Acyl carrier protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

acyl carrier protein, mitochondrial, putative

Species:

Leishmania braziliensis

UniProt:

A4HFE7_LEIBR

TriTrypDb:

LbrM.27.0300 , LBRM2903_270008000

Length:

150

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 25

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 8

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	1
GO:0005747	mitochondrial respiratory chain complex I	4	1
GO:0005759	mitochondrial matrix	5	1
GO:0030964	NADH dehydrogenase complex	3	1
GO:0031974	membrane-enclosed lumen	2	1
GO:0032991	protein-containing complex	1	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0043233	organelle lumen	3	1
GO:0045271	respiratory chain complex I	4	1
GO:0070013	intracellular organelle lumen	4	1
GO:0098796	membrane protein complex	2	1
GO:0098798	mitochondrial protein-containing complex	2	1
GO:0098800	inner mitochondrial membrane protein complex	3	1
GO:0098803	respiratory chain complex	3	1
GO:0110165	cellular anatomical entity	1	1
GO:1902494	catalytic complex	2	1
GO:1902495	transmembrane transporter complex	3	1
GO:1990204	oxidoreductase complex	3	1
GO:1990351	transporter complex	2	1

Expansion

Sequence features

A4HFE7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HFE7

PDB structure(s): 2m5r_A , 5zws_A , 5zws_B , 5zwt_A , 5zwt_B , 7am2_CC

Function

Biological processes
Term	Name	Level	Count
GO:0006082	organic acid metabolic process	3	11
GO:0006629	lipid metabolic process	3	11
GO:0006631	fatty acid metabolic process	4	11
GO:0006633	fatty acid biosynthetic process	5	11
GO:0008152	metabolic process	1	11
GO:0008610	lipid biosynthetic process	4	11
GO:0009058	biosynthetic process	2	11
GO:0009987	cellular process	1	11
GO:0016053	organic acid biosynthetic process	4	11
GO:0019752	carboxylic acid metabolic process	5	11
GO:0032787	monocarboxylic acid metabolic process	6	11
GO:0043436	oxoacid metabolic process	4	11
GO:0044237	cellular metabolic process	2	11
GO:0044238	primary metabolic process	2	11
GO:0044249	cellular biosynthetic process	3	11
GO:0044255	cellular lipid metabolic process	3	11
GO:0044281	small molecule metabolic process	2	11
GO:0044283	small molecule biosynthetic process	3	11
GO:0046394	carboxylic acid biosynthetic process	5	11
GO:0071704	organic substance metabolic process	2	11
GO:0072330	monocarboxylic acid biosynthetic process	6	11
GO:1901576	organic substance biosynthetic process	3	11

Molecular functions
Term	Name	Level	Count
GO:0000035	acyl binding	2	1
GO:0000036	acyl carrier activity	3	1
GO:0005488	binding	1	1
GO:0044620	ACP phosphopantetheine attachment site binding	3	1
GO:0051192	prosthetic group binding	2	1
GO:0140104	molecular carrier activity	1	1
GO:0140414	phosphopantetheine-dependent carrier activity	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	135	139	PF00656	0.501
CLV_C14_Caspase3-7	86	90	PF00656	0.501
CLV_NRD_NRD_1	7	9	PF00675	0.600
CLV_PCSK_KEX2_1	7	9	PF00082	0.691
CLV_PCSK_PC7_1	3	9	PF00082	0.726
CLV_PCSK_SKI1_1	12	16	PF00082	0.619
DEG_COP1_1	35	45	PF00400	0.461
DEG_Nend_UBRbox_3	1	3	PF02207	0.649
DOC_MAPK_HePTP_8	9	21	PF00069	0.465
DOC_MAPK_MEF2A_6	12	21	PF00069	0.466
DOC_PP2B_LxvP_1	123	126	PF13499	0.501
DOC_PP4_FxxP_1	45	48	PF00568	0.468
DOC_USP7_MATH_1	22	26	PF00917	0.673
DOC_USP7_UBL2_3	83	87	PF12436	0.501
DOC_WW_Pin1_4	91	96	PF00397	0.493
LIG_14-3-3_CanoR_1	23	31	PF00244	0.661
LIG_14-3-3_CanoR_1	34	43	PF00244	0.621
LIG_FHA_1	22	28	PF00498	0.599
LIG_FHA_1	74	80	PF00498	0.353
LIG_LIR_Apic_2	44	48	PF02991	0.465
LIG_LIR_Nem_3	13	18	PF02991	0.701
LIG_MAD2	40	48	PF02301	0.596
LIG_PCNA_yPIPBox_3	71	79	PF02747	0.525
LIG_SH2_STAT3	142	145	PF00017	0.572
LIG_SH2_STAT5	142	145	PF00017	0.572
LIG_SH2_STAT5	67	70	PF00017	0.526
LIG_Sin3_3	15	22	PF02671	0.469
LIG_SUMO_SIM_anti_2	107	112	PF11976	0.501
LIG_SUMO_SIM_par_1	120	127	PF11976	0.501
LIG_WRC_WIRS_1	42	47	PF05994	0.715
MOD_CK1_1	35	41	PF00069	0.534
MOD_CK1_1	91	97	PF00069	0.373
MOD_GlcNHglycan	12	15	PF01048	0.714
MOD_GlcNHglycan	34	37	PF01048	0.657
MOD_GlcNHglycan	52	55	PF01048	0.662
MOD_GlcNHglycan	63	66	PF01048	0.589
MOD_N-GLC_1	10	15	PF02516	0.714
MOD_NEK2_1	1	6	PF00069	0.580
MOD_PIKK_1	22	28	PF00454	0.688
MOD_PK_1	132	138	PF00069	0.348
MOD_PKA_2	22	28	PF00069	0.683
MOD_Plk_1	10	16	PF00069	0.714
MOD_Plk_4	41	47	PF00069	0.714
MOD_ProDKin_1	91	97	PF00069	0.343
TRG_ER_diArg_1	6	8	PF00400	0.723

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5S1	Leptomonas seymouri	88%	100%
A0A0S4KI16	Bodo saltans	82%	100%
A0A1X0NLX3	Trypanosomatidae	64%	100%
A0A3Q8ICI1	Leishmania donovani	86%	100%
A0A422NXN1	Trypanosoma rangeli	64%	100%
A4I2L8	Leishmania infantum	87%	100%
C9ZKW7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	80%	100%
E9AD06	Leishmania major	87%	100%
E9AYT1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
O80800	Arabidopsis thaliana	56%	100%
P11943	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	47%	100%
P32463	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	37%	100%
P53665	Arabidopsis thaliana	51%	100%
P93092	Casuarina glauca	32%	100%
Q10217	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	49%	100%
Q94519	Drosophila melanogaster	45%	99%