Dolichyl-diphosphooligosaccharide--protein glycotransferase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

oligosaccharyl transferase-like protein

Species:

Leishmania braziliensis

UniProt:

A4HFF9_LEIBR

TriTrypDb:

LbrM.27.0430 , LBRM2903_340016700

Length:

859

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 36

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 26
NetGPI	no	yes: 0, no: 26

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	27
GO:0110165	cellular anatomical entity	1	27
GO:0005635	nuclear envelope	4	4
GO:0005783	endoplasmic reticulum	5	4
GO:0031967	organelle envelope	3	4
GO:0031975	envelope	2	4
GO:0043226	organelle	2	4
GO:0043227	membrane-bounded organelle	3	4
GO:0043229	intracellular organelle	3	4
GO:0043231	intracellular membrane-bounded organelle	4	4

Expansion

Sequence features

A4HFF9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HFF9

Function

Biological processes
Term	Name	Level	Count
GO:0006486	protein glycosylation	4	27
GO:0006807	nitrogen compound metabolic process	2	27
GO:0008152	metabolic process	1	27
GO:0019538	protein metabolic process	3	27
GO:0036211	protein modification process	4	27
GO:0043170	macromolecule metabolic process	3	27
GO:0043412	macromolecule modification	4	27
GO:0043413	macromolecule glycosylation	3	27
GO:0044238	primary metabolic process	2	27
GO:0070085	glycosylation	2	27
GO:0071704	organic substance metabolic process	2	27
GO:1901564	organonitrogen compound metabolic process	3	27

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	27
GO:0004576	oligosaccharyl transferase activity	5	27
GO:0004579	dolichyl-diphosphooligosaccharide-protein glycotransferase activity	6	27
GO:0005488	binding	1	27
GO:0016740	transferase activity	2	27
GO:0016757	glycosyltransferase activity	3	27
GO:0016758	hexosyltransferase activity	4	27
GO:0043167	ion binding	2	27
GO:0043169	cation binding	3	27
GO:0046872	metal ion binding	4	27

