Vacuolar iron transporter 1

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Vacuolar iron transporter 1, putative

Species:

Leishmania braziliensis

UniProt:

A4HFD9_LEIBR

TriTrypDb:

LbrM.27.0220 , LBRM2903_270007400

Length:

289

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	12
GO:0110165	cellular anatomical entity	1	12
GO:0005737	cytoplasm	2	1
GO:0020022	acidocalcisome	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1

Expansion

Sequence features

A4HFD9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HFD9

Function

Biological processes
Term	Name	Level	Count
GO:0006873	intracellular monoatomic ion homeostasis	4	12
GO:0006875	obsolete intracellular metal ion homeostasis	6	12
GO:0009987	cellular process	1	12
GO:0019725	cellular homeostasis	2	12
GO:0030003	intracellular monoatomic cation homeostasis	5	12
GO:0030026	intracellular manganese ion homeostasis	8	12
GO:0042592	homeostatic process	3	12
GO:0046916	obsolete intracellular transition metal ion homeostasis	7	12
GO:0048878	chemical homeostasis	4	12
GO:0050801	monoatomic ion homeostasis	5	12
GO:0055065	obsolete metal ion homeostasis	7	12
GO:0055071	manganese ion homeostasis	9	12
GO:0055076	obsolete transition metal ion homeostasis	8	12
GO:0055080	monoatomic cation homeostasis	6	12
GO:0055082	intracellular chemical homeostasis	3	12
GO:0065007	biological regulation	1	12
GO:0065008	regulation of biological quality	2	12
GO:0098771	inorganic ion homeostasis	6	12
GO:0006880	intracellular sequestering of iron ion	4	1
GO:0051179	localization	1	1
GO:0051235	maintenance of location	2	1
GO:0051238	sequestering of metal ion	3	1
GO:0051651	maintenance of location in cell	2	1
GO:0097577	sequestering of iron ion	3	1

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	12
GO:0005384	manganese ion transmembrane transporter activity	7	12
GO:0008324	monoatomic cation transmembrane transporter activity	4	12
GO:0015075	monoatomic ion transmembrane transporter activity	3	12
GO:0015318	inorganic molecular entity transmembrane transporter activity	3	12
GO:0022857	transmembrane transporter activity	2	12
GO:0022890	inorganic cation transmembrane transporter activity	4	12
GO:0046873	metal ion transmembrane transporter activity	5	12
GO:0046915	transition metal ion transmembrane transporter activity	6	12
GO:0005381	iron ion transmembrane transporter activity	7	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	36	38	PF00675	0.393
CLV_PCSK_KEX2_1	36	38	PF00082	0.388
CLV_PCSK_SKI1_1	24	28	PF00082	0.338
DOC_CDC14_PxL_1	202	210	PF14671	0.340
DOC_CYCLIN_RxL_1	143	152	PF00134	0.539
DOC_MAPK_gen_1	162	170	PF00069	0.450
DOC_MAPK_MEF2A_6	162	170	PF00069	0.464
DOC_MAPK_MEF2A_6	190	199	PF00069	0.392
DOC_MAPK_MEF2A_6	240	248	PF00069	0.558
DOC_PP1_RVXF_1	144	151	PF00149	0.536
DOC_PP1_RVXF_1	55	62	PF00149	0.453
DOC_USP7_MATH_1	22	26	PF00917	0.549
DOC_USP7_MATH_1	283	287	PF00917	0.409
DOC_USP7_MATH_1	77	81	PF00917	0.305
DOC_WD40_RPTOR_TOS_1	132	138	PF00400	0.464
LIG_BIR_II_1	1	5	PF00653	0.617
LIG_BIR_III_4	184	188	PF00653	0.530
LIG_BRCT_BRCA1_1	231	235	PF00533	0.469
LIG_BRCT_BRCA1_1	261	265	PF00533	0.292
LIG_BRCT_BRCA1_1	57	61	PF00533	0.453
LIG_Clathr_ClatBox_1	179	183	PF01394	0.539
LIG_deltaCOP1_diTrp_1	124	132	PF00928	0.464
LIG_FHA_1	216	222	PF00498	0.206
LIG_FHA_1	276	282	PF00498	0.382
LIG_FHA_1	68	74	PF00498	0.355
LIG_FHA_1	84	90	PF00498	0.321
LIG_GBD_Chelix_1	193	201	PF00786	0.335
LIG_LIR_Gen_1	169	178	PF02991	0.498
LIG_LIR_Gen_1	198	207	PF02991	0.321
LIG_LIR_Gen_1	225	235	PF02991	0.349
LIG_LIR_Gen_1	262	273	PF02991	0.393
LIG_LIR_Gen_1	69	78	PF02991	0.294
LIG_LIR_Nem_3	169	173	PF02991	0.519
LIG_LIR_Nem_3	198	202	PF02991	0.317
LIG_LIR_Nem_3	262	268	PF02991	0.393
LIG_LIR_Nem_3	58	64	PF02991	0.297
LIG_LIR_Nem_3	69	74	PF02991	0.281
LIG_PDZ_Class_2	284	289	PF00595	0.471
LIG_Pex14_2	100	104	PF04695	0.305
LIG_Pex14_2	223	227	PF04695	0.460
LIG_SH2_CRK	84	88	PF00017	0.275
LIG_SH2_SRC	210	213	PF00017	0.340
LIG_SH2_STAP1	84	88	PF00017	0.261
LIG_SH2_STAT5	107	110	PF00017	0.464
LIG_SH2_STAT5	210	213	PF00017	0.305
LIG_SH2_STAT5	242	245	PF00017	0.478
LIG_SH2_STAT5	55	58	PF00017	0.510
LIG_SUMO_SIM_par_1	178	184	PF11976	0.456
LIG_UBA3_1	207	214	PF00899	0.362
LIG_WRC_WIRS_1	196	201	PF05994	0.305
LIG_WRC_WIRS_1	264	269	PF05994	0.340
LIG_WRC_WIRS_1	68	73	PF05994	0.305
MOD_CK1_1	47	53	PF00069	0.541
MOD_CK2_1	32	38	PF00069	0.547
MOD_CK2_1	48	54	PF00069	0.599
MOD_GlcNHglycan	108	111	PF01048	0.244
MOD_GlcNHglycan	24	27	PF01048	0.392
MOD_GlcNHglycan	250	253	PF01048	0.263
MOD_GlcNHglycan	261	264	PF01048	0.299
MOD_GlcNHglycan	3	6	PF01048	0.448
MOD_GlcNHglycan	50	53	PF01048	0.432
MOD_GlcNHglycan	79	82	PF01048	0.546
MOD_GlcNHglycan	9	12	PF01048	0.437
MOD_GSK3_1	222	229	PF00069	0.426
MOD_GSK3_1	244	251	PF00069	0.481
MOD_GSK3_1	259	266	PF00069	0.229
MOD_GSK3_1	281	288	PF00069	0.285
MOD_GSK3_1	44	51	PF00069	0.544
MOD_N-GLC_1	281	286	PF02516	0.477
MOD_N-GLC_1	48	53	PF02516	0.497
MOD_N-GLC_1	7	12	PF02516	0.503
MOD_NEK2_1	1	6	PF00069	0.727
MOD_NEK2_1	195	200	PF00069	0.305
MOD_NEK2_1	201	206	PF00069	0.305
MOD_NEK2_1	222	227	PF00069	0.321
MOD_NEK2_1	235	240	PF00069	0.321
MOD_NEK2_1	248	253	PF00069	0.413
MOD_NEK2_1	7	12	PF00069	0.654
MOD_NEK2_1	90	95	PF00069	0.292
MOD_Plk_1	128	134	PF00069	0.539
MOD_Plk_4	152	158	PF00069	0.464
MOD_Plk_4	229	235	PF00069	0.362
MOD_Plk_4	55	61	PF00069	0.449
MOD_Plk_4	83	89	PF00069	0.258
MOD_SUMO_rev_2	10	19	PF00179	0.608
MOD_SUMO_rev_2	161	167	PF00179	0.478
TRG_DiLeu_BaEn_1	174	179	PF01217	0.478
TRG_DiLeu_BaLyEn_6	203	208	PF01217	0.340
TRG_ENDOCYTIC_2	186	189	PF00928	0.377
TRG_ENDOCYTIC_2	84	87	PF00928	0.207

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCC2	Leptomonas seymouri	79%	99%
A0A0S4J3A7	Bodo saltans	58%	100%
A0A1X0NM64	Trypanosomatidae	68%	100%
A0A3Q8IE64	Leishmania donovani	86%	100%
A0A3Q8IFA4	Leishmania donovani	29%	100%
A0A3R7MYU7	Trypanosoma rangeli	65%	100%
A4I355	Leishmania infantum	86%	100%
C9ZKW1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	66%	100%
E9ACZ8	Leishmania major	85%	100%
E9AE74	Leishmania major	29%	100%
E9AYS3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
P0DO17	Eucalyptus grandis	28%	100%
P47818	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	25%	90%
Q6ERE5	Oryza sativa subsp. japonica	30%	100%
Q6MWE5	Oryza sativa subsp. japonica	29%	100%
Q9P6J2	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	23%	100%
Q9ZUA5	Arabidopsis thaliana	30%	100%
V5BKT4	Trypanosoma cruzi	68%	100%