Protein kinase domain-containing protein

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

protein kinase, putative

Species:

Leishmania braziliensis

UniProt:

A4HFF3_LEIBR

TriTrypDb:

LbrM.27.0360 , LBRM2903_270008600

Length:

500

Annotations

LeishMANIAdb annotations

A large and apprently artificial collection of diverse kinetoplastid protein kinases. None of them appear to be TM.

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005737	cytoplasm	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1
GO:0005964	phosphorylase kinase complex	7	1
GO:0032991	protein-containing complex	1	1
GO:0061695	transferase complex, transferring phosphorus-containing groups	4	1
GO:1902494	catalytic complex	2	1
GO:1902554	serine/threonine protein kinase complex	6	1
GO:1902911	protein kinase complex	5	1
GO:1990234	transferase complex	3	1

Expansion

Sequence features

A4HFF3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HFF3

Function

Biological processes
Term	Name	Level	Count
GO:0006468	protein phosphorylation	5	10
GO:0006793	phosphorus metabolic process	3	10
GO:0006796	phosphate-containing compound metabolic process	4	10
GO:0006807	nitrogen compound metabolic process	2	10
GO:0008152	metabolic process	1	10
GO:0009987	cellular process	1	10
GO:0016310	phosphorylation	5	10
GO:0019538	protein metabolic process	3	10
GO:0036211	protein modification process	4	10
GO:0043170	macromolecule metabolic process	3	10
GO:0043412	macromolecule modification	4	10
GO:0044237	cellular metabolic process	2	10
GO:0044238	primary metabolic process	2	10
GO:0071704	organic substance metabolic process	2	10
GO:1901564	organonitrogen compound metabolic process	3	10
GO:0007165	signal transduction	2	1
GO:0018105	peptidyl-serine phosphorylation	6	1
GO:0018193	peptidyl-amino acid modification	5	1
GO:0018209	peptidyl-serine modification	6	1
GO:0035556	intracellular signal transduction	3	1
GO:0046777	protein autophosphorylation	6	1
GO:0050789	regulation of biological process	2	1
GO:0050794	regulation of cellular process	3	1
GO:0065007	biological regulation	1	1
GO:0000271	polysaccharide biosynthetic process	5	1
GO:0005975	carbohydrate metabolic process	3	1
GO:0005976	polysaccharide metabolic process	4	1
GO:0005977	glycogen metabolic process	6	1
GO:0005978	glycogen biosynthetic process	7	1
GO:0006073	obsolete cellular glucan metabolic process	5	1
GO:0006091	generation of precursor metabolites and energy	3	1
GO:0006112	energy reserve metabolic process	5	1
GO:0009058	biosynthetic process	2	1
GO:0009059	macromolecule biosynthetic process	4	1
GO:0009250	glucan biosynthetic process	6	1
GO:0015980	energy derivation by oxidation of organic compounds	4	1
GO:0016051	carbohydrate biosynthetic process	4	1
GO:0033692	obsolete cellular polysaccharide biosynthetic process	5	1
GO:0034637	obsolete cellular carbohydrate biosynthetic process	4	1
GO:0034645	obsolete cellular macromolecule biosynthetic process	4	1
GO:0044042	glucan metabolic process	5	1
GO:0044249	cellular biosynthetic process	3	1
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0044262	obsolete cellular carbohydrate metabolic process	3	1
GO:0044264	obsolete cellular polysaccharide metabolic process	4	1
GO:1901576	organic substance biosynthetic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	10
