Sema domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HFG2_LEIBR

TriTrypDb:

LbrM.27.0460 , LBRM2903_270010000

Length:

194

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005643	nuclear pore	3	1
GO:0032991	protein-containing complex	1	1
GO:0140513	nuclear protein-containing complex	2	1

Expansion

Sequence features

A4HFG2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HFG2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	51	55	PF00656	0.357
CLV_NRD_NRD_1	143	145	PF00675	0.601
CLV_PCSK_SKI1_1	115	119	PF00082	0.451
CLV_PCSK_SKI1_1	134	138	PF00082	0.565
CLV_PCSK_SKI1_1	144	148	PF00082	0.476
CLV_PCSK_SKI1_1	8	12	PF00082	0.612
DEG_Nend_UBRbox_3	1	3	PF02207	0.663
DEG_SPOP_SBC_1	94	98	PF00917	0.640
DOC_USP7_MATH_1	130	134	PF00917	0.635
DOC_USP7_MATH_1	185	189	PF00917	0.467
DOC_USP7_MATH_1	94	98	PF00917	0.588
DOC_WW_Pin1_4	118	123	PF00397	0.400
LIG_14-3-3_CanoR_1	115	124	PF00244	0.574
LIG_BRCT_BRCA1_1	97	101	PF00533	0.548
LIG_FHA_1	112	118	PF00498	0.358
LIG_FHA_1	66	72	PF00498	0.618
LIG_FHA_2	145	151	PF00498	0.545
LIG_LIR_Apic_2	65	70	PF02991	0.715
LIG_LIR_Gen_1	14	23	PF02991	0.628
LIG_LIR_Nem_3	126	131	PF02991	0.473
LIG_LIR_Nem_3	14	20	PF02991	0.617
LIG_PDZ_Class_2	189	194	PF00595	0.494
LIG_Rb_LxCxE_1	31	51	PF01857	0.567
LIG_SH2_PTP2	17	20	PF00017	0.578
LIG_SH2_STAT3	82	85	PF00017	0.519
LIG_SH2_STAT5	111	114	PF00017	0.561
LIG_SH2_STAT5	166	169	PF00017	0.497
LIG_SH2_STAT5	17	20	PF00017	0.578
LIG_SH2_STAT5	176	179	PF00017	0.471
LIG_SH2_STAT5	67	70	PF00017	0.515
LIG_SH2_STAT5	82	85	PF00017	0.578
LIG_SH3_4	56	63	PF00018	0.592
LIG_SUMO_SIM_anti_2	153	158	PF11976	0.620
LIG_WRPW_2	128	131	PF00400	0.506
MOD_CK1_1	123	129	PF00069	0.376
MOD_CK1_1	188	194	PF00069	0.523
MOD_CK1_1	65	71	PF00069	0.436
MOD_CK2_1	144	150	PF00069	0.643
MOD_CK2_1	165	171	PF00069	0.547
MOD_CK2_1	63	69	PF00069	0.592
MOD_GlcNHglycan	101	104	PF01048	0.460
MOD_GlcNHglycan	89	92	PF01048	0.732
MOD_GSK3_1	111	118	PF00069	0.530
MOD_GSK3_1	89	96	PF00069	0.578
MOD_NEK2_1	62	67	PF00069	0.592
MOD_NEK2_1	71	76	PF00069	0.632
MOD_PIKK_1	81	87	PF00454	0.544
MOD_PIKK_1	89	95	PF00454	0.573
MOD_PKA_1	144	150	PF00069	0.624
MOD_Plk_1	48	54	PF00069	0.364
MOD_Plk_4	123	129	PF00069	0.560
MOD_Plk_4	188	194	PF00069	0.559
MOD_Plk_4	78	84	PF00069	0.554
MOD_ProDKin_1	118	124	PF00069	0.390
MOD_SUMO_rev_2	126	136	PF00179	0.600
MOD_SUMO_rev_2	140	147	PF00179	0.548
MOD_SUMO_rev_2	148	154	PF00179	0.687
MOD_SUMO_rev_2	49	57	PF00179	0.575
TRG_DiLeu_BaEn_1	31	36	PF01217	0.618
TRG_ENDOCYTIC_2	17	20	PF00928	0.578
TRG_Pf-PMV_PEXEL_1	144	148	PF00026	0.551
TRG_Pf-PMV_PEXEL_1	50	54	PF00026	0.567

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PEC1	Leptomonas seymouri	64%	99%
A0A0S4JRB9	Bodo saltans	29%	100%
A0A1X0P3W2	Trypanosomatidae	37%	95%
A0A3Q8ID94	Leishmania donovani	87%	100%
A0A3R7KLB2	Trypanosoma rangeli	33%	94%
A4I2M4	Leishmania infantum	87%	100%
D0A5N7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	92%
E9AD14	Leishmania major	85%	100%
E9AYT9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%