LeishMANIAdb
  • Home
  • Browse
  • Manual
  • FAQ
  • Download

Putative ATPase

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Putative ATPase
Gene product:
ATPase, putative
Species:
Leishmania braziliensis
UniProt:
A4HFG1_LEIBR
TriTrypDb:
LbrM.27.0450 , LBRM2903_270009900
Length:
656

Annotations

LeishMANIAdb annotations

A large and likely artifical grouping of protease domain carrying proteins related to proteasomal proteases. Only a tiny subgroup (the AFG3-related mitochondrail proteins) seem to have a TM segment.. Localization: Cytoplasmic (by homology) / Mitochondrial (by homology)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 1
GO:0110165 cellular anatomical entity 1 1

Expansion

Sequence features

A4HFG1
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HFG1

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0000166 nucleotide binding 3 12
GO:0003824 catalytic activity 1 12
GO:0005488 binding 1 12
GO:0005524 ATP binding 5 12
GO:0016462 pyrophosphatase activity 5 12
GO:0016787 hydrolase activity 2 12
GO:0016817 hydrolase activity, acting on acid anhydrides 3 12
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 4 12
GO:0016887 ATP hydrolysis activity 7 12
GO:0017076 purine nucleotide binding 4 12
GO:0017111 ribonucleoside triphosphate phosphatase activity 6 12
GO:0030554 adenyl nucleotide binding 5 12
GO:0032553 ribonucleotide binding 3 12
GO:0032555 purine ribonucleotide binding 4 12
GO:0032559 adenyl ribonucleotide binding 5 12
GO:0035639 purine ribonucleoside triphosphate binding 4 12
GO:0036094 small molecule binding 2 12
GO:0043167 ion binding 2 12
GO:0043168 anion binding 3 12
GO:0097159 organic cyclic compound binding 2 12
GO:0097367 carbohydrate derivative binding 2 12
GO:1901265 nucleoside phosphate binding 3 12
GO:1901363 heterocyclic compound binding 2 12