GO:0003824	catalytic activity	1	10
GO:0004672	protein kinase activity	3	10
GO:0004674	protein serine/threonine kinase activity	4	7
GO:0005488	binding	1	10
GO:0005524	ATP binding	5	10
GO:0016301	kinase activity	4	10
GO:0016740	transferase activity	2	10
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	10
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	10
GO:0017076	purine nucleotide binding	4	10
GO:0030554	adenyl nucleotide binding	5	10
GO:0032553	ribonucleotide binding	3	10
GO:0032555	purine ribonucleotide binding	4	10
GO:0032559	adenyl ribonucleotide binding	5	10
GO:0035639	purine ribonucleoside triphosphate binding	4	10
GO:0036094	small molecule binding	2	10
GO:0043167	ion binding	2	10
GO:0043168	anion binding	3	10
GO:0097159	organic cyclic compound binding	2	10
GO:0097367	carbohydrate derivative binding	2	10
GO:0140096	catalytic activity, acting on a protein	2	10
GO:1901265	nucleoside phosphate binding	3	10
GO:1901363	heterocyclic compound binding	2	10
GO:0004683	calmodulin-dependent protein kinase activity	5	2
GO:0005515	protein binding	2	2
GO:0005516	calmodulin binding	3	2
GO:0009931	calcium-dependent protein serine/threonine kinase activity	5	1
GO:0010857	calcium-dependent protein kinase activity	4	1
GO:0004689	phosphorylase kinase activity	6	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	391	395	PF00656	0.700
CLV_NRD_NRD_1	289	291	PF00675	0.251
CLV_NRD_NRD_1	293	295	PF00675	0.251
CLV_NRD_NRD_1	498	500	PF00675	0.685
CLV_NRD_NRD_1	79	81	PF00675	0.283
CLV_PCSK_KEX2_1	289	291	PF00082	0.251
CLV_PCSK_KEX2_1	329	331	PF00082	0.275
CLV_PCSK_KEX2_1	79	81	PF00082	0.283
CLV_PCSK_PC1ET2_1	329	331	PF00082	0.275
CLV_PCSK_PC7_1	325	331	PF00082	0.174
CLV_PCSK_SKI1_1	147	151	PF00082	0.271
CLV_PCSK_SKI1_1	290	294	PF00082	0.251
CLV_PCSK_SKI1_1	329	333	PF00082	0.275
CLV_PCSK_SKI1_1	425	429	PF00082	0.565
CLV_PCSK_SKI1_1	477	481	PF00082	0.628
CLV_PCSK_SKI1_1	53	57	PF00082	0.258
CLV_PCSK_SKI1_1	75	79	PF00082	0.300
CLV_Separin_Metazoa	335	339	PF03568	0.368
CLV_Separin_Metazoa	76	80	PF03568	0.268
DEG_APCC_DBOX_1	289	297	PF00400	0.251
DEG_APCC_DBOX_1	446	454	PF00400	0.384
DEG_SCF_FBW7_1	223	230	PF00400	0.251
DEG_SPOP_SBC_1	411	415	PF00917	0.624
DOC_CKS1_1	11	16	PF01111	0.388
DOC_CYCLIN_yCln2_LP_2	3	6	PF00134	0.477
DOC_MAPK_gen_1	147	156	PF00069	0.251
DOC_MAPK_gen_1	294	302	PF00069	0.251
DOC_MAPK_gen_1	366	375	PF00069	0.545
DOC_MAPK_gen_1	477	486	PF00069	0.615
DOC_MAPK_MEF2A_6	150	158	PF00069	0.275
DOC_MAPK_MEF2A_6	202	209	PF00069	0.249
DOC_PP1_RVXF_1	96	102	PF00149	0.310
DOC_PP2B_LxvP_1	3	6	PF13499	0.477
DOC_PP2B_LxvP_1	390	393	PF13499	0.504
DOC_USP7_MATH_1	393	397	PF00917	0.563
DOC_USP7_MATH_1	404	408	PF00917	0.554
DOC_WW_Pin1_4	10	15	PF00397	0.399
DOC_WW_Pin1_4	179	184	PF00397	0.363
DOC_WW_Pin1_4	223	228	PF00397	0.251
DOC_WW_Pin1_4	385	390	PF00397	0.716
DOC_WW_Pin1_4	400	405	PF00397	0.502
LIG_14-3-3_CanoR_1	330	337	PF00244	0.251
LIG_14-3-3_CanoR_1	60	64	PF00244	0.376
LIG_14-3-3_CanoR_1	79	87	PF00244	0.267
LIG_Actin_RPEL_3	318	337	PF02755	0.174
LIG_deltaCOP1_diTrp_1	261	269	PF00928	0.251
LIG_eIF4E_1	100	106	PF01652	0.251
LIG_FHA_1	11	17	PF00498	0.392
LIG_FHA_1	250	256	PF00498	0.194
LIG_FHA_1	368	374	PF00498	0.640
LIG_FHA_1	385	391	PF00498	0.697
LIG_FHA_1	47	53	PF00498	0.250
LIG_FHA_2	173	179	PF00498	0.314
LIG_FHA_2	182	188	PF00498	0.345
LIG_FHA_2	21	27	PF00498	0.320
LIG_FHA_2	283	289	PF00498	0.253
LIG_FHA_2	330	336	PF00498	0.368
LIG_FHA_2	86	92	PF00498	0.310
LIG_LIR_Apic_2	230	236	PF02991	0.251
LIG_LIR_Gen_1	108	119	PF02991	0.287
LIG_LIR_Gen_1	88	97	PF02991	0.303
LIG_LIR_Nem_3	108	114	PF02991	0.267
LIG_LIR_Nem_3	88	93	PF02991	0.317
LIG_LIR_Nem_3	97	103	PF02991	0.343
LIG_PCNA_yPIPBox_3	107	118	PF02747	0.310
LIG_PTB_Apo_2	341	348	PF02174	0.362
LIG_PTB_Phospho_1	341	347	PF10480	0.277
LIG_Rb_pABgroove_1	19	27	PF01858	0.358
LIG_REV1ctd_RIR_1	425	435	PF16727	0.660
LIG_SH2_NCK_1	90	94	PF00017	0.247
LIG_SH2_PTP2	233	236	PF00017	0.251
LIG_SH2_PTP2	270	273	PF00017	0.406
LIG_SH2_STAT5	100	103	PF00017	0.299
LIG_SH2_STAT5	138	141	PF00017	0.275
LIG_SH2_STAT5	233	236	PF00017	0.251
LIG_SH2_STAT5	270	273	PF00017	0.406
LIG_SH2_STAT5	347	350	PF00017	0.455
LIG_SH3_2	472	477	PF14604	0.685
LIG_SH3_3	398	404	PF00018	0.499
LIG_SH3_3	469	475	PF00018	0.593
LIG_SH3_3	8	14	PF00018	0.399
LIG_SUMO_SIM_anti_2	482	488	PF11976	0.419
LIG_SUMO_SIM_par_1	387	394	PF11976	0.502
LIG_SUMO_SIM_par_1	85	91	PF11976	0.368
LIG_TRAF2_1	332	335	PF00917	0.332
LIG_TYR_ITIM	268	273	PF00017	0.406
LIG_TYR_ITSM	86	93	PF00017	0.247
LIG_UBA3_1	110	118	PF00899	0.310
MOD_CK1_1	167	173	PF00069	0.280
MOD_CK1_1	367	373	PF00069	0.539
MOD_CK1_1	413	419	PF00069	0.644
MOD_CK1_1	436	442	PF00069	0.603
MOD_CK2_1	181	187	PF00069	0.261
MOD_CK2_1	329	335	PF00069	0.368
MOD_CK2_1	85	91	PF00069	0.380
MOD_Cter_Amidation	64	67	PF01082	0.310
MOD_GlcNHglycan	133	136	PF01048	0.404
MOD_GlcNHglycan	263	266	PF01048	0.275
MOD_GSK3_1	164	171	PF00069	0.263
MOD_GSK3_1	190	197	PF00069	0.469
MOD_GSK3_1	223	230	PF00069	0.251
MOD_GSK3_1	325	332	PF00069	0.251
MOD_GSK3_1	384	391	PF00069	0.651
MOD_GSK3_1	400	407	PF00069	0.661
MOD_GSK3_1	410	417	PF00069	0.657
MOD_GSK3_1	429	436	PF00069	0.748
MOD_GSK3_1	466	473	PF00069	0.587
MOD_N-GLC_1	309	314	PF02516	0.266
MOD_NEK2_1	420	425	PF00069	0.526
MOD_NEK2_1	78	83	PF00069	0.225
MOD_NEK2_2	228	233	PF00069	0.251
MOD_NEK2_2	85	90	PF00069	0.358
MOD_PIKK_1	164	170	PF00454	0.196
MOD_PIKK_1	25	31	PF00454	0.403
MOD_PIKK_1	364	370	PF00454	0.425
MOD_PIKK_1	393	399	PF00454	0.591
MOD_PKA_1	329	335	PF00069	0.275
MOD_PKA_2	324	330	PF00069	0.180
MOD_PKA_2	59	65	PF00069	0.346
MOD_PKA_2	78	84	PF00069	0.197
MOD_Plk_1	140	146	PF00069	0.310
MOD_Plk_1	465	471	PF00069	0.574
MOD_Plk_2-3	20	26	PF00069	0.450
MOD_Plk_2-3	309	315	PF00069	0.200
MOD_Plk_4	140	146	PF00069	0.275
MOD_Plk_4	20	26	PF00069	0.384
MOD_Plk_4	228	234	PF00069	0.251
MOD_Plk_4	416	422	PF00069	0.602
MOD_Plk_4	59	65	PF00069	0.467
MOD_ProDKin_1	10	16	PF00069	0.395
MOD_ProDKin_1	179	185	PF00069	0.363
MOD_ProDKin_1	223	229	PF00069	0.251
MOD_ProDKin_1	385	391	PF00069	0.716
MOD_ProDKin_1	400	406	PF00069	0.504
MOD_SUMO_for_1	149	152	PF00179	0.251
MOD_SUMO_rev_2	143	151	PF00179	0.275
MOD_SUMO_rev_2	163	167	PF00179	0.130
MOD_SUMO_rev_2	201	210	PF00179	0.284
MOD_SUMO_rev_2	309	318	PF00179	0.252
MOD_SUMO_rev_2	473	482	PF00179	0.629
TRG_DiLeu_BaEn_1	314	319	PF01217	0.275
TRG_ENDOCYTIC_2	100	103	PF00928	0.284
TRG_ENDOCYTIC_2	270	273	PF00928	0.406
TRG_ENDOCYTIC_2	90	93	PF00928	0.284
TRG_ER_diArg_1	443	446	PF00400	0.603
TRG_ER_diArg_1	78	80	PF00400	0.300
TRG_NES_CRM1_1	190	201	PF08389	0.174
TRG_Pf-PMV_PEXEL_1	240	244	PF00026	0.368

