Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HFE1_LEIBR

TriTrypDb:

LbrM.27.0240 , LBRM2903_270007600

Length:

187

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HFE1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HFE1

PDB structure(s): 7aih_Aw , 7am2_Aw , 7ane_Aw

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	165	167	PF00675	0.509
CLV_NRD_NRD_1	21	23	PF00675	0.574
CLV_PCSK_FUR_1	163	167	PF00082	0.526
CLV_PCSK_KEX2_1	165	167	PF00082	0.505
CLV_PCSK_KEX2_1	21	23	PF00082	0.545
CLV_PCSK_KEX2_1	74	76	PF00082	0.508
CLV_PCSK_PC1ET2_1	74	76	PF00082	0.603
CLV_PCSK_PC7_1	161	167	PF00082	0.604
CLV_PCSK_SKI1_1	41	45	PF00082	0.613
CLV_PCSK_SKI1_1	81	85	PF00082	0.618
DOC_CKS1_1	126	131	PF01111	0.525
DOC_CKS1_1	134	139	PF01111	0.533
DOC_CKS1_1	180	185	PF01111	0.633
DOC_USP7_MATH_1	59	63	PF00917	0.514
DOC_WW_Pin1_4	113	118	PF00397	0.617
DOC_WW_Pin1_4	125	130	PF00397	0.526
DOC_WW_Pin1_4	133	138	PF00397	0.560
DOC_WW_Pin1_4	16	21	PF00397	0.571
DOC_WW_Pin1_4	179	184	PF00397	0.639
LIG_14-3-3_CanoR_1	123	127	PF00244	0.651
LIG_BIR_II_1	1	5	PF00653	0.511
LIG_FHA_1	78	84	PF00498	0.634
LIG_FHA_1	92	98	PF00498	0.512
LIG_FHA_2	134	140	PF00498	0.602
LIG_FHA_2	37	43	PF00498	0.371
LIG_LIR_Apic_2	125	129	PF02991	0.524
LIG_LIR_Apic_2	131	137	PF02991	0.493
LIG_LIR_Gen_1	10	18	PF02991	0.570
LIG_LIR_Gen_1	29	36	PF02991	0.542
LIG_LIR_Nem_3	10	14	PF02991	0.476
LIG_LIR_Nem_3	29	34	PF02991	0.546
LIG_Pex14_2	54	58	PF04695	0.459
LIG_PTB_Apo_2	25	32	PF02174	0.554
LIG_PTB_Apo_2	62	69	PF02174	0.452
LIG_PTB_Phospho_1	25	31	PF10480	0.559
LIG_SH2_CRK	31	35	PF00017	0.386
LIG_SH2_GRB2like	26	29	PF00017	0.556
LIG_SH2_NCK_1	140	144	PF00017	0.636
LIG_SH2_NCK_1	27	31	PF00017	0.529
LIG_SH2_STAT5	134	137	PF00017	0.516
LIG_SH2_STAT5	140	143	PF00017	0.501
LIG_SH3_3	156	162	PF00018	0.554
LIG_SH3_3	177	183	PF00018	0.532
LIG_TRAF2_1	136	139	PF00917	0.579
LIG_TRAF2_2	117	122	PF00917	0.564
LIG_UBA3_1	67	74	PF00899	0.602
MOD_CDK_SPK_2	16	21	PF00069	0.407
MOD_CDK_SPxK_1	16	22	PF00069	0.406
MOD_CK1_1	10	16	PF00069	0.464
MOD_CK1_1	125	131	PF00069	0.559
MOD_CK2_1	133	139	PF00069	0.577
MOD_CK2_1	36	42	PF00069	0.551
MOD_GlcNHglycan	2	5	PF01048	0.500
MOD_GlcNHglycan	28	31	PF01048	0.585
MOD_GSK3_1	22	29	PF00069	0.555
MOD_GSK3_1	77	84	PF00069	0.637
MOD_LATS_1	79	85	PF00433	0.521
MOD_NEK2_1	36	41	PF00069	0.376
MOD_NEK2_2	7	12	PF00069	0.653
MOD_PIKK_1	91	97	PF00454	0.383
MOD_PKA_2	122	128	PF00069	0.659
MOD_PKA_2	7	13	PF00069	0.495
MOD_Plk_4	10	16	PF00069	0.610
MOD_Plk_4	22	28	PF00069	0.487
MOD_ProDKin_1	113	119	PF00069	0.621
MOD_ProDKin_1	125	131	PF00069	0.527
MOD_ProDKin_1	133	139	PF00069	0.560
MOD_ProDKin_1	16	22	PF00069	0.571
MOD_ProDKin_1	179	185	PF00069	0.636
MOD_SUMO_rev_2	51	59	PF00179	0.447
TRG_DiLeu_BaEn_1	82	87	PF01217	0.362
TRG_ENDOCYTIC_2	31	34	PF00928	0.488
TRG_ER_diArg_1	160	163	PF00400	0.548
TRG_ER_diArg_1	164	166	PF00400	0.522
TRG_ER_diArg_1	20	22	PF00400	0.566
TRG_ER_diArg_1	87	90	PF00400	0.518
TRG_Pf-PMV_PEXEL_1	81	85	PF00026	0.528

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HUR0	Leptomonas seymouri	81%	100%
A0A0S4ISI6	Bodo saltans	46%	94%
A0A1X0NMF2	Trypanosomatidae	56%	99%
A0A381MKM9	Leishmania infantum	91%	100%
A0A3S7X0C8	Leishmania donovani	91%	100%
A0A422NXI0	Trypanosoma rangeli	58%	99%
C9ZKW3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	59%	99%
E9AD00	Leishmania major	91%	100%
E9AYS5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%