LeishMANIAdb
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C3H1-type domain-containing protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
C3H1-type domain-containing protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania braziliensis
UniProt:
A4HFD8_LEIBR
TriTrypDb:
LbrM.27.0210 , LBRM2903_270007300 *
Length:
365

Annotations

LeishMANIAdb annotations

A Zn-finger protein with a TM segment on the C-terminus (2 paralogous lineages in Kinetoplastids: A4HSS9_LEIINvs. A4I356_LEIIN). Unlikely to be GPI-anchored due to reverse topology. Weakly similar to NLRC3/NOD3 intracellular immune receptor.

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 1, no: 14
NetGPI no yes: 0, no: 15
Cellular components
Term Name Level Count
GO:0005929 cilium 4 16
GO:0016020 membrane 2 12
GO:0042995 cell projection 2 16
GO:0043226 organelle 2 16
GO:0043227 membrane-bounded organelle 3 16
GO:0110165 cellular anatomical entity 1 16
GO:0120025 plasma membrane bounded cell projection 3 16
GO:0005737 cytoplasm 2 2
GO:0005741 mitochondrial outer membrane 5 1
GO:0019867 outer membrane 3 1
GO:0031090 organelle membrane 3 1
GO:0031966 mitochondrial membrane 4 1
GO:0031968 organelle outer membrane 4 1
GO:0098588 bounding membrane of organelle 4 1

Expansion

Sequence features

A4HFD8
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HFD8

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0005488 binding 1 14
GO:0043167 ion binding 2 14
GO:0043169 cation binding 3 14
GO:0046872 metal ion binding 4 14
GO:0003676 nucleic acid binding 3 5
GO:0003723 RNA binding 4 5
GO:0097159 organic cyclic compound binding 2 5
GO:1901363 heterocyclic compound binding 2 5
GO:0003729 mRNA binding 5 4

