Ribokinase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Ribokinase

Gene product:

ribokinase, putative

Species:

Leishmania braziliensis

UniProt:

A4HFG6_LEIBR

TriTrypDb:

LbrM.27.0510 , LBRM2903_270010500

Length:

329

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 25

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 8

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	12
GO:0005737	cytoplasm	2	11
GO:0043226	organelle	2	12
GO:0043227	membrane-bounded organelle	3	12
GO:0043229	intracellular organelle	3	12
GO:0043231	intracellular membrane-bounded organelle	4	12
GO:0110165	cellular anatomical entity	1	12
GO:0005777	peroxisome	6	1
GO:0020015	glycosome	7	1
GO:0042579	microbody	5	1

Expansion

Sequence features

A4HFG6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HFG6

PDB structure(s): 6a8a_A , 6a8a_B , 6a8b_A , 6a8b_B , 6a8c_A , 6a8c_B

Function

Biological processes
Term	Name	Level	Count
GO:0005975	carbohydrate metabolic process	3	12
GO:0005996	monosaccharide metabolic process	3	12
GO:0006014	D-ribose metabolic process	5	12
GO:0008152	metabolic process	1	12
GO:0009056	catabolic process	2	12
GO:0016052	carbohydrate catabolic process	4	12
GO:0019303	D-ribose catabolic process	6	12
GO:0019321	pentose metabolic process	4	12
GO:0019323	pentose catabolic process	5	12
GO:0044238	primary metabolic process	2	12
GO:0044281	small molecule metabolic process	2	12
GO:0044282	small molecule catabolic process	3	12
GO:0046365	monosaccharide catabolic process	4	12
GO:0071704	organic substance metabolic process	2	12
GO:1901575	organic substance catabolic process	3	12

