C3H1-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HFD3_LEIBR

TriTrypDb:

LbrM.27.0160 , LBRM2903_270006800

Length:

218

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HFD3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HFD3

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	12
GO:0043167	ion binding	2	12
GO:0043169	cation binding	3	12
GO:0046872	metal ion binding	4	12
GO:0003676	nucleic acid binding	3	1
GO:0003723	RNA binding	4	1
GO:0097159	organic cyclic compound binding	2	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_SKI1_1	150	154	PF00082	0.706
DEG_COP1_1	5	12	PF00400	0.509
DEG_Nend_Nbox_1	1	3	PF02207	0.589
DOC_CKS1_1	111	116	PF01111	0.488
DOC_CYCLIN_yClb1_LxF_4	90	96	PF00134	0.625
DOC_CYCLIN_yCln2_LP_2	196	202	PF00134	0.635
DOC_PP2B_LxvP_1	175	178	PF13499	0.649
DOC_PP2B_LxvP_1	190	193	PF13499	0.461
DOC_PP2B_LxvP_1	200	203	PF13499	0.507
DOC_USP7_MATH_1	140	144	PF00917	0.662
DOC_USP7_MATH_1	157	161	PF00917	0.518
DOC_USP7_UBL2_3	201	205	PF12436	0.629
DOC_WW_Pin1_4	107	112	PF00397	0.663
DOC_WW_Pin1_4	116	121	PF00397	0.604
DOC_WW_Pin1_4	126	131	PF00397	0.418
DOC_WW_Pin1_4	163	168	PF00397	0.573
LIG_Actin_WH2_2	111	127	PF00022	0.487
LIG_BRCT_BRCA1_1	142	146	PF00533	0.642
LIG_CtBP_PxDLS_1	156	160	PF00389	0.700
LIG_EVH1_1	175	179	PF00568	0.677
LIG_FHA_1	130	136	PF00498	0.747
LIG_FHA_1	206	212	PF00498	0.613
LIG_FHA_1	56	62	PF00498	0.470
LIG_LIR_Gen_1	185	195	PF02991	0.675
LIG_LIR_Nem_3	185	190	PF02991	0.549
LIG_SH2_NCK_1	181	185	PF00017	0.591
LIG_SH2_PTP2	25	28	PF00017	0.454
LIG_SH2_STAT5	187	190	PF00017	0.675
LIG_SH2_STAT5	25	28	PF00017	0.616
LIG_SH2_STAT5	64	67	PF00017	0.284
LIG_SH2_STAT5	78	81	PF00017	0.280
LIG_SH3_1	180	186	PF00018	0.536
LIG_SH3_2	120	125	PF14604	0.659
LIG_SH3_3	105	111	PF00018	0.656
LIG_SH3_3	117	123	PF00018	0.658
LIG_SH3_3	142	148	PF00018	0.641
LIG_SH3_3	173	179	PF00018	0.693
LIG_SH3_3	180	186	PF00018	0.515
LIG_SH3_3	23	29	PF00018	0.658
LIG_SH3_3	48	54	PF00018	0.598
LIG_TRFH_1	95	99	PF08558	0.537
LIG_WW_1	178	181	PF00397	0.547
MOD_CK1_1	110	116	PF00069	0.601
MOD_CK1_1	129	135	PF00069	0.703
MOD_CK1_1	160	166	PF00069	0.651
MOD_CK1_1	5	11	PF00069	0.552
MOD_GlcNHglycan	159	162	PF01048	0.651
MOD_GlcNHglycan	163	166	PF01048	0.626
MOD_GlcNHglycan	29	32	PF01048	0.512
MOD_GlcNHglycan	40	43	PF01048	0.535
MOD_GSK3_1	129	136	PF00069	0.607
MOD_GSK3_1	155	162	PF00069	0.588
MOD_GSK3_1	201	208	PF00069	0.678
MOD_GSK3_1	4	11	PF00069	0.516
MOD_N-GLC_1	12	17	PF02516	0.658
MOD_N-GLC_1	138	143	PF02516	0.626
MOD_N-GLC_1	2	7	PF02516	0.567
MOD_NEK2_1	124	129	PF00069	0.609
MOD_NEK2_1	133	138	PF00069	0.535
MOD_NEK2_1	159	164	PF00069	0.647
MOD_NEK2_1	38	43	PF00069	0.495
MOD_NEK2_1	4	9	PF00069	0.509
MOD_PIKK_1	118	124	PF00454	0.718
MOD_PIKK_1	134	140	PF00454	0.406
MOD_PIKK_1	55	61	PF00454	0.299
MOD_Plk_4	129	135	PF00069	0.628
MOD_ProDKin_1	107	113	PF00069	0.664
MOD_ProDKin_1	116	122	PF00069	0.601
MOD_ProDKin_1	126	132	PF00069	0.417
MOD_ProDKin_1	163	169	PF00069	0.573
TRG_ENDOCYTIC_2	187	190	PF00928	0.675
TRG_ENDOCYTIC_2	25	28	PF00928	0.486

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I344	Leptomonas seymouri	71%	100%
A0A0S4ISK2	Bodo saltans	43%	100%
A0A1X0NLP8	Trypanosomatidae	46%	90%
A0A3S7X0C4	Leishmania donovani	90%	100%
A0A422NXG6	Trypanosoma rangeli	54%	81%
A4I361	Leishmania infantum	91%	100%
C9ZKV4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	44%	89%
E9ACZ2	Leishmania major	89%	100%
E9AYR7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
V5DCD8	Trypanosoma cruzi	51%	81%