Putative heat shock protein DNAJ

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

heat shock protein DNAJ, putative

Species:

Leishmania braziliensis

UniProt:

A4HFG5_LEIBR

TriTrypDb:

LbrM.27.0500 , LBRM2903_270010400

Length:

378

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	11
GO:0110165	cellular anatomical entity	1	11
GO:0005737	cytoplasm	2	1

Expansion

Sequence features

A4HFG5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HFG5

Function

Biological processes
Term	Name	Level	Count
GO:0006457	protein folding	2	1
GO:0006458	'de novo' protein folding	3	1
GO:0009987	cellular process	1	1
GO:0042026	protein refolding	3	1
GO:0051084	'de novo' post-translational protein folding	4	1
GO:0051085	chaperone cofactor-dependent protein refolding	4	1
GO:0061077	chaperone-mediated protein folding	3	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0051082	unfolded protein binding	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	130	132	PF00675	0.266
CLV_NRD_NRD_1	2	4	PF00675	0.456
CLV_NRD_NRD_1	42	44	PF00675	0.436
CLV_NRD_NRD_1	62	64	PF00675	0.446
CLV_PCSK_FUR_1	127	131	PF00082	0.274
CLV_PCSK_FUR_1	263	267	PF00082	0.435
CLV_PCSK_KEX2_1	129	131	PF00082	0.266
CLV_PCSK_KEX2_1	2	4	PF00082	0.472
CLV_PCSK_KEX2_1	265	267	PF00082	0.502
CLV_PCSK_KEX2_1	42	44	PF00082	0.439
CLV_PCSK_KEX2_1	62	64	PF00082	0.404
CLV_PCSK_PC1ET2_1	129	131	PF00082	0.318
CLV_PCSK_PC1ET2_1	265	267	PF00082	0.429
CLV_PCSK_SKI1_1	188	192	PF00082	0.336
CLV_PCSK_SKI1_1	2	6	PF00082	0.469
CLV_PCSK_SKI1_1	223	227	PF00082	0.460
CLV_PCSK_SKI1_1	233	237	PF00082	0.420
CLV_PCSK_SKI1_1	25	29	PF00082	0.486
CLV_PCSK_SKI1_1	265	269	PF00082	0.444
CLV_PCSK_SKI1_1	95	99	PF00082	0.238
DEG_Nend_UBRbox_1	1	4	PF02207	0.675
DOC_CYCLIN_RxL_1	90	99	PF00134	0.450
DOC_PP4_FxxP_1	309	312	PF00568	0.708
DOC_SPAK_OSR1_1	266	270	PF12202	0.688
DOC_USP7_MATH_1	138	142	PF00917	0.588
DOC_USP7_MATH_1	20	24	PF00917	0.694
DOC_USP7_MATH_1	277	281	PF00917	0.621
DOC_USP7_MATH_1	32	36	PF00917	0.722
DOC_USP7_UBL2_3	90	94	PF12436	0.430
DOC_WW_Pin1_4	326	331	PF00397	0.649
DOC_WW_Pin1_4	35	40	PF00397	0.627
LIG_14-3-3_CanoR_1	137	146	PF00244	0.536
LIG_14-3-3_CanoR_1	266	270	PF00244	0.607
LIG_BRCT_BRCA1_1	305	309	PF00533	0.684
LIG_BRCT_BRCA1_1	53	57	PF00533	0.617
LIG_FHA_1	339	345	PF00498	0.296
LIG_FHA_2	224	230	PF00498	0.626
LIG_FHA_2	256	262	PF00498	0.608
LIG_FHA_2	56	62	PF00498	0.533
LIG_FHA_2	83	89	PF00498	0.534
LIG_Integrin_RGD_1	170	172	PF01839	0.335
LIG_Integrin_RGD_1	213	215	PF01839	0.381
LIG_LIR_Apic_2	256	262	PF02991	0.548
LIG_LIR_Apic_2	306	312	PF02991	0.706
LIG_LIR_Gen_1	118	128	PF02991	0.464
LIG_LIR_Gen_1	346	356	PF02991	0.309
LIG_LIR_Gen_1	73	82	PF02991	0.455
LIG_LIR_Nem_3	111	117	PF02991	0.439
LIG_LIR_Nem_3	118	124	PF02991	0.447
LIG_LIR_Nem_3	184	190	PF02991	0.528
LIG_LIR_Nem_3	197	203	PF02991	0.544
LIG_LIR_Nem_3	229	235	PF02991	0.647
LIG_LIR_Nem_3	346	352	PF02991	0.276
LIG_LIR_Nem_3	73	78	PF02991	0.431
LIG_NRBOX	343	349	PF00104	0.357
LIG_Pex14_2	187	191	PF04695	0.524
LIG_Pex14_2	232	236	PF04695	0.628
LIG_Pex14_2	40	44	PF04695	0.779
LIG_REV1ctd_RIR_1	233	241	PF16727	0.547
