TSNAXIP1_N domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HFF1_LEIBR

TriTrypDb:

LbrM.27.0340 , LBRM2903_270008400

Length:

730

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005929	cilium	4	1
GO:0042995	cell projection	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0110165	cellular anatomical entity	1	1
GO:0120025	plasma membrane bounded cell projection	3	1

Expansion

Sequence features

A4HFF1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HFF1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	396	400	PF00656	0.555
CLV_NRD_NRD_1	107	109	PF00675	0.737
CLV_NRD_NRD_1	127	129	PF00675	0.386
CLV_NRD_NRD_1	255	257	PF00675	0.637
CLV_NRD_NRD_1	287	289	PF00675	0.679
CLV_NRD_NRD_1	557	559	PF00675	0.552
CLV_NRD_NRD_1	608	610	PF00675	0.586
CLV_NRD_NRD_1	721	723	PF00675	0.439
CLV_PCSK_FUR_1	104	108	PF00082	0.738
CLV_PCSK_KEX2_1	106	108	PF00082	0.688
CLV_PCSK_KEX2_1	127	129	PF00082	0.405
CLV_PCSK_KEX2_1	255	257	PF00082	0.637
CLV_PCSK_KEX2_1	316	318	PF00082	0.675
CLV_PCSK_KEX2_1	556	558	PF00082	0.564
CLV_PCSK_KEX2_1	607	609	PF00082	0.600
CLV_PCSK_KEX2_1	657	659	PF00082	0.643
CLV_PCSK_KEX2_1	721	723	PF00082	0.439
CLV_PCSK_PC1ET2_1	255	257	PF00082	0.637
CLV_PCSK_PC1ET2_1	316	318	PF00082	0.468
CLV_PCSK_PC1ET2_1	657	659	PF00082	0.643
CLV_PCSK_SKI1_1	164	168	PF00082	0.394
CLV_PCSK_SKI1_1	284	288	PF00082	0.700
CLV_PCSK_SKI1_1	302	306	PF00082	0.525
CLV_PCSK_SKI1_1	514	518	PF00082	0.569
CLV_PCSK_SKI1_1	537	541	PF00082	0.424
CLV_PCSK_SKI1_1	544	548	PF00082	0.432
CLV_Separin_Metazoa	6	10	PF03568	0.787
DEG_APCC_DBOX_1	536	544	PF00400	0.506
DEG_APCC_DBOX_1	555	563	PF00400	0.520
DEG_MDM2_SWIB_1	631	639	PF02201	0.561
DEG_Nend_Nbox_1	1	3	PF02207	0.819
DEG_SPOP_SBC_1	66	70	PF00917	0.799
DOC_CDC14_PxL_1	391	399	PF14671	0.555
DOC_CYCLIN_RxL_1	468	478	PF00134	0.558
DOC_MAPK_gen_1	104	112	PF00069	0.509
DOC_MAPK_gen_1	113	122	PF00069	0.396
DOC_MAPK_gen_1	453	461	PF00069	0.598
DOC_MAPK_gen_1	469	477	PF00069	0.503
DOC_MAPK_gen_1	514	523	PF00069	0.368
DOC_MAPK_gen_1	556	564	PF00069	0.568
DOC_MAPK_gen_1	657	663	PF00069	0.501
DOC_MAPK_gen_1	712	719	PF00069	0.443
DOC_MAPK_HePTP_8	110	122	PF00069	0.458
DOC_MAPK_MEF2A_6	113	122	PF00069	0.566
DOC_MAPK_MEF2A_6	469	477	PF00069	0.573
DOC_MAPK_MEF2A_6	514	523	PF00069	0.430
DOC_PP2B_LxvP_1	496	499	PF13499	0.368
DOC_PP2B_PxIxI_1	691	697	PF00149	0.633
DOC_SPAK_OSR1_1	602	606	PF12202	0.567
DOC_USP7_MATH_1	111	115	PF00917	0.580
DOC_USP7_MATH_1	138	142	PF00917	0.490
DOC_USP7_MATH_1	405	409	PF00917	0.700
DOC_USP7_MATH_1	417	421	PF00917	0.780
DOC_USP7_MATH_1	492	496	PF00917	0.657
DOC_USP7_MATH_1	591	595	PF00917	0.487
DOC_USP7_MATH_1	8	12	PF00917	0.798
DOC_USP7_MATH_1	99	103	PF00917	0.738
DOC_WW_Pin1_4	113	118	PF00397	0.462
DOC_WW_Pin1_4	340	345	PF00397	0.609
DOC_WW_Pin1_4	411	416	PF00397	0.837
DOC_WW_Pin1_4	45	50	PF00397	0.732
DOC_WW_Pin1_4	59	64	PF00397	0.623
DOC_WW_Pin1_4	67	72	PF00397	0.633
DOC_WW_Pin1_4	720	725	PF00397	0.476
DOC_WW_Pin1_4	76	81	PF00397	0.680
LIG_14-3-3_CanoR_1	317	321	PF00244	0.688
LIG_14-3-3_CanoR_1	326	335	PF00244	0.674
LIG_14-3-3_CanoR_1	418	426	PF00244	0.779
LIG_14-3-3_CanoR_1	471	476	PF00244	0.573
LIG_14-3-3_CanoR_1	52	58	PF00244	0.778
LIG_14-3-3_CanoR_1	602	606	PF00244	0.546
LIG_14-3-3_CanoR_1	607	617	PF00244	0.538
LIG_14-3-3_CanoR_1	712	718	PF00244	0.453
LIG_14-3-3_CanoR_1	82	90	PF00244	0.672
LIG_Actin_WH2_2	197	212	PF00022	0.497
LIG_Actin_WH2_2	547	565	PF00022	0.586
LIG_Actin_WH2_2	632	647	PF00022	0.560
LIG_APCC_ABBA_1	146	151	PF00400	0.470
LIG_BRCT_BRCA1_1	361	365	PF00533	0.746
LIG_Clathr_ClatBox_1	247	251	PF01394	0.667
LIG_CtBP_PxDLS_1	548	552	PF00389	0.539
LIG_FHA_1	330	336	PF00498	0.674
LIG_FHA_1	365	371	PF00498	0.710
LIG_FHA_1	386	392	PF00498	0.687
LIG_FHA_1	443	449	PF00498	0.715
LIG_FHA_1	463	469	PF00498	0.323
LIG_FHA_1	476	482	PF00498	0.442
LIG_FHA_1	568	574	PF00498	0.488
LIG_FHA_1	641	647	PF00498	0.437
LIG_FHA_1	665	671	PF00498	0.505
LIG_FHA_1	701	707	PF00498	0.516
LIG_FHA_1	89	95	PF00498	0.811
LIG_FHA_2	195	201	PF00498	0.501
LIG_FHA_2	256	262	PF00498	0.665
LIG_FHA_2	46	52	PF00498	0.574
LIG_FHA_2	570	576	PF00498	0.506
LIG_FHA_2	609	615	PF00498	0.558
LIG_LIR_Gen_1	319	328	PF02991	0.783
LIG_LIR_Gen_1	578	586	PF02991	0.483
LIG_LIR_Gen_1	624	631	PF02991	0.428
LIG_LIR_Gen_1	679	688	PF02991	0.585
LIG_LIR_LC3C_4	70	75	PF02991	0.584
LIG_LIR_Nem_3	161	166	PF02991	0.373
LIG_LIR_Nem_3	319	323	PF02991	0.703
LIG_LIR_Nem_3	422	428	PF02991	0.567
LIG_LIR_Nem_3	578	582	PF02991	0.519
LIG_LIR_Nem_3	624	630	PF02991	0.475
LIG_LIR_Nem_3	679	685	PF02991	0.586
LIG_Pex14_2	156	160	PF04695	0.435
LIG_Pex14_2	501	505	PF04695	0.520
LIG_Pex14_2	579	583	PF04695	0.576
LIG_Pex14_2	627	631	PF04695	0.552
LIG_SH2_CRK	163	167	PF00017	0.428
LIG_SH2_CRK	682	686	PF00017	0.581
LIG_SH2_NCK_1	320	324	PF00017	0.777
LIG_SH2_PTP2	684	687	PF00017	0.581
