Kinetoplast-associated protein-like protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

kinetoplast-associated protein-like protein

Species:

Leishmania braziliensis

UniProt:

A4HFE2_LEIBR

TriTrypDb:

LbrM.27.0250 , LbrM.27.0260 , LBRM2903_270007700

Length:

923

Annotations

LeishMANIAdb annotations

A family of very long coiled-coil proteins, likely performing cytoskeletal functions.. Two varieties have evolved, one with an N-terminal FYVE domain (Non-TM) and another with a C-terminal PDZ domain (might be TM)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	4
GO:0110165	cellular anatomical entity	1	4

Expansion

Sequence features

A4HFE2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HFE2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_MEL_PAP_1	819	825	PF00089	0.480
CLV_NRD_NRD_1	860	862	PF00675	0.476
CLV_NRD_NRD_1	866	868	PF00675	0.488
CLV_PCSK_KEX2_1	860	862	PF00082	0.478
CLV_PCSK_KEX2_1	866	868	PF00082	0.490
CLV_PCSK_PC7_1	856	862	PF00082	0.462
CLV_PCSK_SKI1_1	861	865	PF00082	0.447
CLV_PCSK_SKI1_1	877	881	PF00082	0.476
DEG_Nend_UBRbox_3	1	3	PF02207	0.510
DOC_CYCLIN_RxL_1	873	881	PF00134	0.482
DOC_USP7_UBL2_3	9	13	PF12436	0.457
DOC_WW_Pin1_4	814	819	PF00397	0.460
LIG_14-3-3_CanoR_1	822	829	PF00244	0.487
LIG_14-3-3_CanoR_1	833	839	PF00244	0.469
LIG_14-3-3_CanoR_1	866	871	PF00244	0.486
LIG_14-3-3_CanoR_1	882	888	PF00244	0.531
LIG_Actin_WH2_2	829	846	PF00022	0.475
LIG_FHA_1	798	804	PF00498	0.411
LIG_FHA_2	825	831	PF00498	0.485
LIG_Pex14_2	870	874	PF04695	0.504
LIG_Pex14_2	903	907	PF04695	0.467
LIG_SH2_PTP2	835	838	PF00017	0.477
LIG_SH2_STAP1	854	858	PF00017	0.452
LIG_SH2_STAT5	835	838	PF00017	0.482
LIG_SH3_3	872	878	PF00018	0.575
LIG_SH3_4	9	16	PF00018	0.439
MOD_CK1_1	824	830	PF00069	0.478
MOD_CK2_1	824	830	PF00069	0.478
MOD_PKA_1	866	872	PF00069	0.491
MOD_PKA_2	821	827	PF00069	0.482
MOD_PKA_2	866	872	PF00069	0.497
MOD_ProDKin_1	814	820	PF00069	0.465
MOD_SUMO_rev_2	837	846	PF00179	0.448
TRG_ENDOCYTIC_2	835	838	PF00928	0.477
TRG_ER_diArg_1	860	862	PF00400	0.449

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IJE1	Leishmania donovani	49%	100%
A4I2L3	Leishmania infantum	88%	100%
A4I850	Leishmania infantum	53%	78%
E9AD01	Leishmania major	88%	100%
E9AYS6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	69%
Q4QJH9	Leishmania major	49%	100%