Kri1_C domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Nucleolar protein 111, putative

Species:

Leishmania braziliensis

UniProt:

A4HFF6_LEIBR

TriTrypDb:

LbrM.27.0390 , LBRM2903_270008900

Length:

1055

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005730	nucleolus	5	1
GO:0030684	preribosome	3	1
GO:0030686	90S preribosome	4	1
GO:0032991	protein-containing complex	1	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1
GO:1990904	ribonucleoprotein complex	2	1

Expansion

Sequence features

A4HFF6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HFF6

Function

Biological processes
Term	Name	Level	Count
GO:0000447	endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	10	1
GO:0000469	cleavage involved in rRNA processing	7	1
GO:0000478	endonucleolytic cleavage involved in rRNA processing	8	1
GO:0000479	endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	9	1
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	1
GO:0016070	RNA metabolic process	5	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0046483	heterocycle metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:0090304	nucleic acid metabolic process	4	1
GO:0090305	nucleic acid phosphodiester bond hydrolysis	5	1
GO:0090501	RNA phosphodiester bond hydrolysis	6	1
GO:0090502	RNA phosphodiester bond hydrolysis, endonucleolytic	7	1
GO:1901360	organic cyclic compound metabolic process	3	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	101	105	PF00656	0.653
CLV_C14_Caspase3-7	110	114	PF00656	0.677
CLV_C14_Caspase3-7	183	187	PF00656	0.653
CLV_C14_Caspase3-7	26	30	PF00656	0.666
CLV_C14_Caspase3-7	745	749	PF00656	0.546
CLV_C14_Caspase3-7	806	810	PF00656	0.466
CLV_C14_Caspase3-7	872	876	PF00656	0.416
CLV_C14_Caspase3-7	990	994	PF00656	0.621
CLV_MEL_PAP_1	278	284	PF00089	0.702
CLV_NRD_NRD_1	169	171	PF00675	0.735
CLV_NRD_NRD_1	208	210	PF00675	0.517
CLV_NRD_NRD_1	273	275	PF00675	0.514
CLV_NRD_NRD_1	345	347	PF00675	0.576
CLV_NRD_NRD_1	351	353	PF00675	0.551
CLV_NRD_NRD_1	393	395	PF00675	0.573
CLV_NRD_NRD_1	475	477	PF00675	0.719
CLV_NRD_NRD_1	479	481	PF00675	0.551
CLV_NRD_NRD_1	52	54	PF00675	0.589
CLV_NRD_NRD_1	521	523	PF00675	0.621
CLV_NRD_NRD_1	583	585	PF00675	0.439
CLV_NRD_NRD_1	620	622	PF00675	0.566
CLV_NRD_NRD_1	626	628	PF00675	0.517
CLV_NRD_NRD_1	634	636	PF00675	0.467
CLV_NRD_NRD_1	656	658	PF00675	0.364
CLV_NRD_NRD_1	711	713	PF00675	0.446
CLV_NRD_NRD_1	933	935	PF00675	0.357
CLV_NRD_NRD_1	938	940	PF00675	0.362
CLV_NRD_NRD_1	953	955	PF00675	0.558
CLV_PCSK_FUR_1	50	54	PF00082	0.592
CLV_PCSK_FUR_1	631	635	PF00082	0.512
CLV_PCSK_FUR_1	930	934	PF00082	0.444
CLV_PCSK_KEX2_1	208	210	PF00082	0.515
