Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HFF4_LEIBR

TriTrypDb:

LbrM.27.0370 , LBRM2903_270008700

Length:

592

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HFF4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HFF4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	172	176	PF00656	0.557
CLV_C14_Caspase3-7	237	241	PF00656	0.665
CLV_C14_Caspase3-7	282	286	PF00656	0.819
CLV_C14_Caspase3-7	89	93	PF00656	0.801
CLV_NRD_NRD_1	107	109	PF00675	0.742
CLV_NRD_NRD_1	111	113	PF00675	0.733
CLV_NRD_NRD_1	117	119	PF00675	0.699
CLV_NRD_NRD_1	134	136	PF00675	0.841
CLV_NRD_NRD_1	155	157	PF00675	0.777
CLV_NRD_NRD_1	18	20	PF00675	0.864
CLV_NRD_NRD_1	215	217	PF00675	0.714
CLV_NRD_NRD_1	238	240	PF00675	0.731
CLV_NRD_NRD_1	271	273	PF00675	0.744
CLV_NRD_NRD_1	292	294	PF00675	0.694
CLV_NRD_NRD_1	386	388	PF00675	0.528
CLV_NRD_NRD_1	419	421	PF00675	0.669
CLV_NRD_NRD_1	489	491	PF00675	0.536
CLV_NRD_NRD_1	586	588	PF00675	0.527
CLV_NRD_NRD_1	60	62	PF00675	0.758
CLV_NRD_NRD_1	67	69	PF00675	0.690
CLV_NRD_NRD_1	84	86	PF00675	0.534
CLV_NRD_NRD_1	87	89	PF00675	0.548
CLV_PCSK_FUR_1	108	112	PF00082	0.757
CLV_PCSK_FUR_1	213	217	PF00082	0.581
CLV_PCSK_FUR_1	384	388	PF00082	0.528
CLV_PCSK_FUR_1	58	62	PF00082	0.825
CLV_PCSK_FUR_1	85	89	PF00082	0.576
CLV_PCSK_KEX2_1	107	109	PF00082	0.749
CLV_PCSK_KEX2_1	110	112	PF00082	0.728
CLV_PCSK_KEX2_1	117	119	PF00082	0.683
CLV_PCSK_KEX2_1	134	136	PF00082	0.841
CLV_PCSK_KEX2_1	139	141	PF00082	0.723
CLV_PCSK_KEX2_1	17	19	PF00082	0.663
CLV_PCSK_KEX2_1	215	217	PF00082	0.714
CLV_PCSK_KEX2_1	230	232	PF00082	0.676
CLV_PCSK_KEX2_1	238	240	PF00082	0.692
CLV_PCSK_KEX2_1	271	273	PF00082	0.744
CLV_PCSK_KEX2_1	292	294	PF00082	0.673
CLV_PCSK_KEX2_1	386	388	PF00082	0.483
CLV_PCSK_KEX2_1	586	588	PF00082	0.527
CLV_PCSK_KEX2_1	60	62	PF00082	0.753
CLV_PCSK_KEX2_1	67	69	PF00082	0.694
CLV_PCSK_KEX2_1	84	86	PF00082	0.535
CLV_PCSK_KEX2_1	87	89	PF00082	0.549
CLV_PCSK_PC1ET2_1	139	141	PF00082	0.760
CLV_PCSK_PC1ET2_1	230	232	PF00082	0.667
CLV_PCSK_PC7_1	107	113	PF00082	0.696
CLV_PCSK_PC7_1	135	141	PF00082	0.747
CLV_PCSK_SKI1_1	230	234	PF00082	0.643
CLV_PCSK_SKI1_1	353	357	PF00082	0.491
CLV_PCSK_SKI1_1	390	394	PF00082	0.635
CLV_PCSK_SKI1_1	490	494	PF00082	0.688
CLV_PCSK_SKI1_1	569	573	PF00082	0.387
DEG_APCC_DBOX_1	352	360	PF00400	0.496
DEG_SPOP_SBC_1	442	446	PF00917	0.715
DOC_ANK_TNKS_1	60	67	PF00023	0.856
DOC_CKS1_1	541	546	PF01111	0.781
DOC_CYCLIN_RxL_1	228	237	PF00134	0.673
DOC_CYCLIN_yCln2_LP_2	535	541	PF00134	0.526
DOC_PP1_RVXF_1	229	236	PF00149	0.676
DOC_PP2B_LxvP_1	413	416	PF13499	0.661
DOC_PP2B_LxvP_1	533	536	PF13499	0.571
DOC_PP4_MxPP_1	263	266	PF00568	0.681
DOC_USP7_MATH_1	179	183	PF00917	0.671
