Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HFE5_LEIBR

TriTrypDb:

LbrM.27.0280

Length:

290

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	4
GO:0110165	cellular anatomical entity	1	4

Expansion

Sequence features

A4HFE5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HFE5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	108	110	PF00675	0.320
CLV_NRD_NRD_1	92	94	PF00675	0.503
CLV_PCSK_KEX2_1	108	110	PF00082	0.320
CLV_PCSK_KEX2_1	92	94	PF00082	0.503
CLV_PCSK_PC1ET2_1	92	94	PF00082	0.503
CLV_PCSK_SKI1_1	135	139	PF00082	0.427
CLV_PCSK_SKI1_1	212	216	PF00082	0.521
DEG_APCC_DBOX_1	92	100	PF00400	0.580
DEG_Nend_Nbox_1	1	3	PF02207	0.472
DEG_SPOP_SBC_1	185	189	PF00917	0.605
DOC_MAPK_gen_1	92	101	PF00069	0.577
DOC_MAPK_MEF2A_6	92	101	PF00069	0.577
DOC_PP2B_LxvP_1	4	7	PF13499	0.293
DOC_SPAK_OSR1_1	191	195	PF12202	0.505
DOC_USP7_MATH_1	14	18	PF00917	0.309
DOC_USP7_MATH_1	172	176	PF00917	0.720
DOC_USP7_MATH_1	185	189	PF00917	0.578
DOC_USP7_MATH_1	247	251	PF00917	0.751
DOC_USP7_MATH_1	80	84	PF00917	0.474
DOC_WW_Pin1_4	140	145	PF00397	0.555
DOC_WW_Pin1_4	32	37	PF00397	0.334
LIG_14-3-3_CanoR_1	251	261	PF00244	0.547
LIG_14-3-3_CanoR_1	26	32	PF00244	0.320
LIG_14-3-3_CanoR_1	276	280	PF00244	0.606
LIG_deltaCOP1_diTrp_1	270	274	PF00928	0.575
LIG_FHA_1	181	187	PF00498	0.639
LIG_FHA_1	220	226	PF00498	0.646
LIG_FHA_1	76	82	PF00498	0.496
LIG_FHA_2	253	259	PF00498	0.632
LIG_LIR_Apic_2	140	144	PF02991	0.558
LIG_LIR_Gen_1	128	138	PF02991	0.542
LIG_LIR_Gen_1	189	200	PF02991	0.567
LIG_LIR_Gen_1	256	266	PF02991	0.631
LIG_LIR_Gen_1	27	36	PF02991	0.334
LIG_LIR_Nem_3	128	134	PF02991	0.547
LIG_LIR_Nem_3	162	167	PF02991	0.747
LIG_LIR_Nem_3	189	195	PF02991	0.554
LIG_LIR_Nem_3	208	214	PF02991	0.648
LIG_LIR_Nem_3	256	262	PF02991	0.634
LIG_LIR_Nem_3	269	274	PF02991	0.612
LIG_LIR_Nem_3	27	31	PF02991	0.322
LIG_PDZ_Class_2	285	290	PF00595	0.596
LIG_Rb_LxCxE_1	55	70	PF01857	0.312
LIG_SH2_CRK	141	145	PF00017	0.559
LIG_SH2_CRK	164	168	PF00017	0.752
LIG_SH2_NCK_1	141	145	PF00017	0.559
LIG_SH2_STAP1	207	211	PF00017	0.713
LIG_SH2_STAT5	237	240	PF00017	0.617
LIG_SH2_STAT5	28	31	PF00017	0.357
LIG_SH2_STAT5	45	48	PF00017	0.350
LIG_SH3_3	192	198	PF00018	0.600
LIG_SUMO_SIM_anti_2	15	23	PF11976	0.448
LIG_SUMO_SIM_anti_2	95	101	PF11976	0.517
LIG_SUMO_SIM_par_1	145	150	PF11976	0.691
LIG_SUMO_SIM_par_1	193	199	PF11976	0.634
LIG_SUMO_SIM_par_1	77	83	PF11976	0.319
LIG_TRAF2_1	255	258	PF00917	0.546
LIG_UBA3_1	210	215	PF00899	0.654
LIG_WRC_WIRS_1	28	33	PF05994	0.405
MOD_CK1_1	17	23	PF00069	0.452
MOD_CK1_1	199	205	PF00069	0.662
MOD_CK1_1	27	33	PF00069	0.635
MOD_CK2_1	173	179	PF00069	0.691
MOD_CK2_1	252	258	PF00069	0.544
MOD_CK2_1	49	55	PF00069	0.464
MOD_CK2_1	6	12	PF00069	0.417
MOD_GlcNHglycan	102	105	PF01048	0.451
MOD_GlcNHglycan	117	120	PF01048	0.404
MOD_GlcNHglycan	16	19	PF01048	0.381
MOD_GlcNHglycan	201	204	PF01048	0.492
MOD_GlcNHglycan	281	284	PF01048	0.478
MOD_GSK3_1	180	187	PF00069	0.438
MOD_GSK3_1	215	222	PF00069	0.571
MOD_GSK3_1	275	282	PF00069	0.578
MOD_GSK3_1	75	82	PF00069	0.356
MOD_GSK3_1	8	15	PF00069	0.481
MOD_N-GLC_1	32	37	PF02516	0.422
MOD_NEK2_1	115	120	PF00069	0.358
MOD_NEK2_1	147	152	PF00069	0.525
MOD_NEK2_1	180	185	PF00069	0.534
MOD_NEK2_1	206	211	PF00069	0.576
MOD_NEK2_1	279	284	PF00069	0.485
MOD_PKA_2	275	281	PF00069	0.708
MOD_Plk_2-3	49	55	PF00069	0.464
MOD_Plk_4	17	23	PF00069	0.427
MOD_Plk_4	196	202	PF00069	0.653
MOD_Plk_4	206	212	PF00069	0.496
MOD_Plk_4	49	55	PF00069	0.399
MOD_ProDKin_1	140	146	PF00069	0.422
MOD_ProDKin_1	32	38	PF00069	0.381
TRG_DiLeu_BaLyEn_6	143	148	PF01217	0.653
TRG_DiLeu_BaLyEn_6	221	226	PF01217	0.684
TRG_ENDOCYTIC_2	112	115	PF00928	0.295
TRG_ENDOCYTIC_2	164	167	PF00928	0.692
TRG_ENDOCYTIC_2	207	210	PF00928	0.502
TRG_ENDOCYTIC_2	28	31	PF00928	0.389
TRG_ER_diArg_1	108	110	PF00400	0.356
TRG_Pf-PMV_PEXEL_1	204	208	PF00026	0.412
TRG_Pf-PMV_PEXEL_1	94	98	PF00026	0.568

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HX16	Leptomonas seymouri	42%	84%
A0A3Q8IE36	Leishmania donovani	73%	88%
A4I2L5	Leishmania infantum	73%	88%
E9AD03	Leishmania major	74%	100%
E9AYS8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	73%	88%