RNA-binding protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

RNA-binding protein

Gene product:

RNA recognition motif (a.k.a. RRM, RBD, or RNP domain), putative

Species:

Leishmania braziliensis

UniProt:

A4HFG0_LEIBR

TriTrypDb:

LbrM.27.0440 , LBRM2903_270009800

Length:

493

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005737	cytoplasm	2	1
GO:0005829	cytosol	2	1
GO:0032991	protein-containing complex	1	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1
GO:1990904	ribonucleoprotein complex	2	1

Expansion

Sequence features

A4HFG0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HFG0

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	11
GO:0003723	RNA binding	4	11
GO:0005488	binding	1	11
GO:0097159	organic cyclic compound binding	2	11
GO:1901363	heterocyclic compound binding	2	11
GO:0003727	single-stranded RNA binding	5	1
GO:0003729	mRNA binding	5	1
GO:0003730	mRNA 3'-UTR binding	6	1
GO:0008143	poly(A) binding	7	1
GO:0008187	poly-pyrimidine tract binding	6	1
GO:0008266	poly(U) RNA binding	7	1
GO:0070717	poly-purine tract binding	6	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	68	72	PF00656	0.496
CLV_NRD_NRD_1	120	122	PF00675	0.522
CLV_NRD_NRD_1	165	167	PF00675	0.594
CLV_NRD_NRD_1	318	320	PF00675	0.457
CLV_PCSK_KEX2_1	120	122	PF00082	0.573
CLV_PCSK_KEX2_1	165	167	PF00082	0.580
CLV_PCSK_KEX2_1	318	320	PF00082	0.457
CLV_PCSK_PC7_1	314	320	PF00082	0.382
CLV_PCSK_SKI1_1	215	219	PF00082	0.342
CLV_PCSK_SKI1_1	487	491	PF00082	0.347
CLV_PCSK_SKI1_1	7	11	PF00082	0.679
CLV_PCSK_SKI1_1	75	79	PF00082	0.258
CLV_Separin_Metazoa	135	139	PF03568	0.290
DOC_CDC14_PxL_1	383	391	PF14671	0.414
DOC_CKS1_1	364	369	PF01111	0.488
DOC_CYCLIN_RxL_1	212	220	PF00134	0.369
DOC_CYCLIN_yCln2_LP_2	77	83	PF00134	0.536
DOC_MAPK_gen_1	120	128	PF00069	0.416
DOC_MAPK_gen_1	138	147	PF00069	0.605
DOC_MAPK_gen_1	165	173	PF00069	0.453
DOC_PP4_FxxP_1	101	104	PF00568	0.537
DOC_USP7_MATH_1	263	267	PF00917	0.326
DOC_USP7_MATH_1	350	354	PF00917	0.565
DOC_WW_Pin1_4	100	105	PF00397	0.536
DOC_WW_Pin1_4	166	171	PF00397	0.496
DOC_WW_Pin1_4	182	187	PF00397	0.532
DOC_WW_Pin1_4	197	202	PF00397	0.502
DOC_WW_Pin1_4	339	344	PF00397	0.642
DOC_WW_Pin1_4	363	368	PF00397	0.673
LIG_14-3-3_CanoR_1	120	128	PF00244	0.403
LIG_14-3-3_CanoR_1	262	268	PF00244	0.291
LIG_14-3-3_CanoR_1	290	294	PF00244	0.460
LIG_BIR_III_4	467	471	PF00653	0.501