CLV_PCSK_KEX2_1	287	289	PF00082	0.634
CLV_PCSK_KEX2_1	345	347	PF00082	0.537
CLV_PCSK_KEX2_1	350	352	PF00082	0.513
CLV_PCSK_KEX2_1	367	369	PF00082	0.520
CLV_PCSK_KEX2_1	52	54	PF00082	0.574
CLV_PCSK_KEX2_1	523	525	PF00082	0.525
CLV_PCSK_KEX2_1	633	635	PF00082	0.511
CLV_PCSK_KEX2_1	650	652	PF00082	0.342
CLV_PCSK_KEX2_1	656	658	PF00082	0.341
CLV_PCSK_KEX2_1	932	934	PF00082	0.355
CLV_PCSK_KEX2_1	937	939	PF00082	0.358
CLV_PCSK_KEX2_1	953	955	PF00082	0.558
CLV_PCSK_KEX2_1	983	985	PF00082	0.538
CLV_PCSK_PC1ET2_1	208	210	PF00082	0.515
CLV_PCSK_PC1ET2_1	287	289	PF00082	0.634
CLV_PCSK_PC1ET2_1	350	352	PF00082	0.539
CLV_PCSK_PC1ET2_1	367	369	PF00082	0.520
CLV_PCSK_PC1ET2_1	523	525	PF00082	0.543
CLV_PCSK_PC1ET2_1	650	652	PF00082	0.359
CLV_PCSK_PC1ET2_1	656	658	PF00082	0.320
CLV_PCSK_PC1ET2_1	983	985	PF00082	0.627
CLV_PCSK_PC7_1	346	352	PF00082	0.660
CLV_PCSK_PC7_1	933	939	PF00082	0.403
CLV_PCSK_SKI1_1	112	116	PF00082	0.695
CLV_PCSK_SKI1_1	17	21	PF00082	0.649
CLV_PCSK_SKI1_1	268	272	PF00082	0.442
CLV_PCSK_SKI1_1	274	278	PF00082	0.463
CLV_PCSK_SKI1_1	367	371	PF00082	0.548
CLV_PCSK_SKI1_1	407	411	PF00082	0.545
CLV_PCSK_SKI1_1	42	46	PF00082	0.669
CLV_PCSK_SKI1_1	425	429	PF00082	0.706
CLV_PCSK_SKI1_1	459	463	PF00082	0.473
CLV_PCSK_SKI1_1	508	512	PF00082	0.474
CLV_PCSK_SKI1_1	650	654	PF00082	0.331
CLV_PCSK_SKI1_1	789	793	PF00082	0.485
CLV_Separin_Metazoa	422	426	PF03568	0.761
DEG_APCC_DBOX_1	826	834	PF00400	0.636
DEG_SPOP_SBC_1	834	838	PF00917	0.481
DOC_CKS1_1	996	1001	PF01111	0.533
DOC_CYCLIN_RxL_1	1	11	PF00134	0.519
DOC_CYCLIN_yCln2_LP_2	701	707	PF00134	0.444
DOC_MAPK_gen_1	223	232	PF00069	0.739
DOC_MAPK_gen_1	274	282	PF00069	0.620
DOC_MAPK_MEF2A_6	274	282	PF00069	0.661
DOC_PP1_RVXF_1	15	21	PF00149	0.728
DOC_PP1_RVXF_1	2	9	PF00149	0.742
DOC_PP2B_LxvP_1	701	704	PF13499	0.444
DOC_PP4_FxxP_1	328	331	PF00568	0.487
DOC_USP7_MATH_1	1013	1017	PF00917	0.738
DOC_USP7_MATH_1	184	188	PF00917	0.733
DOC_USP7_MATH_1	293	297	PF00917	0.800
DOC_USP7_MATH_1	430	434	PF00917	0.714
DOC_USP7_MATH_1	437	441	PF00917	0.695
DOC_USP7_MATH_1	475	479	PF00917	0.650
DOC_USP7_MATH_1	538	542	PF00917	0.768
DOC_USP7_MATH_1	834	838	PF00917	0.481
DOC_USP7_MATH_1	871	875	PF00917	0.485
DOC_USP7_UBL2_3	167	171	PF12436	0.682
DOC_USP7_UBL2_3	219	223	PF12436	0.619
DOC_USP7_UBL2_3	353	357	PF12436	0.706
DOC_USP7_UBL2_3	367	371	PF12436	0.436
DOC_USP7_UBL2_3	477	481	PF12436	0.722
DOC_USP7_UBL2_3	783	787	PF12436	0.683
DOC_WW_Pin1_4	300	305	PF00397	0.768
DOC_WW_Pin1_4	995	1000	PF00397	0.525
LIG_14-3-3_CanoR_1	123	133	PF00244	0.729
LIG_14-3-3_CanoR_1	274	279	PF00244	0.501
LIG_14-3-3_CanoR_1	4	9	PF00244	0.524
LIG_14-3-3_CanoR_1	425	435	PF00244	0.723