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4E3	Leptomonas seymouri	24%	74%
A0A0N0P6T0	Leptomonas seymouri	26%	91%
A0A0N0P787	Leptomonas seymouri	25%	100%
A0A0N1HZY0	Leptomonas seymouri	28%	83%
A0A0N1I0C1	Leptomonas seymouri	23%	100%
A0A0N1I6Q7	Leptomonas seymouri	28%	100%
A0A0N1I9B7	Leptomonas seymouri	23%	100%
A0A0N1IHY4	Leptomonas seymouri	23%	100%
A0A0N1IM47	Leptomonas seymouri	25%	100%
A0A0N1PBE9	Leptomonas seymouri	72%	99%
A0A0N1PBJ1	Leptomonas seymouri	26%	73%
A0A0N1PC32	Leptomonas seymouri	29%	100%
A0A0N1PE80	Leptomonas seymouri	30%	89%
A0A0S4IVQ6	Bodo saltans	27%	100%
A0A0S4IZ14	Bodo saltans	29%	84%
A0A0S4IZY3	Bodo saltans	25%	100%
A0A0S4J1U0	Bodo saltans	26%	68%
A0A0S4J6L4	Bodo saltans	27%	100%
A0A0S4JC94	Bodo saltans	21%	71%
A0A0S4JCI5	Bodo saltans	24%	78%
A0A0S4JCK1	Bodo saltans	26%	100%
A0A0S4JI27	Bodo saltans	26%	69%
A0A0S4JI67	Bodo saltans	24%	100%
A0A0S4JPZ7	Bodo saltans	28%	100%
A0A0S4JQP0	Bodo saltans	27%	100%
A0A0S4JWD5	Bodo saltans	53%	100%
A0A0S4JXW9	Bodo saltans	23%	100%
A0A0S4KFT7	Bodo saltans	26%	100%
A0A0S4KKJ1	Bodo saltans	28%	79%
A0A1X0NJ50	Trypanosomatidae	28%	75%
A0A1X0NJJ7	Trypanosomatidae	25%	66%
A0A1X0NUQ4	Trypanosomatidae	27%	100%
A0A1X0P2H8	Trypanosomatidae	28%	100%
A0A1X0P4Z7	Trypanosomatidae	29%	90%
A0A1X0P692	Trypanosomatidae	28%	100%
A0A1X0P6E7	Trypanosomatidae	27%	100%
A0A1X0P795	Trypanosomatidae	26%	74%
A0A1X0P7V0	Trypanosomatidae	27%	100%
A0A1X0P859	Trypanosomatidae	23%	100%
A0A1X0P8F7	Trypanosomatidae	26%	100%
A0A2I0BVG8	Plasmodium falciparum (isolate NF54)	32%	95%
A0A3Q8IAQ1	Leishmania donovani	24%	100%
A0A3Q8IB74	Leishmania donovani	24%	100%
A0A3Q8IC87	Leishmania donovani	29%	100%
A0A3Q8IE25	Leishmania donovani	24%	76%
A0A3Q8II44	Leishmania donovani	23%	100%
A0A3Q8INQ4	Leishmania donovani	30%	100%
A0A3Q8IRT6	Leishmania donovani	26%	98%
A0A3Q8IU22	Leishmania donovani	28%	78%
A0A3Q8IVR8	Leishmania donovani	23%	100%
A0A3R7K5U6	Trypanosoma rangeli	24%	85%
A0A3R7K681	Trypanosoma rangeli	47%	98%
A0A3R7L9Q6	Trypanosoma rangeli	26%	100%
A0A3R7M819	Trypanosoma rangeli	24%	100%
A0A3R7MPF2	Trypanosoma rangeli	30%	77%
A0A3R7MWP2	Trypanosoma rangeli	23%	100%
A0A3R7N5S4	Trypanosoma rangeli	26%	100%
A0A3S5H5G0	Leishmania donovani	25%	100%
A0A3S5H5U5	Leishmania donovani	25%	100%
A0A3S5H789	Leishmania donovani	27%	100%
A0A3S5H7N7	Leishmania donovani	25%	99%
A0A3S5IR34	Trypanosoma rangeli	27%	78%
A0A3S7WSP5	Leishmania donovani	25%	100%
A0A3S7WTN9	Leishmania donovani	24%	100%
A0A3S7WVR6	Leishmania donovani	26%	81%
A0A3S7X8Z8	Leishmania donovani	79%	100%
A0A3S7X9R4	Leishmania donovani	27%	100%
A0A3S7X9S2	Leishmania donovani	27%	100%
A0A3S7XA45	Leishmania donovani	28%	100%
