Putative nucleoporin

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Nuclear pore complex protein 158

Species:

Leishmania braziliensis

UniProt:

A4HFG3_LEIBR

TriTrypDb:

LbrM.27.0470 , LBRM2903_270010100

Length:

951

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0005643	nuclear pore	3	6
GO:0032991	protein-containing complex	1	6
GO:0140513	nuclear protein-containing complex	2	6
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HFG3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HFG3

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	6
GO:0008104	protein localization	4	6
GO:0009987	cellular process	1	6
GO:0015031	protein transport	4	6
GO:0015931	nucleobase-containing compound transport	5	6
GO:0033036	macromolecule localization	2	6
GO:0045184	establishment of protein localization	3	6
GO:0050657	nucleic acid transport	6	6
GO:0050658	RNA transport	4	6
GO:0051028	mRNA transport	5	6
GO:0051179	localization	1	6
GO:0051234	establishment of localization	2	6
GO:0051236	establishment of RNA localization	3	6
GO:0051641	cellular localization	2	6
GO:0070727	cellular macromolecule localization	3	6
GO:0071702	organic substance transport	4	6
GO:0071705	nitrogen compound transport	4	6

Molecular functions
Term	Name	Level	Count
GO:0005198	structural molecule activity	1	6
GO:0017056	structural constituent of nuclear pore	2	6
GO:0003824	catalytic activity	1	1
GO:0004386	helicase activity	2	1
GO:0140640	catalytic activity, acting on a nucleic acid	2	1
GO:0140657	ATP-dependent activity	1	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	163	167	PF00656	0.470
CLV_C14_Caspase3-7	293	297	PF00656	0.777
CLV_C14_Caspase3-7	316	320	PF00656	0.768
CLV_C14_Caspase3-7	442	446	PF00656	0.662
CLV_C14_Caspase3-7	777	781	PF00656	0.338
CLV_NRD_NRD_1	113	115	PF00675	0.818
CLV_NRD_NRD_1	155	157	PF00675	0.362
CLV_NRD_NRD_1	164	166	PF00675	0.262
CLV_NRD_NRD_1	329	331	PF00675	0.774
CLV_NRD_NRD_1	340	342	PF00675	0.649
CLV_NRD_NRD_1	346	348	PF00675	0.664
CLV_NRD_NRD_1	382	384	PF00675	0.708
CLV_NRD_NRD_1	45	47	PF00675	0.747
CLV_NRD_NRD_1	473	475	PF00675	0.586
CLV_NRD_NRD_1	745	747	PF00675	0.470
CLV_NRD_NRD_1	773	775	PF00675	0.429
CLV_PCSK_KEX2_1	113	115	PF00082	0.818
CLV_PCSK_KEX2_1	155	157	PF00082	0.362
CLV_PCSK_KEX2_1	164	166	PF00082	0.262
