Putative MP44

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Putative MP44

Gene product:

MP44, putative

Species:

Leishmania braziliensis

UniProt:

A4HFF2_LEIBR

TriTrypDb:

LbrM.27.0350 , LBRM2903_270008500

Length:

429

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 10

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 1, no: 8
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HFF2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HFF2

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	9
GO:0006396	RNA processing	6	9
GO:0006725	cellular aromatic compound metabolic process	3	9
GO:0006807	nitrogen compound metabolic process	2	9
GO:0008152	metabolic process	1	9
GO:0009987	cellular process	1	9
GO:0016070	RNA metabolic process	5	9
GO:0034641	cellular nitrogen compound metabolic process	3	9
GO:0043170	macromolecule metabolic process	3	9
GO:0044237	cellular metabolic process	2	9
GO:0044238	primary metabolic process	2	9
GO:0046483	heterocycle metabolic process	3	9
GO:0071704	organic substance metabolic process	2	9
GO:0090304	nucleic acid metabolic process	4	9
GO:1901360	organic cyclic compound metabolic process	3	9

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	9
GO:0004518	nuclease activity	4	9
GO:0004519	endonuclease activity	5	9
GO:0004521	RNA endonuclease activity	5	9
GO:0004525	ribonuclease III activity	6	9
GO:0004540	RNA nuclease activity	4	9
GO:0016787	hydrolase activity	2	9
GO:0016788	hydrolase activity, acting on ester bonds	3	9
GO:0016891	RNA endonuclease activity, producing 5'-phosphomonoesters	6	9
GO:0016893	endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	6	9
GO:0032296	double-stranded RNA-specific ribonuclease activity	5	9
GO:0140098	catalytic activity, acting on RNA	3	9
GO:0140640	catalytic activity, acting on a nucleic acid	2	9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	411	415	PF00656	0.681
CLV_NRD_NRD_1	115	117	PF00675	0.413
CLV_NRD_NRD_1	128	130	PF00675	0.421
CLV_NRD_NRD_1	217	219	PF00675	0.636
CLV_NRD_NRD_1	71	73	PF00675	0.422
CLV_NRD_NRD_1	9	11	PF00675	0.596
CLV_PCSK_KEX2_1	115	117	PF00082	0.401
CLV_PCSK_KEX2_1	128	130	PF00082	0.404
CLV_PCSK_KEX2_1	217	219	PF00082	0.672
CLV_PCSK_KEX2_1	294	296	PF00082	0.576
CLV_PCSK_KEX2_1	71	73	PF00082	0.456
CLV_PCSK_KEX2_1	9	11	PF00082	0.593
CLV_PCSK_KEX2_1	92	94	PF00082	0.374
CLV_PCSK_PC1ET2_1	294	296	PF00082	0.576
CLV_PCSK_PC1ET2_1	92	94	PF00082	0.374
CLV_PCSK_PC7_1	213	219	PF00082	0.438
CLV_PCSK_SKI1_1	115	119	PF00082	0.543
CLV_PCSK_SKI1_1	121	125	PF00082	0.494
CLV_PCSK_SKI1_1	171	175	PF00082	0.500
CLV_PCSK_SKI1_1	75	79	PF00082	0.486
DEG_APCC_DBOX_1	120	128	PF00400	0.429
DEG_APCC_DBOX_1	168	176	PF00400	0.492
DEG_APCC_DBOX_1	70	78	PF00400	0.557
DEG_SCF_FBW7_1	57	63	PF00400	0.515
DOC_CKS1_1	57	62	PF01111	0.479
DOC_CYCLIN_RxL_1	71	80	PF00134	0.569
DOC_MAPK_gen_1	115	126	PF00069	0.441
DOC_MAPK_gen_1	128	134	PF00069	0.407
DOC_MAPK_gen_1	71	79	PF00069	0.412
DOC_MAPK_MEF2A_6	119	126	PF00069	0.479
DOC_MAPK_MEF2A_6	61	70	PF00069	0.522
DOC_MAPK_NFAT4_5	119	127	PF00069	0.510
DOC_MAPK_NFAT4_5	61	69	PF00069	0.403
DOC_MAPK_RevD_3	77	93	PF00069	0.353
DOC_PP2B_LxvP_1	257	260	PF13499	0.498
DOC_PP4_FxxP_1	365	368	PF00568	0.662
DOC_PP4_FxxP_1	375	378	PF00568	0.657
DOC_USP7_MATH_1	34	38	PF00917	0.687
DOC_USP7_MATH_1	357	361	PF00917	0.751
DOC_USP7_UBL2_3	337	341	PF12436	0.548
DOC_WW_Pin1_4	218	223	PF00397	0.647
DOC_WW_Pin1_4	308	313	PF00397	0.691
DOC_WW_Pin1_4	56	61	PF00397	0.493
DOC_WW_Pin1_4	81	86	PF00397	0.465
LIG_14-3-3_CanoR_1	225	235	PF00244	0.538
LIG_14-3-3_CanoR_1	313	319	PF00244	0.461
LIG_14-3-3_CanoR_1	348	354	PF00244	0.538
LIG_14-3-3_CanoR_1	398	402	PF00244	0.686
LIG_14-3-3_CanoR_1	56	60	PF00244	0.659
LIG_14-3-3_CanoR_1	61	67	PF00244	0.566
LIG_14-3-3_CanoR_1	71	75	PF00244	0.463
LIG_CaM_IQ_9	336	352	PF13499	0.477
LIG_EH1_1	203	211	PF00400	0.567
LIG_FHA_1	168	174	PF00498	0.429
LIG_FHA_1	269	275	PF00498	0.519
LIG_FHA_1	61	67	PF00498	0.677
LIG_FHA_1	84	90	PF00498	0.483
LIG_FHA_2	147	153	PF00498	0.457
LIG_FHA_2	329	335	PF00498	0.646
LIG_FHA_2	37	43	PF00498	0.709
LIG_FHA_2	406	412	PF00498	0.650
LIG_LIR_Apic_2	364	368	PF02991	0.664
LIG_LIR_Gen_1	150	159	PF02991	0.479
LIG_LIR_Gen_1	280	291	PF02991	0.415
LIG_LIR_Nem_3	150	156	PF02991	0.409
LIG_LIR_Nem_3	280	286	PF02991	0.363
LIG_LIR_Nem_3	369	375	PF02991	0.554
LIG_NRBOX	133	139	PF00104	0.364
LIG_NRBOX	73	79	PF00104	0.513
LIG_PCNA_yPIPBox_3	128	138	PF02747	0.383
LIG_PCNA_yPIPBox_3	355	366	PF02747	0.491
LIG_SH2_CRK	130	134	PF00017	0.496
LIG_SH2_CRK	380	384	PF00017	0.660
LIG_SH2_NCK_1	283	287	PF00017	0.447
LIG_SH2_STAP1	181	185	PF00017	0.563
LIG_SH2_STAT3	204	207	PF00017	0.558
LIG_SH2_STAT5	184	187	PF00017	0.514
LIG_SH3_1	174	180	PF00018	0.509
LIG_SH3_3	174	180	PF00018	0.509
LIG_SH3_3	209	215	PF00018	0.364
LIG_SH3_3	282	288	PF00018	0.448
LIG_SH3_3	295	301	PF00018	0.452
LIG_SH3_3	321	327	PF00018	0.626
LIG_SH3_3	54	60	PF00018	0.503
LIG_SH3_3	82	88	PF00018	0.480
LIG_SUMO_SIM_anti_2	261	267	PF11976	0.531
LIG_SUMO_SIM_par_1	14	19	PF11976	0.478
LIG_SUMO_SIM_par_1	326	332	PF11976	0.442
LIG_SUMO_SIM_par_1	62	67	PF11976	0.656
LIG_TYR_ITIM	281	286	PF00017	0.381
LIG_WRC_WIRS_1	362	367	PF05994	0.678
MOD_CDK_SPK_2	308	313	PF00069	0.691
MOD_CDK_SPK_2	56	61	PF00069	0.493
MOD_CDK_SPxxK_3	218	225	PF00069	0.668
MOD_CK1_1	111	117	PF00069	0.546
MOD_CK1_1	141	147	PF00069	0.556
MOD_CK1_1	303	309	PF00069	0.610
MOD_CK1_1	316	322	PF00069	0.601
MOD_CK1_1	36	42	PF00069	0.687
MOD_CK2_1	146	152	PF00069	0.466
MOD_CK2_1	326	332	PF00069	0.611
MOD_CK2_1	36	42	PF00069	0.625
MOD_DYRK1A_RPxSP_1	218	222	PF00069	0.698
MOD_DYRK1A_RPxSP_1	56	60	PF00069	0.495
MOD_GlcNHglycan	218	221	PF01048	0.704
MOD_GlcNHglycan	30	33	PF01048	0.632
MOD_GlcNHglycan	403	406	PF01048	0.687
MOD_GlcNHglycan	414	417	PF01048	0.568
MOD_GSK3_1	111	118	PF00069	0.485
MOD_GSK3_1	143	150	PF00069	0.449
MOD_GSK3_1	159	166	PF00069	0.484
MOD_GSK3_1	33	40	PF00069	0.623
MOD_GSK3_1	357	364	PF00069	0.613
MOD_GSK3_1	397	404	PF00069	0.671
MOD_GSK3_1	42	49	PF00069	0.591
MOD_GSK3_1	55	62	PF00069	0.487
MOD_N-GLC_1	147	152	PF02516	0.439
MOD_N-GLC_1	99	104	PF02516	0.551
MOD_N-GLC_2	359	361	PF02516	0.672
MOD_NEK2_1	108	113	PF00069	0.485
MOD_NEK2_1	159	164	PF00069	0.415
MOD_NEK2_1	16	21	PF00069	0.640
MOD_NEK2_1	226	231	PF00069	0.543
MOD_NEK2_1	28	33	PF00069	0.571
MOD_NEK2_1	70	75	PF00069	0.538
MOD_PIKK_1	303	309	PF00454	0.610
MOD_PIKK_1	34	40	PF00454	0.615
MOD_PIKK_1	83	89	PF00454	0.622
MOD_PKA_1	115	121	PF00069	0.520
MOD_PKA_2	115	121	PF00069	0.460
MOD_PKA_2	216	222	PF00069	0.603
MOD_PKA_2	366	372	PF00069	0.583
MOD_PKA_2	397	403	PF00069	0.670
MOD_PKA_2	55	61	PF00069	0.660
MOD_PKA_2	70	76	PF00069	0.461
MOD_Plk_1	357	363	PF00069	0.725
MOD_Plk_1	396	402	PF00069	0.685
MOD_Plk_1	99	105	PF00069	0.548
MOD_Plk_4	159	165	PF00069	0.415
MOD_Plk_4	361	367	PF00069	0.661
MOD_ProDKin_1	218	224	PF00069	0.639
MOD_ProDKin_1	308	314	PF00069	0.687
MOD_ProDKin_1	56	62	PF00069	0.484
MOD_ProDKin_1	81	87	PF00069	0.471
MOD_SUMO_rev_2	287	296	PF00179	0.527
TRG_DiLeu_BaEn_1	334	339	PF01217	0.434
TRG_DiLeu_BaLyEn_6	12	17	PF01217	0.481
TRG_DiLeu_BaLyEn_6	168	173	PF01217	0.495
TRG_ENDOCYTIC_2	130	133	PF00928	0.493
TRG_ENDOCYTIC_2	283	286	PF00928	0.385
TRG_ENDOCYTIC_2	372	375	PF00928	0.567
TRG_ENDOCYTIC_2	380	383	PF00928	0.579
TRG_ENDOCYTIC_2	95	98	PF00928	0.427
TRG_ER_diArg_1	101	104	PF00400	0.527
TRG_ER_diArg_1	115	117	PF00400	0.328
TRG_ER_diArg_1	119	122	PF00400	0.284
TRG_ER_diArg_1	127	129	PF00400	0.412
TRG_ER_diArg_1	168	171	PF00400	0.396
TRG_ER_diArg_1	70	72	PF00400	0.471
TRG_ER_diArg_1	8	10	PF00400	0.615
TRG_NES_CRM1_1	287	300	PF08389	0.558
TRG_Pf-PMV_PEXEL_1	75	80	PF00026	0.570

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I6V9	Leptomonas seymouri	57%	99%
A0A1X0P3V7	Trypanosomatidae	51%	100%
A0A3Q8ID52	Leishmania donovani	89%	100%
A0A3R7MNH0	Trypanosoma rangeli	51%	100%
A4I2M1	Leishmania infantum	89%	100%
D0A5N3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	53%	100%
E9AD11	Leishmania major	89%	100%
E9AYT6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%