A0A422N215	Trypanosoma rangeli	25%	81%
A0A422N3U8	Trypanosoma rangeli	28%	69%
A0A422NCX4	Trypanosoma rangeli	26%	100%
A0A422NFN4	Trypanosoma rangeli	25%	98%
A0A422P2B2	Trypanosoma rangeli	23%	100%
A0A422P3N8	Trypanosoma rangeli	25%	85%
A0A422P3P9	Trypanosoma rangeli	26%	100%
A0A422P4L8	Trypanosoma rangeli	23%	100%
A0A509AQE6	Plasmodium berghei (strain Anka)	29%	89%
A0AUV4	Mus musculus	27%	98%
A2XFF4	Oryza sativa subsp. indica	33%	98%
A4H459	Leishmania braziliensis	28%	100%
A4H4S9	Leishmania braziliensis	26%	100%
A4H7F4	Leishmania braziliensis	24%	100%
A4H8C4	Leishmania braziliensis	24%	100%
A4H9X5	Leishmania braziliensis	24%	100%
A4HA94	Leishmania braziliensis	24%	86%
A4HA97	Leishmania braziliensis	27%	88%
A4HCE6	Leishmania braziliensis	25%	100%
A4HDU3	Leishmania braziliensis	25%	100%
A4HED7	Leishmania braziliensis	28%	100%
A4HFC9	Leishmania braziliensis	25%	76%
A4HG27	Leishmania braziliensis	28%	92%
A4HHN1	Leishmania braziliensis	27%	100%
A4HI35	Leishmania braziliensis	27%	98%
A4HIM5	Leishmania braziliensis	26%	99%
A4HLN2	Leishmania braziliensis	27%	78%
A4HN71	Leishmania braziliensis	27%	100%
A4HNG3	Leishmania braziliensis	30%	100%
A4HNT2	Leishmania braziliensis	24%	100%
A4HSE2	Leishmania infantum	26%	100%
A4HVU2	Leishmania infantum	25%	100%
A4HWP5	Leishmania infantum	24%	100%
A4HYH4	Leishmania infantum	24%	100%
A4HYH7	Leishmania infantum	26%	81%
A4HYX6	Leishmania infantum	27%	100%
A4HZV1	Leishmania infantum	29%	100%
A4HZW8	Leishmania infantum	24%	100%
A4I1T4	Leishmania infantum	30%	100%
A4I2K6	Leishmania infantum	24%	76%
A4I5B1	Leishmania infantum	26%	98%
A4I5X0	Leishmania infantum	25%	99%
A4I967	Leishmania infantum	28%	78%
A4IB02	Leishmania infantum	79%	100%
A4IBT4	Leishmania infantum	27%	100%
A4IBT9	Leishmania infantum	27%	100%
A4IC54	Leishmania infantum	28%	100%
A4ICA4	Leishmania infantum	23%	100%
A4ICR2	Leishmania infantum	23%	100%
A7MB74	Bos taurus	29%	100%
A8WXF6	Caenorhabditis briggsae	29%	94%
B8BBT7	Oryza sativa subsp. indica	33%	98%
B9FKW9	Oryza sativa subsp. japonica	26%	96%
C9ZIW2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	81%
C9ZKE1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	100%
C9ZKU8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	23%	86%
C9ZN29	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	100%
C9ZQP5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	100%
C9ZXP1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	25%	100%
C9ZYF0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	100%
C9ZYT4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	25%	100%
D0A0D6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	100%
D0A2M0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	100%