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 520 524 PF00656 0.344
CLV_NRD_NRD_1 112 114 PF00675 0.699
CLV_NRD_NRD_1 286 288 PF00675 0.501
CLV_NRD_NRD_1 483 485 PF00675 0.393
CLV_NRD_NRD_1 501 503 PF00675 0.276
CLV_NRD_NRD_1 53 55 PF00675 0.602
CLV_PCSK_FUR_1 481 485 PF00082 0.449
CLV_PCSK_KEX2_1 112 114 PF00082 0.699
CLV_PCSK_KEX2_1 483 485 PF00082 0.434
CLV_PCSK_KEX2_1 501 503 PF00082 0.193
CLV_PCSK_KEX2_1 53 55 PF00082 0.600
CLV_PCSK_SKI1_1 104 108 PF00082 0.468
CLV_PCSK_SKI1_1 230 234 PF00082 0.537
CLV_PCSK_SKI1_1 342 346 PF00082 0.379
CLV_PCSK_SKI1_1 428 432 PF00082 0.344
CLV_PCSK_SKI1_1 476 480 PF00082 0.328
DEG_APCC_DBOX_1 229 237 PF00400 0.563
DEG_Nend_Nbox_1 1 3 PF02207 0.461
DEG_SCF_FBW7_1 68 75 PF00400 0.371
DOC_CKS1_1 69 74 PF01111 0.376
DOC_CYCLIN_yCln2_LP_2 542 548 PF00134 0.449
DOC_MAPK_FxFP_2 334 337 PF00069 0.449
DOC_MAPK_gen_1 256 266 PF00069 0.353
DOC_MAPK_gen_1 481 491 PF00069 0.348
DOC_MAPK_gen_1 549 559 PF00069 0.328
DOC_MAPK_MEF2A_6 259 267 PF00069 0.322
DOC_MAPK_MEF2A_6 305 312 PF00069 0.410
DOC_MAPK_MEF2A_6 483 491 PF00069 0.366
DOC_MAPK_MEF2A_6 552 561 PF00069 0.338
DOC_MAPK_MEF2A_6 567 575 PF00069 0.384
DOC_PP1_RVXF_1 386 393 PF00149 0.466
DOC_PP1_RVXF_1 405 412 PF00149 0.425
DOC_PP2B_LxvP_1 318 321 PF13499 0.555
DOC_PP4_FxxP_1 334 337 PF00568 0.449
DOC_SPAK_OSR1_1 421 425 PF12202 0.473
DOC_USP7_MATH_1 205 209 PF00917 0.600
DOC_USP7_MATH_1 232 236 PF00917 0.522
DOC_USP7_MATH_1 303 307 PF00917 0.535
DOC_USP7_MATH_1 337 341 PF00917 0.493
DOC_USP7_MATH_1 446 450 PF00917 0.379
DOC_USP7_MATH_1 72 76 PF00917 0.633
DOC_WW_Pin1_4 247 252 PF00397 0.493
DOC_WW_Pin1_4 422 427 PF00397 0.509
DOC_WW_Pin1_4 68 73 PF00397 0.422
LIG_14-3-3_CanoR_1 116 122 PF00244 0.562
LIG_14-3-3_CanoR_1 391 398 PF00244 0.525
LIG_14-3-3_CanoR_1 46 50 PF00244 0.548
LIG_14-3-3_CanoR_1 513 519 PF00244 0.328
LIG_14-3-3_CanoR_1 53 62 PF00244 0.527
LIG_Actin_WH2_2 461 478 PF00022 0.315
LIG_BRCT_BRCA1_1 245 249 PF00533 0.548
LIG_BRCT_BRCA1_1 56 60 PF00533 0.552
LIG_Clathr_ClatBox_1 455 459 PF01394 0.449
LIG_eIF4E_1 155 161 PF01652 0.465
LIG_FHA_1 237 243 PF00498 0.572
LIG_FHA_1 260 266 PF00498 0.502
LIG_FHA_1 32 38 PF00498 0.605
LIG_FHA_1 327 333 PF00498 0.393
LIG_FHA_1 439 445 PF00498 0.328
LIG_FHA_1 580 586 PF00498 0.417
LIG_FHA_1 624 630 PF00498 0.452
LIG_FHA_1 63 69 PF00498 0.462
LIG_FHA_2 266 272 PF00498 0.547
LIG_FHA_2 366 372 PF00498 0.544
LIG_FHA_2 518 524 PF00498 0.341
LIG_FHA_2 561 567 PF00498 0.448
LIG_FHA_2 576 582 PF00498 0.325
LIG_FHA_2 637 643 PF00498 0.498
LIG_LIR_Gen_1 329 337 PF02991 0.439
LIG_LIR_Gen_1 417 427 PF02991 0.393