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	661	665	PF00656	0.319
CLV_NRD_NRD_1	527	529	PF00675	0.597
CLV_NRD_NRD_1	550	552	PF00675	0.464
CLV_NRD_NRD_1	560	562	PF00675	0.453
CLV_NRD_NRD_1	6	8	PF00675	0.390
CLV_PCSK_FUR_1	525	529	PF00082	0.397
CLV_PCSK_KEX2_1	527	529	PF00082	0.551
CLV_PCSK_KEX2_1	550	552	PF00082	0.466
CLV_PCSK_SKI1_1	391	395	PF00082	0.456
CLV_PCSK_SKI1_1	467	471	PF00082	0.415
CLV_PCSK_SKI1_1	562	566	PF00082	0.473
CLV_PCSK_SKI1_1	574	578	PF00082	0.195
CLV_PCSK_SKI1_1	678	682	PF00082	0.504
CLV_PCSK_SKI1_1	784	788	PF00082	0.604
DEG_SCF_FBW7_2	17	24	PF00400	0.597
DEG_SPOP_SBC_1	134	138	PF00917	0.473
DOC_AGCK_PIF_2	119	124	PF00069	0.302
DOC_ANK_TNKS_1	33	40	PF00023	0.587
DOC_CKS1_1	440	445	PF01111	0.158
DOC_CYCLIN_RxL_1	388	398	PF00134	0.263
DOC_CYCLIN_yClb5_NLxxxL_5	440	449	PF00134	0.158
DOC_MAPK_gen_1	239	248	PF00069	0.363
DOC_MAPK_gen_1	343	350	PF00069	0.493
DOC_MAPK_gen_1	550	558	PF00069	0.720
DOC_PP1_RVXF_1	64	71	PF00149	0.158
DOC_PP1_RVXF_1	640	647	PF00149	0.310
DOC_PP2B_LxvP_1	438	441	PF13499	0.224
DOC_PP4_FxxP_1	432	435	PF00568	0.404
DOC_PP4_MxPP_1	42	45	PF00568	0.564
DOC_USP7_MATH_1	15	19	PF00917	0.710
DOC_USP7_MATH_1	317	321	PF00917	0.288
DOC_USP7_MATH_1	540	544	PF00917	0.662
DOC_USP7_MATH_1	759	763	PF00917	0.404
DOC_USP7_UBL2_3	4	8	PF12436	0.624
DOC_WW_Pin1_4	17	22	PF00397	0.624
DOC_WW_Pin1_4	313	318	PF00397	0.288
DOC_WW_Pin1_4	37	42	PF00397	0.630
DOC_WW_Pin1_4	375	380	PF00397	0.188
DOC_WW_Pin1_4	439	444	PF00397	0.230
DOC_WW_Pin1_4	509	514	PF00397	0.571
DOC_WW_Pin1_4	604	609	PF00397	0.266
DOC_WW_Pin1_4	634	639	PF00397	0.329
DOC_WW_Pin1_4	679	684	PF00397	0.312
DOC_WW_Pin1_4	708	713	PF00397	0.339
LIG_14-3-3_CanoR_1	239	245	PF00244	0.311
LIG_14-3-3_CanoR_1	285	289	PF00244	0.538
LIG_14-3-3_CanoR_1	361	366	PF00244	0.458
LIG_14-3-3_CanoR_1	550	556	PF00244	0.710
LIG_14-3-3_CanoR_1	642	647	PF00244	0.256
LIG_14-3-3_CanoR_1	659	663	PF00244	0.324
LIG_14-3-3_CanoR_1	716	722	PF00244	0.324
LIG_14-3-3_CanoR_1	749	753	PF00244	0.375
LIG_14-3-3_CanoR_1	84	89	PF00244	0.288
LIG_14-3-3_CanoR_1	852	857	PF00244	0.520
LIG_Actin_WH2_2	488	504	PF00022	0.453
LIG_AP2alpha_2	99	101	PF02296	0.288
LIG_BRCT_BRCA1_1	115	119	PF00533	0.380
LIG_Clathr_ClatBox_1	183	187	PF01394	0.218
LIG_Clathr_ClatBox_1	555	559	PF01394	0.586
LIG_eIF4E_1	446	452	PF01652	0.382
LIG_FHA_1	187	193	PF00498	0.291
LIG_FHA_1	228	234	PF00498	0.289
LIG_FHA_1	385	391	PF00498	0.385
LIG_FHA_1	440	446	PF00498	0.401
LIG_FHA_1	461	467	PF00498	0.406
LIG_FHA_1	551	557	PF00498	0.715
LIG_FHA_1	575	581	PF00498	0.440
LIG_FHA_1	618	624	PF00498	0.266
LIG_FHA_1	679	685	PF00498	0.313
LIG_FHA_1	69	75	PF00498	0.404
LIG_FHA_1	81	87	PF00498	0.153
LIG_FHA_2	30	36	PF00498	0.592
LIG_FHA_2	38	44	PF00498	0.611
LIG_FHA_2	543	549	PF00498	0.652
LIG_FHA_2	635	641	PF00498	0.309
LIG_FHA_2	853	859	PF00498	0.394
LIG_GBD_Chelix_1	176	184	PF00786	0.266
LIG_LIR_Apic_2	380	385	PF02991	0.314
LIG_LIR_Apic_2	739	744	PF02991	0.383
LIG_LIR_Apic_2	812	816	PF02991	0.456
LIG_LIR_Gen_1	116	125	PF02991	0.340
LIG_LIR_Gen_1	195	205	PF02991	0.439
LIG_LIR_Gen_1	230	238	PF02991	0.345
LIG_LIR_Gen_1	549	560	PF02991	0.548
LIG_LIR_Gen_1	628	638	PF02991	0.310
LIG_LIR_Gen_1	696	702	PF02991	0.356
LIG_LIR_Gen_1	720	730	PF02991	0.440
LIG_LIR_Gen_1	770	780	PF02991	0.416
LIG_LIR_Nem_3	116	122	PF02991	0.283
LIG_LIR_Nem_3	126	130	PF02991	0.272
LIG_LIR_Nem_3	136	142	PF02991	0.261
LIG_LIR_Nem_3	195	200	PF02991	0.359
LIG_LIR_Nem_3	230	235	PF02991	0.330
LIG_LIR_Nem_3	316	321	PF02991	0.282
LIG_LIR_Nem_3	380	386	PF02991	0.288
LIG_LIR_Nem_3	549	555	PF02991	0.602
LIG_LIR_Nem_3	628	633	PF02991	0.316
LIG_LIR_Nem_3	645	649	PF02991	0.263
LIG_LIR_Nem_3	696	700	PF02991	0.292
LIG_LIR_Nem_3	720	725	PF02991	0.340
LIG_LIR_Nem_3	770	775	PF02991	0.365
LIG_LIR_Nem_3	777	783	PF02991	0.309
LIG_LIR_Nem_3	90	94	PF02991	0.291
LIG_LIR_Nem_3	99	104	PF02991	0.289
LIG_LYPXL_yS_3	139	142	PF13949	0.387
LIG_MLH1_MIPbox_1	115	119	PF16413	0.380
LIG_NRBOX	326	332	PF00104	0.393
LIG_PAM2_1	441	453	PF00658	0.355
LIG_Pex14_1	115	119	PF04695	0.288
LIG_Pex14_1	647	651	PF04695	0.300
LIG_Pex14_2	118	122	PF04695	0.215
LIG_Pex14_2	492	496	PF04695	0.592
LIG_Pex14_2	592	596	PF04695	0.314
LIG_Pex14_2	98	102	PF04695	0.267
LIG_PTB_Apo_2	421	428	PF02174	0.155
LIG_PTB_Apo_2	716	723	PF02174	0.329
LIG_PTB_Phospho_1	421	427	PF10480	0.155
LIG_PTB_Phospho_1	716	722	PF10480	0.324
LIG_SH2_CRK	173	177	PF00017	0.188
LIG_SH2_CRK	446	450	PF00017	0.496
LIG_SH2_CRK	552	556	PF00017	0.594
LIG_SH2_CRK	58	62	PF00017	0.487
LIG_SH2_CRK	65	69	PF00017	0.197
LIG_SH2_CRK	741	745	PF00017	0.376
LIG_SH2_CRK	780	784	PF00017	0.299
LIG_SH2_CRK	91	95	PF00017	0.302
LIG_SH2_GRB2like	422	425	PF00017	0.347
LIG_SH2_PTP2	264	267	PF00017	0.363
LIG_SH2_PTP2	697	700	PF00017	0.291
LIG_SH2_SRC	422	425	PF00017	0.265
LIG_SH2_SRC	626	629	PF00017	0.296
LIG_SH2_SRC	93	96	PF00017	0.312
LIG_SH2_STAP1	296	300	PF00017	0.363
LIG_SH2_STAP1	446	450	PF00017	0.511
LIG_SH2_STAP1	454	458	PF00017	0.289
LIG_SH2_STAP1	552	556	PF00017	0.548
LIG_SH2_STAP1	58	62	PF00017	0.635
LIG_SH2_STAP1	75	79	PF00017	0.242
LIG_SH2_STAP1	776	780	PF00017	0.409
LIG_SH2_STAT3	649	652	PF00017	0.292
LIG_SH2_STAT5	232	235	PF00017	0.387
LIG_SH2_STAT5	264	267	PF00017	0.363
LIG_SH2_STAT5	300	303	PF00017	0.443
LIG_SH2_STAT5	382	385	PF00017	0.275
LIG_SH2_STAT5	419	422	PF00017	0.232
LIG_SH2_STAT5	427	430	PF00017	0.244
LIG_SH2_STAT5	460	463	PF00017	0.336
LIG_SH2_STAT5	49	52	PF00017	0.643
LIG_SH2_STAT5	552	555	PF00017	0.600
LIG_SH2_STAT5	595	598	PF00017	0.346
LIG_SH2_STAT5	626	629	PF00017	0.320
LIG_SH2_STAT5	63	66	PF00017	0.282
LIG_SH2_STAT5	697	700	PF00017	0.291
LIG_SH2_STAT5	93	96	PF00017	0.351
LIG_SH3_3	164	170	PF00018	0.387
LIG_SH3_3	373	379	PF00018	0.342
LIG_SH3_3	38	44	PF00018	0.607
LIG_SH3_3	724	730	PF00018	0.392
LIG_SH3_3	796	802	PF00018	0.358
LIG_SH3_3	803	809	PF00018	0.364
LIG_SUMO_SIM_par_1	619	625	PF11976	0.248
LIG_SUMO_SIM_par_1	83	90	PF11976	0.312
LIG_SxIP_EBH_1	198	211	PF03271	0.348
LIG_TYR_ITIM	420	425	PF00017	0.202
LIG_TYR_ITSM	228	235	PF00017	0.329
LIG_WRC_WIRS_1	228	233	PF05994	0.329
MOD_CDC14_SPxK_1	316	319	PF00782	0.380
MOD_CDK_SPxK_1	313	319	PF00069	0.288
MOD_CK1_1	237	243	PF00069	0.363
MOD_CK1_1	481	487	PF00069	0.186
MOD_CK1_1	597	603	PF00069	0.352
MOD_CK1_1	604	610	PF00069	0.341
MOD_CK1_1	792	798	PF00069	0.341
MOD_CK1_1	87	93	PF00069	0.292
MOD_CK2_1	37	43	PF00069	0.592
MOD_CK2_1	404	410	PF00069	0.256
MOD_CK2_1	542	548	PF00069	0.628
MOD_CK2_1	852	858	PF00069	0.412
MOD_Cter_Amidation	571	574	PF01082	0.365
MOD_Cter_Amidation	838	841	PF01082	0.587
MOD_GlcNHglycan	110	113	PF01048	0.532
MOD_GlcNHglycan	115	118	PF01048	0.569
MOD_GlcNHglycan	194	197	PF01048	0.322
MOD_GlcNHglycan	478	481	PF01048	0.227
MOD_GlcNHglycan	483	486	PF01048	0.233
MOD_GlcNHglycan	521	524	PF01048	0.543
MOD_GlcNHglycan	580	583	PF01048	0.331
MOD_GlcNHglycan	761	764	PF01048	0.623
MOD_GlcNHglycan	791	794	PF01048	0.575
MOD_GSK3_1	113	120	PF00069	0.355
