Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HFD5_LEIBR

TriTrypDb:

LbrM.27.0180 , LBRM2903_270007000

Length:

470

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005654	nucleoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HFD5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HFD5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	225	229	PF00656	0.275
CLV_C14_Caspase3-7	320	324	PF00656	0.562
CLV_C14_Caspase3-7	97	101	PF00656	0.526
CLV_NRD_NRD_1	161	163	PF00675	0.704
CLV_NRD_NRD_1	17	19	PF00675	0.629
CLV_NRD_NRD_1	95	97	PF00675	0.684
CLV_NRD_NRD_1	98	100	PF00675	0.697
CLV_PCSK_FUR_1	15	19	PF00082	0.679
CLV_PCSK_FUR_1	96	100	PF00082	0.701
CLV_PCSK_KEX2_1	17	19	PF00082	0.636
CLV_PCSK_KEX2_1	358	360	PF00082	0.746
CLV_PCSK_KEX2_1	95	97	PF00082	0.684
CLV_PCSK_KEX2_1	98	100	PF00082	0.697
CLV_PCSK_PC1ET2_1	358	360	PF00082	0.746
CLV_PCSK_SKI1_1	18	22	PF00082	0.613
CLV_PCSK_SKI1_1	27	31	PF00082	0.604
CLV_PCSK_SKI1_1	35	39	PF00082	0.496
CLV_PCSK_SKI1_1	443	447	PF00082	0.386
DEG_Nend_UBRbox_3	1	3	PF02207	0.584
DEG_SPOP_SBC_1	37	41	PF00917	0.406
DOC_CKS1_1	425	430	PF01111	0.536
DOC_CYCLIN_RxL_1	382	392	PF00134	0.440
DOC_MAPK_gen_1	358	368	PF00069	0.480
DOC_MAPK_MEF2A_6	361	370	PF00069	0.495
DOC_MAPK_RevD_3	149	164	PF00069	0.434
DOC_PP1_RVXF_1	110	116	PF00149	0.386
DOC_PP2B_LxvP_1	246	249	PF13499	0.449
DOC_USP7_MATH_1	212	216	PF00917	0.460
DOC_USP7_MATH_1	60	64	PF00917	0.368
DOC_USP7_UBL2_3	232	236	PF12436	0.418
DOC_WW_Pin1_4	223	228	PF00397	0.419
DOC_WW_Pin1_4	424	429	PF00397	0.528
LIG_14-3-3_CanoR_1	112	116	PF00244	0.544
LIG_14-3-3_CanoR_1	359	368	PF00244	0.442
LIG_14-3-3_CanoR_1	391	396	PF00244	0.362
LIG_14-3-3_CanoR_1	415	419	PF00244	0.673
LIG_BRCT_BRCA1_1	187	191	PF00533	0.372
LIG_BRCT_BRCA1_1	330	334	PF00533	0.256
LIG_Clathr_ClatBox_1	201	205	PF01394	0.393
LIG_Clathr_ClatBox_1	406	410	PF01394	0.342
LIG_Clathr_ClatBox_1	87	91	PF01394	0.457
LIG_CtBP_PxDLS_1	153	157	PF00389	0.417
LIG_eIF4E_1	433	439	PF01652	0.732
LIG_FHA_1	123	129	PF00498	0.412
LIG_FHA_1	228	234	PF00498	0.435
LIG_FHA_1	365	371	PF00498	0.416
LIG_FHA_1	377	383	PF00498	0.396
LIG_FHA_1	394	400	PF00498	0.192
LIG_FHA_1	411	417	PF00498	0.402
LIG_FHA_1	461	467	PF00498	0.539
LIG_FHA_1	77	83	PF00498	0.410
LIG_FHA_2	156	162	PF00498	0.442
LIG_FHA_2	236	242	PF00498	0.453
LIG_LIR_Gen_1	240	251	PF02991	0.391
LIG_LIR_Gen_1	392	401	PF02991	0.362
LIG_LIR_Gen_1	444	454	PF02991	0.490
LIG_LIR_Nem_3	240	246	PF02991	0.382
LIG_LIR_Nem_3	272	277	PF02991	0.301
LIG_LIR_Nem_3	392	398	PF02991	0.298
LIG_LIR_Nem_3	444	449	PF02991	0.476
LIG_Pex14_2	274	278	PF04695	0.320
LIG_SH2_STAT5	219	222	PF00017	0.308
LIG_SH2_STAT5	237	240	PF00017	0.304
LIG_SH2_STAT5	265	268	PF00017	0.355
LIG_SH2_STAT5	28	31	PF00017	0.460
LIG_SH2_STAT5	343	346	PF00017	0.412
LIG_SH2_STAT5	377	380	PF00017	0.369
LIG_SH2_STAT5	64	67	PF00017	0.317
LIG_SH2_STAT5	86	89	PF00017	0.349
LIG_SH3_3	56	62	PF00018	0.442
LIG_SUMO_SIM_anti_2	367	373	PF11976	0.273
LIG_SUMO_SIM_anti_2	396	403	PF11976	0.354
LIG_SUMO_SIM_par_1	119	125	PF11976	0.380
LIG_SUMO_SIM_par_1	396	403	PF11976	0.402
LIG_TRAF2_1	238	241	PF00917	0.311
LIG_UBA3_1	198	207	PF00899	0.246
LIG_WRC_WIRS_1	271	276	PF05994	0.243