LIG_BRCT_BRCA1_1	38	42	PF00533	0.666
LIG_BRCT_BRCA1_1	416	420	PF00533	0.526
LIG_Clathr_ClatBox_1	221	225	PF01394	0.314
LIG_Clathr_ClatBox_1	267	271	PF01394	0.243
LIG_Dynein_DLC8_1	317	323	PF01221	0.303
LIG_EH1_1	242	250	PF00400	0.257
LIG_eIF4E_1	254	260	PF01652	0.459
LIG_FHA_1	155	161	PF00498	0.435
LIG_FHA_1	277	283	PF00498	0.245
LIG_FHA_1	378	384	PF00498	0.297
LIG_FHA_1	444	450	PF00498	0.474
LIG_FHA_2	66	72	PF00498	0.457
LIG_FHA_2	86	92	PF00498	0.350
LIG_LIR_Gen_1	292	302	PF02991	0.341
LIG_LIR_Gen_1	417	428	PF02991	0.445
LIG_LIR_Nem_3	200	206	PF02991	0.432
LIG_LIR_Nem_3	292	297	PF02991	0.349
LIG_LIR_Nem_3	39	45	PF02991	0.605
LIG_LIR_Nem_3	417	423	PF02991	0.445
LIG_LIR_Nem_3	76	81	PF02991	0.537
LIG_LYPXL_SIV_4	252	260	PF13949	0.452
LIG_MYND_1	387	391	PF01753	0.498
LIG_NRBOX	213	219	PF00104	0.459
LIG_NRBOX	394	400	PF00104	0.473
LIG_PCNA_yPIPBox_3	303	317	PF02747	0.284
LIG_SH2_CRK	416	420	PF00017	0.442
LIG_SH2_STAP1	152	156	PF00017	0.500
LIG_SH2_STAP1	416	420	PF00017	0.386
LIG_SH2_STAP1	445	449	PF00017	0.466
LIG_SH2_STAT3	370	373	PF00017	0.505
LIG_SH2_STAT5	254	257	PF00017	0.427
LIG_SH2_STAT5	316	319	PF00017	0.503
LIG_SH2_STAT5	320	323	PF00017	0.516
LIG_SH2_STAT5	382	385	PF00017	0.455
LIG_SH2_STAT5	445	448	PF00017	0.453
LIG_SH3_1	365	371	PF00018	0.474
LIG_SH3_3	301	307	PF00018	0.501
LIG_SH3_3	365	371	PF00018	0.559
LIG_SH3_3	469	475	PF00018	0.322
LIG_SUMO_SIM_anti_2	146	154	PF11976	0.491
LIG_SUMO_SIM_par_1	220	226	PF11976	0.315
LIG_SUMO_SIM_par_1	393	400	PF11976	0.536
LIG_WRC_WIRS_1	206	211	PF05994	0.398
LIG_WRC_WIRS_1	37	42	PF05994	0.610
LIG_WW_1	367	370	PF00397	0.476
MOD_CK1_1	18	24	PF00069	0.586
MOD_CK1_1	197	203	PF00069	0.447
MOD_CK1_1	25	31	PF00069	0.615
MOD_CK1_1	289	295	PF00069	0.351
MOD_CK1_1	335	341	PF00069	0.619
MOD_CK1_1	66	72	PF00069	0.293
MOD_CK2_1	205	211	PF00069	0.418
MOD_CK2_1	217	223	PF00069	0.262
MOD_CK2_1	24	30	PF00069	0.588
MOD_CK2_1	67	73	PF00069	0.389
MOD_CK2_1	85	91	PF00069	0.469
MOD_DYRK1A_RPxSP_1	166	170	PF00069	0.404
MOD_GlcNHglycan	160	163	PF01048	0.494
MOD_GlcNHglycan	24	27	PF01048	0.606
MOD_GlcNHglycan	338	341	PF01048	0.539
MOD_GlcNHglycan	352	355	PF01048	0.611
MOD_GSK3_1	11	18	PF00069	0.598
MOD_GSK3_1	150	157	PF00069	0.433
MOD_GSK3_1	20	27	PF00069	0.557
MOD_GSK3_1	213	220	PF00069	0.443
MOD_GSK3_1	272	279	PF00069	0.218
MOD_GSK3_1	332	339	PF00069	0.589
MOD_GSK3_1	352	359	PF00069	0.586