CLV_PCSK_KEX2_1	329	331	PF00082	0.774
CLV_PCSK_KEX2_1	340	342	PF00082	0.649
CLV_PCSK_KEX2_1	346	348	PF00082	0.664
CLV_PCSK_KEX2_1	382	384	PF00082	0.684
CLV_PCSK_KEX2_1	45	47	PF00082	0.747
CLV_PCSK_KEX2_1	773	775	PF00082	0.429
CLV_PCSK_KEX2_1	880	882	PF00082	0.369
CLV_PCSK_PC1ET2_1	880	882	PF00082	0.470
CLV_PCSK_PC7_1	876	882	PF00082	0.470
CLV_PCSK_SKI1_1	28	32	PF00082	0.718
CLV_PCSK_SKI1_1	418	422	PF00082	0.659
CLV_PCSK_SKI1_1	474	478	PF00082	0.520
CLV_PCSK_SKI1_1	486	490	PF00082	0.453
CLV_PCSK_SKI1_1	522	526	PF00082	0.546
CLV_PCSK_SKI1_1	579	583	PF00082	0.465
CLV_PCSK_SKI1_1	607	611	PF00082	0.594
CLV_PCSK_SKI1_1	712	716	PF00082	0.314
CLV_PCSK_SKI1_1	83	87	PF00082	0.708
DOC_ANK_TNKS_1	645	652	PF00023	0.470
DOC_CDC14_PxL_1	403	411	PF14671	0.667
DOC_CYCLIN_RxL_1	709	719	PF00134	0.470
DOC_CYCLIN_yClb5_NLxxxL_5	584	593	PF00134	0.401
DOC_CYCLIN_yCln2_LP_2	86	92	PF00134	0.730
DOC_MAPK_DCC_7	83	92	PF00069	0.722
DOC_MAPK_MEF2A_6	594	601	PF00069	0.521
DOC_MAPK_MEF2A_6	83	92	PF00069	0.722
DOC_MAPK_MEF2A_6	834	842	PF00069	0.470
DOC_PP2B_LxvP_1	740	743	PF13499	0.369
DOC_PP4_FxxP_1	173	176	PF00568	0.314
DOC_PP4_FxxP_1	356	359	PF00568	0.621
DOC_SPAK_OSR1_1	159	163	PF12202	0.470
DOC_USP7_MATH_1	112	116	PF00917	0.739
DOC_USP7_MATH_1	206	210	PF00917	0.470
DOC_USP7_MATH_1	394	398	PF00917	0.660
DOC_USP7_MATH_1	436	440	PF00917	0.665
DOC_USP7_MATH_1	501	505	PF00917	0.541
DOC_USP7_MATH_1	629	633	PF00917	0.426
DOC_USP7_MATH_1	790	794	PF00917	0.353
DOC_USP7_MATH_1	802	806	PF00917	0.381
DOC_USP7_UBL2_3	27	31	PF12436	0.806
DOC_USP7_UBL2_3	471	475	PF12436	0.589
DOC_USP7_UBL2_3	941	945	PF12436	0.636
DOC_WW_Pin1_4	108	113	PF00397	0.629
DOC_WW_Pin1_4	147	152	PF00397	0.470
DOC_WW_Pin1_4	201	206	PF00397	0.411
DOC_WW_Pin1_4	363	368	PF00397	0.664
DOC_WW_Pin1_4	462	467	PF00397	0.698
DOC_WW_Pin1_4	6	11	PF00397	0.718
DOC_WW_Pin1_4	609	614	PF00397	0.623
DOC_WW_Pin1_4	724	729	PF00397	0.351
DOC_WW_Pin1_4	75	80	PF00397	0.632
DOC_WW_Pin1_4	864	869	PF00397	0.470
DOC_WW_Pin1_4	96	101	PF00397	0.719
LIG_14-3-3_CanoR_1	106	112	PF00244	0.746
LIG_14-3-3_CanoR_1	113	117	PF00244	0.727
LIG_14-3-3_CanoR_1	159	163	PF00244	0.470
LIG_14-3-3_CanoR_1	257	267	PF00244	0.729
LIG_14-3-3_CanoR_1	346	356	PF00244	0.656
LIG_14-3-3_CanoR_1	382	390	PF00244	0.712
LIG_14-3-3_CanoR_1	46	52	PF00244	0.671
LIG_14-3-3_CanoR_1	474	484	PF00244	0.443
LIG_14-3-3_CanoR_1	509	516	PF00244	0.536
LIG_14-3-3_CanoR_1	549	557	PF00244	0.382
LIG_14-3-3_CanoR_1	630	636	PF00244	0.470
LIG_14-3-3_CanoR_1	674	679	PF00244	0.381
LIG_14-3-3_CanoR_1	773	779	PF00244	0.470
LIG_14-3-3_CanoR_1	885	892	PF00244	0.414
LIG_Actin_WH2_2	139	157	PF00022	0.470
LIG_Actin_WH2_2	614	629	PF00022	0.338
LIG_Actin_WH2_2	78	93	PF00022	0.711
LIG_APCC_ABBA_1	196	201	PF00400	0.416
LIG_APCC_ABBA_1	751	756	PF00400	0.411
LIG_BIR_II_1	1	5	PF00653	0.756
LIG_BRCT_BRCA1_1	433	437	PF00533	0.676
LIG_Clathr_ClatBox_1	179	183	PF01394	0.470
LIG_Clathr_ClatBox_1	783	787	PF01394	0.470
LIG_CtBP_PxDLS_1	151	155	PF00389	0.470
LIG_CtBP_PxDLS_1	176	180	PF00389	0.338
LIG_deltaCOP1_diTrp_1	852	857	PF00928	0.341
LIG_eIF4E_1	11	17	PF01652	0.608
LIG_FHA_1	202	208	PF00498	0.443
LIG_FHA_1	221	227	PF00498	0.648
LIG_FHA_1	269	275	PF00498	0.754
LIG_FHA_1	430	436	PF00498	0.669
LIG_FHA_1	48	54	PF00498	0.689
LIG_FHA_1	523	529	PF00498	0.460
LIG_FHA_1	549	555	PF00498	0.496
LIG_FHA_1	758	764	PF00498	0.470
LIG_FHA_1	808	814	PF00498	0.328
LIG_FHA_1	843	849	PF00498	0.371
LIG_FHA_1	867	873	PF00498	0.470
LIG_FHA_2	131	137	PF00498	0.585
LIG_FHA_2	148	154	PF00498	0.283
LIG_FHA_2	30	36	PF00498	0.808
LIG_FHA_2	322	328	PF00498	0.765
LIG_FHA_2	725	731	PF00498	0.338
LIG_FHA_2	775	781	PF00498	0.470
LIG_GBD_Chelix_1	589	597	PF00786	0.530
LIG_LIR_Apic_2	170	176	PF02991	0.314
LIG_LIR_Apic_2	18	23	PF02991	0.767
LIG_LIR_Apic_2	353	359	PF02991	0.600
LIG_LIR_Apic_2	559	565	PF02991	0.375
LIG_LIR_Apic_2	910	915	PF02991	0.416
LIG_LIR_Gen_1	814	824	PF02991	0.369
LIG_LIR_Gen_1	898	906	PF02991	0.470
LIG_LIR_Nem_3	402	406	PF02991	0.649
LIG_LIR_Nem_3	689	695	PF02991	0.470
LIG_LIR_Nem_3	710	714	PF02991	0.314
LIG_LIR_Nem_3	719	724	PF02991	0.314
LIG_LIR_Nem_3	814	819	PF02991	0.342
LIG_LIR_Nem_3	853	859	PF02991	0.315
LIG_LIR_Nem_3	898	902	PF02991	0.369
LIG_LIR_Nem_3	9	14	PF02991	0.597
LIG_LYPXL_yS_3	406	409	PF13949	0.685
LIG_MYND_1	408	412	PF01753	0.681
LIG_NRBOX	596	602	PF00104	0.560
LIG_NRBOX	837	843	PF00104	0.470
LIG_PALB2_WD40_1	851	859	PF16756	0.338
LIG_PCNA_yPIPBox_3	634	645	PF02747	0.459
LIG_PTB_Apo_2	131	138	PF02174	0.641
LIG_PTB_Phospho_1	131	137	PF10480	0.643
LIG_SH2_CRK	11	15	PF00017	0.601
LIG_SH2_CRK	692	696	PF00017	0.470