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	12
GO:0003824	catalytic activity	1	12
GO:0004747	ribokinase activity	5	12
GO:0005488	binding	1	12
GO:0005524	ATP binding	5	12
GO:0016301	kinase activity	4	12
GO:0016740	transferase activity	2	12
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	12
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	12
GO:0017076	purine nucleotide binding	4	12
GO:0019200	carbohydrate kinase activity	5	12
GO:0030554	adenyl nucleotide binding	5	12
GO:0032553	ribonucleotide binding	3	12
GO:0032555	purine ribonucleotide binding	4	12
GO:0032559	adenyl ribonucleotide binding	5	12
GO:0035639	purine ribonucleoside triphosphate binding	4	12
GO:0036094	small molecule binding	2	12
GO:0043167	ion binding	2	12
GO:0043168	anion binding	3	12
GO:0043169	cation binding	3	12
GO:0046872	metal ion binding	4	12
GO:0097159	organic cyclic compound binding	2	12
GO:0097367	carbohydrate derivative binding	2	12
GO:1901265	nucleoside phosphate binding	3	12
GO:1901363	heterocyclic compound binding	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	77	81	PF00656	0.529
CLV_NRD_NRD_1	175	177	PF00675	0.229
CLV_NRD_NRD_1	193	195	PF00675	0.229
CLV_NRD_NRD_1	299	301	PF00675	0.316
CLV_NRD_NRD_1	311	313	PF00675	0.340
CLV_PCSK_KEX2_1	175	177	PF00082	0.283
CLV_PCSK_KEX2_1	266	268	PF00082	0.348
CLV_PCSK_KEX2_1	299	301	PF00082	0.322
CLV_PCSK_KEX2_1	311	313	PF00082	0.329
CLV_PCSK_PC1ET2_1	266	268	PF00082	0.348
CLV_PCSK_SKI1_1	194	198	PF00082	0.324
CLV_PCSK_SKI1_1	229	233	PF00082	0.344
CLV_PCSK_SKI1_1	266	270	PF00082	0.377
CLV_PCSK_SKI1_1	292	296	PF00082	0.390
CLV_Separin_Metazoa	135	139	PF03568	0.609
DOC_CKS1_1	131	136	PF01111	0.568
DOC_CYCLIN_RxL_1	289	296	PF00134	0.609
DOC_MAPK_gen_1	229	239	PF00069	0.520
DOC_PP2B_PxIxI_1	15	21	PF00149	0.475
DOC_USP7_MATH_1	319	323	PF00917	0.652
DOC_USP7_MATH_1	70	74	PF00917	0.531
DOC_USP7_UBL2_3	86	90	PF12436	0.525
DOC_WW_Pin1_4	130	135	PF00397	0.590
LIG_14-3-3_CanoR_1	100	110	PF00244	0.583
LIG_14-3-3_CanoR_1	176	182	PF00244	0.516
LIG_AP2alpha_1	25	29	PF02296	0.415
LIG_BRCT_BRCA1_1	43	47	PF00533	0.510
LIG_BRCT_BRCA1_2	43	49	PF00533	0.516
LIG_eIF4E_1	131	137	PF01652	0.498
LIG_eIF4E_1	14	20	PF01652	0.484
LIG_FHA_1	131	137	PF00498	0.538
LIG_FHA_1	256	262	PF00498	0.429
