SET domain-containing protein

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

SET domain containing protein, putative

Species:

Leishmania braziliensis

UniProt:

A4HFD4_LEIBR

TriTrypDb:

LbrM.27.0170 , LBRM2903_270006900

Length:

261

Annotations

LeishMANIAdb annotations

Homologous to human SMYD1, but contains an unexpected C-terminal tail-anchor segment. Localization: Inner nuclear membrane (by feature)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Show entries

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0016020	membrane	2	10
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	10

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Expansion

Sequence features

A4HFD4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HFD4

Function

Show entries

Biological processes
Term	Name	Level	Count
GO:0006479	protein methylation	4	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0008213	protein alkylation	5	1
GO:0009987	cellular process	1	1
GO:0016570	histone modification	5	1
GO:0016571	histone methylation	5	1
GO:0018022	peptidyl-lysine methylation	5	1
GO:0018193	peptidyl-amino acid modification	5	1
GO:0018205	peptidyl-lysine modification	6	1

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Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0008168	methyltransferase activity	4	1
GO:0008170	N-methyltransferase activity	5	1
GO:0008276	protein methyltransferase activity	3	1
GO:0008757	S-adenosylmethionine-dependent methyltransferase activity	5	1
GO:0016278	lysine N-methyltransferase activity	6	1
GO:0016279	protein-lysine N-methyltransferase activity	4	1
GO:0016740	transferase activity	2	1
GO:0016741	transferase activity, transferring one-carbon groups	3	1
GO:0018024	obsolete histone lysine N-methyltransferase activity	5	1

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Putative motif mimicry

Show entries


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	142	144	PF00675	0.280
CLV_NRD_NRD_1	247	249	PF00675	0.594
CLV_PCSK_FUR_1	140	144	PF00082	0.338
CLV_PCSK_KEX2_1	142	144	PF00082	0.290
CLV_PCSK_KEX2_1	212	214	PF00082	0.335
CLV_PCSK_KEX2_1	247	249	PF00082	0.594
CLV_PCSK_PC1ET2_1	212	214	PF00082	0.335
CLV_PCSK_SKI1_1	11	15	PF00082	0.274
CLV_PCSK_SKI1_1	205	209	PF00082	0.338
CLV_PCSK_SKI1_1	52	56	PF00082	0.277

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HWF5	Leptomonas seymouri	89%	79%
A0A0S4IND3	Bodo saltans	57%	78%
A0A1X0NLS4	Trypanosomatidae	70%	78%
A0A1X0NMZ6	Trypanosomatidae	27%	79%
A0A3Q8IG56	Leishmania donovani	94%	100%
A0A422NXJ8	Trypanosoma rangeli	70%	78%
A4I360	Leishmania infantum	94%	100%
C9ZKV5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	68%	78%
E9ACZ3	Leishmania major	94%	100%
E9AYR8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%

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