Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HFF0_LEIBR

TriTrypDb:

LbrM.27.0330 , LBRM2903_270008300

Length:

494

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HFF0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HFF0

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	3
GO:0016787	hydrolase activity	2	3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	232	234	PF00675	0.422
CLV_NRD_NRD_1	343	345	PF00675	0.447
CLV_NRD_NRD_1	365	367	PF00675	0.471
CLV_NRD_NRD_1	375	377	PF00675	0.386
CLV_NRD_NRD_1	413	415	PF00675	0.584
CLV_NRD_NRD_1	468	470	PF00675	0.587
CLV_NRD_NRD_1	475	477	PF00675	0.504
CLV_NRD_NRD_1	485	487	PF00675	0.409
CLV_PCSK_FUR_1	483	487	PF00082	0.375
CLV_PCSK_KEX2_1	232	234	PF00082	0.422
CLV_PCSK_KEX2_1	343	345	PF00082	0.450
CLV_PCSK_KEX2_1	365	367	PF00082	0.444
CLV_PCSK_KEX2_1	375	377	PF00082	0.325
CLV_PCSK_KEX2_1	413	415	PF00082	0.584
CLV_PCSK_KEX2_1	468	470	PF00082	0.587
CLV_PCSK_KEX2_1	475	477	PF00082	0.504
CLV_PCSK_KEX2_1	485	487	PF00082	0.409
CLV_PCSK_PC1ET2_1	485	487	PF00082	0.451
CLV_PCSK_SKI1_1	315	319	PF00082	0.465
CLV_PCSK_SKI1_1	344	348	PF00082	0.364
CLV_PCSK_SKI1_1	375	379	PF00082	0.422
CLV_PCSK_SKI1_1	469	473	PF00082	0.680
DEG_Nend_UBRbox_1	1	4	PF02207	0.586
DEG_SPOP_SBC_1	125	129	PF00917	0.396
DOC_CKS1_1	252	257	PF01111	0.478
DOC_CYCLIN_RxL_1	340	351	PF00134	0.449
DOC_CYCLIN_RxL_1	372	381	PF00134	0.464
DOC_CYCLIN_yCln2_LP_2	252	258	PF00134	0.441
DOC_MAPK_gen_1	170	180	PF00069	0.362
DOC_MAPK_gen_1	340	350	PF00069	0.428
DOC_MAPK_gen_1	365	373	PF00069	0.500
DOC_MAPK_gen_1	413	420	PF00069	0.510
DOC_MAPK_gen_1	462	472	PF00069	0.641
DOC_MAPK_gen_1	81	90	PF00069	0.537
DOC_MAPK_MEF2A_6	343	350	PF00069	0.435
DOC_MAPK_NFAT4_5	343	351	PF00069	0.476
DOC_MAPK_RevD_3	217	233	PF00069	0.420
DOC_PP1_RVXF_1	466	473	PF00149	0.567
DOC_PP4_FxxP_1	441	444	PF00568	0.504
DOC_PP4_FxxP_1	97	100	PF00568	0.484
DOC_USP7_MATH_1	158	162	PF00917	0.495
DOC_USP7_MATH_1	186	190	PF00917	0.561
DOC_USP7_MATH_1	258	262	PF00917	0.611
DOC_USP7_MATH_1	28	32	PF00917	0.481
DOC_USP7_MATH_1	79	83	PF00917	0.560
DOC_USP7_UBL2_3	195	199	PF12436	0.418
DOC_WW_Pin1_4	251	256	PF00397	0.674
DOC_WW_Pin1_4	260	265	PF00397	0.534
DOC_WW_Pin1_4	385	390	PF00397	0.519
DOC_WW_Pin1_4	406	411	PF00397	0.438
DOC_WW_Pin1_4	43	48	PF00397	0.447
DOC_WW_Pin1_4	448	453	PF00397	0.610
DOC_WW_Pin1_4	96	101	PF00397	0.483
LIG_14-3-3_CanoR_1	116	121	PF00244	0.572
LIG_14-3-3_CanoR_1	247	255	PF00244	0.638
LIG_14-3-3_CanoR_1	303	312	PF00244	0.544
