Methylmalonyl-CoA mutase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

methylmalonyl-coenzyme a mutase, putative

Species:

Leishmania braziliensis

UniProt:

A4HFE8_LEIBR

TriTrypDb:

LbrM.27.0310 , LBRM2903_270008100

Length:

723

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005739	mitochondrion	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HFE8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HFE8

Function

Biological processes
Term	Name	Level	Count
GO:0006082	organic acid metabolic process	3	1
GO:0006629	lipid metabolic process	3	1
GO:0006631	fatty acid metabolic process	4	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	1
GO:0019541	propionate metabolic process	6	1
GO:0019678	propionate metabolic process, methylmalonyl pathway	7	1
GO:0019752	carboxylic acid metabolic process	5	1
GO:0032787	monocarboxylic acid metabolic process	6	1
GO:0043436	oxoacid metabolic process	4	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044255	cellular lipid metabolic process	3	1
GO:0044281	small molecule metabolic process	2	1
GO:0046459	short-chain fatty acid metabolic process	5	1
GO:0071704	organic substance metabolic process	2	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	8
GO:0004494	methylmalonyl-CoA mutase activity	4	8
GO:0005488	binding	1	8
GO:0016853	isomerase activity	2	8
GO:0016866	intramolecular transferase activity	3	8
GO:0019842	vitamin binding	3	8
GO:0031419	cobalamin binding	4	8
GO:0036094	small molecule binding	2	8
GO:0043167	ion binding	2	8
GO:0043169	cation binding	3	8
GO:0046872	metal ion binding	4	8
GO:0046906	tetrapyrrole binding	3	8
GO:0097159	organic cyclic compound binding	2	8
GO:1901363	heterocyclic compound binding	2	8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	253	257	PF00656	0.457
CLV_MEL_PAP_1	274	280	PF00089	0.278
CLV_NRD_NRD_1	3	5	PF00675	0.514
CLV_NRD_NRD_1	447	449	PF00675	0.274
CLV_NRD_NRD_1	592	594	PF00675	0.336
CLV_PCSK_KEX2_1	224	226	PF00082	0.278
CLV_PCSK_KEX2_1	3	5	PF00082	0.514
CLV_PCSK_KEX2_1	413	415	PF00082	0.192
CLV_PCSK_KEX2_1	447	449	PF00082	0.274
CLV_PCSK_KEX2_1	592	594	PF00082	0.336
CLV_PCSK_PC1ET2_1	224	226	PF00082	0.278
CLV_PCSK_PC1ET2_1	413	415	PF00082	0.192
CLV_PCSK_SKI1_1	144	148	PF00082	0.231
CLV_PCSK_SKI1_1	23	27	PF00082	0.462
CLV_PCSK_SKI1_1	307	311	PF00082	0.284
CLV_PCSK_SKI1_1	316	320	PF00082	0.267
CLV_PCSK_SKI1_1	508	512	PF00082	0.249
CLV_PCSK_SKI1_1	608	612	PF00082	0.231
CLV_PCSK_SKI1_1	698	702	PF00082	0.274
CLV_PCSK_SKI1_1	97	101	PF00082	0.231
DEG_APCC_DBOX_1	531	539	PF00400	0.431
DEG_SCF_TRCP1_1	453	458	PF00400	0.431
DEG_SPOP_SBC_1	559	563	PF00917	0.264
DOC_CKS1_1	207	212	PF01111	0.474
DOC_CKS1_1	630	635	PF01111	0.431
DOC_CKS1_1	703	708	PF01111	0.524
DOC_MAPK_gen_1	26	35	PF00069	0.462
DOC_MAPK_gen_1	3	9	PF00069	0.558
DOC_MAPK_gen_1	376	385	PF00069	0.431
DOC_MAPK_gen_1	515	524	PF00069	0.413
DOC_MAPK_gen_1	589	598	PF00069	0.344
DOC_MAPK_MEF2A_6	518	526	PF00069	0.385
DOC_MAPK_MEF2A_6	589	598	PF00069	0.344
DOC_PP1_RVXF_1	142	148	PF00149	0.431
DOC_PP1_RVXF_1	42	49	PF00149	0.376
DOC_PP1_RVXF_1	696	702	PF00149	0.478
DOC_PP2B_PxIxI_1	593	599	PF00149	0.325
DOC_PP4_FxxP_1	630	633	PF00568	0.431
