEL_1	437	442	PF00026	0.388
TRG_Pf-PMV_PEXEL_1	69	73	PF00026	0.387

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IKI5	Leptomonas seymouri	52%	99%
A0A1X0P429	Trypanosomatidae	26%	100%
A0A3R7MVK8	Trypanosoma rangeli	27%	100%
A0A3S7X0E6	Leishmania donovani	79%	100%
A4I2N0	Leishmania infantum	79%	100%
D0A5P5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	98%
E9AD21	Leishmania major	79%	99%
E9AYU6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	100%
V5DP58	Trypanosoma cruzi	27%	100%