LIG_FHA_2	163	169	PF00498	0.504
LIG_FHA_2	75	81	PF00498	0.590
LIG_LIR_Apic_2	129	134	PF02991	0.568
LIG_LIR_Apic_2	317	321	PF02991	0.547
LIG_LIR_Gen_1	141	152	PF02991	0.516
LIG_LIR_Gen_1	201	208	PF02991	0.525
LIG_LIR_LC3C_4	17	21	PF02991	0.589
LIG_LIR_Nem_3	141	147	PF02991	0.504
LIG_LIR_Nem_3	201	205	PF02991	0.525
LIG_LIR_Nem_3	226	231	PF02991	0.589
LIG_LIR_Nem_3	23	28	PF02991	0.505
LIG_PCNA_yPIPBox_3	229	243	PF02747	0.612
LIG_Pex14_2	25	29	PF04695	0.415
LIG_Pex14_2	47	51	PF04695	0.504
LIG_SH2_GRB2like	144	147	PF00017	0.429
LIG_SH2_PTP2	202	205	PF00017	0.545
LIG_SH2_SRC	144	147	PF00017	0.429
LIG_SH2_SRC	31	34	PF00017	0.542
LIG_SH2_STAP1	144	148	PF00017	0.609
LIG_SH2_STAT5	131	134	PF00017	0.540
LIG_SH2_STAT5	154	157	PF00017	0.545
LIG_SH2_STAT5	179	182	PF00017	0.504
LIG_SH2_STAT5	202	205	PF00017	0.534
LIG_SH2_STAT5	28	31	PF00017	0.491
LIG_SH2_STAT5	286	289	PF00017	0.566
LIG_SH2_STAT5	84	87	PF00017	0.504
LIG_SH3_3	120	126	PF00018	0.504
LIG_SUMO_SIM_anti_2	17	23	PF11976	0.527
LIG_SUMO_SIM_par_1	109	114	PF11976	0.609
LIG_SUMO_SIM_par_1	17	23	PF11976	0.525
LIG_TYR_ITIM	200	205	PF00017	0.545
LIG_UBA3_1	111	116	PF00899	0.572
MOD_CK1_1	201	207	PF00069	0.477
MOD_CK2_1	115	121	PF00069	0.516
MOD_CK2_1	166	172	PF00069	0.618
MOD_Cter_Amidation	264	267	PF01082	0.348
MOD_GlcNHglycan	223	226	PF01048	0.303
MOD_GSK3_1	126	133	PF00069	0.516
MOD_GSK3_1	162	169	PF00069	0.611
MOD_GSK3_1	177	184	PF00069	0.528
MOD_GSK3_1	219	226	PF00069	0.544
MOD_GSK3_1	251	258	PF00069	0.535
MOD_GSK3_1	307	314	PF00069	0.543
MOD_GSK3_1	6	13	PF00069	0.419
MOD_GSK3_1	70	77	PF00069	0.564
MOD_GSK3_1	98	105	PF00069	0.576
MOD_N-GLC_1	126	131	PF02516	0.304
MOD_N-GLC_1	255	260	PF02516	0.229
MOD_N-GLC_2	302	304	PF02516	0.316
MOD_NEK2_1	280	285	PF00069	0.519
MOD_NEK2_1	98	103	PF00069	0.550
MOD_NEK2_2	177	182	PF00069	0.504
MOD_PIKK_1	311	317	PF00454	0.504
MOD_PKA_1	311	317	PF00069	0.516
MOD_PKA_2	311	317	PF00069	0.429
MOD_Plk_4	177	183	PF00069	0.503
MOD_Plk_4	198	204	PF00069	0.505
MOD_Plk_4	280	286	PF00069	0.538
MOD_Plk_4	70	76	PF00069	0.517
MOD_ProDKin_1	130	136	PF00069	0.590
TRG_ENDOCYTIC_2	144	147	PF00928	0.516
TRG_ENDOCYTIC_2	179	182	PF00928	0.504
TRG_ENDOCYTIC_2	202	205	PF00928	0.545
TRG_NLS_MonoExtC_3	193	198	PF00514	0.429
TRG_Pf-PMV_PEXEL_1	292	296	PF00026	0.345