DOC_USP7_MATH_1	136	140	PF00917	0.474
DOC_USP7_MATH_1	176	180	PF00917	0.431
DOC_USP7_MATH_1	208	212	PF00917	0.431
DOC_USP7_MATH_1	312	316	PF00917	0.395
DOC_USP7_MATH_1	368	372	PF00917	0.431
DOC_USP7_MATH_1	451	455	PF00917	0.431
DOC_USP7_MATH_1	89	93	PF00917	0.434
DOC_USP7_MATH_2	151	157	PF00917	0.376
DOC_USP7_UBL2_3	144	148	PF12436	0.395
DOC_USP7_UBL2_3	22	26	PF12436	0.419
DOC_USP7_UBL2_3	566	570	PF12436	0.343
DOC_USP7_UBL2_3	97	101	PF12436	0.474
DOC_WW_Pin1_4	206	211	PF00397	0.474
DOC_WW_Pin1_4	34	39	PF00397	0.309
DOC_WW_Pin1_4	629	634	PF00397	0.431
DOC_WW_Pin1_4	702	707	PF00397	0.431
LIG_14-3-3_CanoR_1	201	205	PF00244	0.431
LIG_14-3-3_CanoR_1	277	281	PF00244	0.449
LIG_14-3-3_CanoR_1	296	302	PF00244	0.395
LIG_14-3-3_CanoR_1	321	329	PF00244	0.431
LIG_14-3-3_CanoR_1	379	385	PF00244	0.431
LIG_14-3-3_CanoR_1	414	422	PF00244	0.392
LIG_14-3-3_CanoR_1	530	536	PF00244	0.431
LIG_AP2alpha_2	396	398	PF02296	0.431
LIG_BRCT_BRCA1_1	107	111	PF00533	0.431
LIG_BRCT_BRCA1_1	278	282	PF00533	0.431
LIG_BRCT_BRCA1_1	91	95	PF00533	0.431
LIG_BRCT_BRCA1_2	91	97	PF00533	0.474
LIG_EVH1_1	206	210	PF00568	0.474
LIG_FHA_1	30	36	PF00498	0.462
LIG_FHA_1	379	385	PF00498	0.431
LIG_FHA_1	427	433	PF00498	0.455
LIG_FHA_1	473	479	PF00498	0.431
LIG_FHA_1	63	69	PF00498	0.436
LIG_FHA_2	251	257	PF00498	0.431
LIG_FHA_2	330	336	PF00498	0.431
LIG_FHA_2	341	347	PF00498	0.431
LIG_FHA_2	532	538	PF00498	0.431
LIG_FHA_2	630	636	PF00498	0.431
LIG_FHA_2	86	92	PF00498	0.431
LIG_GBD_Chelix_1	250	258	PF00786	0.231
LIG_LIR_Apic_2	203	207	PF02991	0.431
LIG_LIR_Gen_1	287	297	PF02991	0.376
LIG_LIR_Gen_1	687	697	PF02991	0.433
LIG_LIR_Nem_3	279	284	PF02991	0.431
LIG_LIR_Nem_3	287	292	PF02991	0.431
LIG_LIR_Nem_3	300	305	PF02991	0.428
LIG_LIR_Nem_3	433	439	PF02991	0.433
LIG_LIR_Nem_3	543	549	PF02991	0.474
LIG_LIR_Nem_3	687	692	PF02991	0.433
LIG_MLH1_MIPbox_1	278	282	PF16413	0.431
LIG_PCNA_yPIPBox_3	185	199	PF02747	0.431
LIG_PCNA_yPIPBox_3	493	507	PF02747	0.392
LIG_Pex14_1	398	402	PF04695	0.431
LIG_Pex14_2	278	282	PF04695	0.478
LIG_SH2_GRB2like	221	224	PF00017	0.395
LIG_SH2_GRB2like	465	468	PF00017	0.431
LIG_SH2_PTP2	204	207	PF00017	0.431
LIG_SH2_PTP2	465	468	PF00017	0.474
LIG_SH2_STAP1	560	564	PF00017	0.304
LIG_SH2_STAP1	622	626	PF00017	0.431
LIG_SH2_STAT3	237	240	PF00017	0.431
LIG_SH2_STAT5	204	207	PF00017	0.431
LIG_SH2_STAT5	221	224	PF00017	0.431
LIG_SH2_STAT5	260	263	PF00017	0.431
LIG_SH2_STAT5	289	292	PF00017	0.474
LIG_SH2_STAT5	305	308	PF00017	0.389
LIG_SH2_STAT5	465	468	PF00017	0.431
LIG_SH2_STAT5	47	50	PF00017	0.465
LIG_SH2_STAT5	549	552	PF00017	0.446
LIG_SH2_STAT5	564	567	PF00017	0.340
LIG_SH2_STAT5	64	67	PF00017	0.375
LIG_SH2_STAT5	73	76	PF00017	0.431
LIG_SH3_1	204	210	PF00018	0.431
LIG_SH3_1	53	59	PF00018	0.395
LIG_SH3_3	204	210	PF00018	0.431
LIG_SH3_3	32	38	PF00018	0.322
LIG_SH3_3	364	370	PF00018	0.431
LIG_SH3_3	391	397	PF00018	0.431
LIG_SH3_3	53	59	PF00018	0.438
LIG_SH3_3	680	686	PF00018	0.431
LIG_SH3_3	700	706	PF00018	0.345
LIG_SH3_5	685	689	PF00018	0.431
LIG_SUMO_SIM_par_1	31	37	PF11976	0.462
LIG_SUMO_SIM_par_1	712	719	PF11976	0.405
LIG_SxIP_EBH_1	700	709	PF03271	0.431
LIG_TRAF2_1	175	178	PF00917	0.431
LIG_TRAF2_1	541	544	PF00917	0.474