LIG_14-3-3_CanoR_1	452	461	PF00244	0.640
LIG_14-3-3_CanoR_1	850	856	PF00244	0.562
LIG_Actin_WH2_2	266	283	PF00022	0.634
LIG_AP2alpha_1	795	799	PF02296	0.764
LIG_BRCT_BRCA1_1	502	506	PF00533	0.654
LIG_EVH1_2	891	895	PF00568	0.233
LIG_FHA_1	150	156	PF00498	0.766
LIG_FHA_1	275	281	PF00498	0.593
LIG_FHA_1	418	424	PF00498	0.624
LIG_FHA_1	615	621	PF00498	0.723
LIG_FHA_1	749	755	PF00498	0.742
LIG_FHA_1	894	900	PF00498	0.344
LIG_FHA_1	959	965	PF00498	0.545
LIG_FHA_2	105	111	PF00498	0.763
LIG_FHA_2	177	183	PF00498	0.628
LIG_FHA_2	213	219	PF00498	0.667
LIG_FHA_2	24	30	PF00498	0.540
LIG_FHA_2	306	312	PF00498	0.578
LIG_FHA_2	359	365	PF00498	0.537
LIG_FHA_2	437	443	PF00498	0.737
LIG_FHA_2	841	847	PF00498	0.663
LIG_FHA_2	870	876	PF00498	0.420
LIG_GBD_Chelix_1	977	985	PF00786	0.623
LIG_LIR_Apic_2	607	611	PF02991	0.634
LIG_LIR_Gen_1	420	427	PF02991	0.765
LIG_LIR_Gen_1	447	454	PF02991	0.449
LIG_LIR_Gen_1	553	562	PF02991	0.601
LIG_LIR_Nem_3	420	424	PF02991	0.722
LIG_LIR_Nem_3	447	453	PF02991	0.457
LIG_LIR_Nem_3	553	558	PF02991	0.619
LIG_LIR_Nem_3	859	865	PF02991	0.344
LIG_LIR_Nem_3	952	958	PF02991	0.525
LIG_LYPXL_L_2	814	823	PF13949	0.648
LIG_NRP_CendR_1	1052	1055	PF00754	0.684
LIG_Pex14_1	577	581	PF04695	0.508
LIG_Pex14_2	506	510	PF04695	0.498
LIG_Pex14_2	795	799	PF04695	0.764
LIG_Rb_pABgroove_1	712	720	PF01858	0.485
LIG_SH2_CRK	555	559	PF00017	0.546
LIG_SH2_CRK	955	959	PF00017	0.612
LIG_SH2_STAP1	200	204	PF00017	0.533
LIG_SH2_STAP1	555	559	PF00017	0.433
LIG_SH2_STAP1	919	923	PF00017	0.344
LIG_SH2_STAT3	204	207	PF00017	0.610
LIG_SH2_STAT3	586	589	PF00017	0.583
LIG_SH2_STAT5	1019	1022	PF00017	0.644
LIG_SH2_STAT5	140	143	PF00017	0.560
LIG_SH2_STAT5	735	738	PF00017	0.444
LIG_SH2_STAT5	922	925	PF00017	0.344
LIG_SH3_1	67	73	PF00018	0.750
LIG_SH3_3	1007	1013	PF00018	0.547
LIG_SH3_3	128	134	PF00018	0.647
LIG_SH3_3	301	307	PF00018	0.736
LIG_SH3_3	67	73	PF00018	0.724
LIG_SH3_3	701	707	PF00018	0.444
LIG_SH3_3	755	761	PF00018	0.494
LIG_SH3_3	989	995	PF00018	0.679
LIG_SUMO_SIM_anti_2	808	815	PF11976	0.536
LIG_SUMO_SIM_par_1	893	901	PF11976	0.344
LIG_TRAF2_1	107	110	PF00917	0.747
LIG_TRAF2_1	319	322	PF00917	0.567
LIG_TRAF2_1	331	334	PF00917	0.415
LIG_TRAF2_1	384	387	PF00917	0.685
LIG_TRAF2_1	454	457	PF00917	0.604
LIG_TRAF2_1	541	544	PF00917	0.692
LIG_TRAF2_1	562	565	PF00917	0.600
LIG_TRAF2_1	591	594	PF00917	0.673
LIG_TRAF2_1	768	771	PF00917	0.582
LIG_TRAF2_1	898	901	PF00917	0.344
LIG_TRAF2_2	966	971	PF00917	0.703
LIG_UBA3_1	775	783	PF00899	0.436
LIG_UBA3_1	847	856	PF00899	0.569
MOD_CK1_1	1017	1023	PF00069	0.639
MOD_CK1_1	1025	1031	PF00069	0.658
MOD_CK1_1	22	28	PF00069	0.586
MOD_CK1_1	303	309	PF00069	0.786
MOD_CK1_1	417	423	PF00069	0.608