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 260 264 PF00656 0.489
CLV_NRD_NRD_1 228 230 PF00675 0.534
CLV_NRD_NRD_1 28 30 PF00675 0.490
CLV_NRD_NRD_1 312 314 PF00675 0.654
CLV_NRD_NRD_1 356 358 PF00675 0.529
CLV_NRD_NRD_1 5 7 PF00675 0.511
CLV_PCSK_KEX2_1 28 30 PF00082 0.593
CLV_PCSK_KEX2_1 302 304 PF00082 0.732
CLV_PCSK_KEX2_1 311 313 PF00082 0.637
CLV_PCSK_KEX2_1 356 358 PF00082 0.493
CLV_PCSK_KEX2_1 4 6 PF00082 0.532
CLV_PCSK_PC1ET2_1 302 304 PF00082 0.737
CLV_PCSK_SKI1_1 5 9 PF00082 0.505
CLV_PCSK_SKI1_1 82 86 PF00082 0.528
DEG_APCC_DBOX_1 4 12 PF00400 0.315
DEG_Nend_UBRbox_2 1 3 PF02207 0.530
DEG_SPOP_SBC_1 34 38 PF00917 0.234
DOC_CYCLIN_yCln2_LP_2 207 213 PF00134 0.290
DOC_MAPK_gen_1 136 144 PF00069 0.307
DOC_MAPK_gen_1 28 34 PF00069 0.292
DOC_PP4_FxxP_1 42 45 PF00568 0.234
DOC_USP7_MATH_1 126 130 PF00917 0.266
DOC_USP7_MATH_1 153 157 PF00917 0.273
DOC_WW_Pin1_4 144 149 PF00397 0.271
DOC_WW_Pin1_4 317 322 PF00397 0.552
DOC_WW_Pin1_4 329 334 PF00397 0.593
DOC_WW_Pin1_4 356 361 PF00397 0.577
LIG_14-3-3_CanoR_1 229 235 PF00244 0.322
LIG_14-3-3_CanoR_1 33 42 PF00244 0.241
LIG_Actin_WH2_2 103 120 PF00022 0.279
LIG_Actin_WH2_2 153 170 PF00022 0.302
LIG_APCC_ABBA_1 84 89 PF00400 0.293
LIG_BRCT_BRCA1_1 102 106 PF00533 0.253
LIG_BRCT_BRCA1_1 270 274 PF00533 0.401
LIG_BRCT_BRCA1_1 90 94 PF00533 0.298
LIG_eIF4E_1 233 239 PF01652 0.338
LIG_FHA_1 167 173 PF00498 0.267
LIG_FHA_1 321 327 PF00498 0.399
LIG_FHA_2 11 17 PF00498 0.388
LIG_FHA_2 145 151 PF00498 0.281
LIG_IBAR_NPY_1 164 166 PF08397 0.264
LIG_LIR_Apic_2 293 297 PF02991 0.432
LIG_LIR_Apic_2 40 45 PF02991 0.244
LIG_LIR_Gen_1 36 47 PF02991 0.253
LIG_LIR_Gen_1 59 69 PF02991 0.454
LIG_LIR_Nem_3 329 334 PF02991 0.475
LIG_LIR_Nem_3 36 42 PF02991 0.307
LIG_LIR_Nem_3 59 64 PF02991 0.462
LIG_LIR_Nem_3 67 72 PF02991 0.426
LIG_LIR_Nem_3 88 93 PF02991 0.357
LIG_MLH1_MIPbox_1 90 94 PF16413 0.393
LIG_MYND_3 44 48 PF01753 0.240
LIG_Pex14_2 90 94 PF04695 0.289
LIG_PTB_Apo_2 63 70 PF02174 0.295
LIG_SH2_CRK 61 65 PF00017 0.374
LIG_SH2_GRB2like 61 64 PF00017 0.445
LIG_SH2_NCK_1 61 65 PF00017 0.342
LIG_SH2_PTP2 141 144 PF00017 0.282
LIG_SH2_SRC 250 253 PF00017 0.466
LIG_SH2_STAP1 100 104 PF00017 0.264
LIG_SH2_STAP1 250 254 PF00017 0.336
LIG_SH2_STAT5 141 144 PF00017 0.387
LIG_SH2_STAT5 166 169 PF00017 0.266
LIG_SH2_STAT5 233 236 PF00017 0.305
LIG_SH2_STAT5 53 56 PF00017 0.384
LIG_SH2_STAT5 61 64 PF00017 0.412
LIG_SH3_3 282 288 PF00018 0.390
LIG_SUMO_SIM_par_1 168 175 PF11976 0.273
LIG_TYR_ITIM 139 144 PF00017 0.328
LIG_WRC_WIRS_1 39 44 PF05994 0.287
LIG_WW_3 284 288 PF00397 0.564
MOD_CK1_1 359 365 PF00069 0.487
MOD_CK1_1 38 44 PF00069 0.499
MOD_CK1_1 59 65 PF00069 0.452
MOD_CK1_1 80 86 PF00069 0.282
MOD_CK2_1 10 16 PF00069 0.546
MOD_CK2_1 126 132 PF00069 0.358
MOD_CK2_1 144 150 PF00069 0.336
MOD_CK2_1 191 197 PF00069 0.425
MOD_CK2_1 34 40 PF00069 0.331
MOD_GlcNHglycan 256 259 PF01048 0.510
MOD_GlcNHglycan 266 269 PF01048 0.501
MOD_GlcNHglycan 335 338 PF01048 0.486
MOD_GlcNHglycan 361 364 PF01048 0.650
MOD_GlcNHglycan 88 93 PF01048 0.382
MOD_GSK3_1 12 19 PF00069 0.634
MOD_GSK3_1 250 257 PF00069 0.449
MOD_GSK3_1 264 271 PF00069 0.464
MOD_GSK3_1 286 293 PF00069 0.701
MOD_GSK3_1 316 323 PF00069 0.732
MOD_GSK3_1 329 336 PF00069 0.692
MOD_GSK3_1 34 41 PF00069 0.323
MOD_GSK3_1 52 59 PF00069 0.545
MOD_GSK3_1 73 80 PF00069 0.320
MOD_N-GLC_1 108 113 PF02516 0.353
MOD_N-GLC_1 120 125 PF02516 0.353
MOD_N-GLC_1 191 196 PF02516 0.368
MOD_N-GLC_1 317 322 PF02516 0.663
MOD_N-GLC_1 59 64 PF02516 0.640
MOD_N-GLC_1 77 82 PF02516 0.243
MOD_NEK2_1 134 139 PF00069 0.339
MOD_NEK2_1 191 196 PF00069 0.491
MOD_NEK2_1 254 259 PF00069 0.459
MOD_NEK2_1 77 82 PF00069 0.339
MOD_PKA_2 228 234 PF00069 0.371
MOD_PKA_2 286 292 PF00069 0.671
MOD_Plk_1 108 114 PF00069 0.354
MOD_Plk_1 172 178 PF00069 0.378
MOD_Plk_1 203 209 PF00069 0.456
MOD_Plk_1 262 268 PF00069 0.544
MOD_Plk_1 73 79 PF00069 0.409
MOD_Plk_4 172 178 PF00069 0.363
MOD_Plk_4 203 209 PF00069 0.456
MOD_ProDKin_1 144 150 PF00069 0.323
MOD_ProDKin_1 317 323 PF00069 0.710
MOD_ProDKin_1 329 335 PF00069 0.763
MOD_ProDKin_1 356 362 PF00069 0.463
MOD_SUMO_for_1 22 25 PF00179 0.428
MOD_SUMO_rev_2 298 304 PF00179 0.560
TRG_DiLeu_BaEn_1 26 31 PF01217 0.371
TRG_DiLeu_BaEn_1 68 73 PF01217 0.299
TRG_ENDOCYTIC_2 141 144 PF00928 0.445
TRG_ENDOCYTIC_2 39 42 PF00928 0.293
TRG_ENDOCYTIC_2 61 64 PF00928 0.580
TRG_ENDOCYTIC_2 87 90 PF00928 0.489
TRG_ER_diArg_1 135 138 PF00400 0.478
TRG_ER_diArg_1 28 30 PF00400 0.342
TRG_ER_diArg_1 311 313 PF00400 0.625
TRG_ER_diArg_1 328 331 PF00400 0.536
TRG_ER_diArg_1 356 358 PF00400 0.606
TRG_ER_diArg_1 4 6 PF00400 0.491
TRG_Pf-PMV_PEXEL_1 12 16 PF00026 0.537

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P4T9 Leptomonas seymouri 74% 98%
A0A0S4ISK7 Bodo saltans 37% 100%
A0A1X0NNG2 Trypanosomatidae 50% 98%
A0A3R7NQS8 Trypanosoma rangeli 56% 100%
A0A3S5H5P9 Leishmania donovani 21% 91%
A0A3S7X0C2 Leishmania donovani 85% 98%
A4HSS9 Leishmania infantum 21% 91%
A4I356 Leishmania infantum 84% 98%
C9ZKV9 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 50% 100%
E9ACZ7 Leishmania major 86% 99%
E9AKR6 Leishmania mexicana (strain MHOM/GT/2001/U1103) 22% 98%
E9AYS2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 84% 98%
Q4QJ41 Leishmania major 23% 100%
V5DCE2 Trypanosoma cruzi 58% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS