Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HFG7_LEIBR

TriTrypDb:

LbrM.27.0520 , LBRM2903_270010600

Length:

610

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0000776	kinetochore	3	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0099080	supramolecular complex	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HFG7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HFG7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	354	358	PF00656	0.628
CLV_C14_Caspase3-7	427	431	PF00656	0.725
CLV_NRD_NRD_1	132	134	PF00675	0.720
CLV_NRD_NRD_1	157	159	PF00675	0.555
CLV_NRD_NRD_1	192	194	PF00675	0.599
CLV_NRD_NRD_1	20	22	PF00675	0.631
CLV_NRD_NRD_1	206	208	PF00675	0.593
CLV_NRD_NRD_1	210	212	PF00675	0.611
CLV_NRD_NRD_1	235	237	PF00675	0.663
CLV_NRD_NRD_1	322	324	PF00675	0.560
CLV_NRD_NRD_1	417	419	PF00675	0.687
CLV_NRD_NRD_1	446	448	PF00675	0.637
CLV_NRD_NRD_1	481	483	PF00675	0.653
CLV_NRD_NRD_1	505	507	PF00675	0.722
CLV_NRD_NRD_1	542	544	PF00675	0.685
CLV_NRD_NRD_1	58	60	PF00675	0.659
CLV_NRD_NRD_1	584	586	PF00675	0.675
CLV_PCSK_KEX2_1	157	159	PF00082	0.586
CLV_PCSK_KEX2_1	192	194	PF00082	0.615
CLV_PCSK_KEX2_1	20	22	PF00082	0.631
CLV_PCSK_KEX2_1	206	208	PF00082	0.576
CLV_PCSK_KEX2_1	210	212	PF00082	0.597
CLV_PCSK_KEX2_1	235	237	PF00082	0.665
CLV_PCSK_KEX2_1	253	255	PF00082	0.696
CLV_PCSK_KEX2_1	324	326	PF00082	0.550
CLV_PCSK_KEX2_1	338	340	PF00082	0.576
CLV_PCSK_KEX2_1	379	381	PF00082	0.756
CLV_PCSK_KEX2_1	412	414	PF00082	0.675
CLV_PCSK_KEX2_1	419	421	PF00082	0.623
CLV_PCSK_KEX2_1	446	448	PF00082	0.637
CLV_PCSK_KEX2_1	481	483	PF00082	0.679
CLV_PCSK_KEX2_1	505	507	PF00082	0.722
CLV_PCSK_KEX2_1	541	543	PF00082	0.708
CLV_PCSK_KEX2_1	57	59	PF00082	0.659
CLV_PCSK_KEX2_1	584	586	PF00082	0.707
CLV_PCSK_KEX2_1	608	610	PF00082	0.640
CLV_PCSK_PC1ET2_1	206	208	PF00082	0.664
CLV_PCSK_PC1ET2_1	253	255	PF00082	0.696
CLV_PCSK_PC1ET2_1	324	326	PF00082	0.550
CLV_PCSK_PC1ET2_1	338	340	PF00082	0.576
CLV_PCSK_PC1ET2_1	379	381	PF00082	0.756
CLV_PCSK_PC1ET2_1	412	414	PF00082	0.688
CLV_PCSK_PC1ET2_1	419	421	PF00082	0.612
CLV_PCSK_PC7_1	153	159	PF00082	0.535
CLV_PCSK_SKI1_1	226	230	PF00082	0.597
CLV_PCSK_SKI1_1	384	388	PF00082	0.736
CLV_PCSK_SKI1_1	413	417	PF00082	0.652
CLV_PCSK_SKI1_1	59	63	PF00082	0.630
DEG_APCC_DBOX_1	19	27	PF00400	0.708
DEG_APCC_DBOX_1	324	332	PF00400	0.619
DEG_SCF_FBW7_1	452	457	PF00400	0.516
DOC_CKS1_1	91	96	PF01111	0.523
DOC_CYCLIN_yCln2_LP_2	48	54	PF00134	0.686
DOC_MAPK_DCC_7	90	99	PF00069	0.722
DOC_MAPK_gen_1	20	28	PF00069	0.706