LIG_SH2_CRK	721	725	PF00017	0.470
LIG_SH2_CRK	899	903	PF00017	0.470
LIG_SH2_GRB2like	403	406	PF00017	0.653
LIG_SH2_NCK_1	20	24	PF00017	0.774
LIG_SH2_NCK_1	331	335	PF00017	0.768
LIG_SH2_PTP2	360	363	PF00017	0.709
LIG_SH2_STAP1	754	758	PF00017	0.315
LIG_SH2_STAT3	137	140	PF00017	0.470
LIG_SH2_STAT3	580	583	PF00017	0.455
LIG_SH2_STAT5	137	140	PF00017	0.338
LIG_SH2_STAT5	149	152	PF00017	0.338
LIG_SH2_STAT5	189	192	PF00017	0.470
LIG_SH2_STAT5	233	236	PF00017	0.590
LIG_SH2_STAT5	360	363	PF00017	0.709
LIG_SH2_STAT5	391	394	PF00017	0.553
LIG_SH2_STAT5	403	406	PF00017	0.532
LIG_SH2_STAT5	580	583	PF00017	0.455
LIG_SH2_STAT5	657	660	PF00017	0.395
LIG_SH2_STAT5	692	695	PF00017	0.470
LIG_SH2_STAT5	812	815	PF00017	0.332
LIG_SH3_1	331	337	PF00018	0.714
LIG_SH3_1	747	753	PF00018	0.470
LIG_SH3_3	117	123	PF00018	0.789
LIG_SH3_3	216	222	PF00018	0.432
LIG_SH3_3	330	336	PF00018	0.667
LIG_SH3_3	36	42	PF00018	0.742
LIG_SH3_3	401	407	PF00018	0.654
LIG_SH3_3	432	438	PF00018	0.676
LIG_SH3_3	495	501	PF00018	0.562
LIG_SH3_3	747	753	PF00018	0.470
LIG_SH3_3	822	828	PF00018	0.470
LIG_SH3_3	914	920	PF00018	0.416
LIG_SH3_4	471	478	PF00018	0.559
LIG_SUMO_SIM_anti_2	553	559	PF11976	0.428
LIG_SUMO_SIM_anti_2	595	602	PF11976	0.563
LIG_SUMO_SIM_anti_2	837	842	PF11976	0.470
LIG_SUMO_SIM_par_1	553	559	PF11976	0.440
LIG_SUMO_SIM_par_1	674	680	PF11976	0.342
LIG_SUMO_SIM_par_1	782	787	PF11976	0.470
LIG_TRAF2_1	150	153	PF00917	0.470
LIG_TRAF2_1	297	300	PF00917	0.768
LIG_TRAF2_1	574	577	PF00917	0.558
LIG_TRAF2_1	613	616	PF00917	0.599
LIG_TRAF2_1	637	640	PF00917	0.470
LIG_TRAF2_1	919	922	PF00917	0.717
LIG_TRFH_1	137	141	PF08558	0.338
LIG_TYR_ITIM	404	409	PF00017	0.677
LIG_TYR_ITSM	717	724	PF00017	0.470
LIG_UBA3_1	86	91	PF00899	0.729
LIG_WRC_WIRS_1	717	722	PF05994	0.470
MOD_CDC14_SPxK_1	111	114	PF00782	0.814
MOD_CDK_SPK_2	108	113	PF00069	0.763
MOD_CDK_SPK_2	363	368	PF00069	0.664
MOD_CDK_SPxK_1	108	114	PF00069	0.813
MOD_CDK_SPxxK_3	363	370	PF00069	0.669
MOD_CDK_SPxxK_3	864	871	PF00069	0.470
MOD_CK1_1	116	122	PF00069	0.700
MOD_CK1_1	158	164	PF00069	0.470
MOD_CK1_1	263	269	PF00069	0.753
MOD_CK1_1	350	356	PF00069	0.723
MOD_CK1_1	413	419	PF00069	0.533
MOD_CK1_1	512	518	PF00069	0.431
MOD_CK1_1	530	536	PF00069	0.323
MOD_CK1_1	556	562	PF00069	0.506
MOD_CK1_1	632	638	PF00069	0.426