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0H2WZY4	Staphylococcus aureus (strain COL)	33%	100%
A0A0N0P5S6	Leptomonas seymouri	79%	100%
A0A0S4JY74	Bodo saltans	58%	99%
A0A1X0P4P4	Trypanosomatidae	63%	98%
A0A3R7NMP1	Trypanosoma rangeli	66%	100%
A0A3S7X0F5	Leishmania donovani	90%	100%
A1A6H3	Arabidopsis thaliana	28%	87%
A1AFX4	Escherichia coli O1:K1 / APEC	23%	69%
A1AV12	Pelobacter propionicus (strain DSM 2379 / NBRC 103807 / OttBd1)	24%	67%
A2WXV8	Oryza sativa subsp. indica	27%	100%
A2YQL4	Oryza sativa subsp. indica	27%	98%
A3MZC0	Actinobacillus pleuropneumoniae serotype 5b (strain L20)	23%	69%
A4HI44	Leishmania braziliensis	26%	95%
A4I2M8	Leishmania infantum	90%	100%
A4VR47	Pseudomonas stutzeri (strain A1501)	24%	70%
A4WEI4	Enterobacter sp. (strain 638)	23%	69%
A6Q4Z6	Nitratiruptor sp. (strain SB155-2)	26%	71%
A6VP06	Actinobacillus succinogenes (strain ATCC 55618 / DSM 22257 / CCUG 43843 / 130Z)	23%	69%
A7GZF6	Campylobacter curvus (strain 525.92)	24%	70%
A7H2L7	Campylobacter jejuni subsp. doylei (strain ATCC BAA-1458 / RM4099 / 269.97)	24%	71%
A7MP93	Cronobacter sakazakii (strain ATCC BAA-894)	25%	69%
A7ZE26	Campylobacter concisus (strain 13826)	25%	70%
A7ZRT3	Escherichia coli O139:H28 (strain E24377A / ETEC)	23%	69%
A8A4K6	Escherichia coli O9:H4 (strain HS)	23%	69%
A8APT1	Citrobacter koseri (strain ATCC BAA-895 / CDC 4225-83 / SGSC4696)	23%	69%
A8EVR4	Aliarcobacter butzleri (strain RM4018)	25%	69%
A8FMK8	Campylobacter jejuni subsp. jejuni serotype O:6 (strain 81116 / NCTC 11828)	24%	71%
A8FZZ3	Shewanella sediminis (strain HAW-EB3)	22%	69%
B0T663	Caulobacter sp. (strain K31)	26%	67%
B1IRR4	Escherichia coli (strain ATCC 8739 / DSM 1576 / NBRC 3972 / NCIMB 8545 / WDCM 00012 / Crooks)	23%	69%
B1LF43	Escherichia coli (strain SMS-3-5 / SECEC)	23%	69%
B1XG57	Escherichia coli (strain K12 / DH10B)	23%	69%
B2U1F7	Shigella boydii serotype 18 (strain CDC 3083-94 / BS512)	23%	69%
B2USX2	Helicobacter pylori (strain Shi470)	23%	71%
B2VGJ9	Erwinia tasmaniensis (strain DSM 17950 / CFBP 7177 / CIP 109463 / NCPPB 4357 / Et1/99)	26%	69%
B3E5M9	Trichlorobacter lovleyi (strain ATCC BAA-1151 / DSM 17278 / SZ)	26%	67%
B4EW46	Proteus mirabilis (strain HI4320)	25%	69%
B5EEZ1	Citrifermentans bemidjiense (strain ATCC BAA-1014 / DSM 16622 / JCM 12645 / Bem)	24%	68%
B5FHT5	Salmonella dublin (strain CT_02021853)	23%	69%
B5YR91	Escherichia coli O157:H7 (strain EC4115 / EHEC)	23%	69%
B5Z7L8	Helicobacter pylori (strain G27)	26%	71%
B6I423	Escherichia coli (strain SE11)	23%	69%
B7LGY7	Escherichia coli (strain 55989 / EAEC)	23%	69%
B7LQC9	Escherichia fergusonii (strain ATCC 35469 / DSM 13698 / CCUG 18766 / IAM 14443 / JCM 21226 / LMG 7866 / NBRC 102419 / NCTC 12128 / CDC 0568-73)	23%	69%
B7LZK1	Escherichia coli O8 (strain IAI1)	23%	69%
B7MAC8	Escherichia coli O45:K1 (strain S88 / ExPEC)	23%	69%
B7N0K1	Escherichia coli O81 (strain ED1a)	23%	69%
B7ND40	Escherichia coli O17:K52:H18 (strain UMN026 / ExPEC)	23%	69%
B7NJR5	Escherichia coli O7:K1 (strain IAI39 / ExPEC)	23%	69%
B7UIW0	Escherichia coli O127:H6 (strain E2348/69 / EPEC)	23%	69%
B8CVJ1	Shewanella piezotolerans (strain WP3 / JCM 13877)	22%	69%
B8FB71	Desulfatibacillum aliphaticivorans	26%	67%
C4ZQW9	Escherichia coli (strain K12 / MC4100 / BW2952)	23%	69%
D0A5P3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	59%	99%
D4GSE6	Haloferax volcanii (strain ATCC 29605 / DSM 3757 / JCM 8879 / NBRC 14742 / NCIMB 2012 / VKM B-1768 / DS2)	24%	100%
E9AD19	Leishmania major	91%	100%