LIG_LIR_Gen_1 450 461 PF02991 0.332
LIG_LIR_Gen_1 523 533 PF02991 0.475
LIG_LIR_LC3C_4 262 267 PF02991 0.475
LIG_LIR_Nem_3 210 215 PF02991 0.305
LIG_LIR_Nem_3 329 333 PF02991 0.395
LIG_LIR_Nem_3 417 422 PF02991 0.382
LIG_LIR_Nem_3 450 456 PF02991 0.334
LIG_LIR_Nem_3 523 528 PF02991 0.475
LIG_NRBOX 197 203 PF00104 0.551
LIG_NRBOX 514 520 PF00104 0.328
LIG_NRBOX 570 576 PF00104 0.516
LIG_NRBOX 604 610 PF00104 0.264
LIG_Pex14_1 245 249 PF04695 0.548
LIG_Pex14_2 330 334 PF04695 0.464
LIG_PTB_Apo_2 19 26 PF02174 0.314
LIG_PTB_Phospho_1 19 25 PF10480 0.319
LIG_SH2_CRK 155 159 PF00017 0.477
LIG_SH2_CRK 433 437 PF00017 0.328
LIG_SH2_NCK_1 641 645 PF00017 0.450
LIG_SH2_PTP2 130 133 PF00017 0.428
LIG_SH2_SRC 457 460 PF00017 0.344
LIG_SH2_STAP1 39 43 PF00017 0.556
LIG_SH2_STAP1 641 645 PF00017 0.488
LIG_SH2_STAT3 628 631 PF00017 0.547
LIG_SH2_STAT5 130 133 PF00017 0.409
LIG_SH2_STAT5 144 147 PF00017 0.423
LIG_SH2_STAT5 25 28 PF00017 0.532
LIG_SH2_STAT5 457 460 PF00017 0.336
LIG_SH2_STAT5 467 470 PF00017 0.344
LIG_SH2_STAT5 474 477 PF00017 0.328
LIG_SH2_STAT5 628 631 PF00017 0.521
LIG_SH2_STAT5 70 73 PF00017 0.450
LIG_SH2_STAT5 79 82 PF00017 0.422
LIG_SH3_3 105 111 PF00018 0.573
LIG_SH3_3 556 562 PF00018 0.329
LIG_SH3_3 66 72 PF00018 0.527
LIG_SUMO_SIM_anti_2 262 269 PF11976 0.465
LIG_SUMO_SIM_anti_2 306 311 PF11976 0.402
LIG_SUMO_SIM_anti_2 493 499 PF11976 0.344
LIG_SUMO_SIM_par_1 239 247 PF11976 0.309
LIG_SUMO_SIM_par_1 262 269 PF11976 0.549
LIG_UBA3_1 198 207 PF00899 0.559
LIG_UBA3_1 570 577 PF00899 0.459
LIG_UBA3_1 605 610 PF00899 0.449
LIG_UBA3_1 98 104 PF00899 0.346
LIG_WRC_WIRS_1 327 332 PF05994 0.425
LIG_WW_3 425 429 PF00397 0.437
MOD_CDK_SPxK_1 422 428 PF00069 0.505
MOD_CK1_1 247 253 PF00069 0.547
MOD_CK1_1 560 566 PF00069 0.481
MOD_CK1_1 83 89 PF00069 0.501
MOD_CK2_1 247 253 PF00069 0.575
MOD_CK2_1 265 271 PF00069 0.431
MOD_CK2_1 365 371 PF00069 0.517
MOD_CK2_1 45 51 PF00069 0.523
MOD_CK2_1 72 78 PF00069 0.611
MOD_Cter_Amidation 499 502 PF01082 0.344
MOD_GlcNHglycan 177 180 PF01048 0.659
MOD_GlcNHglycan 206 210 PF01048 0.608
MOD_GlcNHglycan 300 303 PF01048 0.502
MOD_GlcNHglycan 352 355 PF01048 0.586
MOD_GlcNHglycan 459 462 PF01048 0.336
MOD_GlcNHglycan 464 467 PF01048 0.319
MOD_GlcNHglycan 503 506 PF01048 0.437
MOD_GlcNHglycan 592 595 PF01048 0.368
MOD_GlcNHglycan 611 614 PF01048 0.438
MOD_GlcNHglycan 633 636 PF01048 0.528
MOD_GlcNHglycan 74 77 PF01048 0.593
MOD_GlcNHglycan 82 85 PF01048 0.542
MOD_GSK3_1 232 239 PF00069 0.510
MOD_GSK3_1 243 250 PF00069 0.485
MOD_GSK3_1 31 38 PF00069 0.572
MOD_GSK3_1 365 372 PF00069 0.493
MOD_GSK3_1 41 48 PF00069 0.473