MOD_CK1_1	550	556	PF00069	0.626
MOD_CK1_1	74	80	PF00069	0.743
MOD_CK1_1	774	780	PF00069	0.631
MOD_CK1_1	803	809	PF00069	0.579
MOD_CK1_1	873	879	PF00069	0.233
MOD_CK1_1	948	954	PF00069	0.631
MOD_CK1_1	98	104	PF00069	0.671
MOD_CK2_1	100	106	PF00069	0.758
MOD_CK2_1	1025	1031	PF00069	0.536
MOD_CK2_1	184	190	PF00069	0.796
MOD_CK2_1	212	218	PF00069	0.666
MOD_CK2_1	231	237	PF00069	0.560
MOD_CK2_1	241	247	PF00069	0.711
MOD_CK2_1	25	31	PF00069	0.753
MOD_CK2_1	309	315	PF00069	0.543
MOD_CK2_1	381	387	PF00069	0.618
MOD_CK2_1	436	442	PF00069	0.732
MOD_CK2_1	452	458	PF00069	0.508
MOD_CK2_1	538	544	PF00069	0.683
MOD_CK2_1	569	575	PF00069	0.397
MOD_CK2_1	673	679	PF00069	0.233
MOD_CK2_1	765	771	PF00069	0.588
MOD_CK2_1	840	846	PF00069	0.641
MOD_CK2_1	895	901	PF00069	0.344
MOD_Cter_Amidation	478	481	PF01082	0.738
MOD_GlcNHglycan	135	138	PF01048	0.707
MOD_GlcNHglycan	146	150	PF01048	0.665
MOD_GlcNHglycan	284	287	PF01048	0.769
MOD_GlcNHglycan	295	298	PF01048	0.625
MOD_GlcNHglycan	415	419	PF01048	0.503
MOD_GlcNHglycan	428	431	PF01048	0.749
MOD_GlcNHglycan	441	446	PF01048	0.700
MOD_GlcNHglycan	470	473	PF01048	0.610
MOD_GlcNHglycan	477	480	PF01048	0.716
MOD_GlcNHglycan	486	489	PF01048	0.648
MOD_GlcNHglycan	548	552	PF01048	0.740
MOD_GlcNHglycan	59	62	PF01048	0.695
MOD_GlcNHglycan	600	603	PF01048	0.754
MOD_GlcNHglycan	74	77	PF01048	0.685
MOD_GlcNHglycan	776	779	PF01048	0.645
MOD_GlcNHglycan	789	792	PF01048	0.555
MOD_GlcNHglycan	8	11	PF01048	0.763
MOD_GlcNHglycan	804	808	PF01048	0.495
MOD_GlcNHglycan	875	878	PF01048	0.433
MOD_GSK3_1	1013	1020	PF00069	0.753
MOD_GSK3_1	119	126	PF00069	0.806
MOD_GSK3_1	145	152	PF00069	0.746
MOD_GSK3_1	172	179	PF00069	0.610
MOD_GSK3_1	19	26	PF00069	0.537
MOD_GSK3_1	236	243	PF00069	0.722
MOD_GSK3_1	305	312	PF00069	0.718
MOD_GSK3_1	4	11	PF00069	0.721
MOD_GSK3_1	426	433	PF00069	0.777
MOD_GSK3_1	437	444	PF00069	0.561
MOD_GSK3_1	466	473	PF00069	0.541
MOD_GSK3_1	71	78	PF00069	0.721
MOD_GSK3_1	799	806	PF00069	0.668
MOD_GSK3_1	834	841	PF00069	0.691
MOD_GSK3_1	869	876	PF00069	0.233
MOD_GSK3_1	945	952	PF00069	0.628
MOD_GSK3_1	95	102	PF00069	0.668
MOD_N-GLC_1	262	267	PF02516	0.580
MOD_N-GLC_1	500	505	PF02516	0.520
MOD_N-GLC_1	748	753	PF02516	0.632
MOD_N-GLC_1	979	984	PF02516	0.593
MOD_NEK2_1	124	129	PF00069	0.715
MOD_NEK2_1	174	179	PF00069	0.698
MOD_NEK2_1	280	285	PF00069	0.713
MOD_NEK2_1	466	471	PF00069	0.588
MOD_NEK2_1	6	11	PF00069	0.674
MOD_NEK2_1	666	671	PF00069	0.335
MOD_NEK2_1	673	678	PF00069	0.341
MOD_NEK2_1	833	838	PF00069	0.690
MOD_NEK2_1	851	856	PF00069	0.541
MOD_PKA_1	274	280	PF00069	0.549
MOD_PKA_1	785	791	PF00069	0.644
MOD_PKA_2	1034	1040	PF00069	0.750
MOD_PKA_2	175	181	PF00069	0.673