D0A2P2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	23%	100%
E8NHS0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	24%	100%
E9ACY7	Leishmania major	24%	76%
E9AET0	Leishmania major	79%	98%
E9AFM1	Leishmania major	27%	98%
E9AFX4	Leishmania major	28%	98%
E9AG71	Leishmania infantum	25%	100%
E9AGS0	Leishmania infantum	24%	100%
E9AKB7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	100%
E9AKZ7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	24%	100%
E9AQF3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	100%
E9ARW9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	24%	100%
E9AS98	Leishmania mexicana (strain MHOM/GT/2001/U1103)	24%	100%
E9ASA1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	24%	81%
E9AVR5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	100%
E9AVS7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	100%
E9AXW8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	100%
E9AYR2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	24%	76%
E9B0K7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	98%
E9B164	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	99%
E9B296	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	100%
E9B408	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	78%
E9B5Y5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	100%
E9B6S4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	100%
E9B6S9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	100%
E9B727	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	100%
F1QGZ6	Danio rerio	28%	74%
O00141	Homo sapiens	29%	100%
O08605	Mus musculus	27%	100%
O22932	Arabidopsis thaliana	28%	100%
O22971	Arabidopsis thaliana	30%	100%
O49717	Arabidopsis thaliana	25%	90%
O55173	Rattus norvegicus	28%	89%
O59790	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	27%	100%
O62305	Caenorhabditis elegans	29%	69%
O65554	Arabidopsis thaliana	30%	100%
O94168	Candida tropicalis	30%	81%
O94547	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	34%	86%
P00518	Oryctolagus cuniculus	30%	100%
P06782	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	30%	79%
P07934	Mus musculus	29%	100%
P08413	Rattus norvegicus	28%	92%
P0C8M8	Zea mays	32%	80%
P10665	Xenopus laevis	28%	68%
P12688	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	28%	74%
P18652	Gallus gallus	28%	66%
P18653	Mus musculus	27%	69%
P20794	Homo sapiens	28%	80%
P23298	Mus musculus	27%	73%
P28582	Daucus carota	27%	94%
P28652	Mus musculus	28%	92%
P34100	Dictyostelium discoideum	28%	70%
P34331	Caenorhabditis elegans	29%	77%
P34947	Homo sapiens	29%	85%
P38623	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	29%	82%