MOD_CK1_1	677	683	PF00069	0.411
MOD_CK1_1	71	77	PF00069	0.670
MOD_CK1_1	805	811	PF00069	0.470
MOD_CK1_1	932	938	PF00069	0.518
MOD_CK2_1	112	118	PF00069	0.772
MOD_CK2_1	130	136	PF00069	0.329
MOD_CK2_1	139	145	PF00069	0.312
MOD_CK2_1	147	153	PF00069	0.172
MOD_CK2_1	294	300	PF00069	0.725
MOD_CK2_1	321	327	PF00069	0.767
MOD_CK2_1	366	372	PF00069	0.666
MOD_CK2_1	436	442	PF00069	0.679
MOD_CK2_1	523	529	PF00069	0.486
MOD_CK2_1	538	544	PF00069	0.343
MOD_CK2_1	609	615	PF00069	0.558
MOD_CK2_1	724	730	PF00069	0.338
MOD_GlcNHglycan	208	211	PF01048	0.470
MOD_GlcNHglycan	349	352	PF01048	0.731
MOD_GlcNHglycan	516	519	PF01048	0.504
MOD_GlcNHglycan	532	535	PF01048	0.293
MOD_GlcNHglycan	558	561	PF01048	0.503
MOD_GlcNHglycan	631	634	PF01048	0.435
MOD_GlcNHglycan	662	665	PF01048	0.416
MOD_GlcNHglycan	679	682	PF01048	0.154
MOD_GlcNHglycan	74	77	PF01048	0.627
MOD_GlcNHglycan	792	795	PF01048	0.373
MOD_GlcNHglycan	807	810	PF01048	0.453
MOD_GlcNHglycan	886	889	PF01048	0.470
MOD_GSK3_1	108	115	PF00069	0.690
MOD_GSK3_1	135	142	PF00069	0.440
MOD_GSK3_1	201	208	PF00069	0.438
MOD_GSK3_1	220	227	PF00069	0.583
MOD_GSK3_1	26	33	PF00069	0.713
MOD_GSK3_1	290	297	PF00069	0.729
MOD_GSK3_1	377	384	PF00069	0.696
MOD_GSK3_1	427	434	PF00069	0.633
MOD_GSK3_1	47	54	PF00069	0.706
MOD_GSK3_1	523	530	PF00069	0.491
MOD_GSK3_1	544	551	PF00069	0.486
MOD_GSK3_1	628	635	PF00069	0.381
MOD_GSK3_1	68	75	PF00069	0.636
MOD_GSK3_1	803	810	PF00069	0.338
MOD_N-GLC_1	253	258	PF02516	0.544
MOD_N-GLC_1	294	299	PF02516	0.672
MOD_N-GLC_1	6	11	PF02516	0.686
MOD_N-GLC_1	602	607	PF02516	0.557
MOD_N-GLC_1	790	795	PF02516	0.470
MOD_NEK2_1	160	165	PF00069	0.470
MOD_NEK2_1	253	258	PF00069	0.644
MOD_NEK2_1	290	295	PF00069	0.791
MOD_NEK2_1	321	326	PF00069	0.672
MOD_NEK2_1	378	383	PF00069	0.748
MOD_NEK2_1	421	426	PF00069	0.627
MOD_NEK2_1	601	606	PF00069	0.513
MOD_NEK2_1	660	665	PF00069	0.418
MOD_NEK2_1	72	77	PF00069	0.723
MOD_NEK2_1	884	889	PF00069	0.402
MOD_NEK2_2	501	506	PF00069	0.544
MOD_NEK2_2	716	721	PF00069	0.435
MOD_PIKK_1	475	481	PF00454	0.519
MOD_PIKK_1	51	57	PF00454	0.748
MOD_PIKK_1	579	585	PF00454	0.450
MOD_PKA_1	155	161	PF00069	0.470
MOD_PKA_2	105	111	PF00069	0.782
MOD_PKA_2	112	118	PF00069	0.684
MOD_PKA_2	130	136	PF00069	0.329
MOD_PKA_2	155	161	PF00069	0.470
MOD_PKA_2	263	269	PF00069	0.785
