Kinetoplast-associated protein-like protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

kinetoplast-associated protein-like protein (fragment)

Species:

Leishmania braziliensis

UniProt:

A4HFE3_LEIBR

TriTrypDb:

LbrM.27.0260 , LBRM2903_270007700

Length:

485

Annotations

LeishMANIAdb annotations

A family of very long coiled-coil proteins, likely performing cytoskeletal functions.. Two varieties have evolved, one with an N-terminal FYVE domain (Non-TM) and another with a C-terminal PDZ domain (might be TM)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 3
NetGPI	no	yes: 0, no: 3

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HFE3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HFE3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_MEL_PAP_1	419	425	PF00089	0.574
CLV_NRD_NRD_1	460	462	PF00675	0.569
CLV_NRD_NRD_1	466	468	PF00675	0.560
CLV_PCSK_KEX2_1	460	462	PF00082	0.569
CLV_PCSK_KEX2_1	466	468	PF00082	0.560
CLV_PCSK_PC7_1	456	462	PF00082	0.531
CLV_PCSK_SKI1_1	461	465	PF00082	0.533
DEG_Nend_UBRbox_3	1	3	PF02207	0.594
DOC_PP1_RVXF_1	475	482	PF00149	0.545
DOC_USP7_UBL2_3	9	13	PF12436	0.555
DOC_WW_Pin1_4	414	419	PF00397	0.543
LIG_14-3-3_CanoR_1	422	429	PF00244	0.568
LIG_14-3-3_CanoR_1	433	439	PF00244	0.459
LIG_14-3-3_CanoR_1	466	471	PF00244	0.542
LIG_Actin_WH2_2	429	446	PF00022	0.552
LIG_FHA_1	398	404	PF00498	0.473
LIG_FHA_2	425	431	PF00498	0.564
LIG_Pex14_2	470	474	PF04695	0.542
LIG_SH2_PTP2	435	438	PF00017	0.559
LIG_SH2_STAP1	454	458	PF00017	0.528
LIG_SH2_STAT5	435	438	PF00017	0.559
LIG_SH3_3	472	478	PF00018	0.541
LIG_SH3_4	9	16	PF00018	0.536
MOD_CK1_1	424	430	PF00069	0.565
MOD_CK2_1	424	430	PF00069	0.565
MOD_GlcNHglycan	481	484	PF01048	0.551
MOD_PKA_1	466	472	PF00069	0.540
MOD_PKA_2	421	427	PF00069	0.571
MOD_PKA_2	466	472	PF00069	0.540
MOD_ProDKin_1	414	420	PF00069	0.549
MOD_SUMO_rev_2	437	446	PF00179	0.540
TRG_ENDOCYTIC_2	435	438	PF00928	0.559
TRG_ER_diArg_1	460	462	PF00400	0.569

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A4I2L3	Leishmania infantum	85%	73%
E9AD01	Leishmania major	85%	67%