Putative proteasome alpha 7 subunit

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

proteasome alpha 7 subunit, putative

Species:

Leishmania braziliensis

UniProt:

A4HFD7_LEIBR

TriTrypDb:

LbrM.27.0200 , LBRM2903_270007200

Length:

238

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	yes	yes: 1
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 3
Pissara et al.	yes	yes: 9

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 4

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 4

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

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Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	12
GO:0005654	nucleoplasm	2	1
GO:0005737	cytoplasm	2	12
GO:0005839	proteasome core complex	3	1
GO:0019773	proteasome core complex, alpha-subunit complex	2	12
GO:0032991	protein-containing complex	1	12
GO:0043226	organelle	2	12
GO:0043227	membrane-bounded organelle	3	12
GO:0043229	intracellular organelle	3	12
GO:0043231	intracellular membrane-bounded organelle	4	12

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Expansion

Sequence features

A4HFD7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HFD7

PDB structure(s): 6qm7_G , 6qm7_U , 6qm8_G , 6qm8_U , 6tcz_g , 6td5_g

Function

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Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	12
GO:0006511	ubiquitin-dependent protein catabolic process	7	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0009056	catabolic process	2	12
GO:0009057	macromolecule catabolic process	4	12
GO:0009987	cellular process	1	12
GO:0010498	proteasomal protein catabolic process	5	1
GO:0019538	protein metabolic process	3	12
GO:0019941	modification-dependent protein catabolic process	6	12

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Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	8
GO:0016787	hydrolase activity	2	8

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_MEL_PAP_1	112	118	PF00089	0.437
CLV_NRD_NRD_1	221	223	PF00675	0.748
CLV_PCSK_SKI1_1	100	104	PF00082	0.362
CLV_PCSK_SKI1_1	222	226	PF00082	0.707
DOC_CKS1_1	103	108	PF01111	0.575
DOC_MAPK_MEF2A_6	43	50	PF00069	0.562
DOC_PP1_RVXF_1	176	182	PF00149	0.562
DOC_PP4_FxxP_1	103	106	PF00568	0.562
DOC_PP4_MxPP_1	231	234	PF00568	0.724
DOC_USP7_MATH_1	87	91	PF00917	0.557

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2I1	Leptomonas seymouri	33%	98%
A0A0N0P4E6	Leptomonas seymouri	90%	100%
A0A0N1I173	Leptomonas seymouri	31%	100%
A0A0N1I278	Leptomonas seymouri	31%	96%
A0A0N1I2E0	Leptomonas seymouri	35%	95%
A0A0N1ILS9	Leptomonas seymouri	33%	90%
A0A0N1PBJ3	Leptomonas seymouri	28%	84%
A0A0S4INC9	Bodo saltans	73%	100%
A0A0S4IQU5	Bodo saltans	32%	89%
A0A0S4IU58	Bodo saltans	32%	100%

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