LIG_TRAF2_1	632	635	PF00917	0.474
LIG_TRAF2_1	88	91	PF00917	0.431
LIG_UBA3_1	146	154	PF00899	0.431
LIG_UBA3_1	218	224	PF00899	0.395
LIG_UBA3_1	660	669	PF00899	0.474
LIG_UBA3_1	714	723	PF00899	0.428
MOD_CDK_SPxxK_3	206	213	PF00069	0.474
MOD_CDK_SPxxK_3	702	709	PF00069	0.526
MOD_CK1_1	121	127	PF00069	0.376
MOD_CK1_1	179	185	PF00069	0.431
MOD_CK1_1	324	330	PF00069	0.436
MOD_CK1_1	357	363	PF00069	0.431
MOD_CK1_1	371	377	PF00069	0.431
MOD_CK2_1	327	333	PF00069	0.431
MOD_CK2_1	340	346	PF00069	0.431
MOD_CK2_1	451	457	PF00069	0.431
MOD_CK2_1	531	537	PF00069	0.431
MOD_CK2_1	629	635	PF00069	0.431
MOD_CK2_1	84	90	PF00069	0.433
MOD_Cter_Amidation	590	593	PF01082	0.362
MOD_GlcNHglycan	177	181	PF01048	0.231
MOD_GlcNHglycan	234	237	PF01048	0.231
MOD_GlcNHglycan	326	329	PF01048	0.231
MOD_GlcNHglycan	415	418	PF01048	0.274
MOD_GlcNHglycan	442	446	PF01048	0.250
MOD_GlcNHglycan	453	456	PF01048	0.207
MOD_GlcNHglycan	539	542	PF01048	0.274
MOD_GlcNHglycan	9	12	PF01048	0.520
MOD_GSK3_1	153	160	PF00069	0.431
MOD_GSK3_1	228	235	PF00069	0.431
MOD_GSK3_1	297	304	PF00069	0.428
MOD_GSK3_1	3	10	PF00069	0.486
MOD_GSK3_1	319	326	PF00069	0.431
MOD_GSK3_1	368	375	PF00069	0.431
MOD_GSK3_1	386	393	PF00069	0.431
MOD_GSK3_1	451	458	PF00069	0.431
MOD_GSK3_1	67	74	PF00069	0.557
MOD_GSK3_1	85	92	PF00069	0.403
MOD_NEK2_1	186	191	PF00069	0.431
MOD_NEK2_1	228	233	PF00069	0.423
MOD_NEK2_1	250	255	PF00069	0.431
MOD_NEK2_1	301	306	PF00069	0.468
MOD_NEK2_1	319	324	PF00069	0.367
MOD_NEK2_2	276	281	PF00069	0.431
MOD_NEK2_2	31	36	PF00069	0.327
MOD_NEK2_2	354	359	PF00069	0.431
MOD_PIKK_1	179	185	PF00454	0.431
MOD_PIKK_1	321	327	PF00454	0.431
MOD_PIKK_1	378	384	PF00454	0.431
MOD_PIKK_1	405	411	PF00454	0.466
MOD_PIKK_1	550	556	PF00454	0.414
MOD_PK_1	3	9	PF00069	0.486
MOD_PKA_1	3	9	PF00069	0.486
MOD_PKA_1	413	419	PF00069	0.478
MOD_PKA_1	508	514	PF00069	0.474
MOD_PKA_2	186	192	PF00069	0.457
MOD_PKA_2	200	206	PF00069	0.394
MOD_PKA_2	276	282	PF00069	0.431
MOD_PKA_2	3	9	PF00069	0.516
MOD_PKA_2	341	347	PF00069	0.431
MOD_PKA_2	378	384	PF00069	0.431
MOD_PKA_2	413	419	PF00069	0.392
MOD_PKA_2	531	537	PF00069	0.431
MOD_Plk_1	121	127	PF00069	0.376
MOD_Plk_1	386	392	PF00069	0.474
MOD_Plk_4	200	206	PF00069	0.431
MOD_Plk_4	3	9	PF00069	0.486
MOD_Plk_4	301	307	PF00069	0.455
MOD_Plk_4	314	320	PF00069	0.399
MOD_Plk_4	398	404	PF00069	0.412
MOD_Plk_4	455	461	PF00069	0.431
MOD_Plk_4	560	566	PF00069	0.423
MOD_Plk_4	68	74	PF00069	0.460
MOD_ProDKin_1	206	212	PF00069	0.474
MOD_ProDKin_1	34	40	PF00069	0.310
MOD_ProDKin_1	629	635	PF00069	0.431
MOD_ProDKin_1	702	708	PF00069	0.431
MOD_SUMO_for_1	21	24	PF00179	0.442
MOD_SUMO_rev_2	138	146	PF00179	0.431
MOD_SUMO_rev_2	37	46	PF00179	0.266
MOD_SUMO_rev_2	474	483	PF00179	0.491
MOD_SUMO_rev_2	50	54	PF00179	0.431
MOD_SUMO_rev_2	512	519	PF00179	0.452
TRG_DiLeu_BaEn_1	141	146	PF01217	0.474
TRG_ENDOCYTIC_2	289	292	PF00928	0.431
TRG_ENDOCYTIC_2	465	468	PF00928	0.376
TRG_ENDOCYTIC_2	689	692	PF00928	0.431
TRG_ENDOCYTIC_2	83	86	PF00928	0.431
TRG_ER_diArg_1	2	4	PF00400	0.522
TRG_ER_diArg_1	592	595	PF00400	0.338
TRG_Pf-PMV_PEXEL_1	213	217	PF00026	0.231
TRG_Pf-PMV_PEXEL_1	267	272	PF00026	0.225
TRG_Pf-PMV_PEXEL_1	658	663	PF00026	0.231