LIG_REV1ctd_RIR_1	38	47	PF16727	0.578
LIG_SH2_CRK	121	125	PF00017	0.430
LIG_SH2_CRK	75	79	PF00017	0.407
LIG_SH2_CRK	93	97	PF00017	0.390
LIG_SH2_NCK_1	121	125	PF00017	0.472
LIG_SH2_STAT3	133	136	PF00017	0.596
LIG_SH2_STAT5	259	262	PF00017	0.636
LIG_SH3_3	16	22	PF00018	0.586
LIG_SH3_3	353	359	PF00018	0.292
LIG_SUMO_SIM_anti_2	364	370	PF11976	0.362
LIG_SUMO_SIM_par_1	340	346	PF11976	0.409
LIG_TRAF2_1	179	182	PF00917	0.546
LIG_WRPW_2	232	235	PF00400	0.550
MOD_CDK_SPxxK_3	35	42	PF00069	0.565
MOD_CK1_1	147	153	PF00069	0.540
MOD_CK1_1	162	168	PF00069	0.635
MOD_CK1_1	238	244	PF00069	0.557
MOD_CK1_1	35	41	PF00069	0.665
MOD_CK2_1	176	182	PF00069	0.435
MOD_CK2_1	55	61	PF00069	0.416
MOD_CK2_1	82	88	PF00069	0.264
MOD_Cter_Amidation	263	266	PF01082	0.556
MOD_GlcNHglycan	117	120	PF01048	0.400
MOD_GlcNHglycan	140	143	PF01048	0.450
MOD_GlcNHglycan	149	152	PF01048	0.544
MOD_GlcNHglycan	153	156	PF01048	0.565
MOD_GlcNHglycan	157	160	PF01048	0.563
MOD_GlcNHglycan	161	164	PF01048	0.423
MOD_GlcNHglycan	34	37	PF01048	0.610
MOD_GlcNHglycan	47	50	PF01048	0.560
MOD_GlcNHglycan	67	70	PF01048	0.528
MOD_GSK3_1	115	122	PF00069	0.367
MOD_GSK3_1	147	154	PF00069	0.493
MOD_GSK3_1	155	162	PF00069	0.515
MOD_GSK3_1	221	228	PF00069	0.613
MOD_GSK3_1	27	34	PF00069	0.531
MOD_GSK3_1	310	317	PF00069	0.592
MOD_GSK3_1	322	329	PF00069	0.577
MOD_GSK3_1	45	52	PF00069	0.587
MOD_N-GLC_1	277	282	PF02516	0.531
MOD_N-GLC_1	28	33	PF02516	0.753
MOD_N-GLC_1	303	308	PF02516	0.535
MOD_NEK2_1	254	259	PF00069	0.498
MOD_NEK2_1	27	32	PF00069	0.669
MOD_NEK2_1	316	321	PF00069	0.470
MOD_NEK2_1	361	366	PF00069	0.304
MOD_NEK2_1	5	10	PF00069	0.586
MOD_NEK2_1	51	56	PF00069	0.570
MOD_PIKK_1	304	310	PF00454	0.667
MOD_PIKK_1	314	320	PF00454	0.587
MOD_PIKK_1	55	61	PF00454	0.663
MOD_PIKK_1	82	88	PF00454	0.357
MOD_PK_1	113	119	PF00069	0.344
MOD_PKA_1	265	271	PF00069	0.600
MOD_PKA_2	12	18	PF00069	0.557
MOD_PKA_2	265	271	PF00069	0.527
MOD_PKA_2	310	316	PF00069	0.688
MOD_Plk_1	238	244	PF00069	0.495
MOD_Plk_1	254	260	PF00069	0.511
MOD_Plk_2-3	255	261	PF00069	0.508
MOD_Plk_4	119	125	PF00069	0.357
MOD_Plk_4	316	322	PF00069	0.451
MOD_Plk_4	343	349	PF00069	0.264
MOD_Plk_4	361	367	PF00069	0.264
MOD_ProDKin_1	326	332	PF00069	0.564
MOD_ProDKin_1	35	41	PF00069	0.544
MOD_SUMO_rev_2	83	92	PF00179	0.264
TRG_ENDOCYTIC_2	121	124	PF00928	0.264
TRG_ENDOCYTIC_2	175	178	PF00928	0.466
TRG_ENDOCYTIC_2	75	78	PF00928	0.266
TRG_ENDOCYTIC_2	93	96	PF00928	0.145
TRG_ER_diArg_1	1	3	PF00400	0.613
TRG_ER_diArg_1	289	292	PF00400	0.464
TRG_ER_diArg_1	41	43	PF00400	0.588
TRG_ER_diArg_1	62	64	PF00400	0.568
TRG_NES_CRM1_1	184	197	PF08389	0.430
TRG_Pf-PMV_PEXEL_1	201	205	PF00026	0.518

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PD75	Leptomonas seymouri	69%	100%
A0A0S4JV26	Bodo saltans	41%	100%
A0A1X0P3X0	Trypanosomatidae	56%	100%
A0A3S5IRT6	Trypanosoma rangeli	54%	100%
A0A3S7X0F2	Leishmania donovani	82%	79%
A4I2M7	Leishmania infantum	82%	100%
D0A5P1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	50%	100%
E9AD18	Leishmania major	83%	100%
E9AYU3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	100%
V5BN28	Trypanosoma cruzi	54%	92%