DOC_MAPK_gen_1	343	351	PF00069	0.609
DOC_MAPK_gen_1	384	393	PF00069	0.721
DOC_MAPK_gen_1	57	63	PF00069	0.664
DOC_MAPK_MEF2A_6	90	99	PF00069	0.722
DOC_PP1_RVXF_1	57	64	PF00149	0.630
DOC_PP1_SILK_1	97	102	PF00149	0.716
DOC_PP2B_LxvP_1	525	528	PF13499	0.532
DOC_PP2B_LxvP_1	600	603	PF13499	0.632
DOC_PP4_FxxP_1	564	567	PF00568	0.549
DOC_USP7_MATH_1	102	106	PF00917	0.620
DOC_USP7_MATH_1	111	115	PF00917	0.540
DOC_USP7_MATH_1	125	129	PF00917	0.658
DOC_USP7_MATH_1	143	147	PF00917	0.530
DOC_USP7_MATH_1	278	282	PF00917	0.706
DOC_USP7_MATH_1	289	293	PF00917	0.582
DOC_USP7_MATH_1	454	458	PF00917	0.660
DOC_USP7_MATH_1	565	569	PF00917	0.570
DOC_USP7_UBL2_3	404	408	PF12436	0.705
DOC_WW_Pin1_4	13	18	PF00397	0.648
DOC_WW_Pin1_4	137	142	PF00397	0.653
DOC_WW_Pin1_4	238	243	PF00397	0.653
DOC_WW_Pin1_4	43	48	PF00397	0.620
DOC_WW_Pin1_4	450	455	PF00397	0.643
DOC_WW_Pin1_4	563	568	PF00397	0.583
DOC_WW_Pin1_4	84	89	PF00397	0.652
DOC_WW_Pin1_4	90	95	PF00397	0.660
LIG_14-3-3_CanoR_1	145	154	PF00244	0.548
LIG_14-3-3_CanoR_1	210	219	PF00244	0.575
LIG_14-3-3_CanoR_1	254	259	PF00244	0.735
LIG_14-3-3_CanoR_1	279	283	PF00244	0.626
LIG_14-3-3_CanoR_1	382	391	PF00244	0.639
LIG_14-3-3_CanoR_1	420	428	PF00244	0.673
LIG_14-3-3_CanoR_1	456	461	PF00244	0.662
LIG_14-3-3_CanoR_1	498	504	PF00244	0.647
LIG_14-3-3_CanoR_1	542	548	PF00244	0.652
LIG_14-3-3_CanoR_1	57	62	PF00244	0.625
LIG_APCC_ABBA_1	556	561	PF00400	0.662
LIG_BRCT_BRCA1_1	127	131	PF00533	0.521
LIG_BRCT_BRCA1_1	430	434	PF00533	0.675
LIG_BRCT_BRCA1_1	59	63	PF00533	0.630
LIG_FHA_1	214	220	PF00498	0.518
LIG_FHA_1	453	459	PF00498	0.656
LIG_FHA_2	180	186	PF00498	0.642
LIG_FHA_2	365	371	PF00498	0.778
LIG_FHA_2	529	535	PF00498	0.671
LIG_LIR_Apic_2	561	567	PF02991	0.570
LIG_LIR_Gen_1	32	41	PF02991	0.626
LIG_LIR_Gen_1	352	360	PF02991	0.676
LIG_LIR_Gen_1	457	467	PF02991	0.711
LIG_LIR_Gen_1	568	577	PF02991	0.566
LIG_LIR_Nem_3	104	109	PF02991	0.518
LIG_LIR_Nem_3	32	36	PF02991	0.658
LIG_LIR_Nem_3	352	356	PF02991	0.665
LIG_MAD2	478	486	PF02301	0.541
LIG_MYND_1	441	445	PF01753	0.704
LIG_NRP_CendR_1	608	610	PF00754	0.640
LIG_Pex14_2	560	564	PF04695	0.589
LIG_SH2_CRK	33	37	PF00017	0.638
LIG_SH2_NCK_1	33	37	PF00017	0.657
LIG_SH2_NCK_1	76	80	PF00017	0.683
LIG_SH2_SRC	168	171	PF00017	0.533
LIG_SH2_STAP1	168	172	PF00017	0.517
LIG_SH2_STAP1	80	84	PF00017	0.787
LIG_SH2_STAT5	176	179	PF00017	0.496
LIG_SH2_STAT5	460	463	PF00017	0.713
LIG_SH3_1	549	555	PF00018	0.665
LIG_SH3_2	483	488	PF14604	0.551
LIG_SH3_2	53	58	PF14604	0.633
LIG_SH3_2	85	90	PF14604	0.726