P43249	Bos taurus	29%	85%
P45894	Caenorhabditis elegans	29%	85%
P49071	Drosophila melanogaster	27%	100%
P49101	Zea mays	27%	97%
P50530	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	26%	72%
P52497	Candida albicans	31%	81%
P53683	Oryza sativa subsp. japonica	27%	94%
P62343	Plasmodium falciparum (isolate K1 / Thailand)	32%	95%
P62344	Plasmodium falciparum (isolate 3D7)	32%	95%
Q02723	Secale cereale	30%	100%
Q06226	Rattus norvegicus	29%	100%
Q06850	Arabidopsis thaliana	28%	82%
Q07832	Mus musculus	30%	83%
Q09170	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	29%	100%
Q0JI49	Oryza sativa subsp. japonica	28%	100%
Q0VD22	Bos taurus	27%	100%
Q10292	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	29%	100%
Q12701	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	26%	84%
Q15349	Homo sapiens	29%	68%
Q15418	Homo sapiens	28%	68%
Q16566	Homo sapiens	31%	100%
Q1PFH8	Arabidopsis thaliana	27%	91%
Q2HJF7	Bos taurus	29%	100%
Q2QVG8	Oryza sativa subsp. japonica	27%	89%
Q2QX45	Oryza sativa subsp. japonica	28%	95%
Q2QYM3	Oryza sativa subsp. japonica	27%	100%
Q38868	Arabidopsis thaliana	25%	92%
Q38869	Arabidopsis thaliana	27%	100%
Q38873	Arabidopsis thaliana	28%	93%
Q38997	Arabidopsis thaliana	33%	98%
Q3E9C0	Arabidopsis thaliana	27%	96%
Q3MHJ9	Bos taurus	28%	92%
Q3UHL1	Mus musculus	26%	98%
Q42438	Arabidopsis thaliana	28%	94%
Q43531	Lilium longiflorum	26%	96%
Q4G050	Rattus norvegicus	27%	100%
Q4Q0B0	Leishmania major	22%	100%
Q4Q204	Leishmania major	23%	100%
Q4Q416	Leishmania major	27%	78%
Q4Q701	Leishmania major	26%	99%
Q4Q7M5	Leishmania major	26%	100%
Q4Q9K2	Leishmania major	29%	100%
Q4QBQ2	Leishmania major	24%	100%
Q4QBR6	Leishmania major	28%	100%
Q4QD63	Leishmania major	25%	81%
Q4QD66	Leishmania major	24%	94%
Q4QDK3	Leishmania major	25%	100%
Q4QF23	Leishmania major	24%	100%
Q4QIV8	Leishmania major	25%	100%
Q4QJJ0	Leishmania major	26%	99%
Q4R633	Macaca fascicularis	29%	100%
Q54BF0	Dictyostelium discoideum	30%	84%
Q54MH0	Dictyostelium discoideum	32%	67%
Q54PB4	Dictyostelium discoideum	30%	100%
Q54WX4	Dictyostelium discoideum	28%	100%
Q58D94	Bos taurus	27%	100%
Q5Q0U5	Fundulus heteroclitus	29%	100%
Q5QNM6	Oryza sativa subsp. japonica	30%	98%
Q5R7A7	Pongo abelii	28%	100%
Q5U2N4	Rattus norvegicus	28%	100%
Q5VQQ5	Oryza sativa subsp. japonica	26%	97%
Q5ZJH6	Gallus gallus	26%	100%
Q60EY8	Oryza sativa subsp. japonica	26%	100%
Q62833	Rattus norvegicus	29%	85%
Q63092	Rattus norvegicus	26%	99%
Q63531	Rattus norvegicus	28%	68%
Q63553	Rattus norvegicus	28%	67%
Q641K5	Mus musculus	27%	76%
Q64617	Rattus norvegicus	27%	73%
Q66I46	Xenopus tropicalis	28%	100%
Q66JF3	Xenopus tropicalis	27%	100%