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P664	Leptomonas seymouri	86%	99%
A0A0S4ISJ2	Bodo saltans	72%	100%
A0A3S7X0D3	Leishmania donovani	92%	100%
A4I2L1	Leishmania infantum	92%	100%
A7IQE5	Xanthobacter autotrophicus (strain ATCC BAA-1158 / Py2)	32%	100%
E9AD07	Leishmania major	91%	100%
E9AYT2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
I3VE77	Aquincola tertiaricarbonis	41%	100%
O86028	Rhizobium meliloti (strain 1021)	56%	100%
P11653	Propionibacterium freudenreichii subsp. shermanii	57%	99%
P16332	Mus musculus	63%	97%
P22033	Homo sapiens	62%	96%
P27253	Escherichia coli (strain K12)	58%	100%
P65488	Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)	56%	96%
P9WJK4	Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)	56%	96%
P9WJK5	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)	56%	96%
Q05065	Streptomyces virginiae	57%	99%
Q1LRY0	Cupriavidus metallidurans (strain ATCC 43123 / DSM 2839 / NBRC 102507 / CH34)	35%	66%
Q23381	Caenorhabditis elegans	63%	97%
Q3IZ90	Cereibacter sphaeroides (strain ATCC 17023 / DSM 158 / JCM 6121 / CCUG 31486 / LMG 2827 / NBRC 12203 / NCIMB 8253 / ATH 2.4.1.)	32%	100%
Q3J4D7	Cereibacter sphaeroides (strain ATCC 17023 / DSM 158 / JCM 6121 / CCUG 31486 / LMG 2827 / NBRC 12203 / NCIMB 8253 / ATH 2.4.1.)	60%	100%
Q49115	Methylorubrum extorquens (strain ATCC 14718 / DSM 1338 / JCM 2805 / NCIMB 9133 / AM1)	33%	100%
Q59676	Porphyromonas gingivalis (strain ATCC BAA-308 / W83)	26%	100%
Q59677	Porphyromonas gingivalis (strain ATCC BAA-308 / W83)	59%	100%
Q5KUG0	Geobacillus kaustophilus (strain HTA426)	34%	67%
Q5RFN2	Pongo abelii	62%	96%
Q5Z110	Nocardia farcinica (strain IFM 10152)	33%	68%
Q8HXX1	Macaca fascicularis	62%	96%
Q8MI68	Sus scrofa	62%	96%
Q9GK13	Bos taurus	62%	96%