LIG_SH3_3	239	245	PF00018	0.625
LIG_SH3_3	477	483	PF00018	0.737
LIG_SH3_3	50	56	PF00018	0.596
LIG_SH3_3	521	527	PF00018	0.800
LIG_SH3_3	534	540	PF00018	0.683
LIG_SH3_3	549	555	PF00018	0.632
LIG_SH3_3	82	88	PF00018	0.734
LIG_SUMO_SIM_anti_2	299	304	PF11976	0.745
LIG_SUMO_SIM_anti_2	347	352	PF11976	0.575
LIG_TRAF2_1	200	203	PF00917	0.574
LIG_TRAF2_1	366	369	PF00917	0.689
LIG_WRC_WIRS_1	511	516	PF05994	0.793
LIG_WW_3	243	247	PF00397	0.624
LIG_WW_3	482	486	PF00397	0.692
LIG_WW_3	538	542	PF00397	0.713
MOD_CDC14_SPxK_1	243	246	PF00782	0.741
MOD_CDC14_SPxK_1	566	569	PF00782	0.549
MOD_CDC14_SPxK_1	87	90	PF00782	0.692
MOD_CDK_SPxK_1	240	246	PF00069	0.739
MOD_CDK_SPxK_1	450	456	PF00069	0.513
MOD_CDK_SPxK_1	563	569	PF00069	0.556
MOD_CDK_SPxK_1	84	90	PF00069	0.654
MOD_CDK_SPxxK_3	13	20	PF00069	0.644
MOD_CK1_1	137	143	PF00069	0.670
MOD_CK1_1	146	152	PF00069	0.692
MOD_CK1_1	213	219	PF00069	0.562
MOD_CK1_1	301	307	PF00069	0.739
MOD_CK1_1	344	350	PF00069	0.638
MOD_CK1_1	385	391	PF00069	0.671
MOD_CK1_1	402	408	PF00069	0.484
MOD_CK1_1	512	518	PF00069	0.644
MOD_CK2_1	168	174	PF00069	0.524
MOD_CK2_1	179	185	PF00069	0.545
MOD_CK2_1	471	477	PF00069	0.578
MOD_CK2_1	528	534	PF00069	0.668
MOD_CK2_1	65	71	PF00069	0.680
MOD_Cter_Amidation	606	609	PF01082	0.711
MOD_GlcNHglycan	112	116	PF01048	0.722
MOD_GlcNHglycan	127	130	PF01048	0.652
MOD_GlcNHglycan	203	206	PF01048	0.604
MOD_GlcNHglycan	303	306	PF01048	0.584
MOD_GlcNHglycan	310	313	PF01048	0.501
MOD_GlcNHglycan	384	387	PF01048	0.656
MOD_GlcNHglycan	401	404	PF01048	0.784
MOD_GlcNHglycan	409	412	PF01048	0.791
MOD_GlcNHglycan	422	425	PF01048	0.737
MOD_GlcNHglycan	545	548	PF01048	0.753
MOD_GlcNHglycan	80	83	PF01048	0.790
MOD_GSK3_1	143	150	PF00069	0.660
MOD_GSK3_1	236	243	PF00069	0.637
MOD_GSK3_1	31	38	PF00069	0.634
MOD_GSK3_1	351	358	PF00069	0.666
MOD_GSK3_1	395	402	PF00069	0.720
MOD_GSK3_1	43	50	PF00069	0.650
MOD_GSK3_1	450	457	PF00069	0.653
MOD_GSK3_1	494	501	PF00069	0.672
MOD_GSK3_1	510	517	PF00069	0.623
MOD_GSK3_1	80	87	PF00069	0.696
MOD_GSK3_1	9	16	PF00069	0.628
MOD_N-GLC_1	254	259	PF02516	0.735
MOD_N-GLC_1	319	324	PF02516	0.708
MOD_NEK2_1	163	168	PF00069	0.643
MOD_NEK2_1	230	235	PF00069	0.536
MOD_NEK2_1	399	404	PF00069	0.792
MOD_NEK2_1	428	433	PF00069	0.690
MOD_NEK2_1	470	475	PF00069	0.534
MOD_NEK2_1	499	504	PF00069	0.813
MOD_NEK2_1	514	519	PF00069	0.559
MOD_NEK2_2	516	521	PF00069	0.669
MOD_NEK2_2	65	70	PF00069	0.777
MOD_PK_1	236	242	PF00069	0.726
MOD_PK_1	296	302	PF00069	0.768
MOD_PK_1	387	393	PF00069	0.691
MOD_PK_1	57	63	PF00069	0.629