E9AYU4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
O27587	Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H)	25%	100%
O29891	Archaeoglobus fulgidus (strain ATCC 49558 / DSM 4304 / JCM 9628 / NBRC 100126 / VC-16)	26%	100%
O34768	Bacillus subtilis (strain 168)	26%	100%
O59128	Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)	26%	100%
O60116	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	34%	100%
O82616	Arabidopsis thaliana	26%	100%
P0A9J6	Escherichia coli (strain K12)	37%	100%
P0A9J7	Escherichia coli O157:H7	37%	100%
P22824	Vibrio alginolyticus	26%	100%
P25332	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	29%	99%
P30235	Escherichia coli (strain K12)	22%	100%
P32143	Escherichia coli (strain K12)	31%	100%
P33020	Escherichia coli (strain K12)	27%	91%
P36945	Bacillus subtilis (strain 168)	33%	100%
P37829	Solanum tuberosum	29%	100%
P44330	Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)	22%	100%
P44331	Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)	37%	100%
P45416	Dickeya dadantii (strain 3937)	23%	100%
P57168	Buchnera aphidicola subsp. Acyrthosiphon pisum (strain APS)	23%	100%
P76658	Escherichia coli (strain K12)	23%	69%
P77493	Escherichia coli (strain K12)	28%	100%
Q0A4T7	Alkalilimnicola ehrlichii (strain ATCC BAA-1101 / DSM 17681 / MLHE-1)	25%	69%
Q0I1X5	Haemophilus somnus (strain 129Pt)	22%	69%
Q0J8G4	Oryza sativa subsp. japonica	27%	98%
Q0JGZ6	Oryza sativa subsp. japonica	27%	100%
Q0T0L1	Shigella flexneri serotype 5b (strain 8401)	23%	69%
Q0TD55	Escherichia coli O6:K15:H31 (strain 536 / UPEC)	23%	69%
Q17WK1	Helicobacter acinonychis (strain Sheeba)	24%	71%
Q1I411	Pseudomonas entomophila (strain L48)	23%	70%
Q1R6S9	Escherichia coli (strain UTI89 / UPEC)	23%	69%
Q30T22	Sulfurimonas denitrificans (strain ATCC 33889 / DSM 1251)	24%	69%
Q31IC2	Hydrogenovibrio crunogenus (strain DSM 25203 / XCL-2)	22%	69%
Q31WY3	Shigella boydii serotype 4 (strain Sb227)	23%	69%
Q32BR2	Shigella dysenteriae serotype 1 (strain Sd197)	23%	69%
Q3YXJ0	Shigella sonnei (strain Ss046)	23%	69%
Q42896	Solanum lycopersicum	29%	100%
Q48P39	Pseudomonas savastanoi pv. phaseolicola (strain 1448A / Race 6)	23%	69%
Q493X3	Blochmannia pennsylvanicus (strain BPEN)	24%	69%
Q4ZZ15	Pseudomonas syringae pv. syringae (strain B728a)	24%	69%
Q54UQ4	Dictyostelium discoideum	30%	100%
Q5HTW1	Campylobacter jejuni (strain RM1221)	24%	71%
Q5JDG9	Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1)	26%	100%
Q6XZ78	Zea mays	27%	98%
Q6XZ79	Zea mays	27%	100%
Q74BF6	Geobacter sulfurreducens (strain ATCC 51573 / DSM 12127 / PCA)	26%	67%
Q7AAQ7	Escherichia coli O157:H7	23%	69%
Q7UBI8	Shigella flexneri	23%	69%
Q7VFZ3	Helicobacter hepaticus (strain ATCC 51449 / 3B1)	24%	68%
Q7VQQ6	Blochmannia floridanus	23%	69%
Q7XJ81	Solanum habrochaites	28%	100%
Q87VF4	Pseudomonas syringae pv. tomato (strain ATCC BAA-871 / DC3000)	23%	69%
Q8FDH5	Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)	23%	69%
Q8R1Q9	Mus musculus	42%	100%
Q8ZKR2	Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)	27%	100%
Q9CF42	Lactococcus lactis subsp. lactis (strain IL1403)	31%	100%
Q9H477	Homo sapiens	41%	100%
Q9K6K1	Halalkalibacterium halodurans (strain ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125)	35%	100%
Q9LNE3	Arabidopsis thaliana	29%	100%
Q9LNE4	Arabidopsis thaliana	29%	95%
Q9M1B9	Arabidopsis thaliana	28%	100%
Q9SID0	Arabidopsis thaliana	27%	100%
Q9ZKZ0	Helicobacter pylori (strain J99 / ATCC 700824)	26%	71%
V5BXE5	Trypanosoma cruzi	65%	100%