MOD_PKA_2	381	387	PF00069	0.730
MOD_PKA_2	548	554	PF00069	0.466
MOD_PKA_2	629	635	PF00069	0.470
MOD_PKA_2	884	890	PF00069	0.416
MOD_PKB_1	218	226	PF00069	0.640
MOD_PKB_1	672	680	PF00069	0.411
MOD_PKB_1	739	747	PF00069	0.369
MOD_Plk_1	135	141	PF00069	0.384
MOD_Plk_1	413	419	PF00069	0.575
MOD_Plk_1	536	542	PF00069	0.608
MOD_Plk_1	59	65	PF00069	0.666
MOD_Plk_1	836	842	PF00069	0.462
MOD_Plk_1	851	857	PF00069	0.222
MOD_Plk_4	275	281	PF00069	0.779
MOD_Plk_4	394	400	PF00069	0.612
MOD_Plk_4	47	53	PF00069	0.716
MOD_Plk_4	523	529	PF00069	0.532
MOD_Plk_4	550	556	PF00069	0.365
MOD_Plk_4	60	66	PF00069	0.641
MOD_Plk_4	674	680	PF00069	0.411
MOD_Plk_4	836	842	PF00069	0.456
MOD_Plk_4	851	857	PF00069	0.177
MOD_ProDKin_1	108	114	PF00069	0.630
MOD_ProDKin_1	147	153	PF00069	0.470
MOD_ProDKin_1	201	207	PF00069	0.411
MOD_ProDKin_1	363	369	PF00069	0.666
MOD_ProDKin_1	462	468	PF00069	0.698
MOD_ProDKin_1	6	12	PF00069	0.718
MOD_ProDKin_1	609	615	PF00069	0.617
MOD_ProDKin_1	724	730	PF00069	0.351
MOD_ProDKin_1	75	81	PF00069	0.625
MOD_ProDKin_1	864	870	PF00069	0.470
MOD_ProDKin_1	96	102	PF00069	0.724
MOD_SUMO_for_1	593	596	PF00179	0.444
MOD_SUMO_rev_2	34	40	PF00179	0.760
TRG_DiLeu_BaEn_1	175	180	PF01217	0.338
TRG_DiLeu_BaEn_1	596	601	PF01217	0.550
TRG_DiLeu_BaEn_1	837	842	PF01217	0.338
TRG_DiLeu_BaEn_4	576	582	PF01217	0.603
TRG_DiLeu_BaEn_4	690	696	PF01217	0.470
TRG_DiLeu_BaLyEn_6	405	410	PF01217	0.675
TRG_ENDOCYTIC_2	11	14	PF00928	0.598
TRG_ENDOCYTIC_2	406	409	PF00928	0.685
TRG_ENDOCYTIC_2	657	660	PF00928	0.446
TRG_ENDOCYTIC_2	692	695	PF00928	0.470
TRG_ENDOCYTIC_2	721	724	PF00928	0.446
TRG_ENDOCYTIC_2	899	902	PF00928	0.411
TRG_ER_diArg_1	112	114	PF00400	0.816
TRG_ER_diArg_1	154	156	PF00400	0.362
TRG_ER_diArg_1	217	220	PF00400	0.371
TRG_ER_diArg_1	328	330	PF00400	0.770
TRG_ER_diArg_1	340	342	PF00400	0.686
TRG_ER_diArg_1	346	348	PF00400	0.718
TRG_ER_diArg_1	584	587	PF00400	0.397
TRG_ER_diArg_1	671	674	PF00400	0.456
TRG_ER_diArg_1	772	774	PF00400	0.470
TRG_NES_CRM1_1	152	166	PF08389	0.369
TRG_Pf-PMV_PEXEL_1	579	583	PF00026	0.465
TRG_Pf-PMV_PEXEL_1	890	894	PF00026	0.411

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0S4JZS2	Bodo saltans	25%	100%
A0A1X0P500	Trypanosomatidae	36%	85%
A0A422NTI5	Trypanosoma rangeli	37%	84%
V5DP62	Trypanosoma cruzi	36%	82%