MOD_PKA_1	210	216	PF00069	0.601
MOD_PKA_1	253	259	PF00069	0.685
MOD_PKA_1	57	63	PF00069	0.664
MOD_PKA_2	146	152	PF00069	0.511
MOD_PKA_2	210	216	PF00069	0.579
MOD_PKA_2	253	259	PF00069	0.685
MOD_PKA_2	278	284	PF00069	0.616
MOD_PKA_2	361	367	PF00069	0.543
MOD_PKA_2	470	476	PF00069	0.766
MOD_PKA_2	484	490	PF00069	0.743
MOD_PKA_2	57	63	PF00069	0.664
MOD_PKB_1	145	153	PF00069	0.579
MOD_PKB_1	296	304	PF00069	0.700
MOD_PKB_1	380	388	PF00069	0.546
MOD_PKB_1	418	426	PF00069	0.675
MOD_PKB_1	496	504	PF00069	0.810
MOD_PKB_1	541	549	PF00069	0.743
MOD_PKB_1	57	65	PF00069	0.631
MOD_Plk_1	168	174	PF00069	0.524
MOD_Plk_1	254	260	PF00069	0.682
MOD_Plk_1	371	377	PF00069	0.781
MOD_Plk_1	395	401	PF00069	0.731
MOD_Plk_1	471	477	PF00069	0.624
MOD_Plk_1	509	515	PF00069	0.752
MOD_Plk_1	65	71	PF00069	0.680
MOD_Plk_2-3	355	361	PF00069	0.748
MOD_Plk_2-3	472	478	PF00069	0.750
MOD_Plk_4	168	174	PF00069	0.532
MOD_Plk_4	254	260	PF00069	0.634
MOD_Plk_4	331	337	PF00069	0.609
MOD_Plk_4	344	350	PF00069	0.661
MOD_Plk_4	371	377	PF00069	0.557
MOD_Plk_4	395	401	PF00069	0.731
MOD_Plk_4	428	434	PF00069	0.641
MOD_ProDKin_1	13	19	PF00069	0.645
MOD_ProDKin_1	137	143	PF00069	0.655
MOD_ProDKin_1	238	244	PF00069	0.653
MOD_ProDKin_1	43	49	PF00069	0.621
MOD_ProDKin_1	450	456	PF00069	0.646
MOD_ProDKin_1	563	569	PF00069	0.580
MOD_ProDKin_1	84	90	PF00069	0.654
MOD_SUMO_for_1	180	183	PF00179	0.528
MOD_SUMO_rev_2	128	136	PF00179	0.528
TRG_DiLeu_BaEn_1	439	444	PF01217	0.669
TRG_ENDOCYTIC_2	33	36	PF00928	0.611
TRG_ENDOCYTIC_2	460	463	PF00928	0.713
TRG_ER_diArg_1	151	154	PF00400	0.599
TRG_ER_diArg_1	156	158	PF00400	0.555
TRG_ER_diArg_1	19	21	PF00400	0.637
TRG_ER_diArg_1	192	194	PF00400	0.615
TRG_ER_diArg_1	210	212	PF00400	0.575
TRG_ER_diArg_1	234	236	PF00400	0.666
TRG_ER_diArg_1	325	328	PF00400	0.626
TRG_ER_diArg_1	445	447	PF00400	0.637
TRG_ER_diArg_1	480	482	PF00400	0.686
TRG_ER_diArg_1	495	498	PF00400	0.607
TRG_ER_diArg_1	521	524	PF00400	0.795
TRG_ER_diArg_1	540	543	PF00400	0.688
TRG_ER_diArg_1	56	59	PF00400	0.619
TRG_ER_diArg_1	608	610	PF00400	0.642
TRG_NLS_MonoExtC_3	322	327	PF00514	0.553
TRG_NLS_MonoExtN_4	323	328	PF00514	0.553
TRG_Pf-PMV_PEXEL_1	260	264	PF00026	0.655

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HX23	Leptomonas seymouri	65%	100%
A0A1X0P3W6	Trypanosomatidae	33%	84%
A0A3Q8IE02	Leishmania donovani	84%	100%
A4I2M9	Leishmania infantum	84%	100%
E9AD20	Leishmania major	84%	100%
E9AYU5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
V5BSQ4	Trypanosoma cruzi	35%	91%