LIG_14-3-3_CanoR_1	315	323	PF00244	0.486
LIG_14-3-3_CanoR_1	343	349	PF00244	0.436
LIG_14-3-3_CanoR_1	403	407	PF00244	0.555
LIG_Actin_WH2_2	150	168	PF00022	0.397
LIG_BRCT_BRCA1_1	308	312	PF00533	0.483
LIG_DLG_GKlike_1	116	123	PF00625	0.316
LIG_FHA_1	202	208	PF00498	0.628
LIG_FHA_1	31	37	PF00498	0.456
LIG_FHA_1	345	351	PF00498	0.362
LIG_FHA_1	395	401	PF00498	0.475
LIG_FHA_1	421	427	PF00498	0.575
LIG_FHA_1	472	478	PF00498	0.559
LIG_FHA_2	101	107	PF00498	0.619
LIG_FHA_2	195	201	PF00498	0.606
LIG_FHA_2	319	325	PF00498	0.476
LIG_FHA_2	330	336	PF00498	0.513
LIG_Integrin_isoDGR_2	463	465	PF01839	0.620
LIG_LIR_Apic_2	438	444	PF02991	0.495
LIG_LIR_Apic_2	448	452	PF02991	0.523
LIG_LIR_Apic_2	95	100	PF02991	0.471
LIG_LIR_Gen_1	128	139	PF02991	0.413
LIG_LRP6_Inhibitor_1	477	483	PF00058	0.512
LIG_MYND_1	385	389	PF01753	0.396
LIG_NBox_RRM_1	313	323	PF00076	0.392
LIG_NRBOX	296	302	PF00104	0.268
LIG_PCNA_yPIPBox_3	214	223	PF02747	0.435
LIG_REV1ctd_RIR_1	310	319	PF16727	0.388
LIG_SH2_CRK	169	173	PF00017	0.455
LIG_SH2_NCK_1	202	206	PF00017	0.504
LIG_SH2_SRC	333	336	PF00017	0.487
LIG_SH2_STAP1	333	337	PF00017	0.482
LIG_SH2_STAP1	37	41	PF00017	0.284
LIG_SH2_STAP1	424	428	PF00017	0.540
LIG_SH2_STAT5	349	352	PF00017	0.266
LIG_SH2_STAT5	363	366	PF00017	0.540
LIG_SH2_STAT5	481	484	PF00017	0.492
LIG_SH2_STAT5	9	12	PF00017	0.426
LIG_SH3_3	324	330	PF00018	0.552
LIG_SH3_CIN85_PxpxPR_1	452	457	PF14604	0.681
LIG_SUMO_SIM_anti_2	281	287	PF11976	0.404
LIG_SUMO_SIM_anti_2	370	375	PF11976	0.468
LIG_TRAF2_1	208	211	PF00917	0.687
LIG_TRAF2_1	332	335	PF00917	0.505
LIG_TYR_ITIM	157	162	PF00017	0.409
LIG_UBA3_1	89	98	PF00899	0.369
LIG_WW_3	465	469	PF00397	0.545
MOD_CDK_SPK_2	452	457	PF00069	0.649
MOD_CDK_SPxxK_3	406	413	PF00069	0.443
MOD_CK1_1	109	115	PF00069	0.645
MOD_CK1_1	118	124	PF00069	0.483
MOD_CK1_1	190	196	PF00069	0.680
MOD_CK1_1	29	35	PF00069	0.468
MOD_CK1_1	308	314	PF00069	0.435
MOD_CK1_1	380	386	PF00069	0.353
MOD_CK1_1	409	415	PF00069	0.721
MOD_CK2_1	116	122	PF00069	0.534
MOD_CK2_1	178	184	PF00069	0.412
MOD_CK2_1	194	200	PF00069	0.497
MOD_CK2_1	318	324	PF00069	0.497
MOD_CK2_1	329	335	PF00069	0.520
MOD_CK2_1	59	65	PF00069	0.511
MOD_GlcNHglycan	12	15	PF01048	0.682
MOD_GlcNHglycan	122	126	PF01048	0.489
MOD_GlcNHglycan	128	131	PF01048	0.449
MOD_GlcNHglycan	16	19	PF01048	0.665
MOD_GlcNHglycan	264	267	PF01048	0.679
MOD_GlcNHglycan	297	300	PF01048	0.402
MOD_GlcNHglycan	307	311	PF01048	0.510
MOD_GlcNHglycan	334	338	PF01048	0.474
MOD_GSK3_1	10	17	PF00069	0.517
MOD_GSK3_1	105	112	PF00069	0.731