MOD_GSK3_1 513 520 PF00069 0.334
MOD_GSK3_1 575 582 PF00069 0.460
MOD_GSK3_1 586 593 PF00069 0.276
MOD_GSK3_1 623 630 PF00069 0.404
MOD_GSK3_1 68 75 PF00069 0.447
MOD_LATS_1 511 517 PF00433 0.413
MOD_N-GLC_1 169 174 PF02516 0.443
MOD_N-GLC_1 451 456 PF02516 0.413
MOD_N-GLC_1 6 11 PF02516 0.479
MOD_N-GLC_2 22 24 PF02516 0.326
MOD_NEK2_1 243 248 PF00069 0.530
MOD_NEK2_1 332 337 PF00069 0.508
MOD_NEK2_1 345 350 PF00069 0.502
MOD_NEK2_1 41 46 PF00069 0.458
MOD_NEK2_1 514 519 PF00069 0.315
MOD_NEK2_1 575 580 PF00069 0.403
MOD_NEK2_1 609 614 PF00069 0.393
MOD_NEK2_1 636 641 PF00069 0.491
MOD_NEK2_2 142 147 PF00069 0.536
MOD_PIKK_1 169 175 PF00454 0.675
MOD_PIKK_1 337 343 PF00454 0.464
MOD_PIKK_1 54 60 PF00454 0.589
MOD_PIKK_1 62 68 PF00454 0.573
MOD_PIKK_1 627 633 PF00454 0.453
MOD_PKA_1 112 118 PF00069 0.561
MOD_PKA_1 501 507 PF00069 0.437
MOD_PKA_2 112 118 PF00069 0.589
MOD_PKA_2 390 396 PF00069 0.516
MOD_PKA_2 45 51 PF00069 0.496
MOD_PKA_2 501 507 PF00069 0.431
MOD_PKA_2 566 572 PF00069 0.491
MOD_PKA_2 631 637 PF00069 0.412
MOD_Plk_1 104 110 PF00069 0.539
MOD_Plk_1 41 47 PF00069 0.513
MOD_Plk_1 451 457 PF00069 0.413
MOD_Plk_4 238 244 PF00069 0.535
MOD_Plk_4 259 265 PF00069 0.565
MOD_Plk_4 380 386 PF00069 0.630
MOD_Plk_4 439 445 PF00069 0.328
MOD_Plk_4 45 51 PF00069 0.475
MOD_Plk_4 459 465 PF00069 0.366
MOD_Plk_4 514 520 PF00069 0.328
MOD_Plk_4 566 572 PF00069 0.463
MOD_ProDKin_1 247 253 PF00069 0.501
MOD_ProDKin_1 422 428 PF00069 0.505
MOD_ProDKin_1 68 74 PF00069 0.434
MOD_SUMO_rev_2 590 600 PF00179 0.475
TRG_DiLeu_BaEn_1 194 199 PF01217 0.549
TRG_DiLeu_BaEn_1 510 515 PF01217 0.449
TRG_DiLeu_LyEn_5 510 515 PF01217 0.449
TRG_ENDOCYTIC_2 130 133 PF00928 0.428
TRG_ENDOCYTIC_2 155 158 PF00928 0.492
TRG_ER_diArg_1 111 113 PF00400 0.668
TRG_ER_diArg_1 166 169 PF00400 0.547
TRG_ER_diArg_1 481 484 PF00400 0.449
TRG_ER_diArg_1 501 503 PF00400 0.145
TRG_ER_diArg_1 53 55 PF00400 0.608
TRG_Pf-PMV_PEXEL_1 287 292 PF00026 0.456
TRG_Pf-PMV_PEXEL_1 473 477 PF00026 0.344
TRG_Pf-PMV_PEXEL_1 583 587 PF00026 0.475

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1HYP0 Leptomonas seymouri 66% 97%
A0A0S4JUV1 Bodo saltans 37% 100%
A0A1X0P3W8 Trypanosomatidae 43% 100%
A0A3R7L6R6 Trypanosoma rangeli 44% 98%
A0A3S7X0E5 Leishmania donovani 86% 100%
A4I2M3 Leishmania infantum 86% 100%
D0A5N6 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 44% 100%
E9AD13 Leishmania major 86% 100%
E9AYT8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 86% 100%
V5BSQ8 Trypanosoma cruzi 41% 79%

Download

Download
LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS