Helicase C-terminal domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HFE0_LEIBR

TriTrypDb:

LbrM.27.0230 , LBRM2903_270007500

Length:

314

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005739	mitochondrion	5	1
GO:0020023	kinetoplast	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HFE0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HFE0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	3	7	PF00656	0.557
CLV_NRD_NRD_1	178	180	PF00675	0.340
CLV_NRD_NRD_1	281	283	PF00675	0.584
CLV_NRD_NRD_1	293	295	PF00675	0.384
CLV_NRD_NRD_1	74	76	PF00675	0.462
CLV_NRD_NRD_1	83	85	PF00675	0.402
CLV_PCSK_KEX2_1	177	179	PF00082	0.367
CLV_PCSK_KEX2_1	280	282	PF00082	0.592
CLV_PCSK_KEX2_1	293	295	PF00082	0.334
CLV_PCSK_KEX2_1	83	85	PF00082	0.443
CLV_PCSK_PC1ET2_1	177	179	PF00082	0.526
CLV_PCSK_SKI1_1	116	120	PF00082	0.578
CLV_PCSK_SKI1_1	189	193	PF00082	0.538
CLV_PCSK_SKI1_1	202	206	PF00082	0.418
CLV_PCSK_SKI1_1	301	305	PF00082	0.439
CLV_PCSK_SKI1_1	76	80	PF00082	0.510
DEG_APCC_DBOX_1	115	123	PF00400	0.589
DEG_Nend_UBRbox_3	1	3	PF02207	0.426
DOC_CDC14_PxL_1	128	136	PF14671	0.483
DOC_MAPK_gen_1	184	193	PF00069	0.534
DOC_MAPK_gen_1	75	81	PF00069	0.459
DOC_MAPK_MEF2A_6	43	51	PF00069	0.468
DOC_PP1_RVXF_1	74	81	PF00149	0.515
DOC_PP2B_LxvP_1	204	207	PF13499	0.469
DOC_PP4_FxxP_1	141	144	PF00568	0.574
DOC_PP4_FxxP_1	274	277	PF00568	0.459
DOC_USP7_MATH_1	245	249	PF00917	0.580
DOC_USP7_MATH_1	257	261	PF00917	0.603
DOC_USP7_MATH_1	299	303	PF00917	0.358
DOC_USP7_MATH_1	52	56	PF00917	0.495
DOC_WW_Pin1_4	222	227	PF00397	0.491
DOC_WW_Pin1_4	273	278	PF00397	0.434
DOC_WW_Pin1_4	29	34	PF00397	0.549
LIG_14-3-3_CanoR_1	138	144	PF00244	0.498
LIG_14-3-3_CanoR_1	147	156	PF00244	0.515
LIG_14-3-3_CanoR_1	178	187	PF00244	0.532
LIG_Clathr_ClatBox_1	310	314	PF01394	0.567
LIG_FHA_1	285	291	PF00498	0.518
LIG_FHA_1	298	304	PF00498	0.418
LIG_FHA_2	222	228	PF00498	0.561
LIG_FHA_2	248	254	PF00498	0.677
LIG_Integrin_RGD_1	63	65	PF01839	0.501
LIG_LIR_Apic_2	272	277	PF02991	0.455
LIG_LIR_Gen_1	166	176	PF02991	0.481
LIG_LIR_Gen_1	50	57	PF02991	0.295
LIG_LIR_Nem_3	125	131	PF02991	0.481
LIG_LIR_Nem_3	166	172	PF02991	0.477
LIG_LIR_Nem_3	50	56	PF02991	0.296
LIG_LYPXL_S_1	127	131	PF13949	0.510
LIG_LYPXL_yS_3	128	131	PF13949	0.497
LIG_MYND_1	232	236	PF01753	0.367
LIG_NRBOX	118	124	PF00104	0.298
LIG_Pex14_1	96	100	PF04695	0.422
LIG_PTAP_UEV_1	211	216	PF05743	0.504
LIG_SH2_CRK	169	173	PF00017	0.494
LIG_SH2_CRK	53	57	PF00017	0.521
LIG_SH2_NCK_1	53	57	PF00017	0.521
LIG_SH2_STAT3	104	107	PF00017	0.513
LIG_SH3_3	126	132	PF00018	0.406
LIG_SH3_3	209	215	PF00018	0.445
LIG_TRFH_1	128	132	PF08558	0.285
LIG_TYR_ITIM	167	172	PF00017	0.517
LIG_TYR_ITIM	51	56	PF00017	0.518
MOD_CDK_SPxxK_3	273	280	PF00069	0.461
MOD_CK1_1	276	282	PF00069	0.545
MOD_CK2_1	147	153	PF00069	0.472
MOD_CK2_1	245	251	PF00069	0.622
MOD_CK2_1	299	305	PF00069	0.449
MOD_GlcNHglycan	149	152	PF01048	0.509
MOD_GlcNHglycan	212	215	PF01048	0.474
MOD_GlcNHglycan	259	263	PF01048	0.526
MOD_GlcNHglycan	3	6	PF01048	0.527
MOD_GSK3_1	142	149	PF00069	0.481
MOD_GSK3_1	16	23	PF00069	0.427
MOD_GSK3_1	265	272	PF00069	0.406
MOD_GSK3_1	43	50	PF00069	0.399
MOD_N-GLC_1	43	48	PF02516	0.287
MOD_NEK2_1	123	128	PF00069	0.448
MOD_NEK2_1	146	151	PF00069	0.475
MOD_NEK2_1	165	170	PF00069	0.419
MOD_NEK2_1	221	226	PF00069	0.552
MOD_NEK2_1	47	52	PF00069	0.488
MOD_NEK2_1	79	84	PF00069	0.505
MOD_NEK2_2	299	304	PF00069	0.297
MOD_NEK2_2	52	57	PF00069	0.519
MOD_OFUCOSY	264	269	PF10250	0.372
MOD_PK_1	20	26	PF00069	0.511
MOD_PKA_1	20	26	PF00069	0.465
MOD_PKA_2	146	152	PF00069	0.477
MOD_PKA_2	185	191	PF00069	0.571
MOD_Plk_1	165	171	PF00069	0.507
MOD_Plk_4	123	129	PF00069	0.456
MOD_Plk_4	167	173	PF00069	0.470
MOD_Plk_4	230	236	PF00069	0.350
MOD_Plk_4	43	49	PF00069	0.490
MOD_Plk_4	52	58	PF00069	0.505
MOD_Plk_4	91	97	PF00069	0.411
MOD_ProDKin_1	222	228	PF00069	0.483
MOD_ProDKin_1	273	279	PF00069	0.439
MOD_ProDKin_1	29	35	PF00069	0.542
TRG_DiLeu_BaEn_1	305	310	PF01217	0.449
TRG_DiLeu_BaLyEn_6	126	131	PF01217	0.424
TRG_DiLeu_BaLyEn_6	279	284	PF01217	0.461
TRG_ENDOCYTIC_2	128	131	PF00928	0.459
TRG_ENDOCYTIC_2	169	172	PF00928	0.493
TRG_ENDOCYTIC_2	53	56	PF00928	0.524
TRG_ER_diArg_1	280	282	PF00400	0.591
TRG_ER_diArg_1	293	295	PF00400	0.332
TRG_ER_diArg_1	83	86	PF00400	0.472
TRG_Pf-PMV_PEXEL_1	116	120	PF00026	0.588
TRG_Pf-PMV_PEXEL_1	160	164	PF00026	0.281
TRG_Pf-PMV_PEXEL_1	281	286	PF00026	0.664
TRG_Pf-PMV_PEXEL_1	301	305	PF00026	0.532

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4E8	Leptomonas seymouri	60%	100%
A0A0S4IST0	Bodo saltans	30%	91%
A0A1X0NLN1	Trypanosomatidae	40%	92%
A0A381MKM4	Leishmania infantum	84%	100%
A0A3S7X0D1	Leishmania donovani	84%	100%
A0A422NXN0	Trypanosoma rangeli	40%	94%
C9ZKW2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	94%
E9ACZ9	Leishmania major	84%	100%
E9AYS4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%
V5BBP3	Trypanosoma cruzi	40%	94%