DOC_USP7_MATH_1	193	197	PF00917	0.809
DOC_USP7_MATH_1	280	284	PF00917	0.613
DOC_USP7_MATH_1	416	420	PF00917	0.668
DOC_USP7_MATH_1	43	47	PF00917	0.564
DOC_USP7_MATH_1	442	446	PF00917	0.812
DOC_USP7_MATH_1	571	575	PF00917	0.599
DOC_USP7_MATH_1	73	77	PF00917	0.714
DOC_WW_Pin1_4	11	16	PF00397	0.574
DOC_WW_Pin1_4	540	545	PF00397	0.651
LIG_14-3-3_CanoR_1	120	128	PF00244	0.843
LIG_14-3-3_CanoR_1	300	306	PF00244	0.746
LIG_14-3-3_CanoR_1	420	428	PF00244	0.547
LIG_14-3-3_CanoR_1	490	497	PF00244	0.543
LIG_14-3-3_CanoR_1	78	86	PF00244	0.738
LIG_14-3-3_CterR_2	587	592	PF00244	0.520
LIG_BIR_III_4	240	244	PF00653	0.685
LIG_FHA_1	334	340	PF00498	0.521
LIG_FHA_1	423	429	PF00498	0.709
LIG_FHA_1	431	437	PF00498	0.481
LIG_FHA_1	463	469	PF00498	0.644
LIG_FHA_1	491	497	PF00498	0.558
LIG_FHA_1	502	508	PF00498	0.514
LIG_FHA_1	541	547	PF00498	0.557
LIG_FHA_2	145	151	PF00498	0.582
LIG_FHA_2	72	78	PF00498	0.701
LIG_Integrin_isoDGR_2	584	586	PF01839	0.559
LIG_LIR_Apic_2	328	334	PF02991	0.676
LIG_LIR_Gen_1	94	105	PF02991	0.532
LIG_LIR_Nem_3	94	100	PF02991	0.812
LIG_PTB_Apo_2	423	430	PF02174	0.524
LIG_PTB_Apo_2	576	583	PF02174	0.524
LIG_PTB_Phospho_1	576	582	PF10480	0.528
LIG_SH2_CRK	331	335	PF00017	0.497
LIG_SH2_CRK	409	413	PF00017	0.561
LIG_SH2_GRB2like	127	130	PF00017	0.569
LIG_SH2_GRB2like	582	585	PF00017	0.549
LIG_SH2_NCK_1	331	335	PF00017	0.664
LIG_SH2_SRC	547	550	PF00017	0.664
LIG_SH2_SRC	582	585	PF00017	0.549
LIG_SH2_STAT5	547	550	PF00017	0.675
LIG_SH2_STAT5	582	585	PF00017	0.549
LIG_SH3_3	194	200	PF00018	0.635
LIG_SH3_3	258	264	PF00018	0.609
LIG_SH3_3	382	388	PF00018	0.532
LIG_SH3_3	535	541	PF00018	0.695
LIG_SH3_3	543	549	PF00018	0.681
LIG_SH3_3	551	557	PF00018	0.641
LIG_SUMO_SIM_par_1	559	564	PF11976	0.505
MOD_CDC14_SPxK_1	14	17	PF00782	0.578
MOD_CDK_SPxK_1	11	17	PF00069	0.578
MOD_CDK_SPxxK_3	11	18	PF00069	0.579
MOD_CK1_1	170	176	PF00069	0.659
MOD_CK1_1	20	26	PF00069	0.772
MOD_CK1_1	303	309	PF00069	0.561
MOD_CK1_1	319	325	PF00069	0.702
MOD_CK1_1	326	332	PF00069	0.685
MOD_CK1_1	366	372	PF00069	0.531
MOD_CK1_1	419	425	PF00069	0.705
MOD_CK1_1	431	437	PF00069	0.542
MOD_CK1_1	462	468	PF00069	0.746
MOD_CK2_1	118	124	PF00069	0.832
MOD_CK2_1	473	479	PF00069	0.524
MOD_CK2_1	496	502	PF00069	0.543
MOD_CK2_1	71	77	PF00069	0.707
MOD_CK2_1	90	96	PF00069	0.777
MOD_Cter_Amidation	132	135	PF01082	0.741
MOD_Cter_Amidation	137	140	PF01082	0.741
MOD_Cter_Amidation	584	587	PF01082	0.559
MOD_Cter_Amidation	65	68	PF01082	0.586
MOD_GlcNHglycan	143	147	PF01048	0.809
MOD_GlcNHglycan	172	175	PF01048	0.657
MOD_GlcNHglycan	240	244	PF01048	0.685
MOD_GlcNHglycan	285	289	PF01048	0.741
MOD_GlcNHglycan	421	424	PF01048	0.632
MOD_GlcNHglycan	430	433	PF01048	0.560