LIG_SH2_SRC	192	195	PF00017	0.491
LIG_SH2_STAP1	174	178	PF00017	0.385
LIG_SH2_STAP1	361	365	PF00017	0.746
LIG_SH2_STAT3	361	364	PF00017	0.497
LIG_SH2_STAT5	133	136	PF00017	0.375
LIG_SH2_STAT5	192	195	PF00017	0.467
LIG_SH2_STAT5	626	629	PF00017	0.505
LIG_SH2_STAT5	682	685	PF00017	0.555
LIG_SH3_1	32	38	PF00018	0.600
LIG_SH3_3	18	24	PF00018	0.627
LIG_SH3_3	32	38	PF00018	0.666
LIG_SH3_3	4	10	PF00018	0.760
LIG_SH3_3	444	450	PF00018	0.650
LIG_SH3_3	54	60	PF00018	0.752
LIG_SH3_3	699	705	PF00018	0.382
LIG_SUMO_SIM_par_1	246	251	PF11976	0.624
LIG_SUMO_SIM_par_1	68	77	PF11976	0.721
LIG_SUMO_SIM_par_1	692	698	PF11976	0.607
LIG_TRAF2_1	226	229	PF00917	0.532
LIG_TRFH_1	45	49	PF08558	0.784
LIG_UBA3_1	206	210	PF00899	0.497
LIG_UBA3_1	247	255	PF00899	0.640
LIG_UBA3_1	539	544	PF00899	0.328
LIG_WRC_WIRS_1	153	158	PF05994	0.456
LIG_WW_3	6	10	PF00397	0.787
MOD_CDC14_SPxK_1	79	82	PF00782	0.560
MOD_CDK_SPxK_1	76	82	PF00069	0.567
MOD_CDK_SPxxK_3	411	418	PF00069	0.572
MOD_CDK_SPxxK_3	45	52	PF00069	0.575
MOD_CK1_1	277	283	PF00069	0.646
MOD_CK1_1	329	335	PF00069	0.652
MOD_CK1_1	484	490	PF00069	0.552
MOD_CK1_1	569	575	PF00069	0.594
MOD_CK1_1	622	628	PF00069	0.542
MOD_CK1_1	76	82	PF00069	0.608
MOD_CK2_1	194	200	PF00069	0.530
MOD_CK2_1	255	261	PF00069	0.616
MOD_CK2_1	405	411	PF00069	0.711
MOD_CK2_1	608	614	PF00069	0.619
MOD_CK2_1	694	700	PF00069	0.588
MOD_GlcNHglycan	224	227	PF01048	0.530
MOD_GlcNHglycan	328	331	PF01048	0.558
MOD_GlcNHglycan	419	422	PF01048	0.766
MOD_GlcNHglycan	462	465	PF01048	0.653
MOD_GSK3_1	209	216	PF00069	0.390
MOD_GSK3_1	360	367	PF00069	0.579
MOD_GSK3_1	471	478	PF00069	0.570
MOD_GSK3_1	562	569	PF00069	0.611
MOD_GSK3_1	615	622	PF00069	0.490
MOD_GSK3_1	84	91	PF00069	0.742
MOD_N-GLC_1	213	218	PF02516	0.465
MOD_NEK2_1	209	214	PF00069	0.453
MOD_NEK2_1	311	316	PF00069	0.445
MOD_NEK2_1	339	344	PF00069	0.815
MOD_NEK2_1	378	383	PF00069	0.482
MOD_NEK2_1	462	467	PF00069	0.607
MOD_NEK2_1	475	480	PF00069	0.468
MOD_NEK2_1	481	486	PF00069	0.306
MOD_NEK2_1	523	528	PF00069	0.603
MOD_NEK2_1	562	567	PF00069	0.598
MOD_NEK2_1	601	606	PF00069	0.591
MOD_NEK2_1	713	718	PF00069	0.489
MOD_NEK2_1	73	78	PF00069	0.697
MOD_NEK2_2	492	497	PF00069	0.569
MOD_NEK2_2	626	631	PF00069	0.562
MOD_PIKK_1	192	198	PF00454	0.497
MOD_PIKK_1	291	297	PF00454	0.665
MOD_PIKK_1	360	366	PF00454	0.491
MOD_PIKK_1	505	511	PF00454	0.596
MOD_PKA_1	255	261	PF00069	0.630
MOD_PKA_1	291	297	PF00069	0.432
MOD_PKA_1	316	322	PF00069	0.741
MOD_PKA_1	608	614	PF00069	0.607
MOD_PKA_2	255	261	PF00069	0.630
MOD_PKA_2	316	322	PF00069	0.737
MOD_PKA_2	339	345	PF00069	0.738
MOD_PKA_2	417	423	PF00069	0.797
MOD_PKA_2	562	568	PF00069	0.554
MOD_PKA_2	601	607	PF00069	0.500
MOD_PKA_2	608	614	PF00069	0.489
MOD_PKA_2	713	719	PF00069	0.486
MOD_PKA_2	8	14	PF00069	0.853
MOD_Plk_1	213	219	PF00069	0.465
MOD_Plk_1	311	317	PF00069	0.589
MOD_Plk_1	591	597	PF00069	0.489
MOD_Plk_1	615	621	PF00069	0.567
MOD_Plk_1	622	628	PF00069	0.543
MOD_Plk_2-3	194	200	PF00069	0.530
MOD_Plk_2-3	393	399	PF00069	0.556
MOD_Plk_2-3	575	581	PF00069	0.345
MOD_Plk_4	152	158	PF00069	0.435
MOD_Plk_4	165	171	PF00069	0.301
MOD_Plk_4	243	249	PF00069	0.584
MOD_Plk_4	393	399	PF00069	0.556
MOD_Plk_4	481	487	PF00069	0.512
MOD_Plk_4	622	628	PF00069	0.532
MOD_Plk_4	680	686	PF00069	0.566
MOD_Plk_4	713	719	PF00069	0.481
MOD_ProDKin_1	113	119	PF00069	0.456
MOD_ProDKin_1	340	346	PF00069	0.608
MOD_ProDKin_1	411	417	PF00069	0.836
MOD_ProDKin_1	45	51	PF00069	0.733
MOD_ProDKin_1	59	65	PF00069	0.622
MOD_ProDKin_1	67	73	PF00069	0.635
MOD_ProDKin_1	720	726	PF00069	0.491
MOD_ProDKin_1	76	82	PF00069	0.682
MOD_SUMO_for_1	290	293	PF00179	0.443
MOD_SUMO_rev_2	161	166	PF00179	0.497
MOD_SUMO_rev_2	352	358	PF00179	0.749
MOD_SUMO_rev_2	374	381	PF00179	0.560
TRG_DiLeu_BaEn_2	456	462	PF01217	0.640
TRG_DiLeu_BaEn_2	622	628	PF01217	0.594
TRG_DiLeu_BaLyEn_6	665	670	PF01217	0.335
TRG_ENDOCYTIC_2	163	166	PF00928	0.369
TRG_ENDOCYTIC_2	320	323	PF00928	0.693
TRG_ENDOCYTIC_2	682	685	PF00928	0.584
TRG_ER_diArg_1	104	107	PF00400	0.737
TRG_ER_diArg_1	126	128	PF00400	0.405
TRG_ER_diArg_1	556	558	PF00400	0.566
TRG_ER_diArg_1	606	609	PF00400	0.640
TRG_ER_diArg_1	720	722	PF00400	0.499
TRG_NES_CRM1_1	180	194	PF08389	0.506
TRG_NLS_MonoExtC_3	287	292	PF00514	0.453
TRG_Pf-PMV_PEXEL_1	302	306	PF00026	0.544
TRG_Pf-PMV_PEXEL_1	326	331	PF00026	0.671
TRG_Pf-PMV_PEXEL_1	471	476	PF00026	0.542
TRG_Pf-PMV_PEXEL_1	557	561	PF00026	0.601

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IKY0	Leptomonas seymouri	56%	96%
A0A1X0ND09	Trypanosomatidae	32%	100%
A0A3S7X0D8	Leishmania donovani	78%	99%
A0A422NTD8	Trypanosoma rangeli	33%	97%
A4I2M0	Leishmania infantum	81%	100%
D0A5N2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	99%
E9AD10	Leishmania major	78%	100%
E9AYT5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	78%	99%
V5DP68	Trypanosoma cruzi	32%	98%