MOD_GSK3_1	377	384	PF00069	0.402
MOD_GSK3_1	48	55	PF00069	0.520
MOD_GSK3_1	483	490	PF00069	0.530
MOD_GSK3_1	63	70	PF00069	0.186
MOD_N-GLC_1	52	57	PF02516	0.502
MOD_NEK2_1	15	20	PF00069	0.647
MOD_NEK2_1	204	209	PF00069	0.356
MOD_NEK2_1	213	218	PF00069	0.398
MOD_NEK2_1	276	281	PF00069	0.409
MOD_NEK2_1	336	341	PF00069	0.663
MOD_NEK2_1	344	349	PF00069	0.570
MOD_NEK2_1	443	448	PF00069	0.230
MOD_NEK2_1	478	483	PF00069	0.501
MOD_NEK2_1	65	70	PF00069	0.410
MOD_NEK2_2	415	420	PF00069	0.279
MOD_OFUCOSY	274	280	PF10250	0.431
MOD_PIKK_1	120	126	PF00454	0.439
MOD_PIKK_1	154	160	PF00454	0.492
MOD_PIKK_1	2	8	PF00454	0.453
MOD_PIKK_1	318	324	PF00454	0.475
MOD_PIKK_1	356	362	PF00454	0.556
MOD_PIKK_1	478	484	PF00454	0.438
MOD_PKA_1	120	126	PF00069	0.434
MOD_PKA_1	318	324	PF00069	0.524
MOD_PKA_2	120	126	PF00069	0.343
MOD_PKA_2	164	170	PF00069	0.590
MOD_PKA_2	289	295	PF00069	0.464
MOD_PKA_2	318	324	PF00069	0.495
MOD_Plk_1	11	17	PF00069	0.668
MOD_Plk_1	35	41	PF00069	0.534
MOD_Plk_2-3	85	91	PF00069	0.197
MOD_Plk_4	11	17	PF00069	0.587
MOD_Plk_4	213	219	PF00069	0.400
MOD_Plk_4	263	269	PF00069	0.278
MOD_Plk_4	289	295	PF00069	0.355
MOD_Plk_4	36	42	PF00069	0.603
MOD_Plk_4	390	396	PF00069	0.325
MOD_Plk_4	415	421	PF00069	0.279
MOD_Plk_4	73	79	PF00069	0.412
MOD_Plk_4	91	97	PF00069	0.197
MOD_ProDKin_1	100	106	PF00069	0.410
MOD_ProDKin_1	166	172	PF00069	0.494
MOD_ProDKin_1	182	188	PF00069	0.526
MOD_ProDKin_1	197	203	PF00069	0.497
MOD_ProDKin_1	339	345	PF00069	0.631
MOD_ProDKin_1	363	369	PF00069	0.670
MOD_SUMO_rev_2	71	77	PF00179	0.410
TRG_DiLeu_BaLyEn_6	255	260	PF01217	0.399
TRG_ENDOCYTIC_2	16	19	PF00928	0.461
TRG_ENDOCYTIC_2	416	419	PF00928	0.308
TRG_ER_diArg_1	119	121	PF00400	0.560
TRG_ER_diArg_1	137	140	PF00400	0.476
TRG_ER_diArg_1	164	166	PF00400	0.578
TRG_ER_diArg_1	317	319	PF00400	0.457
TRG_ER_diArg_1	362	365	PF00400	0.499
TRG_ER_diArg_1	376	379	PF00400	0.343
TRG_NES_CRM1_1	212	226	PF08389	0.344

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I589	Leptomonas seymouri	63%	96%
A0A1X0P421	Trypanosomatidae	36%	100%
A0A3Q8IG64	Leishmania donovani	76%	100%
A0A3R7NWC3	Trypanosoma rangeli	41%	100%
A4I2M2	Leishmania infantum	76%	100%
D0A5N4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	100%
E9AD12	Leishmania major	77%	100%
E9AYT7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	76%	100%
V5BXF1	Trypanosoma cruzi	41%	100%