MOD_GlcNHglycan	438	441	PF01048	0.800
MOD_GlcNHglycan	445	448	PF01048	0.766
MOD_GlcNHglycan	493	496	PF01048	0.745
MOD_GlcNHglycan	504	507	PF01048	0.661
MOD_GlcNHglycan	6	9	PF01048	0.735
MOD_GlcNHglycan	62	65	PF01048	0.762
MOD_GSK3_1	198	205	PF00069	0.763
MOD_GSK3_1	280	287	PF00069	0.555
MOD_GSK3_1	316	323	PF00069	0.706
MOD_GSK3_1	359	366	PF00069	0.560
MOD_GSK3_1	415	422	PF00069	0.741
MOD_GSK3_1	452	459	PF00069	0.796
MOD_GSK3_1	73	80	PF00069	0.842
MOD_N-GLC_1	319	324	PF02516	0.718
MOD_N-GLC_1	399	404	PF02516	0.535
MOD_N-GLC_1	4	9	PF02516	0.697
MOD_N-GLC_1	436	441	PF02516	0.770
MOD_N-GLC_1	457	462	PF02516	0.729
MOD_N-GLC_1	524	529	PF02516	0.559
MOD_NEK2_1	152	157	PF00069	0.559
MOD_NEK2_1	169	174	PF00069	0.642
MOD_NEK2_1	203	208	PF00069	0.623
MOD_NEK2_1	251	256	PF00069	0.487
MOD_NEK2_1	361	366	PF00069	0.640
MOD_NEK2_1	428	433	PF00069	0.588
MOD_NEK2_1	472	477	PF00069	0.685
MOD_PIKK_1	118	124	PF00454	0.615
MOD_PKA_1	17	23	PF00069	0.587
MOD_PKA_1	490	496	PF00069	0.541
MOD_PKA_1	60	66	PF00069	0.749
MOD_PKA_2	103	109	PF00069	0.718
MOD_PKA_2	152	158	PF00069	0.639
MOD_PKA_2	17	23	PF00069	0.815
MOD_PKA_2	301	307	PF00069	0.559
MOD_PKA_2	419	425	PF00069	0.535
MOD_PKA_2	43	49	PF00069	0.831
MOD_PKA_2	53	59	PF00069	0.825
MOD_PKA_2	60	66	PF00069	0.764
MOD_PKA_2	77	83	PF00069	0.565
MOD_PKB_1	118	126	PF00069	0.739
MOD_PKB_1	140	148	PF00069	0.568
MOD_PKB_1	58	66	PF00069	0.582
MOD_PKB_1	88	96	PF00069	0.556
MOD_Plk_1	251	257	PF00069	0.492
MOD_Plk_1	319	325	PF00069	0.723
MOD_Plk_1	359	365	PF00069	0.525
MOD_Plk_1	463	469	PF00069	0.734
MOD_Plk_1	473	479	PF00069	0.793
MOD_Plk_1	524	530	PF00069	0.613
MOD_Plk_2-3	45	51	PF00069	0.829
MOD_Plk_2-3	96	102	PF00069	0.667
MOD_Plk_4	326	332	PF00069	0.689
MOD_Plk_4	367	373	PF00069	0.491
MOD_Plk_4	431	437	PF00069	0.548
MOD_Plk_4	524	530	PF00069	0.558
MOD_ProDKin_1	11	17	PF00069	0.578
MOD_ProDKin_1	540	546	PF00069	0.648
MOD_SUMO_rev_2	486	493	PF00179	0.541
MOD_SUMO_rev_2	564	571	PF00179	0.341
TRG_ENDOCYTIC_2	97	100	PF00928	0.809
TRG_ER_diArg_1	107	109	PF00400	0.774
TRG_ER_diArg_1	110	112	PF00400	0.751
TRG_ER_diArg_1	17	19	PF00400	0.862
TRG_ER_diArg_1	213	216	PF00400	0.716
TRG_ER_diArg_1	270	272	PF00400	0.716
TRG_ER_diArg_1	275	278	PF00400	0.718
TRG_ER_diArg_1	291	293	PF00400	0.726
TRG_ER_diArg_1	383	386	PF00400	0.538
TRG_ER_diArg_1	58	61	PF00400	0.627
TRG_ER_diArg_1	586	588	PF00400	0.527
TRG_ER_diArg_1	84	87	PF00400	0.709

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3L5	Leptomonas seymouri	51%	100%
A0A3S7X8W4	Leishmania donovani	66%	100%
A4IB03	Leishmania infantum	66%	100%
E9AET1	Leishmania major	67%	97%
E9B5Y6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	65%	100%