MOD_PKA_2	280	286	PF00069	0.719
MOD_PKA_2	475	481	PF00069	0.508
MOD_PKA_2	949	955	PF00069	0.541
MOD_PKB_1	1003	1011	PF00069	0.553
MOD_Plk_1	112	118	PF00069	0.579
MOD_Plk_1	119	125	PF00069	0.572
MOD_Plk_1	262	268	PF00069	0.585
MOD_Plk_1	288	294	PF00069	0.536
MOD_Plk_1	310	316	PF00069	0.723
MOD_Plk_1	893	899	PF00069	0.344
MOD_Plk_2-3	104	110	PF00069	0.720
MOD_Plk_2-3	212	218	PF00069	0.629
MOD_Plk_2-3	236	242	PF00069	0.706
MOD_Plk_2-3	358	364	PF00069	0.435
MOD_Plk_2-3	741	747	PF00069	0.541
MOD_Plk_4	550	556	PF00069	0.686
MOD_Plk_4	759	765	PF00069	0.706
MOD_Plk_4	771	777	PF00069	0.578
MOD_Plk_4	809	815	PF00069	0.629
MOD_ProDKin_1	300	306	PF00069	0.770
MOD_ProDKin_1	995	1001	PF00069	0.529
MOD_SUMO_for_1	319	322	PF00179	0.631
MOD_SUMO_for_1	545	548	PF00179	0.539
MOD_SUMO_rev_2	104	114	PF00179	0.800
MOD_SUMO_rev_2	177	187	PF00179	0.525
MOD_SUMO_rev_2	233	239	PF00179	0.530
MOD_SUMO_rev_2	363	369	PF00179	0.648
MOD_SUMO_rev_2	402	406	PF00179	0.588
MOD_SUMO_rev_2	455	461	PF00179	0.550
MOD_SUMO_rev_2	647	652	PF00179	0.444
MOD_SUMO_rev_2	706	715	PF00179	0.351
TRG_DiLeu_BaEn_1	457	462	PF01217	0.518
TRG_DiLeu_BaEn_3	770	776	PF01217	0.557
TRG_DiLeu_BaEn_4	457	463	PF01217	0.550
TRG_DiLeu_BaEn_4	647	653	PF01217	0.444
TRG_DiLeu_BaEn_4	684	690	PF01217	0.233
TRG_DiLeu_BaEn_4	860	866	PF01217	0.444
TRG_DiLeu_BaEn_4	900	906	PF01217	0.444
TRG_ENDOCYTIC_2	555	558	PF00928	0.556
TRG_ENDOCYTIC_2	862	865	PF00928	0.325
TRG_ENDOCYTIC_2	887	890	PF00928	0.325
TRG_ENDOCYTIC_2	955	958	PF00928	0.512
TRG_ER_diArg_1	1051	1054	PF00400	0.656
TRG_ER_diArg_1	345	347	PF00400	0.653
TRG_ER_diArg_1	62	65	PF00400	0.705
TRG_ER_diArg_1	631	634	PF00400	0.511
TRG_ER_diArg_1	932	934	PF00400	0.378
TRG_ER_diArg_1	937	939	PF00400	0.360
TRG_ER_diArg_1	953	955	PF00400	0.558
TRG_NLS_Bipartite_1	633	654	PF00514	0.444
TRG_NLS_MonoCore_2	349	354	PF00514	0.504
TRG_NLS_MonoExtC_3	393	398	PF00514	0.661
TRG_NLS_MonoExtC_3	521	526	PF00514	0.729
TRG_NLS_MonoExtC_3	784	789	PF00514	0.694
TRG_NLS_MonoExtN_4	522	527	PF00514	0.666
TRG_NLS_MonoExtN_4	783	790	PF00514	0.723
TRG_Pf-PMV_PEXEL_1	394	399	PF00026	0.620
TRG_Pf-PMV_PEXEL_1	459	463	PF00026	0.496
TRG_Pf-PMV_PEXEL_1	610	614	PF00026	0.577
TRG_Pf-PMV_PEXEL_1	944	949	PF00026	0.452
TRG_Pf-PMV_PEXEL_1	983	987	PF00026	0.568

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HZY8	Leptomonas seymouri	60%	100%
A0A1X0NGP0	Trypanosomatidae	38%	100%
A0A3R7NCJ6	Trypanosoma rangeli	40%	100%
A0A3S7X904	Leishmania donovani	79%	100%
A4IB05	Leishmania infantum	79%	100%
E9AET3	Leishmania major	80%	100%
E9B5Y8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	78%	100%
V5ATL2	Trypanosoma cruzi	36%	100%