MOD_GSK3_1	188	195	PF00069	0.282
MOD_GSK3_1	284	291	PF00069	0.529
MOD_GSK3_1	29	36	PF00069	0.726
MOD_GSK3_1	301	308	PF00069	0.219
MOD_GSK3_1	313	320	PF00069	0.306
MOD_GSK3_1	481	488	PF00069	0.224
MOD_GSK3_1	574	581	PF00069	0.492
MOD_GSK3_1	597	604	PF00069	0.352
MOD_GSK3_1	80	87	PF00069	0.333
MOD_N-GLC_1	657	662	PF02516	0.514
MOD_N-GLC_1	789	794	PF02516	0.537
MOD_N-GLC_2	164	166	PF02516	0.443
MOD_N-GLC_2	219	221	PF02516	0.288
MOD_NEK2_1	142	147	PF00069	0.345
MOD_NEK2_1	186	191	PF00069	0.303
MOD_NEK2_1	200	205	PF00069	0.374
MOD_NEK2_1	209	214	PF00069	0.367
MOD_NEK2_1	227	232	PF00069	0.221
MOD_NEK2_1	395	400	PF00069	0.285
MOD_NEK2_1	404	409	PF00069	0.258
MOD_NEK2_1	452	457	PF00069	0.336
MOD_NEK2_1	478	483	PF00069	0.320
MOD_NEK2_1	578	583	PF00069	0.334
MOD_NEK2_1	596	601	PF00069	0.320
MOD_NEK2_1	611	616	PF00069	0.277
MOD_NEK2_1	748	753	PF00069	0.323
MOD_NEK2_1	850	855	PF00069	0.403
MOD_NEK2_2	234	239	PF00069	0.329
MOD_PIKK_1	29	35	PF00454	0.792
MOD_PIKK_1	512	518	PF00454	0.688
MOD_PIKK_1	533	539	PF00454	0.618
MOD_PK_1	361	367	PF00069	0.425
MOD_PK_1	84	90	PF00069	0.322
MOD_PKA_1	550	556	PF00069	0.604
MOD_PKA_2	240	246	PF00069	0.323
MOD_PKA_2	284	290	PF00069	0.538
MOD_PKA_2	33	39	PF00069	0.599
MOD_PKA_2	540	546	PF00069	0.768
MOD_PKA_2	550	556	PF00069	0.669
MOD_PKA_2	658	664	PF00069	0.318
MOD_PKA_2	748	754	PF00069	0.371
MOD_PKB_1	359	367	PF00069	0.512
MOD_Plk_1	657	663	PF00069	0.314
MOD_Plk_4	123	129	PF00069	0.288
MOD_Plk_4	227	233	PF00069	0.329
MOD_Plk_4	276	282	PF00069	0.431
MOD_Plk_4	288	294	PF00069	0.431
MOD_Plk_4	45	51	PF00069	0.708
MOD_Plk_4	478	484	PF00069	0.325
MOD_Plk_4	551	557	PF00069	0.715
MOD_Plk_4	574	580	PF00069	0.431
MOD_Plk_4	583	589	PF00069	0.278
MOD_Plk_4	617	623	PF00069	0.319
MOD_Plk_4	642	648	PF00069	0.259
MOD_Plk_4	686	692	PF00069	0.368
MOD_Plk_4	717	723	PF00069	0.325
MOD_Plk_4	748	754	PF00069	0.363
MOD_Plk_4	767	773	PF00069	0.451
MOD_Plk_4	809	815	PF00069	0.374
MOD_ProDKin_1	17	23	PF00069	0.625
MOD_ProDKin_1	313	319	PF00069	0.288
MOD_ProDKin_1	37	43	PF00069	0.628
MOD_ProDKin_1	375	381	PF00069	0.188
MOD_ProDKin_1	439	445	PF00069	0.230
MOD_ProDKin_1	509	515	PF00069	0.572
MOD_ProDKin_1	604	610	PF00069	0.263
MOD_ProDKin_1	634	640	PF00069	0.330
MOD_ProDKin_1	679	685	PF00069	0.318
MOD_ProDKin_1	708	714	PF00069	0.335
MOD_SUMO_rev_2	559	566	PF00179	0.532
TRG_DiLeu_BaEn_1	686	691	PF01217	0.328
TRG_DiLeu_BaLyEn_6	464	469	PF01217	0.295
TRG_ENDOCYTIC_2	139	142	PF00928	0.428
TRG_ENDOCYTIC_2	173	176	PF00928	0.188
TRG_ENDOCYTIC_2	232	235	PF00928	0.329
TRG_ENDOCYTIC_2	254	257	PF00928	0.329
TRG_ENDOCYTIC_2	264	267	PF00928	0.329
TRG_ENDOCYTIC_2	296	299	PF00928	0.329
TRG_ENDOCYTIC_2	422	425	PF00928	0.276
TRG_ENDOCYTIC_2	446	449	PF00928	0.465
TRG_ENDOCYTIC_2	454	457	PF00928	0.273
TRG_ENDOCYTIC_2	552	555	PF00928	0.733
TRG_ENDOCYTIC_2	58	61	PF00928	0.595
TRG_ENDOCYTIC_2	630	633	PF00928	0.311
TRG_ENDOCYTIC_2	65	68	PF00928	0.292
TRG_ENDOCYTIC_2	697	700	PF00928	0.291
TRG_ENDOCYTIC_2	722	725	PF00928	0.340
TRG_ENDOCYTIC_2	780	783	PF00928	0.293
TRG_ENDOCYTIC_2	91	94	PF00928	0.302
TRG_ER_diArg_1	238	241	PF00400	0.376
TRG_ER_diArg_1	342	345	PF00400	0.505
TRG_ER_diArg_1	350	353	PF00400	0.477
TRG_ER_diArg_1	358	361	PF00400	0.418
TRG_ER_diArg_1	525	528	PF00400	0.598
TRG_ER_diArg_1	550	552	PF00400	0.663
TRG_NES_CRM1_1	322	337	PF08389	0.380
TRG_Pf-PMV_PEXEL_1	319	323	PF00026	0.404
TRG_Pf-PMV_PEXEL_1	84	89	PF00026	0.406
TRG_Pf-PMV_PEXEL_1	854	858	PF00026	0.589

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0S4IZ72	Bodo saltans	50%	100%
A0A1X0NFU7	Trypanosomatidae	55%	100%
A0A3Q8IHT0	Leishmania donovani	78%	100%
A0A3Q8II34	Leishmania donovani	54%	100%
A0A3Q8ILY7	Leishmania donovani	69%	100%
A0A3Q8IV37	Leishmania donovani	71%	100%
A0A422MX14	Trypanosoma rangeli	55%	100%
A4HMD5	Leishmania braziliensis	76%	100%
A4HMD6	Leishmania braziliensis	57%	100%
A4HMD7	Leishmania braziliensis	70%	100%
A4IB08	Leishmania infantum	79%	100%
A4IB09	Leishmania infantum	69%	100%
A4IB10	Leishmania infantum	55%	100%
C9ZNL1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	54%	100%
C9ZQ40	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	53%	100%
E2RG47	Canis lupus familiaris	30%	100%
E9AET6	Leishmania major	78%	100%
E9AET7	Leishmania major	69%	98%
E9AET8	Leishmania major	54%	99%
E9AET9	Leishmania major	65%	100%
E9AHU4	Leishmania infantum	71%	100%
E9B5Z2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	76%	100%
E9B5Z3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	69%	100%
E9B5Z4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	53%	100%
E9B5Z5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	69%	100%
F1PJP5	Canis lupus familiaris	30%	100%
O94335	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	32%	100%
P46975	Caenorhabditis elegans	30%	100%
P46977	Homo sapiens	31%	100%
P46978	Mus musculus	31%	100%
Q2KJI2	Bos taurus	31%	100%
Q3TDQ1	Mus musculus	30%	100%
Q5RCE2	Pongo abelii	31%	100%
Q6F2Z1	Oryza sativa subsp. japonica	30%	100%
Q7XQ88	Oryza sativa subsp. japonica	32%	100%
Q8TCJ2	Homo sapiens	30%	100%
Q93ZY3	Arabidopsis thaliana	31%	100%
Q9FX21	Arabidopsis thaliana	32%	100%
V5BDM6	Trypanosoma cruzi	54%	100%