LIG_WRC_WIRS_1	390	395	PF05994	0.424
MOD_CK1_1	114	120	PF00069	0.278
MOD_CK1_1	235	241	PF00069	0.346
MOD_CK1_1	255	261	PF00069	0.451
MOD_CK1_1	270	276	PF00069	0.399
MOD_CK1_1	324	330	PF00069	0.374
MOD_CK1_1	39	45	PF00069	0.408
MOD_CK1_1	49	55	PF00069	0.320
MOD_CK1_1	70	76	PF00069	0.370
MOD_CK1_1	80	86	PF00069	0.377
MOD_CK1_1	94	100	PF00069	0.458
MOD_CK2_1	155	161	PF00069	0.437
MOD_CK2_1	235	241	PF00069	0.427
MOD_CK2_1	276	282	PF00069	0.251
MOD_GlcNHglycan	100	103	PF01048	0.780
MOD_GlcNHglycan	109	112	PF01048	0.754
MOD_GlcNHglycan	128	131	PF01048	0.620
MOD_GlcNHglycan	208	211	PF01048	0.692
MOD_GlcNHglycan	249	252	PF01048	0.634
MOD_GlcNHglycan	257	260	PF01048	0.592
MOD_GlcNHglycan	315	318	PF01048	0.655
MOD_GlcNHglycan	323	326	PF01048	0.667
MOD_GlcNHglycan	402	405	PF01048	0.335
MOD_GlcNHglycan	449	452	PF01048	0.419
MOD_GlcNHglycan	454	457	PF01048	0.391
MOD_GSK3_1	107	114	PF00069	0.508
MOD_GSK3_1	122	129	PF00069	0.364
MOD_GSK3_1	223	230	PF00069	0.400
MOD_GSK3_1	232	239	PF00069	0.370
MOD_GSK3_1	302	309	PF00069	0.469
MOD_GSK3_1	324	331	PF00069	0.420
MOD_GSK3_1	338	345	PF00069	0.380
MOD_GSK3_1	35	42	PF00069	0.392
MOD_GSK3_1	389	396	PF00069	0.418
MOD_GSK3_1	410	417	PF00069	0.613
MOD_GSK3_1	76	83	PF00069	0.386
MOD_GSK3_1	94	101	PF00069	0.415
MOD_N-GLC_1	309	314	PF02516	0.659
MOD_N-GLC_1	70	75	PF02516	0.535
MOD_N-GLC_1	77	82	PF02516	0.506
MOD_N-GLC_2	301	303	PF02516	0.523
MOD_NEK2_1	154	159	PF00069	0.412
MOD_NEK2_1	185	190	PF00069	0.402
MOD_NEK2_1	342	347	PF00069	0.391
MOD_NEK2_1	389	394	PF00069	0.383
MOD_NEK2_1	400	405	PF00069	0.227
MOD_NEK2_1	414	419	PF00069	0.550
MOD_NEK2_1	55	60	PF00069	0.424
MOD_NEK2_1	76	81	PF00069	0.331
MOD_NEK2_2	213	218	PF00069	0.470
MOD_NEK2_2	227	232	PF00069	0.306
MOD_PIKK_1	114	120	PF00454	0.359
MOD_PKA_1	163	169	PF00069	0.486
MOD_PKA_1	98	104	PF00069	0.483
MOD_PKA_2	111	117	PF00069	0.321
MOD_PKA_2	414	420	PF00069	0.653
MOD_PKA_2	91	97	PF00069	0.507
MOD_PKA_2	98	104	PF00069	0.517
MOD_PKB_1	96	104	PF00069	0.415
MOD_Plk_1	154	160	PF00069	0.427
MOD_Plk_1	21	27	PF00069	0.469
MOD_Plk_1	227	233	PF00069	0.466
MOD_Plk_1	309	315	PF00069	0.469
MOD_Plk_1	49	55	PF00069	0.403
MOD_Plk_2-3	155	161	PF00069	0.437
MOD_Plk_2-3	8	14	PF00069	0.486
MOD_Plk_4	155	161	PF00069	0.363
MOD_Plk_4	270	276	PF00069	0.358
MOD_Plk_4	328	334	PF00069	0.397
MOD_Plk_4	338	344	PF00069	0.378
MOD_Plk_4	42	48	PF00069	0.460
MOD_Plk_4	49	55	PF00069	0.389
MOD_Plk_4	60	66	PF00069	0.200
MOD_ProDKin_1	223	229	PF00069	0.429
MOD_ProDKin_1	424	430	PF00069	0.531
MOD_SUMO_for_1	29	32	PF00179	0.503
MOD_SUMO_rev_2	155	165	PF00179	0.461
TRG_DiLeu_BaEn_1	402	407	PF01217	0.378
TRG_DiLeu_BaLyEn_6	295	300	PF01217	0.416
TRG_ER_diArg_1	15	18	PF00400	0.441
TRG_ER_diArg_1	95	98	PF00400	0.453
TRG_NLS_MonoExtC_3	357	363	PF00514	0.538

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PAF2	Leptomonas seymouri	62%	99%
A0A1X0NLR9	Trypanosomatidae	27%	86%
A0A3Q8ID84	Leishmania donovani	85%	100%
A0A422NXM8	Trypanosoma rangeli	28%	86%
A4I359	Leishmania infantum	85%	100%
C9ZKV6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	85%
E9ACZ4	Leishmania major	84%	100%
E9AYR9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%
V5BKT2	Trypanosoma cruzi	27%	86%