MOD_GSK3_1	121	128	PF00069	0.391
MOD_GSK3_1	186	193	PF00069	0.610
MOD_GSK3_1	258	265	PF00069	0.671
MOD_GSK3_1	26	33	PF00069	0.536
MOD_GSK3_1	295	302	PF00069	0.433
MOD_GSK3_1	329	336	PF00069	0.646
MOD_GSK3_1	344	351	PF00069	0.448
MOD_GSK3_1	402	409	PF00069	0.621
MOD_GSK3_1	448	455	PF00069	0.670
MOD_GSK3_1	471	478	PF00069	0.570
MOD_GSK3_1	92	99	PF00069	0.333
MOD_NEK2_1	115	120	PF00069	0.557
MOD_NEK2_1	201	206	PF00069	0.531
MOD_NEK2_1	234	239	PF00069	0.362
MOD_NEK2_1	246	251	PF00069	0.626
MOD_NEK2_1	26	31	PF00069	0.523
MOD_NEK2_1	391	396	PF00069	0.364
MOD_NEK2_1	8	13	PF00069	0.611
MOD_NEK2_2	111	116	PF00069	0.358
MOD_NEK2_2	79	84	PF00069	0.371
MOD_NEK2_2	92	97	PF00069	0.259
MOD_PK_1	429	435	PF00069	0.602
MOD_PKA_1	475	481	PF00069	0.490
MOD_PKA_2	115	121	PF00069	0.337
MOD_PKA_2	246	252	PF00069	0.425
MOD_PKA_2	267	273	PF00069	0.514
MOD_PKA_2	402	408	PF00069	0.557
MOD_PKA_2	475	481	PF00069	0.498
MOD_PKB_1	303	311	PF00069	0.390
MOD_Plk_1	209	215	PF00069	0.678
MOD_Plk_2-3	329	335	PF00069	0.520
MOD_Plk_4	143	149	PF00069	0.528
MOD_Plk_4	281	287	PF00069	0.431
MOD_Plk_4	308	314	PF00069	0.368
MOD_Plk_4	344	350	PF00069	0.445
MOD_ProDKin_1	251	257	PF00069	0.678
MOD_ProDKin_1	260	266	PF00069	0.536
MOD_ProDKin_1	385	391	PF00069	0.512
MOD_ProDKin_1	406	412	PF00069	0.439
MOD_ProDKin_1	43	49	PF00069	0.447
MOD_ProDKin_1	448	454	PF00069	0.609
MOD_ProDKin_1	96	102	PF00069	0.491
MOD_SUMO_rev_2	439	448	PF00179	0.549
TRG_DiLeu_BaEn_2	271	277	PF01217	0.417
TRG_DiLeu_BaEn_2	436	442	PF01217	0.496
TRG_ENDOCYTIC_2	159	162	PF00928	0.449
TRG_ENDOCYTIC_2	169	172	PF00928	0.239
TRG_ER_diArg_1	231	233	PF00400	0.427
TRG_ER_diArg_1	364	366	PF00400	0.419
TRG_ER_diArg_1	374	376	PF00400	0.316
TRG_ER_diArg_1	413	415	PF00400	0.584
TRG_ER_diArg_1	467	469	PF00400	0.598
TRG_ER_diArg_1	475	477	PF00400	0.493
TRG_NLS_Bipartite_1	468	490	PF00514	0.560
TRG_NLS_MonoCore_2	484	489	PF00514	0.472
TRG_NLS_MonoExtN_4	483	490	PF00514	0.475
TRG_Pf-PMV_PEXEL_1	232	236	PF00026	0.425
TRG_Pf-PMV_PEXEL_1	375	379	PF00026	0.430
TRG_Pf-PMV_PEXEL_1	440	445	PF00026	0.404

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5S3	Leptomonas seymouri	58%	100%
A0A1X0P4N9	Trypanosomatidae	34%	100%
A0A3R7KSE1	Trypanosoma rangeli	33%	100%
A0A3S7X0E2	Leishmania donovani	80%	100%
A4I2L9	Leishmania infantum	80%	100%
D0A5N1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	100%
E9AD09	Leishmania major	80%	100%
E9AYT4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	100%
V5BSR3	Trypanosoma cruzi	32%	100%