Q69IM9	Oryza sativa subsp. japonica	28%	87%
Q6C3J2	Yarrowia lipolytica (strain CLIB 122 / E 150)	28%	100%
Q6C7U0	Yarrowia lipolytica (strain CLIB 122 / E 150)	26%	70%
Q6F3A6	Oryza sativa subsp. japonica	29%	83%
Q6NLQ6	Arabidopsis thaliana	27%	93%
Q6P431	Xenopus laevis	28%	100%
Q6TGC6	Pneumocystis carinii	28%	99%
Q6U1I9	Gallus gallus	29%	100%
Q75GE8	Oryza sativa subsp. japonica	27%	93%
Q75L42	Oryza sativa subsp. japonica	28%	100%
Q7SY49	Danio rerio	28%	100%
Q7TNJ7	Rattus norvegicus	31%	100%
Q7ZTW4	Danio rerio	29%	100%
Q7ZX15	Xenopus laevis	30%	100%
Q84VQ3	Arabidopsis thaliana	28%	100%
Q852Q0	Oryza sativa subsp. japonica	33%	98%
Q852Q1	Oryza sativa subsp. japonica	33%	98%
Q852Q2	Oryza sativa subsp. japonica	33%	99%
Q869W6	Dictyostelium discoideum	29%	100%
Q8CDB0	Mus musculus	28%	100%
Q8INB9	Drosophila melanogaster	29%	82%
Q8MYF1	Dictyostelium discoideum	31%	100%
Q8R4V0	Rattus norvegicus	28%	100%
Q8RWL2	Arabidopsis thaliana	29%	94%
Q8VDF3	Mus musculus	28%	100%
Q8VDU5	Mus musculus	28%	67%
Q8VEB1	Mus musculus	29%	85%
Q8W4I7	Arabidopsis thaliana	27%	95%
Q91820	Xenopus laevis	29%	100%
Q91VB2	Mus musculus	31%	100%
Q924X7	Mus musculus	27%	100%
Q96BR1	Homo sapiens	28%	100%
Q96PF2	Homo sapiens	28%	100%
Q9BYT3	Homo sapiens	28%	97%
Q9C098	Homo sapiens	31%	77%
Q9C562	Arabidopsis thaliana	27%	100%
Q9C6P3	Arabidopsis thaliana	26%	96%
Q9DG02	Xenopus laevis	28%	100%
Q9ERE3	Mus musculus	28%	100%
Q9FJ54	Arabidopsis thaliana	30%	100%
Q9FLZ3	Arabidopsis thaliana	29%	100%
Q9FMP5	Arabidopsis thaliana	26%	95%
Q9GNR4	Leishmania major	27%	100%
Q9H4B4	Homo sapiens	27%	77%
Q9HBH9	Homo sapiens	27%	100%
Q9LWM4	Oryza sativa subsp. japonica	27%	100%
Q9M9V8	Arabidopsis thaliana	28%	92%
Q9NAH6	Caenorhabditis elegans	30%	91%
Q9SIQ7	Arabidopsis thaliana	29%	86%
Q9SSF8	Arabidopsis thaliana	27%	92%
Q9U6V4	Leishmania donovani	24%	100%
Q9UIK4	Homo sapiens	28%	100%
Q9WUT3	Mus musculus	29%	68%
Q9WVC6	Mus musculus	29%	100%
Q9XF67	Arabidopsis thaliana	26%	100%
Q9XT18	Oryctolagus cuniculus	29%	100%
Q9XUJ7	Caenorhabditis elegans	29%	69%
Q9Y1J3	Caenorhabditis elegans	27%	79%
Q9YGW0	Xenopus laevis	27%	100%
Q9ZSA2	Arabidopsis thaliana	27%	94%
U4PR86	Caenorhabditis elegans	27%	71%
V5B8U8	Trypanosoma cruzi	23%	100%
V5B9R6	Trypanosoma cruzi	26%	100%
V5B9Y9	Trypanosoma cruzi	23%	100%
V5BAZ8	Trypanosoma cruzi	26%	100%
V5BCH2	Trypanosoma cruzi	27%	100%
V5BEK5	Trypanosoma cruzi	27%	100%
V5BI43	Trypanosoma cruzi	48%	100%
V5BL06	Trypanosoma cruzi	29%	77%
V5BPE2	Trypanosoma cruzi	28%	100%
V5D9M1	Trypanosoma cruzi	25%	100%
V5DAY8	Trypanosoma cruzi	27%	100%
V5DCD4	Trypanosoma cruzi	24%	85%
V5DI55	Trypanosoma cruzi	26%	100%
V5DQT5	Trypanosoma cruzi	28%	100%
V5DTI8	Trypanosoma cruzi	26%	100%